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Protein

Probable endopeptidase p60

Gene

iap

Organism
Listeria grayi (Listeria murrayi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei423NucleophileBy similarity1
Active sitei473Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endopeptidase p60 (EC:3.4.-.-)
Alternative name(s):
Invasion-associated protein p60
Gene namesi
Name:iap
OrganismiListeria grayi (Listeria murrayi)
Taxonomic identifieri1641 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000001975728 – 511Probable endopeptidase p60Add BLAST484

Proteomic databases

PRIDEiQ01835

Structurei

3D structure databases

ProteinModelPortaliQ01835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 71LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini78 – 142SH3bPROSITE-ProRule annotationAdd BLAST65
Domaini175 – 218LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini297 – 341LysM 3PROSITE-ProRule annotationAdd BLAST45

Domaini

LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the peptidase C40 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105K4H Bacteria
COG0791 LUCA
COG1388 LUCA
COG3103 LUCA

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR000064 NLP_P60_dom
IPR038765 Papain_like_cys_pep_sf
IPR003646 SH3-like_bac-type
PfamiView protein in Pfam
PF01476 LysM, 3 hits
PF00877 NLPC_P60, 1 hit
PF08239 SH3_3, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 3 hits
SM00287 SH3b, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 3 hits
PS51781 SH3B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMKKATIVS AAGIAVTAFA APSVVSANTV VVASGDTLWG IASKTGTTVD
60 70 80 90 100
QLKQLNKLDS DRIVPGQKLT IKEVAAQKVE KSVSATWLNV RHAPDANEKI
110 120 130 140 150
LTSLKGRTVV KVESSEANGW NKISFDNGKT GYVNGKYLSD AKVAAPVVTK
160 170 180 190 200
AVTHKAEAKV AATSTHAVKV DTNASTYKVK SGDTIWALSV KYGVPVQKLI
210 220 230 240 250
EWNNLSSSSI YVGQTIAVKE AAAKAAPTTV KQAAPAKVAP KQEVKQTAPA
260 270 280 290 300
KQEQAKPAAK ETVKPAVSKP KAATPAPTAK PAVEQKASTP AVDTNAATYK
310 320 330 340 350
VQNGDSLGKI ASLFKVSVAD LTNWNNLNAT ITIYAGQELS VKASAAKPKP
360 370 380 390 400
AAPAKPAVSK PATSTPAKVT PTNTTNNSTP TTNVNNNTSQ SSSASFSALY
410 420 430 440 450
AEAKKHLGKP YTWGARGPST FDCSGFTSYV FNQVGLSLSG NSATQYANST
460 470 480 490 500
KISESQAQPG DLVFFNYGSG IAHVGIYIGG GQMIDAQDNG VSIDNIHGNG
510
WGQYLVGFGR V
Length:511
Mass (Da):53,181
Last modified:April 1, 1993 - v1
Checksum:i2FD0ED174E3810D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80352 Genomic DNA Translation: AAA25285.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80352 Genomic DNA Translation: AAA25285.1

3D structure databases

ProteinModelPortaliQ01835
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01835

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105K4H Bacteria
COG0791 LUCA
COG1388 LUCA
COG3103 LUCA

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR000064 NLP_P60_dom
IPR038765 Papain_like_cys_pep_sf
IPR003646 SH3-like_bac-type
PfamiView protein in Pfam
PF01476 LysM, 3 hits
PF00877 NLPC_P60, 1 hit
PF08239 SH3_3, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 3 hits
SM00287 SH3b, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 3 hits
PS51781 SH3B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP60_LISGR
AccessioniPrimary (citable) accession number: Q01835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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