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UniProtKB - Q01844 (EWS_HUMAN)

Protein

RNA-binding protein EWS

Gene

EWSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei348 – 349Breakpoint for insertion to form EWSR1-FEV fusion protein2

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 549RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalmodulin-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ01844

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein EWS
Alternative name(s):
EWS oncogene
Ewing sarcoma breakpoint region 1 protein
Gene namesi
Name:EWSR1
Synonyms:EWS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000182944.17
HGNCiHGNC:3508 EWSR1
MIMi133450 gene
neXtProtiNX_Q01844

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES)4 Publications
The protein represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with Ewing sarcoma. Translocation t(11;22)(q24;q12) with FLI1 (PubMed:1522903, PubMed:15044653). Translocation t(7;22)(p22;q12) with ETV1 (PubMed:7700648). Translocation t(21;22)(q22;q21) with ERG (PubMed:15044653). Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with potential oncogenic activity (PubMed:9121764).4 Publications
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
See also OMIM:612219
A chromosomal aberration involving EWSR1 has been found in extraskeletal myxoid chondrosarcoma. Translocation t(9;22)(q22-31;q11-12) with NR4A3.1 Publication
A chromosomal aberration involving EWSR1 is associated with desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with WT1.1 Publication
A chromosomal aberration involving EWSR1 is associated with malignant melanoma of soft parts (MMSP). Translocation t(12;22)(q13;q12) with ATF1. Malignant melanoma of soft parts, also known as soft tissue clear cell sarcoma, is a rare tumor developing in tendons and aponeuroses.1 Publication
A chromosomal aberration involving EWSR1 is associated with small round cell sarcoma. Translocation t(11;22)(p36.1;q12) with PATZ1.1 Publication
Angiomatoid fibrous histiocytoma (AFH)2 Publications
The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;22)(q13;q12) with ATF1 generates a chimeric EWSR1/ATF1 protein (PubMed:15884099). Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type (PubMed:17724745).2 Publications
Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
See also OMIM:612160
EFPS arise due to chromosomal translocations in which EWSR1 is fused to a variety of cellular transcription factors. EFPS are very potent transcriptional activators dependent on the EAD and a C-terminal DNA-binding domain contributed by the fusion partner. The spectrum of malignancies associated with EFPS are thought to arise via EFP-induced transcriptional deregulation, with the tumor phenotype specified by the EWSR1 fusion partner and cell type. Transcriptional repression of the transforming growth factor beta type II receptor (TGF beta RII) is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene.Curated

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi648R → A: Cytoplasmic localization. 1 Publication1
Mutagenesisi648R → K: No effect on nuclear targeting. 1 Publication1
Mutagenesisi651R → A: No effect on nuclear targeting. 1 Publication1
Mutagenesisi652R → A: Cytoplasmic localization. 1 Publication1
Mutagenesisi652R → K: No effect on nuclear targeting. 1 Publication1
Mutagenesisi653D → A: No effect on nuclear targeting. 1 Publication1
Mutagenesisi654R → A: No effect on nuclear targeting. 1 Publication1
Mutagenesisi655P → A: Cytoplasmic localization. 1 Publication1
Mutagenesisi656Y → A: Cytoplasmic localization. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei265Breakpoint for translocation to form chimeric EWSR1/ATF1 protein1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2130
MalaCardsiEWSR1
MIMi612160 phenotype
612219 phenotype
OpenTargetsiENSG00000182944
Orphaneti83469 Desmoplastic small round cell tumor
319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
209916 Extraskeletal myxoid chondrosarcoma
97338 Melanoma of soft tissue
PharmGKBiPA27921

Polymorphism and mutation databases

BioMutaiEWSR1
DMDMi544261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815861 – 656RNA-binding protein EWSAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266Phosphoserine; by PKCBy similarity1
Modified residuei300Asymmetric dimethylarginine1 Publication1
Modified residuei302Asymmetric dimethylarginine1 Publication1
Modified residuei304Asymmetric dimethylarginine1 Publication1
Modified residuei309Asymmetric dimethylarginine1 Publication1
Modified residuei314Asymmetric dimethylarginine1 Publication1
Modified residuei317Asymmetric dimethylarginine1 Publication1
Modified residuei321Asymmetric dimethylarginine1 Publication1
Modified residuei439N6-acetyllysineBy similarity1
Modified residuei455Asymmetric dimethylarginine1 Publication1
Modified residuei464Asymmetric dimethylarginine1 Publication1
Modified residuei471Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei471Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei486Omega-N-methylarginineCombined sources1
Modified residuei490Asymmetric dimethylarginine; by PRMT82 Publications1
Modified residuei494Asymmetric dimethylarginine2 Publications1
Modified residuei500Asymmetric dimethylarginine1 Publication1
Modified residuei503Asymmetric dimethylarginine1 Publication1
Modified residuei506Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei506Omega-N-methylarginine; alternateBy similarity1
Modified residuei563Asymmetric dimethylarginine1 Publication1
Modified residuei565Asymmetric dimethylarginine1 Publication1
Modified residuei572Asymmetric dimethylarginine; alternate; by PRMT82 Publications1
Modified residuei572Omega-N-methylarginine; alternate; by PRMT82 Publications1
Modified residuei575Asymmetric dimethylarginine1 Publication1
Modified residuei581Asymmetric dimethylarginine1 Publication1
Modified residuei589Asymmetric dimethylarginine1 Publication1
Modified residuei592Asymmetric dimethylarginine1 Publication1
Modified residuei596Asymmetric dimethylarginine; alternate; by PRMT82 Publications1
Modified residuei596Omega-N-methylarginine; alternate; by PRMT82 Publications1
Modified residuei600Asymmetric dimethylarginine1 Publication1
Modified residuei603Asymmetric dimethylarginine; by PRMT82 Publications1
Modified residuei607Asymmetric dimethylarginine; alternate; by PRMT82 Publications1
Modified residuei607Omega-N-methylarginine; alternate; by PRMT82 Publications1
Modified residuei615Asymmetric dimethylarginine; alternate2 Publications1
Modified residuei615Omega-N-methylarginine; alternateCombined sources1
Modified residuei633Asymmetric dimethylarginine1 Publication1
Modified residuei636Asymmetric dimethylarginine1 Publication1

Post-translational modificationi

Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.1 Publication
Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ01844
MaxQBiQ01844
PaxDbiQ01844
PeptideAtlasiQ01844
PRIDEiQ01844
ProteomicsDBi58004
58005 [Q01844-2]
58006 [Q01844-3]
58007 [Q01844-4]
58008 [Q01844-5]

PTM databases

iPTMnetiQ01844
PhosphoSitePlusiQ01844
SwissPalmiQ01844

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000182944 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_EWSR1
ExpressionAtlasiQ01844 baseline and differential
GenevisibleiQ01844 HS

Organism-specific databases

HPAiCAB004230
HPA051771
HPA062953

Interactioni

Subunit structurei

Binds POLR2C, SF1, calmodulin and RNA. Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108431, 650 interactors
CORUMiQ01844
DIPiDIP-34449N
IntActiQ01844, 159 interactors
MINTiQ01844
STRINGi9606.ENSP00000400142

Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00632
ProteinModelPortaliQ01844
SMRiQ01844
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01844

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1619
Repeati17 – 272Add BLAST11
Repeati28 – 3437
Repeati35 – 4248
Repeati43 – 5058
Repeati51 – 5969
Repeati60 – 6879
Repeati69 – 7587
Repeati76 – 8499
Repeati85 – 91107
Repeati92 – 11011Add BLAST19
Repeati111 – 116126
Repeati117 – 125139
Repeati126 – 15614Add BLAST31
Repeati157 – 163157
Repeati164 – 170167
Repeati171 – 177177
Repeati178 – 18818Add BLAST11
Repeati189 – 193195
Repeati194 – 201208
Repeati202 – 206215
Repeati207 – 212226
Repeati213 – 218236
Repeati219 – 224246
Repeati225 – 230256
Repeati231 – 238268
Repeati239 – 245277
Repeati246 – 252287
Repeati253 – 259297
Domaini256 – 285IQAdd BLAST30
Repeati260 – 27630Add BLAST17
Repeati277 – 285319
Domaini361 – 447RRMPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 285EAD (Gln/Pro/Thr-rich)Add BLAST285
Regioni8 – 28531 X approximate tandem repeatsAdd BLAST278

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi639 – 656Nuclear localization signal1 PublicationAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi300 – 340Arg/Gly/Pro-richAdd BLAST41
Compositional biasi454 – 513Arg/Gly/Pro-richAdd BLAST60
Compositional biasi559 – 640Arg/Gly/Pro-richAdd BLAST82

Domaini

EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD.

Sequence similaritiesi

Belongs to the RRM TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 549RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995 Eukaryota
ENOG4111Q2F LUCA
GeneTreeiENSGT00530000063105
HOGENOMiHOG000038010
HOVERGENiHBG000970
InParanoidiQ01844
KOiK13209
OMAiDMRDHRQ
OrthoDBiEOG091G0U8W
PhylomeDBiQ01844
TreeFamiTF322599

Family and domain databases

CDDicd12533 RRM_EWS, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034869 EWS_RRM
IPR033109 EWSR1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034870 TET_fam
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR23238 PTHR23238, 1 hit
PTHR23238:SF3 PTHR23238:SF3, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform EWS (identifier: Q01844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV 
        60         70         80         90        100
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT 
       110        120        130        140        150
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ 
       160        170        180        190        200
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP 
       210        220        230        240        250
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA 
       260        270        280        290        300
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR 
       310        320        330        340        350
GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP 
       360        370        380        390        400
PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI 
       410        420        430        440        450
YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP 
       460        470        480        490        500
MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR 
       510        520        530        540        550
GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG 
       560        570        580        590        600
FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR 
       610        620        630        640        650
GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE 

RRDRPY
Length:656
Mass (Da):68,478
Last modified:June 1, 1994 - v1
Checksum:i0DA02CEE146720BB
GO
Isoform EWS-B (identifier: Q01844-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-338: Missing.

Note: No experimental confirmation available.
Show »
Length:583
Mass (Da):61,217
Checksum:i1B011799A0B290ED
GO
Isoform 3 (identifier: Q01844-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-326: Missing.

Show »
Length:655
Mass (Da):68,391
Checksum:iB539ED1E98C601ED
GO
Isoform 4 (identifier: Q01844-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-354: SAGERGGFNKPGGPMDEGPDLDLGPPVDP → LQSESLVYTSILKKYPYSVLSRQHNEKWD
     355-656: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):37,620
Checksum:iAE4B8FCDF458390B
GO
Isoform 5 (identifier: Q01844-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-74: P → PTVEGTS
     326-326: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):68,966
Checksum:i5F84F52FDCD51269
GO
Isoform 6 (identifier: Q01844-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-191: Missing.

Note: No experimental confirmation available.
Show »
Length:600
Mass (Da):62,508
Checksum:iB3D01637474FFFB0
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYK0B0QYK0_HUMAN
RNA-binding protein EWS
EWSR1
618Annotation score:
C9JGE3C9JGE3_HUMAN
EWS RNA-binding protein variant 6
EWSR1
620Annotation score:
A0A0D9SFL3A0A0D9SFL3_HUMAN
RNA-binding protein EWS
EWSR1
584Annotation score:
H7BY36H7BY36_HUMAN
RNA-binding protein EWS
EWSR1
308Annotation score:
F8WC90F8WC90_HUMAN
RNA-binding protein EWS
EWSR1
292Annotation score:
B0QYJ4B0QYJ4_HUMAN
RNA-binding protein EWS
EWSR1
166Annotation score:
B0QYJ7B0QYJ7_HUMAN
RNA-binding protein EWS
EWSR1
233Annotation score:
B0QYJ6B0QYJ6_HUMAN
RNA-binding protein EWS
EWSR1
180Annotation score:
B0QYJ3B0QYJ3_HUMAN
RNA-binding protein EWS
EWSR1
156Annotation score:
B0QYJ5B0QYJ5_HUMAN
RNA-binding protein EWS
EWSR1
77Annotation score:

Sequence cautioni

The sequence CAA70044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224S → G in BAB71252 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04345174P → PTVEGTS in isoform 5. 1 Publication1
Alternative sequenceiVSP_045412136 – 191Missing in isoform 6. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_005793266 – 338Missing in isoform EWS-B. CuratedAdd BLAST73
Alternative sequenceiVSP_043452326 – 354SAGER…PPVDP → LQSESLVYTSILKKYPYSVL SRQHNEKWD in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_043453326Missing in isoform 3 and isoform 5. 3 Publications1
Alternative sequenceiVSP_043454355 – 656Missing in isoform 4. 1 PublicationAdd BLAST302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66899 mRNA Translation: CAA47350.1
X72990
, X72991, X72992, X72993, X72994, X72995, X72996, X72997, X72998, X72999, X73000, X73001, X73002, X73003, X73004 Genomic DNA Translation: CAA51489.1
Y07848 Genomic DNA Translation: CAA69177.1
CR456490 mRNA Translation: CAG30376.1
AK056309 mRNA Translation: BAB71145.1
AK056681 mRNA Translation: BAB71252.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAI18001.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10937.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10938.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10940.1
CH471095 Genomic DNA Translation: EAW59780.1
CH471095 Genomic DNA Translation: EAW59781.1
CH471095 Genomic DNA Translation: EAW59785.1
CH471095 Genomic DNA Translation: EAW59786.1
CH471095 Genomic DNA Translation: EAW59787.1
BC000527 mRNA Translation: AAH00527.1
BC004817 mRNA Translation: AAH04817.1
BC011048 mRNA Translation: AAH11048.1
BC072442 mRNA Translation: AAH72442.1
Y08806 Genomic DNA Translation: CAA70044.1 Different initiation.
AB016435 Genomic DNA Translation: BAA31990.1
CCDSiCCDS13851.1 [Q01844-1]
CCDS13852.2 [Q01844-5]
CCDS54512.1 [Q01844-4]
CCDS54513.1 [Q01844-3]
CCDS54514.1 [Q01844-6]
PIRiA49358
RefSeqiNP_001156757.1, NM_001163285.1 [Q01844-3]
NP_001156758.1, NM_001163286.1 [Q01844-6]
NP_001156759.1, NM_001163287.1 [Q01844-4]
NP_005234.1, NM_005243.3 [Q01844-1]
NP_053733.2, NM_013986.3 [Q01844-5]
UniGeneiHs.374477

Genome annotation databases

EnsembliENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6]
ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4]
ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1]
ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3]
ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5]
GeneIDi2130
KEGGihsa:2130
UCSCiuc003aes.5 human [Q01844-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66899 mRNA Translation: CAA47350.1
X72990
, X72991, X72992, X72993, X72994, X72995, X72996, X72997, X72998, X72999, X73000, X73001, X73002, X73003, X73004 Genomic DNA Translation: CAA51489.1
Y07848 Genomic DNA Translation: CAA69177.1
CR456490 mRNA Translation: CAG30376.1
AK056309 mRNA Translation: BAB71145.1
AK056681 mRNA Translation: BAB71252.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAI18001.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10937.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10938.1
AL031186, AC000026, AC002059 Genomic DNA Translation: CAQ10940.1
CH471095 Genomic DNA Translation: EAW59780.1
CH471095 Genomic DNA Translation: EAW59781.1
CH471095 Genomic DNA Translation: EAW59785.1
CH471095 Genomic DNA Translation: EAW59786.1
CH471095 Genomic DNA Translation: EAW59787.1
BC000527 mRNA Translation: AAH00527.1
BC004817 mRNA Translation: AAH04817.1
BC011048 mRNA Translation: AAH11048.1
BC072442 mRNA Translation: AAH72442.1
Y08806 Genomic DNA Translation: CAA70044.1 Different initiation.
AB016435 Genomic DNA Translation: BAA31990.1
CCDSiCCDS13851.1 [Q01844-1]
CCDS13852.2 [Q01844-5]
CCDS54512.1 [Q01844-4]
CCDS54513.1 [Q01844-3]
CCDS54514.1 [Q01844-6]
PIRiA49358
RefSeqiNP_001156757.1, NM_001163285.1 [Q01844-3]
NP_001156758.1, NM_001163286.1 [Q01844-6]
NP_001156759.1, NM_001163287.1 [Q01844-4]
NP_005234.1, NM_005243.3 [Q01844-1]
NP_053733.2, NM_013986.3 [Q01844-5]
UniGeneiHs.374477

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPENMR-A353-453[»]
DisProtiDP00632
ProteinModelPortaliQ01844
SMRiQ01844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108431, 650 interactors
CORUMiQ01844
DIPiDIP-34449N
IntActiQ01844, 159 interactors
MINTiQ01844
STRINGi9606.ENSP00000400142

PTM databases

iPTMnetiQ01844
PhosphoSitePlusiQ01844
SwissPalmiQ01844

Polymorphism and mutation databases

BioMutaiEWSR1
DMDMi544261

Proteomic databases

EPDiQ01844
MaxQBiQ01844
PaxDbiQ01844
PeptideAtlasiQ01844
PRIDEiQ01844
ProteomicsDBi58004
58005 [Q01844-2]
58006 [Q01844-3]
58007 [Q01844-4]
58008 [Q01844-5]

Protocols and materials databases

DNASUi2130
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332035; ENSP00000331699; ENSG00000182944 [Q01844-6]
ENST00000333395; ENSP00000327456; ENSG00000182944 [Q01844-4]
ENST00000397938; ENSP00000381031; ENSG00000182944 [Q01844-1]
ENST00000406548; ENSP00000385726; ENSG00000182944 [Q01844-3]
ENST00000414183; ENSP00000400142; ENSG00000182944 [Q01844-5]
GeneIDi2130
KEGGihsa:2130
UCSCiuc003aes.5 human [Q01844-1]

Organism-specific databases

CTDi2130
DisGeNETi2130
EuPathDBiHostDB:ENSG00000182944.17
GeneCardsiEWSR1
HGNCiHGNC:3508 EWSR1
HPAiCAB004230
HPA051771
HPA062953
MalaCardsiEWSR1
MIMi133450 gene
612160 phenotype
612219 phenotype
neXtProtiNX_Q01844
OpenTargetsiENSG00000182944
Orphaneti83469 Desmoplastic small round cell tumor
319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
209916 Extraskeletal myxoid chondrosarcoma
97338 Melanoma of soft tissue
PharmGKBiPA27921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1995 Eukaryota
ENOG4111Q2F LUCA
GeneTreeiENSGT00530000063105
HOGENOMiHOG000038010
HOVERGENiHBG000970
InParanoidiQ01844
KOiK13209
OMAiDMRDHRQ
OrthoDBiEOG091G0U8W
PhylomeDBiQ01844
TreeFamiTF322599

Enzyme and pathway databases

SIGNORiQ01844

Miscellaneous databases

ChiTaRSiEWSR1 human
EvolutionaryTraceiQ01844
GeneWikiiEwing_sarcoma_breakpoint_region_1
GenomeRNAii2130
PROiPR:Q01844
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182944 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_EWSR1
ExpressionAtlasiQ01844 baseline and differential
GenevisibleiQ01844 HS

Family and domain databases

CDDicd12533 RRM_EWS, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034869 EWS_RRM
IPR033109 EWSR1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034870 TET_fam
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR23238 PTHR23238, 1 hit
PTHR23238:SF3 PTHR23238:SF3, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEWS_HUMAN
AccessioniPrimary (citable) accession number: Q01844
Secondary accession number(s): B0QYK1
, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 212 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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