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Protein

Cell division control protein 2 homolog

Gene

CRK

Organism
Crithidia fasciculata
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Activity regulationi

Phosphorylation at Thr-17 or Tyr-18 inactivates the enzyme.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 1365

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK
OrganismiCrithidia fasciculata
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857371 – 474Cell division control protein 2 homologAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphothreonineBy similarity1
Modified residuei18PhosphotyrosineBy similarity1
Modified residuei230PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ01917

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 446Protein kinasePROSITE-ProRule annotationAdd BLAST440

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q01917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLGRYRHV VKLGEGTYGM VYKGTEIQTG RVVAFKRMVV TSDDEGIPGA
60 70 80 90 100
AIREICLLKE LRHNNVVELF EVLFDPPKIT MIFELCDCDL KRYMESRPQR
110 120 130 140 150
LLDANTEMRP ILKQIFLGLE YLHGRCVVHR DMKPQNIFVN VRGPDFAAMT
160 170 180 190 200
ALPSSPQQSM RVPHAGGTNG EAGRASANGN EHAPRPTAAE GSVSPWEEAA
210 220 230 240 250
NTKDAPNQLI IKIGDFGLAR VEEIPVKKYS HEVVTLWYRS PDVLMSSALY
260 270 280 290 300
SYPVDIWSMG AIFFEMATSK VLFSGRNEDE QLLRMFWLLG SPTKETWPSM
310 320 330 340 350
MTYTGTMERL ERSSRAAAER QDLTVNGDVY VQQQQLQAQQ QQPQQGSSPS
360 370 380 390 400
HSSSRAPDLL TQLAHKRFYH SESAMQQRRE SASSAANSYR LPVELWFDRP
410 420 430 440 450
LFKEYMAATR CDVSVSPEGI DLLRRCLMYE PNQRITAAEA VHHPYLERVP
460 470
VPTAGSLDVL ISSLMQTMET IHLL
Length:474
Mass (Da):53,473
Last modified:July 1, 1993 - v1
Checksum:i57CA1361E3651A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12149 Genomic DNA Translation: CAA78133.1
PIRiS26381

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12149 Genomic DNA Translation: CAA78133.1
PIRiS26381

3D structure databases

ProteinModelPortaliQ01917
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01917

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.11.22 1365

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDC2H_CRIFA
AccessioniPrimary (citable) accession number: Q01917
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 10, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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