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UniProtKB - Q01850 (CDR2_HUMAN)
Protein
Cerebellar degeneration-related protein 2
Gene
CDR2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Cerebellar degeneration-related protein 2Alternative name(s): Major Yo paraneoplastic antigen Paraneoplastic cerebellar degeneration-associated antigen |
Gene namesi | Name:CDR2 Synonyms:PCD17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1799, CDR2 |
MIMi | 117340, gene |
neXtProti | NX_Q01850 |
VEuPathDBi | HostDB:ENSG00000140743 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1039 |
OpenTargetsi | ENSG00000140743 |
PharmGKBi | PA26331 |
Miscellaneous databases
Pharosi | Q01850, Tbio |
Genetic variation databases
BioMutai | CDR2 |
DMDMi | 68839004 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089456 | 1 – 454 | Cerebellar degeneration-related protein 2Add BLAST | 454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 311 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q01850 |
jPOSTi | Q01850 |
MassIVEi | Q01850 |
MaxQBi | Q01850 |
PaxDbi | Q01850 |
PeptideAtlasi | Q01850 |
PRIDEi | Q01850 |
ProteomicsDBi | 58009 |
PTM databases
GlyGeni | Q01850, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q01850 |
PhosphoSitePlusi | Q01850 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140743, Expressed in pigmented layer of retina and 222 other tissues |
ExpressionAtlasi | Q01850, baseline and differential |
Genevisiblei | Q01850, HS |
Organism-specific databases
HPAi | ENSG00000140743, Low tissue specificity |
Interactioni
Binary interactionsi
Q01850
Protein-protein interaction databases
BioGRIDi | 107470, 126 interactors |
IntActi | Q01850, 107 interactors |
MINTi | Q01850 |
STRINGi | 9606.ENSP00000268383 |
Miscellaneous databases
RNActi | Q01850, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 134 – 153 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 44 – 142 | Sequence analysisAdd BLAST | 99 | |
Coiled coili | 192 – 265 | Sequence analysisAdd BLAST | 74 | |
Coiled coili | 346 – 380 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the CDR2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QUPP, Eukaryota |
GeneTreei | ENSGT00390000018570 |
HOGENOMi | CLU_048751_0_0_1 |
InParanoidi | Q01850 |
OMAi | KHKAVQT |
OrthoDBi | 1101523at2759 |
PhylomeDBi | Q01850 |
TreeFami | TF326183 |
Family and domain databases
InterProi | View protein in InterPro IPR026079, CDR2 |
PANTHERi | PTHR19232, PTHR19232, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q01850-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ
60 70 80 90 100
QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK
110 120 130 140 150
LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD
160 170 180 190 200
QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK
210 220 230 240 250
TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL
260 270 280 290 300
EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE
310 320 330 340 350
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD
360 370 380 390 400
TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA
410 420 430 440 450
SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL
SSHS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BU23 | H3BU23_HUMAN | Cerebellar degeneration-related pro... | CDR2 | 234 | Annotation score: | ||
H3BN65 | H3BN65_HUMAN | Cerebellar degeneration-related pro... | CDR2 | 62 | Annotation score: | ||
H3BTR1 | H3BTR1_HUMAN | Cerebellar degeneration-related pro... | CDR2 | 116 | Annotation score: | ||
H3BUE0 | H3BUE0_HUMAN | Cerebellar degeneration-related pro... | CDR2 | 80 | Annotation score: | ||
H3BQS4 | H3BQS4_HUMAN | Cerebellar degeneration-related pro... | CDR2 | 46 | Annotation score: |
Sequence cautioni
The sequence AAA51961 differs from that shown. Reason: Frameshift.Curated
The sequence AAB20813 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA02360 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | L → R in AAB20813 (PubMed:2260856).Curated | 1 | |
Sequence conflicti | 7 | V → T in AAB20813 (PubMed:2260856).Curated | 1 | |
Sequence conflicti | 7 | V → T in BAA02360 (PubMed:2260856).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63256 mRNA Translation: AAA51961.1 Sequence problems. AK292273 mRNA Translation: BAF84962.1 CH471249 Genomic DNA Translation: EAW50609.1 BC017503 mRNA Translation: AAH17503.2 D12981 mRNA Translation: BAA02360.1 Different initiation. S78388 mRNA Translation: AAB20813.1 Different initiation. |
CCDSi | CCDS32404.1 |
PIRi | A40448 |
RefSeqi | NP_001793.1, NM_001802.1 XP_005276559.1, XM_005276502.1 |
Genome annotation databases
Ensembli | ENST00000268383; ENSP00000268383; ENSG00000140743 |
GeneIDi | 1039 |
KEGGi | hsa:1039 |
MANE-Selecti | ENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1 |
UCSCi | uc002dkn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63256 mRNA Translation: AAA51961.1 Sequence problems. AK292273 mRNA Translation: BAF84962.1 CH471249 Genomic DNA Translation: EAW50609.1 BC017503 mRNA Translation: AAH17503.2 D12981 mRNA Translation: BAA02360.1 Different initiation. S78388 mRNA Translation: AAB20813.1 Different initiation. |
CCDSi | CCDS32404.1 |
PIRi | A40448 |
RefSeqi | NP_001793.1, NM_001802.1 XP_005276559.1, XM_005276502.1 |
3D structure databases
SMRi | Q01850 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107470, 126 interactors |
IntActi | Q01850, 107 interactors |
MINTi | Q01850 |
STRINGi | 9606.ENSP00000268383 |
PTM databases
GlyGeni | Q01850, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q01850 |
PhosphoSitePlusi | Q01850 |
Genetic variation databases
BioMutai | CDR2 |
DMDMi | 68839004 |
Proteomic databases
EPDi | Q01850 |
jPOSTi | Q01850 |
MassIVEi | Q01850 |
MaxQBi | Q01850 |
PaxDbi | Q01850 |
PeptideAtlasi | Q01850 |
PRIDEi | Q01850 |
ProteomicsDBi | 58009 |
Protocols and materials databases
Antibodypediai | 12516, 397 antibodies from 29 providers |
DNASUi | 1039 |
Genome annotation databases
Ensembli | ENST00000268383; ENSP00000268383; ENSG00000140743 |
GeneIDi | 1039 |
KEGGi | hsa:1039 |
MANE-Selecti | ENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1 |
UCSCi | uc002dkn.3, human |
Organism-specific databases
CTDi | 1039 |
DisGeNETi | 1039 |
GeneCardsi | CDR2 |
HGNCi | HGNC:1799, CDR2 |
HPAi | ENSG00000140743, Low tissue specificity |
MIMi | 117340, gene |
neXtProti | NX_Q01850 |
OpenTargetsi | ENSG00000140743 |
PharmGKBi | PA26331 |
VEuPathDBi | HostDB:ENSG00000140743 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUPP, Eukaryota |
GeneTreei | ENSGT00390000018570 |
HOGENOMi | CLU_048751_0_0_1 |
InParanoidi | Q01850 |
OMAi | KHKAVQT |
OrthoDBi | 1101523at2759 |
PhylomeDBi | Q01850 |
TreeFami | TF326183 |
Enzyme and pathway databases
PathwayCommonsi | Q01850 |
SignaLinki | Q01850 |
SIGNORi | Q01850 |
Miscellaneous databases
BioGRID-ORCSi | 1039, 10 hits in 1054 CRISPR screens |
ChiTaRSi | CDR2, human |
GeneWikii | CDR2_(gene) |
Pharosi | Q01850, Tbio |
PROi | PR:Q01850 |
RNActi | Q01850, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140743, Expressed in pigmented layer of retina and 222 other tissues |
ExpressionAtlasi | Q01850, baseline and differential |
Genevisiblei | Q01850, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026079, CDR2 |
PANTHERi | PTHR19232, PTHR19232, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDR2_HUMAN | |
Accessioni | Q01850Primary (citable) accession number: Q01850 Secondary accession number(s): A8K8A8, Q13977 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families