POU5F1

Functionⁱ

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.1 Publication

Miscellaneous

Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	157	DNABy similarity		1
Binding siteⁱ	164	DNABy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	230 – 289	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding
Source: HGNC
Inferred from direct assayⁱ
- 16153702
DNA-binding transcription factor activity
Source: HGNC
Inferred from direct assayⁱ
- 16153702
DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- 19409607
miRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18710938
- 19409607
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 20713518
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19736317
transcription regulatory region DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
transcription regulatory region sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19409607
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19274063

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 9814708
blastocyst development Source: BHF-UCL
BMP signaling pathway involved in heart induction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19736317
cardiac cell fate determination
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
cell fate commitment involved in formation of primary germ layer
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19736317
endodermal cell fate specification
Source: MGI
Inferred from direct assayⁱ
- 20713518
mRNA transcription by RNA polymerase II Source: BHF-UCL
negative regulation of gene silencing by miRNA
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19409607
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 19409607
positive regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
positive regulation of SMAD protein signal transduction
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
regulation of asymmetric cell division Source: BHF-UCL
regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18388306
regulation of heart induction by regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19736317
regulation of methylation-dependent chromatin silencing
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736317
regulation of transcription, DNA-templated
Source: HGNC
Inferred from direct assayⁱ
- 16153702
response to wounding
Source: UniProtKB
Inferred from expression patternⁱ
- 17982423
somatic stem cell population maintenance
Source: UniProtKB
Inferred from direct assayⁱ
- 19409607
transcription by RNA polymerase II Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkⁱ	Q01860
SIGNORⁱ	Q01860

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 5, transcription factor 1 Alternative name(s): Octamer-binding protein 3 Short name: Oct-3 Octamer-binding protein 4 Short name: Oct-4 Octamer-binding transcription factor 3 Short name: OTF-3
Gene namesⁱ	Name:POU5F1 Synonyms:OCT3, OCT4, OTF3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204531.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9221 POU5F1
MIMⁱ	164177 gene
neXtProtⁱ	NX_Q01860

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Biotechnological useⁱ

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5460
Open Targets More...OpenTargetsⁱ	ENSG00000204531
PharmGKBⁱ	PA33545

Chemistry databases

ChEMBLⁱ	CHEMBL3580526
Drug and drug target database More...DrugBankⁱ	DB00988 Dopamine DB00368 Norepinephrine

Polymorphism and mutation databases

DMDMⁱ	400659

DMDMⁱ

400659

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100747	1 – 360	POU domain, class 5, transcription factor 1Add BLAST		360

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	111	Phosphoserine; by MAPK2 Publications	1
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	235	Phosphothreonine1 Publication	1
Modified residueⁱ	236	Phosphoserine1 Publication	1
Modified residueⁱ	289	Phosphoserine1 Publication	1
Modified residueⁱ	290	Phosphoserine1 Publication	1
Modified residueⁱ	355	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.By similarity

Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.By similarity

ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.2 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q01860
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01860
PaxDbⁱ	Q01860
PeptideAtlas More...PeptideAtlasⁱ	Q01860
PRIDEⁱ	Q01860
ProteomicsDBⁱ	58011 58012 [Q01860-2]

PTM databases

iPTMnetⁱ	Q01860
PhosphoSitePlusⁱ	Q01860

Expressionⁱ

Tissue specificityⁱ

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.2 Publications

Developmental stageⁱ

Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation.1 Publication

Inductionⁱ

Transcriptional activity is positively regulated by PKM.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000204531 Expressed in 85 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	Q01860 baseline and differential
Genevisibleⁱ	Q01860 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025600 CAB026380 HPA058267

HPAⁱ

CAB025600
CAB026380
HPA058267

Interactionⁱ

Subunit structureⁱ

Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2. Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (By similarity). Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355 (By similarity). Interacts (when phosphorylated on Ser-355) with FBXW8 (By similarity). Interacts with FBXW4 (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P03259	2	EBI-475687,EBI-6947456	From Human adenovirus A serotype 12.
CTCF	P49711	2	EBI-475687,EBI-932887
E1A	Q8JSK4	2	EBI-475687,EBI-7453955	From Human adenovirus B serotype 3.
FOXD3	Q9UJU5	2	EBI-475687,EBI-475674
Hmgb1	P63158	3	EBI-475687,EBI-6665811	From Mus musculus.
MBD3	O95983	3	EBI-475687,EBI-1783068
WWP2	O00308	4	EBI-475687,EBI-743923

GO - Molecular functionⁱ

transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19736317
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19274063

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111456, 317 interactors
CORUMⁱ	Q01860
Database of interacting proteins More...DIPⁱ	DIP-33440N
ELMⁱ	Q01860
IntActⁱ	Q01860, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q01860
STRINGⁱ	9606.ENSP00000259915

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01860
SMRⁱ	Q01860
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	138 – 212	POU-specificPROSITE-ProRule annotationAdd BLAST		75

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	180 – 186	DNA bindingBy similarity		7
Regionⁱ	193 – 196	DNA bindingBy similarity		4

Domainⁱ

The POU-specific domain mediates interaction with PKM.1 Publication

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-5 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOVERGENⁱ	HBG057998
InParanoidⁱ	Q01860
KEGG Orthology (KO) More...KOⁱ	K09367
OMAⁱ	LENMFLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	Q01860
TreeFamⁱ	TF316413

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR015585 POU_dom_5
PANTHERⁱ	PTHR11636:SF86 PTHR11636:SF86, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: Q01860-1) [UniParc]FASTA Add to basket

Also known as: Oct-3A, Oct3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG 
        60         70         80         90        100
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG 
       110        120        130        140        150
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA 
       160        170        180        190        200
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL 
       210        220        230        240        250
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL 
       260        270        280        290        300
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 
       310        320        330        340        350
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV 
       360
TTLGSPMHSN

Length:360

Mass (Da):38,571

Last modified:July 1, 1993 - v1

Checksum:ⁱ934C58DAEA0C535B

GO

Isoform B (identifier: Q01860-2) [UniParc]FASTA Add to basket

Also known as: Oct-3B, Oct3B

The sequence of this isoform differs from the canonical sequence as follows:
1-135: MAGHLASDFA...KEKLEQNPEE → MHFYRLFLGA...LTSLLPFKIQ

« Hide

        10         20         30         40         50
MHFYRLFLGA TRRFLNPEWK GEIDNWCVYV LTSLLPFKIQ SQDIKALQKE 
        60         70         80         90        100
LEQFAKLLKQ KRITLGYTQA DVGLTLGVLF GKVFSQTTIC RFEALQLSFK 
       110        120        130        140        150
NMCKLRPLLQ KWVEEADNNE NLQEICKAET LVQARKRKRT SIENRVRGNL 
       160        170        180        190        200
ENLFLQCPKP TLQQISHIAQ QLGLEKDVVR VWFCNRRQKG KRSSSDYAQR 
       210        220        230        240        250
EDFEAAGSPF SGGPVSFPLA PGPHFGTPGY GSPHFTALYS SVPFPEGEAF 
       260 
PPVSVTTLGS PMHSN

Show »

Length:265

Mass (Da):30,085

Checksum:ⁱ41C21E136EFBCBB2

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

U3KQH6	U3KQH6_HUMAN	POU domain protein POU domain protein	POU5F1	190	Annotation score:
M1S623	M1S623_HUMAN	POU domain protein POU domain protein	POU5F1	190	Annotation score:
F2Z381	F2Z381_HUMAN	POU class 5 homeobox 1 transcript v... POU class 5 homeobox 1 transcript variant 6 (POU class 5 homeobox 1 transcript variant OCT4B1) (POU class 5 homeobox 1 transcript variant OCT4B2) (POU class 5 homeobox 1 transcript variant OCT4B3) (POU domain, class 5, transcription factor 1)	POU5F1	164	Annotation score:
A0A1W2PP83	A0A1W2PP83_HUMAN	POU domain, class 5, transcription ... POU domain, class 5, transcription factor 1	POU5F1	123	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	189	A → G in CAA79974 (PubMed:7908264).Curated	1
Sequence conflictⁱ	220	I → T in CAA79974 (PubMed:7908264).Curated	1
Sequence conflictⁱ	227	V → L in CAA79974 (PubMed:7908264).Curated	1
Sequence conflictⁱ	230	R → G in CAA79975 (PubMed:7908264).Curated	1
Sequence conflictⁱ	240	R → Q in CAA79975 (PubMed:7908264).Curated	1
Sequence conflictⁱ	251	Q → R in CAA79975 (PubMed:7908264).Curated	1
Sequence conflictⁱ	272	D → DVVR in AAB35990 (PubMed:8567814).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_046203	226	L → F. Corresponds to variant dbSNP:rs1150767Ensembl.	1
Natural variantⁱVAR_003774	322	T → A1 Publication	1
Natural variantⁱVAR_046204	351	T → I. Corresponds to variant dbSNP:rs1061120Ensembl.	1
Natural variantⁱVAR_003775	357	M → L1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002333	1 – 135	MAGHL…QNPEE → MHFYRLFLGATRRFLNPEWK GEIDNWCVYVLTSLLPFKIQ in isoform B. 1 PublicationAdd BLAST		135

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z11898 mRNA Translation: CAA77951.1 Z11899 mRNA Translation: CAA77952.1 GQ472773 Genomic DNA Translation: ACZ95700.1 AB088113 Genomic DNA Translation: BAC54946.1 AB202105 Genomic DNA Translation: BAE78630.1 AB103619 Genomic DNA Translation: BAF31281.1 BA000025 Genomic DNA Translation: BAB63311.1 AL662833 Genomic DNA No translation available. AL662844 Genomic DNA No translation available. AL773544 Genomic DNA No translation available. BX088580 Genomic DNA No translation available. CR759815 Genomic DNA No translation available. CR388229 Genomic DNA No translation available. CR847794 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03367.1 CH471081 Genomic DNA Translation: EAX03368.1 BC117435 mRNA Translation: AAI17436.1 BC117437 mRNA Translation: AAI17438.1 Z21963 mRNA Translation: CAA79974.1 Z21964 mRNA Translation: CAA79975.1 S81255 mRNA Translation: AAB35990.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34391.1 [Q01860-1]
PIRⁱ	S25561 S32652
NCBI Reference Sequences More...RefSeqⁱ	NP_001272916.1, NM_001285987.1 [Q01860-2] NP_002692.2, NM_002701.5 [Q01860-1]
UniGeneⁱ	Hs.249184 Hs.632482 Hs.646545

Genome annotation databases

Ensemblⁱ	ENST00000259915; ENSP00000259915; ENSG00000204531 [Q01860-1] ENST00000376243; ENSP00000365419; ENSG00000206454 [Q01860-2] ENST00000383524; ENSP00000373016; ENSG00000206454 [Q01860-1] ENST00000412166; ENSP00000387646; ENSG00000229094 [Q01860-2] ENST00000419095; ENSP00000413622; ENSG00000235068 [Q01860-2] ENST00000429314; ENSP00000387619; ENSG00000237582 [Q01860-2] ENST00000429603; ENSP00000392877; ENSG00000233911 [Q01860-1] ENST00000433063; ENSP00000405041; ENSG00000235068 [Q01860-1] ENST00000433348; ENSP00000412665; ENSG00000230336 [Q01860-2] ENST00000434616; ENSP00000388842; ENSG00000229094 [Q01860-1] ENST00000437747; ENSP00000391681; ENSG00000237582 [Q01860-1] ENST00000451077; ENSP00000391507; ENSG00000233911 [Q01860-2] ENST00000454714; ENSP00000400047; ENSG00000230336 [Q01860-1]
GeneIDⁱ	5460
KEGGⁱ	hsa:5460
UCSC genome browser More...UCSCⁱ	uc003nsv.4 human [Q01860-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01860	POU domain protein		HUMAN		360	UniRef100_Q01860
POU domain protein		PANTR		360
POU domain protein		PANPA		360
POU domain protein		GORGO		360
POU domain protein (Fragment)		PONAB		190
+21
Q01860-2	POU domain protein		NOMLE		264	UniRef100_Q01860-2

Protein	Similar proteins		Species	Score	Length	Source
Q01860	POU domain, class 5, transcription factor 1		MACMU		360	UniRef90_Q01860
POU domain, class 5, transcription factor 1		PANTR		360
Putative POU domain, class 5, transcription factor 1B		HUMAN		359
POU domain protein		PANPA		360
POU domain protein		GORGO		360
+89
Q01860-2	POU domain protein		NOMLE		264	UniRef90_Q01860-2
POU domain protein		COLAP		269
POU domain protein		MACFA		268
POU domain protein		CERAT		268
POU domain protein		MANLE		268
+4

Protein	Similar proteins		Species	Score	Length	Source
Q01860	POU domain, class 5, transcription factor 1		PANTR		360	UniRef50_Q01860
POU domain, class 5, transcription factor 1		MACMU		360
Putative POU domain, class 5, transcription factor 1B		HUMAN		359
POU domain, class 5, transcription factor 1		PIG		360
POU domain, class 5, transcription factor 1		BOVIN		360
+206
Q01860-2	POU domain protein		NOMLE		264	UniRef50_Q01860-2
POU domain protein		COLAP		269
POU domain protein		MACFA		268
POU domain protein		CERAT		268
POU domain protein		MANLE		268
+60

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Oct-4 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z11898 mRNA Translation: CAA77951.1 Z11899 mRNA Translation: CAA77952.1 GQ472773 Genomic DNA Translation: ACZ95700.1 AB088113 Genomic DNA Translation: BAC54946.1 AB202105 Genomic DNA Translation: BAE78630.1 AB103619 Genomic DNA Translation: BAF31281.1 BA000025 Genomic DNA Translation: BAB63311.1 AL662833 Genomic DNA No translation available. AL662844 Genomic DNA No translation available. AL773544 Genomic DNA No translation available. BX088580 Genomic DNA No translation available. CR759815 Genomic DNA No translation available. CR388229 Genomic DNA No translation available. CR847794 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03367.1 CH471081 Genomic DNA Translation: EAX03368.1 BC117435 mRNA Translation: AAI17436.1 BC117437 mRNA Translation: AAI17438.1 Z21963 mRNA Translation: CAA79974.1 Z21964 mRNA Translation: CAA79975.1 S81255 mRNA Translation: AAB35990.1
CCDSⁱ	CCDS34391.1 [Q01860-1]
PIRⁱ	S25561 S32652
RefSeqⁱ	NP_001272916.1, NM_001285987.1 [Q01860-2] NP_002692.2, NM_002701.5 [Q01860-1]
UniGeneⁱ	Hs.249184 Hs.632482 Hs.646545

3D structure databases

ProteinModelPortalⁱ	Q01860
SMRⁱ	Q01860
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111456, 317 interactors
CORUMⁱ	Q01860
DIPⁱ	DIP-33440N
ELMⁱ	Q01860
IntActⁱ	Q01860, 16 interactors
MINTⁱ	Q01860
STRINGⁱ	9606.ENSP00000259915

Chemistry databases

ChEMBLⁱ	CHEMBL3580526
DrugBankⁱ	DB00988 Dopamine DB00368 Norepinephrine

PTM databases

iPTMnetⁱ	Q01860
PhosphoSitePlusⁱ	Q01860

Polymorphism and mutation databases

DMDMⁱ	400659

DMDMⁱ

400659

Proteomic databases

EPDⁱ	Q01860
MaxQBⁱ	Q01860
PaxDbⁱ	Q01860
PeptideAtlasⁱ	Q01860
PRIDEⁱ	Q01860
ProteomicsDBⁱ	58011 58012 [Q01860-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5460
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259915; ENSP00000259915; ENSG00000204531 [Q01860-1] ENST00000376243; ENSP00000365419; ENSG00000206454 [Q01860-2] ENST00000383524; ENSP00000373016; ENSG00000206454 [Q01860-1] ENST00000412166; ENSP00000387646; ENSG00000229094 [Q01860-2] ENST00000419095; ENSP00000413622; ENSG00000235068 [Q01860-2] ENST00000429314; ENSP00000387619; ENSG00000237582 [Q01860-2] ENST00000429603; ENSP00000392877; ENSG00000233911 [Q01860-1] ENST00000433063; ENSP00000405041; ENSG00000235068 [Q01860-1] ENST00000433348; ENSP00000412665; ENSG00000230336 [Q01860-2] ENST00000434616; ENSP00000388842; ENSG00000229094 [Q01860-1] ENST00000437747; ENSP00000391681; ENSG00000237582 [Q01860-1] ENST00000451077; ENSP00000391507; ENSG00000233911 [Q01860-2] ENST00000454714; ENSP00000400047; ENSG00000230336 [Q01860-1]
GeneIDⁱ	5460
KEGGⁱ	hsa:5460
UCSCⁱ	uc003nsv.4 human [Q01860-1]

Organism-specific databases

CTDⁱ	5460
DisGeNETⁱ	5460
EuPathDBⁱ	HostDB:ENSG00000204531.15
GeneCardsⁱ	POU5F1
H-InvDBⁱ	HIX0028582 HIX0036717 HIX0159939 HIX0164984 HIX0166817 HIX0167068 HIX0167306 HIX0167552 HIX0168865 HIX0201948
HGNCⁱ	HGNC:9221 POU5F1
HPAⁱ	CAB025600 CAB026380 HPA058267
MIMⁱ	164177 gene
neXtProtⁱ	NX_Q01860
OpenTargetsⁱ	ENSG00000204531
PharmGKBⁱ	PA33545
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
GeneTreeⁱ	ENSGT00760000118935
HOVERGENⁱ	HBG057998
InParanoidⁱ	Q01860
KOⁱ	K09367
OMAⁱ	LENMFLQ
OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	Q01860
TreeFamⁱ	TF316413

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkⁱ	Q01860
SIGNORⁱ	Q01860

Miscellaneous databases

GenomeRNAiⁱ	5460
Protein Ontology More...PROⁱ	PR:Q01860
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204531 Expressed in 85 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	Q01860 baseline and differential
Genevisibleⁱ	Q01860 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR015585 POU_dom_5
PANTHERⁱ	PTHR11636:SF86 PTHR11636:SF86, 1 hit
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO5F1_HUMAN
Accessionⁱ	Q01860Primary (citable) accession number: Q01860 Secondary accession number(s): A6NCS1 Q5STF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q01860 (PO5F1_HUMAN)

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POU domain, class 5, transcription factor 1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Biotechnological useⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ