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Protein

Homeobox protein Hox-D1

Gene

Hoxd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D1
Alternative name(s):
Homeobox protein Hox-4.9
Gene namesi
Name:Hoxd1
Synonyms:Hox-4.9, Hoxd-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96201 Hoxd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002021 – 328Homeobox protein Hox-D1Add BLAST328

Proteomic databases

PaxDbiQ01822
PRIDEiQ01822

PTM databases

PhosphoSitePlusiQ01822

Expressioni

Developmental stagei

Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome.

Gene expression databases

BgeeiENSMUSG00000042448 Expressed in 63 organ(s), highest expression level in head
CleanExiMM_HOXD1
GenevisibleiQ01822 MM

Interactioni

Protein-protein interaction databases

BioGridi200391, 1 interactor
STRINGi10090.ENSMUSP00000043078

Structurei

3D structure databases

ProteinModelPortaliQ01822
SMRiQ01822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 209Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiQ01822
KOiK09301
OMAiYLEYVSC
OrthoDBiEOG091G0LR2
PhylomeDBiQ01822
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q01822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYLEYVSC AAGGGSGGVG GDVLGFAPKF CRADARPVAL QPAFPLGSGD
60 70 80 90 100
GAFVSCLPLA TARPTPSPPA GPAQSPVPQP AAPRYAPCTL EGAYERGAAP
110 120 130 140 150
ASAAEYGFLG SGPAFDFPGA LGRAADEGGA HVHYATSAVF SGGGSFLLSG
160 170 180 190 200
QVDFAAFGEP GPFPACLKEP ADGHPGPFQT VSPAPGACPK PASPTSSLPA
210 220 230 240 250
AHSTFEWMKV KRNAPKKSKL SEYGATSPPS AIRTNFSTKQ LTELEKEFHF
260 270 280 290 300
NKYLTRARRI EIANCLQLND TQVKIWFQNR RMKQKKRERE GLLATAASVA
310 320
SIKLPRSETS PIKSGRNLGS PSQAQEPS
Length:328
Mass (Da):34,180
Last modified:October 16, 2013 - v2
Checksum:i3452480CACED2FF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → A in CAA42637 (PubMed:1356009).Curated1
Sequence conflicti32Missing in CAA42637 (PubMed:1356009).Curated1
Sequence conflicti48S → N in CAA42637 (PubMed:1356009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60034 mRNA Translation: CAA42637.1
AL928733 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL27181.1
BC120537 mRNA Translation: AAI20538.1
BC120539 mRNA Translation: AAI20540.1
M87802 Genomic DNA Translation: AAA37853.1
CCDSiCCDS16147.1
PIRiA56553
RefSeqiNP_034597.2, NM_010467.2
UniGeneiMm.4932

Genome annotation databases

EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448
GeneIDi15429
KEGGimmu:15429
UCSCiuc008kei.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60034 mRNA Translation: CAA42637.1
AL928733 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL27181.1
BC120537 mRNA Translation: AAI20538.1
BC120539 mRNA Translation: AAI20540.1
M87802 Genomic DNA Translation: AAA37853.1
CCDSiCCDS16147.1
PIRiA56553
RefSeqiNP_034597.2, NM_010467.2
UniGeneiMm.4932

3D structure databases

ProteinModelPortaliQ01822
SMRiQ01822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200391, 1 interactor
STRINGi10090.ENSMUSP00000043078

PTM databases

PhosphoSitePlusiQ01822

Proteomic databases

PaxDbiQ01822
PRIDEiQ01822

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448
GeneIDi15429
KEGGimmu:15429
UCSCiuc008kei.1 mouse

Organism-specific databases

CTDi3231
MGIiMGI:96201 Hoxd1

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiQ01822
KOiK09301
OMAiYLEYVSC
OrthoDBiEOG091G0LR2
PhylomeDBiQ01822
TreeFamiTF317730

Miscellaneous databases

PROiPR:Q01822
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042448 Expressed in 63 organ(s), highest expression level in head
CleanExiMM_HOXD1
GenevisibleiQ01822 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD1_MOUSE
AccessioniPrimary (citable) accession number: Q01822
Secondary accession number(s): Q0VBQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 16, 2013
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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