UniProtKB - Q01851 (PO4F1_HUMAN)
POU domain, class 4, transcription factor 1
POU4F1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 356 – 415 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: ParkinsonsUK-UCL
- GTPase binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- single-stranded DNA binding Source: UniProtKB
GO - Biological processi
- axonogenesis Source: BHF-UCL
- cell differentiation Source: GO_Central
- cell migration in hindbrain Source: Ensembl
- cellular response to cytokine stimulus Source: UniProtKB
- cellular response to estradiol stimulus Source: UniProtKB
- central nervous system neuron differentiation Source: Ensembl
- habenula development Source: Ensembl
- heart development Source: ARUK-UCL
- innervation Source: BHF-UCL
- intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
- mesoderm development Source: Ensembl
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of neuron apoptotic process Source: UniProtKB
- negative regulation of programmed cell death Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of transcription elongation by RNA polymerase I Source: Ensembl
- neuron fate specification Source: BHF-UCL
- neuron projection development Source: UniProtKB
- peripheral nervous system neuron development Source: BHF-UCL
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell cycle arrest Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of osteoclast differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
- positive regulation of transcription regulatory region DNA binding Source: UniProtKB
- proprioception involved in equilibrioception Source: Ensembl
- regulation of DNA-binding transcription factor activity Source: UniProtKB
- regulation of neurogenesis Source: Ensembl
- regulation of signal transduction by p53 class mediator Source: Reactome
- sensory system development Source: BHF-UCL
- suckling behavior Source: Ensembl
- synapse assembly Source: ProtInc
- trigeminal nerve development Source: BHF-UCL
- ventricular compact myocardium morphogenesis Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q01851 |
Reactomei | R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors |
SIGNORi | Q01851 |
Names & Taxonomyi
Protein namesi | Recommended name: POU domain, class 4, transcription factor 1ImportedAlternative name(s): Brain-specific homeobox/POU domain protein 3A Short name: Brain-3A Short name: Brn-3A Homeobox/POU domain protein RDC-1 Oct-T1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152192.7 |
HGNCi | HGNC:9218, POU4F1 |
MIMi | 601632, gene |
neXtProti | NX_Q01851 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- neuron projection Source: Ensembl
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5457 |
OpenTargetsi | ENSG00000152192 |
PharmGKBi | PA33542 |
Miscellaneous databases
Pharosi | Q01851, Tbio |
Polymorphism and mutation databases
BioMutai | POU4F1 |
DMDMi | 334302933 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100736 | 1 – 419 | POU domain, class 4, transcription factor 1Add BLAST | 419 |
Proteomic databases
MassIVEi | Q01851 |
PaxDbi | Q01851 |
PeptideAtlasi | Q01851 |
PRIDEi | Q01851 |
ProteomicsDBi | 58010 |
PTM databases
iPTMneti | Q01851 |
PhosphoSitePlusi | Q01851 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000152192, Expressed in secondary oocyte and 64 other tissues |
Genevisiblei | Q01851, HS |
Organism-specific databases
HPAi | ENSG00000152192, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts (via N-terminus) with RIT2; the interaction controls POU4F1 transactivation activity on some neuronal target genes.
Isoform 1 interacts with POU4F2; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Isoform 1 interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction decreases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
By similarityBinary interactionsi
Q01851
With | #Exp. | IntAct |
---|---|---|
MAPRE3 [Q9UPY8] | 3 | EBI-17480471,EBI-726739 |
GO - Molecular functioni
- GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111453, 4 interactors |
IntActi | Q01851, 2 interactors |
MINTi | Q01851 |
STRINGi | 9606.ENSP00000366413 |
Miscellaneous databases
RNActi | Q01851, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 261 – 338 | POU-specificPROSITE-ProRule annotationAdd BLAST | 78 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 57 – 66 | POU-IV box | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 100 – 108 | Poly-His | 9 | |
Compositional biasi | 130 – 186 | Gly-richAdd BLAST | 57 | |
Compositional biasi | 204 – 257 | Ala-richAdd BLAST | 54 |
Domaini
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG1168, Eukaryota |
GeneTreei | ENSGT00940000162154 |
HOGENOMi | CLU_013065_0_0_1 |
InParanoidi | Q01851 |
OMAi | DIMDHIG |
OrthoDBi | 929123at2759 |
PhylomeDBi | Q01851 |
TreeFami | TF316413 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit cd00093, HTH_XRE, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR001387, Cro/C1-type_HTH IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf IPR013847, POU IPR015584, POU4-TF1 IPR000327, POU_dom |
PANTHERi | PTHR11636:SF42, PTHR11636:SF42, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00157, Pou, 1 hit |
PRINTSi | PR00028, POUDOMAIN |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00352, POU, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00035, POU_1, 1 hit PS00465, POU_2, 1 hit PS51179, POU_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL
60 70 80 90 100
DETLLARAEA LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH
110 120 130 140 150
HHHHHHHHQA LEPGDLLDHI SSPSLALMAG AGGAGAAAGG GGAHDGPGGG
160 170 180 190 200
GGPGGGGGPG GGPGGGGGGG PGGGGGGPGG GLLGGSAHPH PHMHSLGHLS
210 220 230 240 250
HPAAAAAMNM PSGLPHPGLV AAAAHHGAAA AAAAAAAGQV AAASAAAAVV
260 270 280 290 300
GAAGLASICD SDTDPRELEA FAERFKQRRI KLGVTQADVG SALANLKIPG
310 320 330 340 350
VGSLSQSTIC RFESLTLSHN NMIALKPILQ AWLEEAEGAQ REKMNKPELF
360 370 380 390 400
NGGEKKRKRT SIAAPEKRSL EAYFAVQPRP SSEKIAAIAE KLDLKKNVVR
410
VWFCNQRQKQ KRMKFSATY
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 – 92 | TS → H in CAA45907 (PubMed:1357630).Curated | 2 | |
Sequence conflicti | 99 | A → R in AAA57161 (PubMed:7623109).Curated | 1 | |
Sequence conflicti | 129 | A → AGAG in AAA57161 (PubMed:7623109).Curated | 1 | |
Sequence conflicti | 146 – 147 | GP → AA in CAA45907 (PubMed:1357630).Curated | 2 | |
Sequence conflicti | 152 – 153 | GP → PR in CAA45907 (PubMed:1357630).Curated | 2 | |
Sequence conflicti | 159 | P → PG in AAA65605 (PubMed:8234287).Curated | 1 | |
Sequence conflicti | 159 | P → PG in AAA57161 (PubMed:7623109).Curated | 1 | |
Sequence conflicti | 159 | P → PG in CAA45907 (PubMed:1357630).Curated | 1 | |
Sequence conflicti | 170 – 171 | GP → AA in CAA45907 (PubMed:1357630).Curated | 2 | |
Sequence conflicti | 185 | G → A in CAA45907 (PubMed:1357630).Curated | 1 | |
Sequence conflicti | 236 | A → S in AAA65605 (PubMed:8234287).Curated | 1 | |
Sequence conflicti | 245 | Missing in CAA45907 (PubMed:1357630).Curated | 1 | |
Sequence conflicti | 252 | A → R in CAA45907 (PubMed:1357630).Curated | 1 | |
Sequence conflicti | 272 – 274 | AER → GS in CAA45907 (PubMed:1357630).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046449 | 163 | Missing . | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058636 | 1 – 84 | Missing in isoform 2. CuratedAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20433 mRNA Translation: AAA65605.1 U10063, U10062 Genomic DNA Translation: AAA57161.1 AL445209 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80585.1 X64624 mRNA Translation: CAA45907.1 Frameshift. |
CCDSi | CCDS31996.1 [Q01851-1] |
PIRi | I59234 S78452 |
RefSeqi | NP_006228.3, NM_006237.3 [Q01851-1] |
Genome annotation databases
Ensembli | ENST00000377208; ENSP00000366413; ENSG00000152192 [Q01851-1] |
GeneIDi | 5457 |
KEGGi | hsa:5457 |
UCSCi | uc001vkv.4, human [Q01851-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20433 mRNA Translation: AAA65605.1 U10063, U10062 Genomic DNA Translation: AAA57161.1 AL445209 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80585.1 X64624 mRNA Translation: CAA45907.1 Frameshift. |
CCDSi | CCDS31996.1 [Q01851-1] |
PIRi | I59234 S78452 |
RefSeqi | NP_006228.3, NM_006237.3 [Q01851-1] |
3D structure databases
SMRi | Q01851 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111453, 4 interactors |
IntActi | Q01851, 2 interactors |
MINTi | Q01851 |
STRINGi | 9606.ENSP00000366413 |
PTM databases
iPTMneti | Q01851 |
PhosphoSitePlusi | Q01851 |
Polymorphism and mutation databases
BioMutai | POU4F1 |
DMDMi | 334302933 |
Proteomic databases
MassIVEi | Q01851 |
PaxDbi | Q01851 |
PeptideAtlasi | Q01851 |
PRIDEi | Q01851 |
ProteomicsDBi | 58010 |
Protocols and materials databases
Antibodypediai | 24689, 145 antibodies |
DNASUi | 5457 |
Genome annotation databases
Ensembli | ENST00000377208; ENSP00000366413; ENSG00000152192 [Q01851-1] |
GeneIDi | 5457 |
KEGGi | hsa:5457 |
UCSCi | uc001vkv.4, human [Q01851-1] |
Organism-specific databases
CTDi | 5457 |
DisGeNETi | 5457 |
EuPathDBi | HostDB:ENSG00000152192.7 |
GeneCardsi | POU4F1 |
HGNCi | HGNC:9218, POU4F1 |
HPAi | ENSG00000152192, Tissue enriched (brain) |
MIMi | 601632, gene |
neXtProti | NX_Q01851 |
OpenTargetsi | ENSG00000152192 |
PharmGKBi | PA33542 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1168, Eukaryota |
GeneTreei | ENSGT00940000162154 |
HOGENOMi | CLU_013065_0_0_1 |
InParanoidi | Q01851 |
OMAi | DIMDHIG |
OrthoDBi | 929123at2759 |
PhylomeDBi | Q01851 |
TreeFami | TF316413 |
Enzyme and pathway databases
PathwayCommonsi | Q01851 |
Reactomei | R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors |
SIGNORi | Q01851 |
Miscellaneous databases
BioGRID-ORCSi | 5457, 3 hits in 871 CRISPR screens |
GeneWikii | POU4F1 |
GenomeRNAii | 5457 |
Pharosi | Q01851, Tbio |
PROi | PR:Q01851 |
RNActi | Q01851, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152192, Expressed in secondary oocyte and 64 other tissues |
Genevisiblei | Q01851, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit cd00093, HTH_XRE, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR001387, Cro/C1-type_HTH IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf IPR013847, POU IPR015584, POU4-TF1 IPR000327, POU_dom |
PANTHERi | PTHR11636:SF42, PTHR11636:SF42, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00157, Pou, 1 hit |
PRINTSi | PR00028, POUDOMAIN |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00352, POU, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00035, POU_1, 1 hit PS00465, POU_2, 1 hit PS51179, POU_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PO4F1_HUMAN | |
Accessioni | Q01851Primary (citable) accession number: Q01851 Secondary accession number(s): Q14986, Q15318, Q5T227 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | May 31, 2011 | |
Last modified: | December 2, 2020 | |
This is version 192 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations