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Entry version 147 (07 Oct 2020)
Sequence version 2 (01 Oct 1996)
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Protein

Genome polyprotein

Gene
N/A
Organism
Papaya ringspot virus (strain P / mutant HA)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication.
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei456For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei465For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei499For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei890For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei963For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2327For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2362For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2431For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1486 – 1493ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C04.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapaya ringspot virus (strain P / mutant HA)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31731 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCarica papaya (Papaya) [TaxID: 3649]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006688 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000007380 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200101 – 3344Genome polyproteinAdd BLAST3344
ChainiPRO_00000403611 – 547P1 proteinaseBy similarityAdd BLAST547
ChainiPRO_0000040362548 – 1004Helper component proteinaseBy similarityAdd BLAST457
ChainiPRO_00000403631005 – 1349Protein P3By similarityAdd BLAST345
ChainiPRO_00000403641350 – 14016 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000403651402 – 2036Cytoplasmic inclusion proteinBy similarityAdd BLAST635
ChainiPRO_00000403662037 – 20936 kDa protein 2By similarityAdd BLAST57
ChainiPRO_00000403672094 – 2282Viral genome-linked proteinBy similarityAdd BLAST189
ChainiPRO_00000403682283 – 2520Nuclear inclusion protein ABy similarityAdd BLAST238
ChainiPRO_00000403692521 – 3057Nuclear inclusion protein BBy similarityAdd BLAST537
ChainiPRO_00000403703058 – 3344Capsid proteinBy similarityAdd BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2156O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei547 – 548Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei1004 – 1005Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1349 – 1350Cleavage; by NIa-proBy similarity2
Sitei1401 – 1402Cleavage; by NIa-proBy similarity2
Sitei2036 – 2037Cleavage; by NIa-proBy similarity2
Sitei2093 – 2094Cleavage; by NIa-proBy similarity2
Sitei2282 – 2283Cleavage; by NIa-proBy similarity2
Sitei2520 – 2521Cleavage; by NIa-proBy similarity2
Sitei3057 – 3058Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q01901

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini408 – 547Peptidase S30PROSITE-ProRule annotationAdd BLAST140
Domaini882 – 1004Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1473 – 1625Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1644 – 1803Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2283 – 2499Peptidase C4PROSITE-ProRule annotationAdd BLAST217
Domaini2761 – 2885RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi598 – 601Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi856 – 858Involved in virions binding and aphid transmissionBy similarity3
Motifi1575 – 1578DECH box4
Motifi2134 – 2141Nuclear localization signalSequence analysis8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR022199, DUF3725
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF12523, DUF3725, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: Q01901-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLYTLRAA AQYDRRLESK KGSGWVEHKL ERKGERGNTH YCSEFDISKG
60 70 80 90 100
AKILQLVQIG NTEVGRTFLE GNRFVRANIF EIIRKTMVGR LGYDFESELW
110 120 130 140 150
VCRNCDKTSE KYFKKCDCGE TYYYSERNLM RTMNDLMYQF DMTPSEINSV
160 170 180 190 200
DLEYLANAVD YAEQLVKRSQ VPEPVELAMM EPIVASGEGI LMVSEPEVMP
210 220 230 240 250
VTTKVEEAWT IQIGEIPVPL VVIKETPVIS GVEGTLNSTG FSLEADITKL
260 270 280 290 300
VEKEILQEEV KEAVHLALEV GNEIAEKKPE LKLIPYWSAS LELHKRIRKH
310 320 330 340 350
KEHAKIAAIQ VQKEREKDQK VFSALELRLN LKSRRRNQAV VCDKRGTLKW
360 370 380 390 400
ETQRGHKKSK LMQQASDFVV TQIHCDFGCK TQYSEPHIPG IKQSTSKKIC
410 420 430 440 450
KPRKHSRIVG NSKINYIMKN LCDTIIERGI PVELVTKRCK RRILQKEGRS
460 470 480 490 500
YVQLRHMNGI RARQDVSSSP DMELLFTQFC KFLVGHKPLK SKNLTFGSSG
510 520 530 540 550
LIFKPKFADN VGRYFGDYFV VRGRLGGKLF DGRSKLARSV YAKMDQYNDV
560 570 580 590 600
AEKFWLGFNR AFLRHRKPTD HTCTSDMDVT MCGEVAALAT IILFPCHKIT
610 620 630 640 650
CNTCMSKVKG RVIDEVGEDL NCELERLRET LSAYGGSFGH VSTLLDQLNR
660 670 680 690 700
VLNARNMNDG AFKEIAKKID EKKESPWTHM TTINNTLYKG SLATGYEFER
710 720 730 740 750
ASNSLREIVR WHLKRTESIK AGSVESFRNK RSGKAHFNPA LTCDNQLDKN
760 770 780 790 800
GNFLWGERQY HAKRFFANYF EKIDHSKGYE YYSQRQNPNG IRKIAIGNLV
810 820 830 840 850
FSTNLERFRQ QMVEHHIDQG PITRECIALR NNNYVHVCSC VTLDDGTPAT
860 870 880 890 900
SELKTPTKNH IVLGNSGDPK YVDLPTLESD SMYIAKKGYC YMNIFLAMLI
910 920 930 940 950
NIPENEAKDF TKRVRDLVGS KLGEWPTMLD VATCANQLVV FHPDAANAEL
960 970 980 990 1000
PQILVDHRQK TMHVIDSFGS VDSGYHILKA NTVNQLIQFA RDPLDSEMKH
1010 1020 1030 1040 1050
YIVGGEFDPT TNCLHQLIRV IYKPHELRSL LRNEPYLIVI ALMSPSVLLT
1060 1070 1080 1090 1100
LFNSGAVEHA LNYWIKRDQD VVEVIVLVEQ LCRKVTLART ILEQFNEIRQ
1110 1120 1130 1140 1150
NARDLHELMD RNNKPWISYD RSLELLSVYA NSQLTDEGLL KQGFSTLDPR
1160 1170 1180 1190 1200
LREAVEKTYA TLLQEEWRAL SLFQKLHLRY FAFKSQPSFS EYLKPKGRAD
1210 1220 1230 1240 1250
LKIVYDFSPK YCVHEVGKAF LLPVKAGAKI ASRIINGCGA FIRKSAAKGC
1260 1270 1280 1290 1300
AYIFKDLFQF VHVVLVLSIL LQIFRSAQGI ATEHLQLKQA KAEVERQKDF
1310 1320 1330 1340 1350
DRLEALYAEL CVKSGEQPTT EEFLDFVMER EPRLKDQAYN LIYIPVIHQA
1360 1370 1380 1390 1400
KSDNEKKLEQ VIAFITLILM MIDVDKSDCV YRILNKFKGV INSSNTNVYH
1410 1420 1430 1440 1450
QSLDDIRDFY EDKQLTIDFD ITGENQINRG PIDVTFEKWW DNQLSNNNTI
1460 1470 1480 1490 1500
GHYRIGGTFV EFSRVNAATV ASEIAHSPER EFLVRGAVGS GKSTNLPFLL
1510 1520 1530 1540 1550
SKHGSVLLIE PTRPLCENVC KQLRGEPFHC NPTIRMRGLT AFGSTNITIM
1560 1570 1580 1590 1600
TSGFALHYYA HNIQQLRLFD FIIFDECHVI DSQAMAFYCL MEGNAIEKKI
1610 1620 1630 1640 1650
LKVSATPPGR EVEFSTQFPT KIVTEQSISF KQLVDNFGTG ANSDVTAFAD
1660 1670 1680 1690 1700
NILVYVASYN EVDQLSKLLS DKGYLVTKID GRTMKVGKTE ISTSGTKFKK
1710 1720 1730 1740 1750
HFIVATNIIE NGVTLDIEAV IDFGMKVVPE MDSDNRMIRY SKQAISFGER
1760 1770 1780 1790 1800
IQRLGRVGRH KEGIALRIGH TEKGIQEIPE MAATEAAFLS FTYGLPVMTH
1810 1820 1830 1840 1850
NVGLSLLKNC TVRQARTMQQ YELSPFFTQN LVNFDGTVHP KIDVLLRPYK
1860 1870 1880 1890 1900
LRDCEVRLSE AAIPHGVQSI WLSARDYEAV GGRLCLEGDV RIPFLIKDVP
1910 1920 1930 1940 1950
ERLYKELWDI VQTYKRDFTF GRINSVSAGK IAYTLRTDVY SIPRTLITID
1960 1970 1980 1990 2000
KLIESENMKH AHFKAMTSCT GLNSSFSLLG VINTIQSRYL VDHSVENIRK
2010 2020 2030 2040 2050
LQLAKAQIQQ LEAHMQENNV ENLIQSLGAV RAVYHQSVDG FKHIKRELGL
2060 2070 2080 2090 2100
KGVWDGSLMI KDAIVCGFTM AGGAMLLYQH FRDKFTNVHV FHQGFSARQR
2110 2120 2130 2140 2150
QKLRFKSAAN AKLGREVYGD DGTIEHYFGE AYTKKGNKKG KMHGMGVKTR
2160 2170 2180 2190 2200
KFVATYGFKP EDYSYVRYLD PLTGETLDES PQTDISMVQD HFSDIRRKYM
2210 2220 2230 2240 2250
DSDSFDRQAL IANNTIKAYY VRNSAKAALE VDLTPHNPLK VCDNKLTIAG
2260 2270 2280 2290 2300
FPDREAELRQ TGPPRTIQVD QVPPPSKSVH HEGKSLCQGM RNYNGIASVV
2310 2320 2330 2340 2350
CHLKNTSGKG KSLFGIGYNS FIITNRHLFK ENNGELIVKS QHGKFIVKNT
2360 2370 2380 2390 2400
TTLQIAPVGK TDLLIIRMPK DFPPFHSRAR FRAMKAGDKV CMIGVDYQEN
2410 2420 2430 2440 2450
HIASKVSETS IISEGTGDFG CHWISTNDGD CGNPLVSVSD GFIVGLHSLS
2460 2470 2480 2490 2500
TSTGDQNFFA KIPAQFEEKV LRKIDDLTWS KHWSYNINEL SWGALKVWES
2510 2520 2530 2540 2550
RPEAIFNAQK EVNQLNVFEQ SGGRWLFDKL HGNLKGVSSA PSNLVTKHVV
2560 2570 2580 2590 2600
KGICPLFRNY LECDEEAKAF FSPLMGHYMK SVLSKEAYIK DLLKYSSDIV
2610 2620 2630 2640 2650
VGEVNHDVFE DSVAQVIELL NDHECPELEY ITDSEVIIQA LNMDAAVGAL
2660 2670 2680 2690 2700
YTGKKRKYFE GSTVEHRQAL VRKSCERLYE GRMGVWNGSL KAELRPAEKV
2710 2720 2730 2740 2750
LAKKTRSFTA APLDTLLGAK VCVDDFNNWF YSKNMECPWT VGMTKFYKGW
2760 2770 2780 2790 2800
DEFLKKFPDG WVYCDADGSQ FDSSLTPYLL NAVLSIRLWA MEDWDIGEQM
2810 2820 2830 2840 2850
LKNLYGEITY TPILTPDGTI VKKFKGNNSG QPSTVVDNTL MVLITMYYAL
2860 2870 2880 2890 2900
RKAGYDTKTQ EDMCVFYING DDLCIAIHPD HEHVLDSFSS SFAELGLKYD
2910 2920 2930 2940 2950
FAQRHRNKQN LWFMSHRGIL IDDIYIPKLE PERIVAILEW DKSKLPEHRL
2960 2970 2980 2990 3000
EAITAAMIES WGYGDLTHQI RRFYQWVLEQ APFNELAKQG RAPYVSEVGL
3010 3020 3030 3040 3050
RRLYTSERGS MDELEAYIDK YFERERGDSP ELLVYHESRG TDDYQLVCSN
3060 3070 3080 3090 3100
NTHVFHQSKN EAVDAGLNEK LKEKEKQKEK EKEKQKEKEK DGASDGNDVS
3110 3120 3130 3140 3150
TSTKTGERDR DVNVGTSGTF TVPRIKSFTD KMVLPRIKGK TVLNLNHLLQ
3160 3170 3180 3190 3200
YNPQQIDISN TRATHSQFEK WYEGVRNDYG LNDNEMQVML NGLMVWCIEN
3210 3220 3230 3240 3250
GTSPDISGVW VMMDGETQVD YPIKPLIEHA TPSFRQIMAH FSNAAEAYIA
3260 3270 3280 3290 3300
KRNATERYMP RYGIKRNLTD ISLARYAFDF YEVNSKTPDR AREAHMQMKA
3310 3320 3330 3340
AALRNTSRRM FGMDGSVSNK EENTERHTVE DVNRDMHSLL GMRN
Note: Produced by conventional translation.
Length:3,344
Mass (Da):381,046
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE90CD7523AC5243D
GO
Isoform P3N-PIPO polyprotein (identifier: P0CJ98-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CJ98.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,228
Mass (Da):140,607
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X67673 Genomic RNA Translation: CAA47905.1
S46722 Genomic RNA Translation: AAB23789.1
X67672 Genomic RNA Translation: CAA47904.1

Protein sequence database of the Protein Information Resource

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PIRi
JQ1899

NCBI Reference Sequences

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RefSeqi
NP_056758.1, NC_001785.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1494043

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:1494043

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67673 Genomic RNA Translation: CAA47905.1
S46722 Genomic RNA Translation: AAB23789.1
X67672 Genomic RNA Translation: CAA47904.1
PIRiJQ1899
RefSeqiNP_056758.1, NC_001785.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC04.009

Proteomic databases

PRIDEiQ01901

Genome annotation databases

GeneIDi1494043
KEGGivg:1494043

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR022199, DUF3725
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF12523, DUF3725, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_PRSVH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01901
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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