Slc18a2

Functionⁱ

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

GO - Molecular functionⁱ

amine transmembrane transporter activity
Source: RGD
Inferred from direct assayⁱ
- 1505023
drug binding
Source: RGD
Inferred from physical interactionⁱ
- 20007701
drug transmembrane transporter activity Source: InterPro
enzyme binding
Source: RGD
Inferred from physical interactionⁱ
- 19903816
heat shock protein binding
Source: RGD
Inferred from physical interactionⁱ
- 19457116
serotonin transmembrane transporter activity
Source: RGD
Inferred from direct assayⁱ
- 20007701

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transport, Transport

Biological process

Neurotransmitter transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptic vesicular amine transporter Alternative name(s): Monoamine transporter Solute carrier family 18 member 2 Vesicular amine transporter 2 Short name: VAT2
Gene namesⁱ	Name:Slc18a2 Synonyms:Svat, Vmat2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	3694 Slc18a2

RGDⁱ

3694 Slc18a2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	21 – 41	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	42 – 130	Lumenal, vesicleSequence analysisAdd BLAST	89
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	152 – 160	CytoplasmicSequence analysis	9
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	182 – 190	Lumenal, vesicleSequence analysis	9
Transmembraneⁱ	191 – 211	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	212 – 220	CytoplasmicSequence analysis	9
Transmembraneⁱ	221 – 243	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	244 – 249	Lumenal, vesicleSequence analysis	6
Transmembraneⁱ	250 – 272	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	273 – 292	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	293 – 312	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	313 – 329	Lumenal, vesicleSequence analysisAdd BLAST	17
Transmembraneⁱ	330 – 353	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	354 – 358	CytoplasmicSequence analysis	5
Transmembraneⁱ	359 – 379	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	380 – 390	Lumenal, vesicleSequence analysisAdd BLAST	11
Transmembraneⁱ	391 – 411	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	412 – 415	CytoplasmicSequence analysis	4
Transmembraneⁱ	416 – 436	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	437 – 441	Lumenal, vesicleSequence analysis	5
Transmembraneⁱ	442 – 463	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	464 – 515	CytoplasmicSequence analysisAdd BLAST	52

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4828
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1012

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127516	1 – 515	Synaptic vesicular amine transporterAdd BLAST		515

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	56	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	89	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	111	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	118 ↔ 325	By similarity
Modified residueⁱ	512	Phosphoserine; by CK2Combined sources1 Publication	1
Modified residueⁱ	514	Phosphoserine; by CK2Combined sources1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q01827
PRIDEⁱ	Q01827

PTM databases

iPTMnetⁱ	Q01827
PhosphoSitePlusⁱ	Q01827

Expressionⁱ

Tissue specificityⁱ

Brainstem and stomach.

Interactionⁱ

Subunit structureⁱ

Interacts with SLC6A3.By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011983

STRINGⁱ

10116.ENSRNOP00000011983

Chemistry databases

BindingDBⁱ

Q01827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01827
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Vesicular transporter family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3764 Eukaryota ENOG410XW69 LUCA
HOGENOMⁱ	HOG000018545
HOVERGENⁱ	HBG055082
InParanoidⁱ	Q01827
KEGG Orthology (KO) More...KOⁱ	K08155
PhylomeDBⁱ	Q01827
TreeFamⁱ	TF313494

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf IPR004734 Multidrug-R
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
TIGRFAMsⁱ	TIGR00880 2_A_01_02, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q01827-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSDLVLLR WLRDSRHSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS 
        60         70         80         90        100
IKHEKNSTEI QTTRPELVVS TSESIFSYYN NSTVLITGNA TGTLPGGQSH 
       110        120        130        140        150
KATSTQHTVA NTTVPSDCPS EDRDLLNENV QVGLLFASKA TVQLLTNPFI 
       160        170        180        190        200
GLLTNRIGYP IPMFAGFCIM FISTVMFAFS SSYAFLLIAR SLQGIGSSCS 
       210        220        230        240        250
SVAGMGMLAS VYTDDEERGK PMGIALGGLA MGVLVGPPFG SVLYEFVGKT 
       260        270        280        290        300
APFLVLAALV LLDGAIQLFV LQPSRVQPES QKGTPLTTLL KDPYILIAAG 
       310        320        330        340        350
SICFANMGIA MLEPALPIWM METMCSRKWQ LGVAFLPASI SYLIGTNIFG 
       360        370        380        390        400
ILAHKMGRWL CALLGMVIVG ISILCIPFAK NIYGLIAPNF GVGFAIGMVD 
       410        420        430        440        450
SSMMPIMGYL VDLRHVSVYG SVYAIADVAF CMGYAIGPSA GGAIAKAIGF 
       460        470        480        490        500
PWLMTIIGII DIAFAPLCFF LRSPPAKEEK MAILMDHNCP IKRKMYTQNN 
       510 
VQSYPIGDDE ESESD

Length:515

Mass (Da):55,690

Last modified:September 19, 2003 - v2

Checksum:ⁱ627A904C1D35D552

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	220 – 221	KP → NA in AAA41627 (PubMed:1438304).Curated	2
Sequence conflictⁱ	397	G → F in AAA42190 (PubMed:1505023).Curated	1
Sequence conflictⁱ	493	R → T in AAA41627 (PubMed:1438304).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97381 mRNA Translation: AAA42190.1 L00603 mRNA Translation: AAA41627.1
PIRⁱ	A46374
NCBI Reference Sequences More...RefSeqⁱ	NP_037163.1, NM_013031.1 XP_006231726.1, XM_006231664.3 XP_017444313.1, XM_017588824.1
UniGeneⁱ	Rn.9686

Genome annotation databases

GeneIDⁱ	25549
KEGGⁱ	rno:25549

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q01827	Uncharacterized protein		NEOLE		530
UPI00038C3EEB		MICOH		523
UPI00042AF746		PERMB		523
UPI0004406436		BALAS		521
UPI0007DA7FF5		CRIGR		521
+55

Protein	Similar proteins		Species	Score	Length
Q01827	Uncharacterized protein		NEOLE		530
UPI00038C3EEB		MICOH		523
UPI00042AF746		PERMB		523
UPI0007DA7FF5		CRIGR		521
UPI0004406436		BALAS		521
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97381 mRNA Translation: AAA42190.1 L00603 mRNA Translation: AAA41627.1
PIRⁱ	A46374
NCBI Reference Sequences More...RefSeqⁱ	NP_037163.1, NM_013031.1 XP_006231726.1, XM_006231664.3 XP_017444313.1, XM_017588824.1
UniGeneⁱ	Rn.9686

3D structure databases

ProteinModelPortalⁱ	Q01827
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011983

STRINGⁱ

10116.ENSRNOP00000011983

Chemistry databases

BindingDBⁱ	Q01827
ChEMBLⁱ	CHEMBL4828
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1012

PTM databases

iPTMnetⁱ	Q01827
PhosphoSitePlusⁱ	Q01827

Proteomic databases

PaxDbⁱ	Q01827
PRIDEⁱ	Q01827

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	25549
KEGGⁱ	rno:25549

Organism-specific databases

CTDⁱ	6571
Rat genome database More...RGDⁱ	3694 Slc18a2

Phylogenomic databases

eggNOGⁱ	KOG3764 Eukaryota ENOG410XW69 LUCA
HOGENOMⁱ	HOG000018545
HOVERGENⁱ	HBG055082
InParanoidⁱ	Q01827
KEGG Orthology (KO) More...KOⁱ	K08155
PhylomeDBⁱ	Q01827
TreeFamⁱ	TF313494

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q01827

PROⁱ

PR:Q01827

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf IPR004734 Multidrug-R
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
TIGRFAMsⁱ	TIGR00880 2_A_01_02, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VMAT2_RAT
Accessionⁱ	Q01827Primary (citable) accession number: Q01827 Secondary accession number(s): Q9QVP1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	September 19, 2003
	Last modified:	June 20, 2018
	This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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Supporting data

UniProtKB - Q01827 (VMAT2_RAT)

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Synaptic vesicular amine transporter

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ