UniProtKB - Q01844 (EWS_HUMAN)
RNA-binding protein EWS
EWSR1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 348 – 349 | Breakpoint for insertion to form EWSR1-FEV fusion protein | 2 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 518 – 549 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 32 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- transcription coregulator activity Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding, Repressor, RNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q01844 |
SIGNORi | Q01844 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein EWSAlternative name(s): EWS oncogene Ewing sarcoma breakpoint region 1 protein |
Gene namesi | Name:EWSR1 Synonyms:EWS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3508, EWSR1 |
MIMi | 133450, gene |
neXtProti | NX_Q01844 |
VEuPathDBi | HostDB:ENSG00000182944.17 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Note: Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Ewing sarcoma (ES)4 Publications
Angiomatoid fibrous histiocytoma (AFH)2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 648 | R → A: Cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 648 | R → K: No effect on nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 651 | R → A: No effect on nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 652 | R → A: Cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 652 | R → K: No effect on nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 653 | D → A: No effect on nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 654 | R → A: No effect on nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 655 | P → A: Cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 656 | Y → A: Cytoplasmic localization. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 265 | Breakpoint for translocation to form chimeric EWSR1/ATF1 protein | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2130 |
MalaCardsi | EWSR1 |
MIMi | 612160, phenotype 612219, phenotype |
OpenTargetsi | ENSG00000182944 |
Orphaneti | 83469, Desmoplastic small round cell tumor 370334, Extraskeletal Ewing sarcoma 209916, Extraskeletal myxoid chondrosarcoma 97338, Melanoma of soft tissue 319, Skeletal Ewing sarcoma |
PharmGKBi | PA27921 |
Miscellaneous databases
Pharosi | Q01844, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3351202 |
Genetic variation databases
BioMutai | EWSR1 |
DMDMi | 544261 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081586 | 1 – 656 | RNA-binding protein EWSAdd BLAST | 656 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 266 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 300 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 302 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 304 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 309 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 314 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 317 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 321 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 439 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 455 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 464 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 471 | Asymmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 471 | Omega-N-methylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 486 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 490 | Asymmetric dimethylarginine; by PRMT82 Publications | 1 | |
Modified residuei | 494 | Asymmetric dimethylarginine2 Publications | 1 | |
Modified residuei | 500 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 503 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 506 | Asymmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 506 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 563 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 565 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 572 | Asymmetric dimethylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 572 | Omega-N-methylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 575 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 581 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 589 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 592 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 596 | Asymmetric dimethylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 596 | Omega-N-methylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 600 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 603 | Asymmetric dimethylarginine; by PRMT82 Publications | 1 | |
Modified residuei | 607 | Asymmetric dimethylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 607 | Omega-N-methylarginine; alternate; by PRMT82 Publications | 1 | |
Modified residuei | 615 | Asymmetric dimethylarginine; alternate2 Publications | 1 | |
Modified residuei | 615 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 633 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 636 | Asymmetric dimethylarginine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q01844 |
jPOSTi | Q01844 |
MassIVEi | Q01844 |
MaxQBi | Q01844 |
PaxDbi | Q01844 |
PeptideAtlasi | Q01844 |
PRIDEi | Q01844 |
ProteomicsDBi | 2658 58004 [Q01844-1] 58005 [Q01844-2] 58006 [Q01844-3] 58007 [Q01844-4] 58008 [Q01844-5] |
PTM databases
GlyGeni | Q01844, 8 sites, 1 O-linked glycan (8 sites) |
iPTMneti | Q01844 |
MetOSitei | Q01844 |
PhosphoSitePlusi | Q01844 |
SwissPalmi | Q01844 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182944, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q01844, baseline and differential |
Genevisiblei | Q01844, HS |
Organism-specific databases
HPAi | ENSG00000182944, Low tissue specificity |
Interactioni
Subunit structurei
Binds POLR2C, SF1, calmodulin and RNA.
Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.
Forms a complex with REC8, PRDM9, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ01844
Isoform 3 [Q01844-3]
With | #Exp. | IntAct |
---|---|---|
ATXN3 [P54252] | 9 | EBI-25973273,EBI-946046 |
Isoform 4 [Q01844-4]
With | #Exp. | IntAct |
---|---|---|
ATXN3 [P54252] | 3 | EBI-25896785,EBI-946046 |
HTT [P42858] | 3 | EBI-25896785,EBI-466029 |
WFS1 [O76024] | 3 | EBI-25896785,EBI-720609 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 108431, 759 interactors |
CORUMi | Q01844 |
DIPi | DIP-34449N |
IntActi | Q01844, 185 interactors |
MINTi | Q01844 |
STRINGi | 9606.ENSP00000400142 |
Chemistry databases
BindingDBi | Q01844 |
Miscellaneous databases
RNActi | Q01844, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q01844 |
SMRi | Q01844 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01844 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 16 | 1 | 9 | |
Repeati | 17 – 27 | 2Add BLAST | 11 | |
Repeati | 28 – 34 | 3 | 7 | |
Repeati | 35 – 42 | 4 | 8 | |
Repeati | 43 – 50 | 5 | 8 | |
Repeati | 51 – 59 | 6 | 9 | |
Repeati | 60 – 68 | 7 | 9 | |
Repeati | 69 – 75 | 8 | 7 | |
Repeati | 76 – 84 | 9 | 9 | |
Repeati | 85 – 91 | 10 | 7 | |
Repeati | 92 – 110 | 11Add BLAST | 19 | |
Repeati | 111 – 116 | 12 | 6 | |
Repeati | 117 – 125 | 13 | 9 | |
Repeati | 126 – 156 | 14Add BLAST | 31 | |
Repeati | 157 – 163 | 15 | 7 | |
Repeati | 164 – 170 | 16 | 7 | |
Repeati | 171 – 177 | 17 | 7 | |
Repeati | 178 – 188 | 18Add BLAST | 11 | |
Repeati | 189 – 193 | 19 | 5 | |
Repeati | 194 – 201 | 20 | 8 | |
Repeati | 202 – 206 | 21 | 5 | |
Repeati | 207 – 212 | 22 | 6 | |
Repeati | 213 – 218 | 23 | 6 | |
Repeati | 219 – 224 | 24 | 6 | |
Repeati | 225 – 230 | 25 | 6 | |
Repeati | 231 – 238 | 26 | 8 | |
Repeati | 239 – 245 | 27 | 7 | |
Repeati | 246 – 252 | 28 | 7 | |
Repeati | 253 – 259 | 29 | 7 | |
Domaini | 256 – 285 | IQAdd BLAST | 30 | |
Repeati | 260 – 276 | 30Add BLAST | 17 | |
Repeati | 277 – 285 | 31 | 9 | |
Domaini | 361 – 447 | RRMPROSITE-ProRule annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 285 | EAD (Gln/Pro/Thr-rich)Add BLAST | 285 | |
Regioni | 8 – 285 | 31 X approximate tandem repeatsAdd BLAST | 278 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 639 – 656 | Nuclear localization signal1 PublicationAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 300 – 340 | Arg/Gly/Pro-richAdd BLAST | 41 | |
Compositional biasi | 454 – 513 | Arg/Gly/Pro-richAdd BLAST | 60 | |
Compositional biasi | 559 – 640 | Arg/Gly/Pro-richAdd BLAST | 82 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 518 – 549 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00940000154191 |
HOGENOMi | CLU_025609_1_1_1 |
InParanoidi | Q01844 |
OMAi | NYGSYTQ |
OrthoDBi | 1539664at2759 |
PhylomeDBi | Q01844 |
TreeFami | TF322599 |
Family and domain databases
CDDi | cd12533, RRM_EWS, 1 hit |
DisProti | DP00632 |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034869, EWS_RRM IPR033109, EWSR1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR23238, PTHR23238, 1 hit PTHR23238:SF3, PTHR23238:SF3, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV
60 70 80 90 100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT
110 120 130 140 150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ
160 170 180 190 200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP
210 220 230 240 250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA
260 270 280 290 300
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR
310 320 330 340 350
GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP
360 370 380 390 400
PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI
410 420 430 440 450
YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP
460 470 480 490 500
MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR
510 520 530 540 550
GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG
560 570 580 590 600
FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR
610 620 630 640 650
GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE
RRDRPY
The sequence of this isoform differs from the canonical sequence as follows:
266-338: Missing.
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QYK0 | B0QYK0_HUMAN | RNA-binding protein EWS | EWSR1 | 618 | Annotation score: | ||
H7BY36 | H7BY36_HUMAN | RNA-binding protein EWS | EWSR1 | 308 | Annotation score: | ||
C9JGE3 | C9JGE3_HUMAN | EWS RNA-binding protein variant 6 | EWSR1 | 620 | Annotation score: | ||
A0A0D9SFL3 | A0A0D9SFL3_HUMAN | RNA-binding protein EWS | EWSR1 | 584 | Annotation score: | ||
B0QYJ4 | B0QYJ4_HUMAN | RNA-binding protein EWS | EWSR1 | 166 | Annotation score: | ||
B0QYJ6 | B0QYJ6_HUMAN | RNA-binding protein EWS | EWSR1 | 180 | Annotation score: | ||
B0QYJ7 | B0QYJ7_HUMAN | RNA-binding protein EWS | EWSR1 | 233 | Annotation score: | ||
B0QYJ3 | B0QYJ3_HUMAN | RNA-binding protein EWS | EWSR1 | 156 | Annotation score: | ||
F8WC90 | F8WC90_HUMAN | RNA-binding protein EWS | EWSR1 | 292 | Annotation score: | ||
B0QYJ5 | B0QYJ5_HUMAN | RNA-binding protein EWS | EWSR1 | 77 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 224 | S → G in BAB71252 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043451 | 74 | P → PTVEGTS in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_045412 | 136 – 191 | Missing in isoform 6. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_005793 | 266 – 338 | Missing in isoform EWS-B. CuratedAdd BLAST | 73 | |
Alternative sequenceiVSP_043452 | 326 – 354 | SAGER…PPVDP → LQSESLVYTSILKKYPYSVL SRQHNEKWD in isoform 4. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_043453 | 326 | Missing in isoform 3 and isoform 5. 3 Publications | 1 | |
Alternative sequenceiVSP_043454 | 355 – 656 | Missing in isoform 4. 1 PublicationAdd BLAST | 302 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6] ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4] ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1] ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3] ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5] |
GeneIDi | 2130 |
KEGGi | hsa:2130 |
UCSCi | uc003aes.5, human [Q01844-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CPE | NMR | - | A | 353-453 | [»] | |
BMRBi | Q01844 | |||||
SMRi | Q01844 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108431, 759 interactors |
CORUMi | Q01844 |
DIPi | DIP-34449N |
IntActi | Q01844, 185 interactors |
MINTi | Q01844 |
STRINGi | 9606.ENSP00000400142 |
Chemistry databases
BindingDBi | Q01844 |
ChEMBLi | CHEMBL3351202 |
PTM databases
GlyGeni | Q01844, 8 sites, 1 O-linked glycan (8 sites) |
iPTMneti | Q01844 |
MetOSitei | Q01844 |
PhosphoSitePlusi | Q01844 |
SwissPalmi | Q01844 |
Genetic variation databases
BioMutai | EWSR1 |
DMDMi | 544261 |
Proteomic databases
EPDi | Q01844 |
jPOSTi | Q01844 |
MassIVEi | Q01844 |
MaxQBi | Q01844 |
PaxDbi | Q01844 |
PeptideAtlasi | Q01844 |
PRIDEi | Q01844 |
ProteomicsDBi | 2658 58004 [Q01844-1] 58005 [Q01844-2] 58006 [Q01844-3] 58007 [Q01844-4] 58008 [Q01844-5] |
Protocols and materials databases
Antibodypediai | 3786, 554 antibodies |
DNASUi | 2130 |
Genome annotation databases
Ensembli | ENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6] ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4] ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1] ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3] ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5] |
GeneIDi | 2130 |
KEGGi | hsa:2130 |
UCSCi | uc003aes.5, human [Q01844-1] |
Organism-specific databases
CTDi | 2130 |
DisGeNETi | 2130 |
GeneCardsi | EWSR1 |
HGNCi | HGNC:3508, EWSR1 |
HPAi | ENSG00000182944, Low tissue specificity |
MalaCardsi | EWSR1 |
MIMi | 133450, gene 612160, phenotype 612219, phenotype |
neXtProti | NX_Q01844 |
OpenTargetsi | ENSG00000182944 |
Orphaneti | 83469, Desmoplastic small round cell tumor 370334, Extraskeletal Ewing sarcoma 209916, Extraskeletal myxoid chondrosarcoma 97338, Melanoma of soft tissue 319, Skeletal Ewing sarcoma |
PharmGKBi | PA27921 |
VEuPathDBi | HostDB:ENSG00000182944.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00940000154191 |
HOGENOMi | CLU_025609_1_1_1 |
InParanoidi | Q01844 |
OMAi | NYGSYTQ |
OrthoDBi | 1539664at2759 |
PhylomeDBi | Q01844 |
TreeFami | TF322599 |
Enzyme and pathway databases
PathwayCommonsi | Q01844 |
SIGNORi | Q01844 |
Miscellaneous databases
BioGRID-ORCSi | 2130, 660 hits in 1015 CRISPR screens |
ChiTaRSi | EWSR1, human |
EvolutionaryTracei | Q01844 |
GeneWikii | Ewing_sarcoma_breakpoint_region_1 |
GenomeRNAii | 2130 |
Pharosi | Q01844, Tbio |
PROi | PR:Q01844 |
RNActi | Q01844, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182944, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q01844, baseline and differential |
Genevisiblei | Q01844, HS |
Family and domain databases
CDDi | cd12533, RRM_EWS, 1 hit |
DisProti | DP00632 |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034869, EWS_RRM IPR033109, EWSR1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR23238, PTHR23238, 1 hit PTHR23238:SF3, PTHR23238:SF3, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EWS_HUMAN | |
Accessioni | Q01844Primary (citable) accession number: Q01844 Secondary accession number(s): B0QYK1 Q9BWA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 231 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families