EWSR1

Functionⁱ

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	348 – 349	Breakpoint for insertion to form EWSR1-FEV fusion protein		2

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	518 – 549	RanBP2-typePROSITE-ProRule annotationAdd BLAST		32

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- "Toward an understanding of the protein interaction network of the human liver."
  Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W., Guan W., Chen H., Jin C., Wei J., Zhang W., Yang Y., Liu Q., Zhou Y., Zhang C.
  Yang X.
  Mol Syst Biol 7:536-536(2011) [PubMed] [Europe PMC] [Abstract]
- "A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins."
  Thomsen C., Grundevik P., Elias P., Stahlberg A., Aman P.
  FASEB J 27:4965-4974(2013) [PubMed] [Europe PMC] [Abstract]
metal ion binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
  Castello A., Fischer B., Eichelbaum K., Horos R., Beckmann B.M., Strein C., Davey N.E., Humphreys D.T., Preiss T., Steinmetz L.M., Krijgsveld J., Hentze M.W.
  Cell 149:1393-1406(2012) [PubMed] [Europe PMC] [Abstract]
- "The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts."
  Baltz A.G., Munschauer M., Schwanhausser B., Vasile A., Murakawa Y., Schueler M., Youngs N., Penfold-Brown D., Drew K., Milek M., Wyler E., Bonneau R., Selbach M., Dieterich C., Landthaler M.
  Mol Cell 46:674-690(2012) [PubMed] [Europe PMC] [Abstract]
transcription coregulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Repressor, RNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q01844
SIGNORⁱ	Q01844

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein EWS Alternative name(s): EWS oncogene Ewing sarcoma breakpoint region 1 protein
Gene namesⁱ	Name:EWSR1 Synonyms:EWS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182944.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3508, EWSR1
MIMⁱ	133450, gene
neXtProtⁱ	NX_Q01844

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ewing sarcoma (ES)4 Publications

The protein represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with Ewing sarcoma. Translocation t(11;22)(q24;q12) with FLI1 (PubMed:1522903, PubMed:15044653). Translocation t(7;22)(p22;q12) with ETV1 (PubMed:7700648). Translocation t(21;22)(q22;q21) with ERG (PubMed:15044653). Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with potential oncogenic activity (PubMed:9121764).4 Publications

Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.

Related information in OMIM

A chromosomal aberration involving EWSR1 has been found in extraskeletal myxoid chondrosarcoma. Translocation t(9;22)(q22-31;q11-12) with NR4A3.1 Publication

A chromosomal aberration involving EWSR1 is associated with desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with WT1.1 Publication

A chromosomal aberration involving EWSR1 is associated with malignant melanoma of soft parts (MMSP). Translocation t(12;22)(q13;q12) with ATF1. Malignant melanoma of soft parts, also known as soft tissue clear cell sarcoma, is a rare tumor developing in tendons and aponeuroses.1 Publication

A chromosomal aberration involving EWSR1 is associated with small round cell sarcoma. Translocation t(11;22)(p36.1;q12) with PATZ1.1 Publication

Angiomatoid fibrous histiocytoma (AFH)2 Publications

The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;22)(q13;q12) with ATF1 generates a chimeric EWSR1/ATF1 protein (PubMed:15884099). Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type (PubMed:17724745).2 Publications

Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.

Related information in OMIM

EFPS arise due to chromosomal translocations in which EWSR1 is fused to a variety of cellular transcription factors. EFPS are very potent transcriptional activators dependent on the EAD and a C-terminal DNA-binding domain contributed by the fusion partner. The spectrum of malignancies associated with EFPS are thought to arise via EFP-induced transcriptional deregulation, with the tumor phenotype specified by the EWSR1 fusion partner and cell type. Transcriptional repression of the transforming growth factor beta type II receptor (TGF beta RII) is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene.Curated

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	648	R → A: Cytoplasmic localization. 1 Publication	1
Mutagenesisⁱ	648	R → K: No effect on nuclear targeting. 1 Publication	1
Mutagenesisⁱ	651	R → A: No effect on nuclear targeting. 1 Publication	1
Mutagenesisⁱ	652	R → A: Cytoplasmic localization. 1 Publication	1
Mutagenesisⁱ	652	R → K: No effect on nuclear targeting. 1 Publication	1
Mutagenesisⁱ	653	D → A: No effect on nuclear targeting. 1 Publication	1
Mutagenesisⁱ	654	R → A: No effect on nuclear targeting. 1 Publication	1
Mutagenesisⁱ	655	P → A: Cytoplasmic localization. 1 Publication	1
Mutagenesisⁱ	656	Y → A: Cytoplasmic localization. 1 Publication	1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	265	Breakpoint for translocation to form chimeric EWSR1/ATF1 protein		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2130
MalaCards human disease database More...MalaCardsⁱ	EWSR1
MIMⁱ	612160, phenotype 612219, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000182944
Orphanetⁱ	83469, Desmoplastic small round cell tumor 370334, Extraskeletal Ewing sarcoma 209916, Extraskeletal myxoid chondrosarcoma 97338, Melanoma of soft tissue 319, Skeletal Ewing sarcoma
PharmGKBⁱ	PA27921

Miscellaneous databases

Pharosⁱ	Q01844, Tbio

Pharosⁱ

Q01844, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL3351202

ChEMBLⁱ

CHEMBL3351202

Polymorphism and mutation databases

BioMutaⁱ	EWSR1
DMDMⁱ	544261

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081586	1 – 656	RNA-binding protein EWSAdd BLAST		656

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	266	Phosphoserine; by PKCBy similarity	1
Modified residueⁱ	300	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	302	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	304	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	309	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	314	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	317	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	321	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	439	N6-acetyllysineBy similarity	1
Modified residueⁱ	455	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	464	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	471	Asymmetric dimethylarginine; alternate1 Publication	1
Modified residueⁱ	471	Omega-N-methylarginine; alternateCombined sources1 Publication	1
Modified residueⁱ	486	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	490	Asymmetric dimethylarginine; by PRMT82 Publications	1
Modified residueⁱ	494	Asymmetric dimethylarginine2 Publications	1
Modified residueⁱ	500	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	503	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	506	Asymmetric dimethylarginine; alternate1 Publication	1
Modified residueⁱ	506	Omega-N-methylarginine; alternateBy similarity	1
Modified residueⁱ	563	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	565	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	572	Asymmetric dimethylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	572	Omega-N-methylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	575	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	581	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	589	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	592	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	596	Asymmetric dimethylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	596	Omega-N-methylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	600	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	603	Asymmetric dimethylarginine; by PRMT82 Publications	1
Modified residueⁱ	607	Asymmetric dimethylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	607	Omega-N-methylarginine; alternate; by PRMT82 Publications	1
Modified residueⁱ	615	Asymmetric dimethylarginine; alternate2 Publications	1
Modified residueⁱ	615	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	633	Asymmetric dimethylarginine1 Publication	1
Modified residueⁱ	636	Asymmetric dimethylarginine1 Publication	1

Post-translational modificationⁱ

Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.1 Publication

Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.3 Publications

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q01844
jPOSTⁱ	Q01844
MassIVEⁱ	Q01844
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01844
PaxDbⁱ	Q01844
PeptideAtlas More...PeptideAtlasⁱ	Q01844
PRIDEⁱ	Q01844
ProteomicsDBⁱ	2658 58004 [Q01844-1] 58005 [Q01844-2] 58006 [Q01844-3] 58007 [Q01844-4] 58008 [Q01844-5]

PTM databases

GlyGenⁱ	Q01844, 8 sites, 1 O-linked glycan (8 sites)
iPTMnetⁱ	Q01844
MetOSiteⁱ	Q01844
PhosphoSitePlusⁱ	Q01844
SwissPalmⁱ	Q01844

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000182944, Expressed in testis and 243 other tissues
ExpressionAtlasⁱ	Q01844, baseline and differential
Genevisibleⁱ	Q01844, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000182944, Low tissue specificity

HPAⁱ

ENSG00000182944, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds POLR2C, SF1, calmodulin and RNA.

Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.

Forms a complex with REC8, PRDM9, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).

By similarity2 Publications

Binary interactionsⁱ

Hide details

Q01844

With	#Exp.	IntAct
ATPAF2 [Q8N5M1]	7	EBI-739737,EBI-1166928
EP300 [Q09472]	2	EBI-739737,EBI-447295
itself	3	EBI-739737,EBI-739737
FUS [P35637]	5	EBI-739737,EBI-400434
KAT5 [Q92993]	2	EBI-739737,EBI-399080
MAPK1IP1L [Q8NDC0]	5	EBI-739737,EBI-741424
PEF1 [Q9UBV8]	3	EBI-739737,EBI-724639
PLSCR1 [O15162]	4	EBI-739737,EBI-740019
PRMT1 [Q99873]	2	EBI-739737,EBI-78738
PRR13 [Q9NZ81]	3	EBI-739737,EBI-740924
RASSF1 - isoform A [Q9NS23-2]	3	EBI-739737,EBI-438698
SEC24A [O95486]	3	EBI-739737,EBI-749911
SEC24D [O94855]	3	EBI-739737,EBI-748817
SMAD4 [Q13485]	3	EBI-739737,EBI-347263
SSBP3 [Q9BWW4]	3	EBI-739737,EBI-2902395
TFG [Q92734]	3	EBI-739737,EBI-357061
TRAF1 [Q13077]	3	EBI-739737,EBI-359224
TRAF2 [Q12933]	3	EBI-739737,EBI-355744
ZNF165 [P49910]	2	EBI-739737,EBI-741694

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108431, 755 interactors
CORUMⁱ	Q01844
Database of interacting proteins More...DIPⁱ	DIP-34449N
IntActⁱ	Q01844, 181 interactors
Molecular INTeraction database More...MINTⁱ	Q01844
STRINGⁱ	9606.ENSP00000400142

Miscellaneous databases

RNActⁱ	Q01844, protein

RNActⁱ

Q01844, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	362 – 366	Combined sources	5
Helixⁱ	374 – 381	Combined sources	8
Turnⁱ	382 – 384	Combined sources	3
Beta strandⁱ	391 – 393	Combined sources	3
Beta strandⁱ	396 – 399	Combined sources	4
Turnⁱ	404 – 406	Combined sources	3
Beta strandⁱ	411 – 419	Combined sources	9
Helixⁱ	420 – 430	Combined sources	11
Beta strandⁱ	441 – 443	Combined sources	3

Show more details

3D structure databases

BMRBⁱ	Q01844
SMRⁱ	Q01844
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q01844

EvolutionaryTraceⁱ

Q01844

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	8 – 16	1	9
Repeatⁱ	17 – 27	2Add BLAST	11
Repeatⁱ	28 – 34	3	7
Repeatⁱ	35 – 42	4	8
Repeatⁱ	43 – 50	5	8
Repeatⁱ	51 – 59	6	9
Repeatⁱ	60 – 68	7	9
Repeatⁱ	69 – 75	8	7
Repeatⁱ	76 – 84	9	9
Repeatⁱ	85 – 91	10	7
Repeatⁱ	92 – 110	11Add BLAST	19
Repeatⁱ	111 – 116	12	6
Repeatⁱ	117 – 125	13	9
Repeatⁱ	126 – 156	14Add BLAST	31
Repeatⁱ	157 – 163	15	7
Repeatⁱ	164 – 170	16	7
Repeatⁱ	171 – 177	17	7
Repeatⁱ	178 – 188	18Add BLAST	11
Repeatⁱ	189 – 193	19	5
Repeatⁱ	194 – 201	20	8
Repeatⁱ	202 – 206	21	5
Repeatⁱ	207 – 212	22	6
Repeatⁱ	213 – 218	23	6
Repeatⁱ	219 – 224	24	6
Repeatⁱ	225 – 230	25	6
Repeatⁱ	231 – 238	26	8
Repeatⁱ	239 – 245	27	7
Repeatⁱ	246 – 252	28	7
Repeatⁱ	253 – 259	29	7
Domainⁱ	256 – 285	IQAdd BLAST	30
Repeatⁱ	260 – 276	30Add BLAST	17
Repeatⁱ	277 – 285	31	9
Domainⁱ	361 – 447	RRMPROSITE-ProRule annotationAdd BLAST	87

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 285	EAD (Gln/Pro/Thr-rich)Add BLAST		285
Regionⁱ	8 – 285	31 X approximate tandem repeatsAdd BLAST		278

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	639 – 656	Nuclear localization signal1 PublicationAdd BLAST		18

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	300 – 340	Arg/Gly/Pro-richAdd BLAST	41
Compositional biasⁱ	454 – 513	Arg/Gly/Pro-richAdd BLAST	60
Compositional biasⁱ	559 – 640	Arg/Gly/Pro-richAdd BLAST	82

Domainⁱ

EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD.

Sequence similaritiesⁱ

Belongs to the RRM TET family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	518 – 549	RanBP2-typePROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1995, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154191
HOGENOMⁱ	CLU_025609_1_1_1
InParanoidⁱ	Q01844
OMAⁱ	NYGSYTQ
Database of Orthologous Groups More...OrthoDBⁱ	1539664at2759
PhylomeDBⁱ	Q01844
TreeFamⁱ	TF322599

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12533, RRM_EWS, 1 hit
Database of protein disorder More...DisProtⁱ	DP00632
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034869, EWS_RRM IPR033109, EWSR1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf
PANTHERⁱ	PTHR23238, PTHR23238, 1 hit PTHR23238:SF3, PTHR23238:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform EWS (identifier: Q01844-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ 
       160        170        180        190        200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP 
       210        220        230        240        250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA 
       260        270        280        290        300
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR 
       310        320        330        340        350
GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP 
       360        370        380        390        400
PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI 
       410        420        430        440        450
YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP 
       460        470        480        490        500
MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR 
       510        520        530        540        550
GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG 
       560        570        580        590        600
FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR 
       610        620        630        640        650
GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE 

RRDRPY

Length:656

Mass (Da):68,478

Last modified:June 1, 1994 - v1

Checksum:ⁱ0DA02CEE146720BB

GO

Isoform EWS-B (identifier: Q01844-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
266-338: Missing.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ 
       160        170        180        190        200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP 
       210        220        230        240        250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA 
       260        270        280        290        300
PSQYSQQSSS YGQQSPMDEG PDLDLGPPVD PDEDSDNSAI YVQGLNDSVT 
       310        320        330        340        350
LDDLADFFKQ CGVVKMNKRT GQPMIHIYLD KETGKPKGDA TVSYEDPPTA 
       360        370        380        390        400
KAAVEWFDGK DFQGSKLKVS LARKKPPMNS MRGGLPPREG RGMPPPLRGG 
       410        420        430        440        450
PGGPGGPGGP MGRMGGRGGD RGGFPPRGPR GSRGNPSGGG NVQHRAGDWQ 
       460        470        480        490        500
CPNPGCGNQN FAWRTECNQC KAPKPEGFLP PPFPPPGGDR GRGGPGGMRG 
       510        520        530        540        550
GRGGLMDRGG PGGMFRGGRG GDRGGFRGGR GMDRGGFGGG RRGGPGGPPG 
       560        570        580 
PLMEQMGGRR GGRGGPGKMD KGEHRQERRD RPY

Show »

Length:583

Mass (Da):61,217

Checksum:ⁱ1B011799A0B290ED

GO

Isoform 3 (identifier: Q01844-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
326-326: Missing.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ 
       160        170        180        190        200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP 
       210        220        230        240        250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA 
       260        270        280        290        300
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR 
       310        320        330        340        350
GRGRGGFDRG GMSRGGRGGG RGGMGAGERG GFNKPGGPMD EGPDLDLGPP 
       360        370        380        390        400
VDPDEDSDNS AIYVQGLNDS VTLDDLADFF KQCGVVKMNK RTGQPMIHIY 
       410        420        430        440        450
LDKETGKPKG DATVSYEDPP TAKAAVEWFD GKDFQGSKLK VSLARKKPPM 
       460        470        480        490        500
NSMRGGLPPR EGRGMPPPLR GGPGGPGGPG GPMGRMGGRG GDRGGFPPRG 
       510        520        530        540        550
PRGSRGNPSG GGNVQHRAGD WQCPNPGCGN QNFAWRTECN QCKAPKPEGF 
       560        570        580        590        600
LPPPFPPPGG DRGRGGPGGM RGGRGGLMDR GGPGGMFRGG RGGDRGGFRG 
       610        620        630        640        650
GRGMDRGGFG GGRRGGPGGP PGPLMEQMGG RRGGRGGPGK MDKGEHRQER 

RDRPY

Show »

Length:655

Mass (Da):68,391

Checksum:ⁱB539ED1E98C601ED

GO

Isoform 4 (identifier: Q01844-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
326-354: SAGERGGFNKPGGPMDEGPDLDLGPPVDP → LQSESLVYTSILKKYPYSVLSRQHNEKWD
355-656: Missing.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ 
       160        170        180        190        200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP 
       210        220        230        240        250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA 
       260        270        280        290        300
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR 
       310        320        330        340        350
GRGRGGFDRG GMSRGGRGGG RGGMGLQSES LVYTSILKKY PYSVLSRQHN 

EKWD

Show »

Length:354

Mass (Da):37,620

Checksum:ⁱAE4B8FCDF458390B

GO

Isoform 5 (identifier: Q01844-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-74: P → PTVEGTS
326-326: Missing.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTVEGTS TGYTTPTAPQ AYSQPVQGYG 
       110        120        130        140        150
TGAYDTTTAT VTTTQASYAA QSAYGTQPAY PAYGQQPAAT APTRPQDGNK 
       160        170        180        190        200
PTETSQPQSS TGGYNQPSLG YGQSNYSYPQ VPGSYPMQPV TAPPSYPPTS 
       210        220        230        240        250
YSSTQPTSYD QSSYSQQNTY GQPSSYGQQS SYGQQSSYGQ QPPTSYPPQT 
       260        270        280        290        300
GSYSQAPSQY SQQSSSYGQQ SSFRQDHPSS MGVYGQESGG FSGPGENRSM 
       310        320        330        340        350
SGPDNRGRGR GGFDRGGMSR GGRGGGRGGM GAGERGGFNK PGGPMDEGPD 
       360        370        380        390        400
LDLGPPVDPD EDSDNSAIYV QGLNDSVTLD DLADFFKQCG VVKMNKRTGQ 
       410        420        430        440        450
PMIHIYLDKE TGKPKGDATV SYEDPPTAKA AVEWFDGKDF QGSKLKVSLA 
       460        470        480        490        500
RKKPPMNSMR GGLPPREGRG MPPPLRGGPG GPGGPGGPMG RMGGRGGDRG 
       510        520        530        540        550
GFPPRGPRGS RGNPSGGGNV QHRAGDWQCP NPGCGNQNFA WRTECNQCKA 
       560        570        580        590        600
PKPEGFLPPP FPPPGGDRGR GGPGGMRGGR GGLMDRGGPG GMFRGGRGGD 
       610        620        630        640        650
RGGFRGGRGM DRGGFGGGRR GGPGGPPGPL MEQMGGRRGG RGGPGKMDKG 
       660 
EHRQERRDRP Y

Show »

Length:661

Mass (Da):68,966

Checksum:ⁱ5F84F52FDCD51269

GO

Isoform 6 (identifier: Q01844-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
136-191: Missing.

« Hide

        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTSYS STQPTSYDQS 
       160        170        180        190        200
SYSQQNTYGQ PSSYGQQSSY GQQSSYGQQP PTSYPPQTGS YSQAPSQYSQ 
       210        220        230        240        250
QSSSYGQQSS FRQDHPSSMG VYGQESGGFS GPGENRSMSG PDNRGRGRGG 
       260        270        280        290        300
FDRGGMSRGG RGGGRGGMGS AGERGGFNKP GGPMDEGPDL DLGPPVDPDE 
       310        320        330        340        350
DSDNSAIYVQ GLNDSVTLDD LADFFKQCGV VKMNKRTGQP MIHIYLDKET 
       360        370        380        390        400
GKPKGDATVS YEDPPTAKAA VEWFDGKDFQ GSKLKVSLAR KKPPMNSMRG 
       410        420        430        440        450
GLPPREGRGM PPPLRGGPGG PGGPGGPMGR MGGRGGDRGG FPPRGPRGSR 
       460        470        480        490        500
GNPSGGGNVQ HRAGDWQCPN PGCGNQNFAW RTECNQCKAP KPEGFLPPPF 
       510        520        530        540        550
PPPGGDRGRG GPGGMRGGRG GLMDRGGPGG MFRGGRGGDR GGFRGGRGMD 
       560        570        580        590        600
RGGFGGGRRG GPGGPPGPLM EQMGGRRGGR GGPGKMDKGE HRQERRDRPY

Show »

Length:600

Mass (Da):62,508

Checksum:ⁱB3D01637474FFFB0

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B0QYK0	B0QYK0_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	618	Annotation score:
H7BY36	H7BY36_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	308	Annotation score:
C9JGE3	C9JGE3_HUMAN	EWS RNA-binding protein variant 6 EWS RNA-binding protein variant 6 (RNA-binding protein EWS)	EWSR1	620	Annotation score:
A0A0D9SFL3	A0A0D9SFL3_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	584	Annotation score:
B0QYJ4	B0QYJ4_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	166	Annotation score:
B0QYJ6	B0QYJ6_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	180	Annotation score:
B0QYJ7	B0QYJ7_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	233	Annotation score:
B0QYJ3	B0QYJ3_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	156	Annotation score:
F8WC90	F8WC90_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	292	Annotation score:
B0QYJ5	B0QYJ5_HUMAN	RNA-binding protein EWS RNA-binding protein EWS	EWSR1	77	Annotation score:

Sequence cautionⁱ

The sequence CAA70044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	224	S → G in BAB71252 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043451	74	P → PTVEGTS in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_045412	136 – 191	Missing in isoform 6. 1 PublicationAdd BLAST	56
Alternative sequenceⁱVSP_005793	266 – 338	Missing in isoform EWS-B. CuratedAdd BLAST	73
Alternative sequenceⁱVSP_043452	326 – 354	SAGER…PPVDP → LQSESLVYTSILKKYPYSVL SRQHNEKWD in isoform 4. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_043453	326	Missing in isoform 3 and isoform 5. 3 Publications	1
Alternative sequenceⁱVSP_043454	355 – 656	Missing in isoform 4. 1 PublicationAdd BLAST	302

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66899 mRNA Translation: CAA47350.1 X72990 X73004 Genomic DNA Translation: CAA51489.1 Y07848 Genomic DNA Translation: CAA69177.1 CR456490 mRNA Translation: CAG30376.1 AK056309 mRNA Translation: BAB71145.1 AK056681 mRNA Translation: BAB71252.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAI18001.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10937.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10938.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10940.1 CH471095 Genomic DNA Translation: EAW59780.1 CH471095 Genomic DNA Translation: EAW59781.1 CH471095 Genomic DNA Translation: EAW59785.1 CH471095 Genomic DNA Translation: EAW59786.1 CH471095 Genomic DNA Translation: EAW59787.1 BC000527 mRNA Translation: AAH00527.1 BC004817 mRNA Translation: AAH04817.1 BC011048 mRNA Translation: AAH11048.1 BC072442 mRNA Translation: AAH72442.1 Y08806 Genomic DNA Translation: CAA70044.1 Different initiation. AB016435 Genomic DNA Translation: BAA31990.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13851.1 [Q01844-1] CCDS13852.2 [Q01844-5] CCDS54512.1 [Q01844-4] CCDS54513.1 [Q01844-3] CCDS54514.1 [Q01844-6]
PIRⁱ	A49358
NCBI Reference Sequences More...RefSeqⁱ	NP_001156757.1, NM_001163285.1 [Q01844-3] NP_001156758.1, NM_001163286.1 [Q01844-6] NP_001156759.1, NM_001163287.1 [Q01844-4] NP_005234.1, NM_005243.3 [Q01844-1] NP_053733.2, NM_013986.3 [Q01844-5]

Genome annotation databases

Ensemblⁱ	ENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6] ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4] ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1] ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3] ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5]
GeneIDⁱ	2130
KEGGⁱ	hsa:2130
UCSC genome browser More...UCSCⁱ	uc003aes.5, human [Q01844-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01844-4	EWS RNA binding protein 1		CALJA		354	UniRef100_F6XXH6
EWSR1 isoform 14		PONAB		354
EWSR1 isoform 14		PANTR		354
Uncharacterized protein		PAPAN		354
Uncharacterized protein		PANPA		354
+7

Protein	Similar proteins		Species	Score	Length	Source
Q01844	EWSR1 (Fragment)		CRIGR		804	UniRef90_Q01844
Uncharacterized protein (Fragment)		NEOLE		693
RNA-binding protein EWS isoform X1		CARSF		679
Uncharacterized protein (Fragment)		MUNMU		672
EWS RNA binding protein 1		MACMU		671
+254
Q01844-2	Isoform 6 of RNA-binding protein EWS		HUMAN		600	UniRef90_Q01844-6
Uncharacterized protein		PROCO		692
EWS RNA binding protein 1		GORGO		650
EWS RNA binding protein 1		PANTR		632
Uncharacterized protein		PANPA		632
+60
Q01844-3	RNA-binding protein EWS		MOUSE		655	UniRef90_Q01844-3
EWS RNA binding protein 1		BOVIN		762
Uncharacterized protein		LYNCA		728
EWS RNA binding protein 1		PIG		680
Uncharacterized protein		BOBOX		662
+224
Q01844-4	RNA-binding protein EWS		MOUSE		354	UniRef90_Q5SUS8
EWS RNA binding protein 1		RHIFE		358
RNA-binding protein EWS isoform X4		PHACI		357
EWS RNA binding protein 1		CAVPO		354
EWS RNA binding protein 1		FELCA		354
+73

Protein	Similar proteins		Species	Score	Length	Source
Q01844	RNA-binding protein EWS		MOUSE		655	UniRef50_Q01844
EWSR1 (Fragment)		CRIGR		804
Uncharacterized protein (Fragment)		NEOLE		693
RNA-binding protein EWS isoform X1		CARSF		679
Uncharacterized protein (Fragment)		MUNMU		672
+603
Q01844-2	Isoform 6 of RNA-binding protein EWS		HUMAN		600	UniRef50_Q01844-6
Uncharacterized protein		PROCO		692
EWS RNA binding protein 1		GORGO		650
EWS RNA binding protein 1		PANTR		632
Uncharacterized protein		PANPA		632
+320
Q01844-4	RNA-binding protein EWS		MOUSE		354	UniRef50_Q5SUS8
EWS RNA binding protein 1		RHIFE		358
RNA-binding protein EWS isoform X4		PHACI		357
EWS RNA binding protein 1		HORSE		354
RNA-binding protein EWS isoform X7		CARSF		354
+83

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66899 mRNA Translation: CAA47350.1 X72990 X73004 Genomic DNA Translation: CAA51489.1 Y07848 Genomic DNA Translation: CAA69177.1 CR456490 mRNA Translation: CAG30376.1 AK056309 mRNA Translation: BAB71145.1 AK056681 mRNA Translation: BAB71252.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAI18001.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10937.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10938.1 AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10940.1 CH471095 Genomic DNA Translation: EAW59780.1 CH471095 Genomic DNA Translation: EAW59781.1 CH471095 Genomic DNA Translation: EAW59785.1 CH471095 Genomic DNA Translation: EAW59786.1 CH471095 Genomic DNA Translation: EAW59787.1 BC000527 mRNA Translation: AAH00527.1 BC004817 mRNA Translation: AAH04817.1 BC011048 mRNA Translation: AAH11048.1 BC072442 mRNA Translation: AAH72442.1 Y08806 Genomic DNA Translation: CAA70044.1 Different initiation. AB016435 Genomic DNA Translation: BAA31990.1
CCDSⁱ	CCDS13851.1 [Q01844-1] CCDS13852.2 [Q01844-5] CCDS54512.1 [Q01844-4] CCDS54513.1 [Q01844-3] CCDS54514.1 [Q01844-6]
PIRⁱ	A49358
RefSeqⁱ	NP_001156757.1, NM_001163285.1 [Q01844-3] NP_001156758.1, NM_001163286.1 [Q01844-6] NP_001156759.1, NM_001163287.1 [Q01844-4] NP_005234.1, NM_005243.3 [Q01844-1] NP_053733.2, NM_013986.3 [Q01844-5]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CPE	NMR	-	A	353-453	[»]
BMRBⁱ	Q01844
SMRⁱ	Q01844
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108431, 755 interactors
CORUMⁱ	Q01844
DIPⁱ	DIP-34449N
IntActⁱ	Q01844, 181 interactors
MINTⁱ	Q01844
STRINGⁱ	9606.ENSP00000400142

Chemistry databases

ChEMBLⁱ	CHEMBL3351202

ChEMBLⁱ

CHEMBL3351202

PTM databases

GlyGenⁱ	Q01844, 8 sites, 1 O-linked glycan (8 sites)
iPTMnetⁱ	Q01844
MetOSiteⁱ	Q01844
PhosphoSitePlusⁱ	Q01844
SwissPalmⁱ	Q01844

Polymorphism and mutation databases

BioMutaⁱ	EWSR1
DMDMⁱ	544261

Proteomic databases

EPDⁱ	Q01844
jPOSTⁱ	Q01844
MassIVEⁱ	Q01844
MaxQBⁱ	Q01844
PaxDbⁱ	Q01844
PeptideAtlasⁱ	Q01844
PRIDEⁱ	Q01844
ProteomicsDBⁱ	2658 58004 [Q01844-1] 58005 [Q01844-2] 58006 [Q01844-3] 58007 [Q01844-4] 58008 [Q01844-5]

Protocols and materials databases

Antibodypediaⁱ	3786, 542 antibodies
The DNASU plasmid repository More...DNASUⁱ	2130

Genome annotation databases

Ensemblⁱ	ENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6] ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4] ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1] ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3] ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5]
GeneIDⁱ	2130
KEGGⁱ	hsa:2130
UCSCⁱ	uc003aes.5, human [Q01844-1]

Organism-specific databases

CTDⁱ	2130
DisGeNETⁱ	2130
EuPathDBⁱ	HostDB:ENSG00000182944.17
GeneCardsⁱ	EWSR1
HGNCⁱ	HGNC:3508, EWSR1
HPAⁱ	ENSG00000182944, Low tissue specificity
MalaCardsⁱ	EWSR1
MIMⁱ	133450, gene 612160, phenotype 612219, phenotype
neXtProtⁱ	NX_Q01844
OpenTargetsⁱ	ENSG00000182944
Orphanetⁱ	83469, Desmoplastic small round cell tumor 370334, Extraskeletal Ewing sarcoma 209916, Extraskeletal myxoid chondrosarcoma 97338, Melanoma of soft tissue 319, Skeletal Ewing sarcoma
PharmGKBⁱ	PA27921
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1995, Eukaryota
GeneTreeⁱ	ENSGT00940000154191
HOGENOMⁱ	CLU_025609_1_1_1
InParanoidⁱ	Q01844
OMAⁱ	NYGSYTQ
OrthoDBⁱ	1539664at2759
PhylomeDBⁱ	Q01844
TreeFamⁱ	TF322599

Enzyme and pathway databases

PathwayCommonsⁱ	Q01844
SIGNORⁱ	Q01844

Miscellaneous databases

BioGRID-ORCSⁱ	2130, 631 hits in 861 CRISPR screens
ChiTaRSⁱ	EWSR1, human
EvolutionaryTraceⁱ	Q01844
GeneWikiⁱ	Ewing_sarcoma_breakpoint_region_1
GenomeRNAiⁱ	2130
Pharosⁱ	Q01844, Tbio
Protein Ontology More...PROⁱ	PR:Q01844
RNActⁱ	Q01844, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182944, Expressed in testis and 243 other tissues
ExpressionAtlasⁱ	Q01844, baseline and differential
Genevisibleⁱ	Q01844, HS

Family and domain databases

CDDⁱ	cd12533, RRM_EWS, 1 hit
DisProtⁱ	DP00632
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034869, EWS_RRM IPR033109, EWSR1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf
PANTHERⁱ	PTHR23238, PTHR23238, 1 hit PTHR23238:SF3, PTHR23238:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EWS_HUMAN
Accessionⁱ	Q01844Primary (citable) accession number: Q01844 Secondary accession number(s): B0QYK1 Q9BWA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	December 2, 2020
	This is version 229 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - Q01844 (EWS_HUMAN)

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RNA-binding protein EWS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Sites

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q01844

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ