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Protein

Structural protein MDM1

Gene

MDM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for mitotic growth. Mediates organelle inheritance.1 Publication

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • mitochondrion inheritance Source: SGD
  • nucleus inheritance Source: SGD
  • vacuole-ER tethering Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32688-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Structural protein MDM1
Alternative name(s):
Mitochondrial distribution and morphology protein 1
Gene namesi
Name:MDM1
Ordered Locus Names:YML104C
ORF Names:YM8339.15C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML104C
SGDiS000004572 MDM1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963301 – 1127Structural protein MDM1Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei670PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei692PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01846
PaxDbiQ01846
PRIDEiQ01846

PTM databases

iPTMnetiQ01846

Interactioni

Protein-protein interaction databases

BioGridi35039, 110 interactors
DIPiDIP-810N
IntActiQ01846, 2 interactors
MINTiQ01846
STRINGi4932.YML104C

Structurei

3D structure databases

ProteinModelPortaliQ01846
SMRiQ01846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 273PXAPROSITE-ProRule annotationAdd BLAST189
Domaini782 – 905PXPROSITE-ProRule annotationAdd BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili705 – 762Sequence analysisAdd BLAST58

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000113508
InParanoidiQ01846
KOiK17887
OMAiFVKPICD
OrthoDBiEOG092C0GMH

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR013937 Sorting_nexin_C
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit

Sequencei

Sequence statusi: Complete.

Q01846-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKFPQFRLI LVLFYLISMI QWSVITFSLG FFLNVCIFAY FVFFKSLPDL
60 70 80 90 100
PKPQPRFVDI VPESSNTVDV DKELKSVEGL IQDGNAQIGK ELESIVNLII
110 120 130 140 150
KDFVQPWFTK IDKNSDAEFL KVIKWRLLQT LLVVKDKLMK NDSASLIVLK
160 170 180 190 200
LLPIFNKHFS TFCDAREAVL SDLTLERHKS ANIDLQIAVE FNKNYKIHKS
210 220 230 240 250
LSLKPNALQK EIEKSIRKTV IGLLPHLFDN DELDSLLVFT LMTEVLTTCI
260 270 280 290 300
ISPLIFKFTD PDSWNLRIVS LSQNYFEEKH KVHKIRRMLS KELQDHRKVM
310 320 330 340 350
NDVANKDVGE PSSEKLELNA EYTGKQFEHY LNQLDSLLDL SDIKYVAYSL
360 370 380 390 400
ALKIYQLKEN EHLTKENLKY KKRLLLSLNL IESKLSFPGS EIDTASKKLA
410 420 430 440 450
REANYPDLNM DNGIVLKEMA SFLTSITLKD IVDDSEFLPF FESFLGSVPE
460 470 480 490 500
TQGSTFLEYS QTIESFKNPL EDATSEDIIS GYSGISTMQL QEISSKFFHN
510 520 530 540 550
NNLQNMKLLD EGLVKNIILF RNSFQINNDE DTFILARKSV LLLQTEAIKY
560 570 580 590 600
LDDRFLPLFK KTPSFLKMLS TSHIISTDIY AHFLSRIGGV NNPEQNKIIK
610 620 630 640 650
DNVKTDFMNP VRIFANPGIT DALDNIVNGS GSKPHKSRIS SNPRYSQLFG
660 670 680 690 700
SENDNIFKDK LFDDENDNTS EISVVEDQLD HPRNMEKVSV SSGNSGLNPS
710 720 730 740 750
QFYGSNNFRD NIASLTISID QIEKELELLR HLILKADLTN NQMQLKILKK
760 770 780 790 800
SQRTLLKELE MKELLKQQYM VQENGNSLFR KTKIYIRSYF SENSSNGLKE
810 820 830 840 850
ITYYIINIHH FNNGQVSSWD MARRYNEFFE LNTYLKKNFR DLMRQLQDLF
860 870 880 890 900
PSKVKMSLKY HVTKTLLYEE RKQKLEKYLR ELLSISEICE DNIFRRFLTD
910 920 930 940 950
PTPFKLNKEY MHDDILEEPL HEPIGSSNST SNSSSVVDLQ SSEDGGELNF
960 970 980 990 1000
YEDERHFFTD SGYPFYSQNK SFVKQICDLF ISLFALNKAN AGWLRGRAII
1010 1020 1030 1040 1050
TVLQQLLGST IEKYIKVSIQ KLRSEDQVFE AIVTFKNMLW GDNGLFERKR
1060 1070 1080 1090 1100
NETAEATRSE GERLRTEQLA LTSLQRLFAD TCGRVVGLRD SHEAAGRVHA
1110 1120
MLQNPYLNAS LLLEALDAIL LDIICND
Length:1,127
Mass (Da):129,981
Last modified:September 26, 2001 - v3
Checksum:i7C9177B87FDAF512
GO

Sequence cautioni

The sequence CAA47014 differs from that shown. Reason: Frameshift at position 638.Curated
The sequence CAA89114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti635H → D in CAA47014 (PubMed:1378448).Curated1
Sequence conflicti772Q → R in CAA47014 (PubMed:1378448).Curated1
Sequence conflicti899T → I in CAA47014 (PubMed:1378448).Curated1
Sequence conflicti1063R → K in CAA47014 (PubMed:1378448).Curated1
Sequence conflicti1081T → S in CAA47014 (PubMed:1378448).Curated1
Sequence conflicti1096G → R in CAA47014 (PubMed:1378448).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA Translation: CAA56793.1
Z49210 Genomic DNA Translation: CAA89114.1 Different initiation.
X66371 Genomic DNA Translation: CAA47014.1 Frameshift.
X65783 Genomic DNA Translation: CAA46664.1
BK006946 Genomic DNA Translation: DAA09794.1
PIRiS47445
RefSeqiNP_013603.1, NM_001182466.1

Genome annotation databases

EnsemblFungiiYML104C; YML104C; YML104C
GeneIDi854867
KEGGisce:YML104C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA Translation: CAA56793.1
Z49210 Genomic DNA Translation: CAA89114.1 Different initiation.
X66371 Genomic DNA Translation: CAA47014.1 Frameshift.
X65783 Genomic DNA Translation: CAA46664.1
BK006946 Genomic DNA Translation: DAA09794.1
PIRiS47445
RefSeqiNP_013603.1, NM_001182466.1

3D structure databases

ProteinModelPortaliQ01846
SMRiQ01846
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35039, 110 interactors
DIPiDIP-810N
IntActiQ01846, 2 interactors
MINTiQ01846
STRINGi4932.YML104C

PTM databases

iPTMnetiQ01846

Proteomic databases

MaxQBiQ01846
PaxDbiQ01846
PRIDEiQ01846

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML104C; YML104C; YML104C
GeneIDi854867
KEGGisce:YML104C

Organism-specific databases

EuPathDBiFungiDB:YML104C
SGDiS000004572 MDM1

Phylogenomic databases

HOGENOMiHOG000113508
InParanoidiQ01846
KOiK17887
OMAiFVKPICD
OrthoDBiEOG092C0GMH

Enzyme and pathway databases

BioCyciYEAST:G3O-32688-MONOMER

Miscellaneous databases

PROiPR:Q01846

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR013937 Sorting_nexin_C
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDM1_YEAST
AccessioniPrimary (citable) accession number: Q01846
Secondary accession number(s): D6W0I0, Q04196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 26, 2001
Last modified: September 12, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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