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UniProtKB - Q01850 (CDR2_HUMAN)

Entry version 157 (23 Feb 2022)
Sequence version 2 (05 Jul 2005)
Previous versions | rss
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Protein

Cerebellar degeneration-related protein 2

Gene

CDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01850

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q01850

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01850

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cerebellar degeneration-related protein 2
Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDR2
Synonyms:PCD17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1799, CDR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		117340, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01850

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140743

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1039

Open Targets

More...OpenTargetsi		ENSG00000140743

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01850, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		68839004

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894561 – 454Cerebellar degeneration-related protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q01850

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01850

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01850

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q01850

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01850

PeptideAtlas

More...PeptideAtlasi		Q01850

PRoteomics IDEntifications database

More...PRIDEi		Q01850

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58009

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q01850, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01850

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01850

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140743, Expressed in pigmented layer of retina and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01850, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01850, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140743, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q01850
With#Exp.IntAct
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-1181367,EBI-10187270
ANKRD36BP1 [Q96IX9]3EBI-1181367,EBI-744859
AQP1 [P29972]3EBI-1181367,EBI-745213
BEX2 [Q9BXY8]3EBI-1181367,EBI-745073
C1orf216 [Q8TAB5]6EBI-1181367,EBI-747505
C2CD6 [Q53TS8]3EBI-1181367,EBI-739879
C4orf46 [Q504U0]7EBI-1181367,EBI-6657981
CCDC120 [Q96HB5]3EBI-1181367,EBI-744556
CCDC13 [Q8IYE1]3EBI-1181367,EBI-10961312
CCDC146 [Q8IYE0]3EBI-1181367,EBI-10749669
CCDC153 [Q494R4]3EBI-1181367,EBI-10241443
CCDC153 - isoform 2 [Q494R4-2]3EBI-1181367,EBI-11974185
CCDC87 [Q9NVE4]3EBI-1181367,EBI-749261
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-1181367,EBI-10175300
CDK18 [Q07002]3EBI-1181367,EBI-746238
CDR2L [Q86X02]5EBI-1181367,EBI-11063830
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-1181367,EBI-10181988
CHIC2 [Q9UKJ5]7EBI-1181367,EBI-741528
COX5B [P10606]7EBI-1181367,EBI-1053725
EIF4E2 [O60573]3EBI-1181367,EBI-398610
ENKD1 [Q9H0I2]6EBI-1181367,EBI-744099
FAM110A [Q9BQ89]3EBI-1181367,EBI-1752811
FAM161A [Q3B820]6EBI-1181367,EBI-719941
FAM161B [Q96MY7]3EBI-1181367,EBI-7225287
FAM50B [Q9Y247]3EBI-1181367,EBI-742802
FAM90A1 [Q86YD7]3EBI-1181367,EBI-6658203
GAS8 [O95995]3EBI-1181367,EBI-1052570
GEM [P55040]3EBI-1181367,EBI-744104
HAUS1 [Q96CS2]3EBI-1181367,EBI-2514791
HDAC4 [P56524]3EBI-1181367,EBI-308629
HDAC4 - isoform 2 [P56524-2]3EBI-1181367,EBI-11953488
HGS [A0A0S2Z4Q4]3EBI-1181367,EBI-16429135
HGS [O14964]6EBI-1181367,EBI-740220
INO80B [Q9C086]3EBI-1181367,EBI-715611
KANSL1 [Q7Z3B3]4EBI-1181367,EBI-740244
KIF5B [P33176]3EBI-1181367,EBI-355878
KIFC3 [Q9BVG8]3EBI-1181367,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-1181367,EBI-14069005
LENG1 [Q96BZ8]6EBI-1181367,EBI-726510
LIN37 [Q96GY3]3EBI-1181367,EBI-748884
MGC50722 [Q8IVT4]3EBI-1181367,EBI-14086479
MICALL2 [Q8IY33]3EBI-1181367,EBI-2555563
MKKS [Q9NPJ1]3EBI-1181367,EBI-721319
MNS1 [Q8NEH6]3EBI-1181367,EBI-743811
MORF4L2 [Q15014]6EBI-1181367,EBI-399257
MRPL28 [Q13084]3EBI-1181367,EBI-723426
NTAQ1 [Q96HA8]4EBI-1181367,EBI-741158
OAZ2 [O95190]3EBI-1181367,EBI-1051861
PDZD4 [Q17RL8]3EBI-1181367,EBI-10239064
PKN1 [Q16512]6EBI-1181367,EBI-602382
PRKAA2 [P54646]3EBI-1181367,EBI-1383852
PRPF18 [Q99633]3EBI-1181367,EBI-2798416
PSMA1 [P25786]3EBI-1181367,EBI-359352
RCOR3 [Q9P2K3]3EBI-1181367,EBI-743428
RSPH14 [Q9UHP6]3EBI-1181367,EBI-748350
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-1181367,EBI-11984663
SCNM1 [Q9BWG6]6EBI-1181367,EBI-748391
SH2D4A [Q9H788]6EBI-1181367,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-1181367,EBI-10308083
SMARCD1 [Q96GM5]3EBI-1181367,EBI-358489
SMARCE1 [Q969G3]6EBI-1181367,EBI-455078
TBC1D22B [Q9NU19]4EBI-1181367,EBI-8787464
TCHP [Q9BT92]8EBI-1181367,EBI-740781
TEAD4 [Q15561]3EBI-1181367,EBI-747736
TEX28P2 [O15482]3EBI-1181367,EBI-751954
TRIM23 [P36406]6EBI-1181367,EBI-740098
TRIML2 [Q8N7C3]3EBI-1181367,EBI-11059915
TSGA10IP [Q3SY00]3EBI-1181367,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]3EBI-1181367,EBI-9090990
TTR [P02766]3EBI-1181367,EBI-711909
TXLNA [P40222]7EBI-1181367,EBI-359793
TXLNB [Q8N3L3]3EBI-1181367,EBI-6116822
UBTFL1 [P0CB47]3EBI-1181367,EBI-17208936
ZGPAT [A0A0S2Z6H0]4EBI-1181367,EBI-16428984
ZGPAT - isoform 2 [Q8N5A5-2]6EBI-1181367,EBI-10183064
ZMAT2 [Q96NC0]3EBI-1181367,EBI-2682299
ZNF250 - isoform 3 [P15622-3]3EBI-1181367,EBI-10177272
ZNF35 [P13682]3EBI-1181367,EBI-11041653
ZNF417 [Q8TAU3]3EBI-1181367,EBI-740727

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107470, 126 interactors

Protein interaction database and analysis system

More...IntActi		Q01850, 107 interactors

Molecular INTeraction database

More...MINTi		Q01850

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000268383

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01850, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01850

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 153DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili44 – 142Sequence analysisAdd BLAST99
Coiled coili192 – 265Sequence analysisAdd BLAST74
Coiled coili346 – 380Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDR2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUPP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048751_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01850

Identification of Orthologs from Complete Genome Data

More...OMAi		KHKAVQT

Database of Orthologous Groups

More...OrthoDBi		1101523at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01850

TreeFam database of animal gene trees

More...TreeFami		TF326183

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026079, CDR2

The PANTHER Classification System

More...PANTHERi		PTHR19232, PTHR19232, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q01850-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ 
        60         70         80         90        100
QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK 
       110        120        130        140        150
LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD 
       160        170        180        190        200
QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK 
       210        220        230        240        250
TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL 
       260        270        280        290        300
EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 
       310        320        330        340        350
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD 
       360        370        380        390        400
TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA 
       410        420        430        440        450
SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL 

SSHS
Length:454
Mass (Da):51,855
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7615F2C5AE08D2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BU23H3BU23_HUMAN
Cerebellar degeneration-related pro...
CDR2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN65H3BN65_HUMAN
Cerebellar degeneration-related pro...
CDR2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTR1H3BTR1_HUMAN
Cerebellar degeneration-related pro...
CDR2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUE0H3BUE0_HUMAN
Cerebellar degeneration-related pro...
CDR2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQS4H3BQS4_HUMAN
Cerebellar degeneration-related pro...
CDR2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51961 differs from that shown. Reason: Frameshift.Curated
The sequence AAB20813 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA02360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6L → R in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in BAA02360 (PubMed:2260856).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M63256 mRNA Translation: AAA51961.1 Sequence problems.
AK292273 mRNA Translation: BAF84962.1
CH471249 Genomic DNA Translation: EAW50609.1
BC017503 mRNA Translation: AAH17503.2
D12981 mRNA Translation: BAA02360.1 Different initiation.
S78388 mRNA Translation: AAB20813.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32404.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40448

NCBI Reference Sequences

More...RefSeqi		NP_001793.1, NM_001802.1
XP_005276559.1, XM_005276502.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000268383; ENSP00000268383; ENSG00000140743

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1039

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1

UCSC genome browser

More...UCSCi		uc002dkn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63256 mRNA Translation: AAA51961.1 Sequence problems.
AK292273 mRNA Translation: BAF84962.1
CH471249 Genomic DNA Translation: EAW50609.1
BC017503 mRNA Translation: AAH17503.2
D12981 mRNA Translation: BAA02360.1 Different initiation.
S78388 mRNA Translation: AAB20813.1 Different initiation.
CCDSiCCDS32404.1
PIRiA40448
RefSeqiNP_001793.1, NM_001802.1
XP_005276559.1, XM_005276502.1

3D structure databases

SMRiQ01850
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107470, 126 interactors
IntActiQ01850, 107 interactors
MINTiQ01850
STRINGi9606.ENSP00000268383

PTM databases

GlyGeniQ01850, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ01850
PhosphoSitePlusiQ01850

Genetic variation databases

BioMutaiCDR2
DMDMi68839004

Proteomic databases

EPDiQ01850
jPOSTiQ01850
MassIVEiQ01850
MaxQBiQ01850
PaxDbiQ01850
PeptideAtlasiQ01850
PRIDEiQ01850
ProteomicsDBi58009

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12516, 397 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		1039

Genome annotation databases

EnsembliENST00000268383; ENSP00000268383; ENSG00000140743
GeneIDi1039
KEGGihsa:1039
MANE-SelectiENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1
UCSCiuc002dkn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1039
DisGeNETi1039

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDR2
HGNCiHGNC:1799, CDR2
HPAiENSG00000140743, Low tissue specificity
MIMi117340, gene
neXtProtiNX_Q01850
OpenTargetsiENSG00000140743
PharmGKBiPA26331
VEuPathDBiHostDB:ENSG00000140743

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUPP, Eukaryota
GeneTreeiENSGT00390000018570
HOGENOMiCLU_048751_0_0_1
InParanoidiQ01850
OMAiKHKAVQT
OrthoDBi1101523at2759
PhylomeDBiQ01850
TreeFamiTF326183

Enzyme and pathway databases

PathwayCommonsiQ01850
SignaLinkiQ01850
SIGNORiQ01850

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1039, 10 hits in 1054 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDR2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDR2_(gene)
PharosiQ01850, Tbio

Protein Ontology

More...PROi		PR:Q01850
RNActiQ01850, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140743, Expressed in pigmented layer of retina and 222 other tissues
ExpressionAtlasiQ01850, baseline and differential
GenevisibleiQ01850, HS

Family and domain databases

InterProiView protein in InterPro
IPR026079, CDR2
PANTHERiPTHR19232, PTHR19232, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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