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Protein

Connectin

Gene

Con

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion.

GO - Biological processi

  • axonal fasciculation Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • synaptic target attraction Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-DME-177929 Signaling by EGFR

Names & Taxonomyi

Protein namesi
Recommended name:
Connectin
Gene namesi
Name:Con
ORF Names:CG7503
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0005775 Con

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000002097925 – 658ConnectinAdd BLAST634
PropeptideiPRO_0000020980659 – 682Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi658GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ01819
PRIDEiQ01819

Expressioni

Tissue specificityi

Predominantly expressed in abdominal and thoracic segment muscle and motorneuron cells.

Developmental stagei

Embryo.

Gene expression databases

BgeeiFBgn0005775
ExpressionAtlasiQ01819 baseline and differential
GenevisibleiQ01819 DM

Interactioni

Protein-protein interaction databases

BioGridi64058, 2 interactors
STRINGi7227.FBpp0301699

Structurei

3D structure databases

ProteinModelPortaliQ01819
SMRiQ01819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 172LRR 1Add BLAST24
Repeati173 – 196LRR 2Add BLAST24
Repeati199 – 220LRR 3Add BLAST22
Repeati223 – 244LRR 4Add BLAST22
Repeati247 – 268LRR 5Add BLAST22
Repeati271 – 292LRR 6Add BLAST22
Repeati295 – 316LRR 7Add BLAST22
Repeati319 – 342LRR 8Add BLAST24
Repeati343 – 364LRR 9Add BLAST22
Repeati367 – 388LRR 10Add BLAST22
Repeati389 – 404LRR 11Add BLAST16
Domaini405 – 462LRRCTAdd BLAST58

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
InParanoidiQ01819
OrthoDBiEOG091G0FU1
PhylomeDBiQ01819

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLADSAIC FLLLSLLLIG ACLVTPTEGR AKDDRRTRGR GSSSGVLSSS
60 70 80 90 100
SSSSNNMNNG YYSGSSSTAG SSSGYVFTSS SAVNSGSTGY SGPMDSTGFC
110 120 130 140 150
TRRRDMKLMC YCTPDENHVP VQKAECWVFS EGLHQNDTTW TRFYQQKRLR
160 170 180 190 200
ELKFVIQNNA RLDYIPTMII EPLKNLSSIV IEYSQVEIVK SYAFANLPFL
210 220 230 240 250
ERIILNNNHI MALDQDAFAN HIRLRELNLE HNQIFEMDRY AFRNLPLCER
260 270 280 290 300
LFLNNNNIST LHEGLFADMA RLTFLNLAHN QINVLTSEIF RGLGNLNVLK
310 320 330 340 350
LTRNNLNFIG DTVFAELWSL SELELDDNRI ERISERALDG LNTLKTLNLR
360 370 380 390 400
NNLLKKIDNG LLRGTPALLS INVQANKLET LTFYTFQPIM DNLVNSTSEL
410 420 430 440 450
LVSDNKFICD CRLQWIFELK NRTRHLQLRD SLEDLHCTLQ EPKLSHFVDP
460 470 480 490 500
VPPTILDVLN IGGFTAIGSN SASMGGVGNS VVGSSYSGLT MDDSRKHLGS
510 520 530 540 550
RSRQALRGQR QFASSAENVV ESKMRRRRKR QEEVKEKDLA AVAPAHKRYD
560 570 580 590 600
YYDDNNGGMS LGHGLDLDDN LSLHKQGFYG AGSPVVGHND VDVLMTSHSA
610 620 630 640 650
SGDALDILTT KNAIYIKLFL LKPEMLPCHD ELSDPTELPL SRDLMDVRSN
660 670 680
VGQDMSTAGA NSLAQGMTII VSLVALMMIS RG
Length:682
Mass (Da):75,995
Last modified:May 10, 2004 - v2
Checksum:iE7F26353438ED06F
GO

Sequence cautioni

The sequence AAF47952 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM50172 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti631E → G in CAA48652 (PubMed:1363542).Curated1
Sequence conflicti674 – 677VALM → QVAL in AAA28424 (PubMed:1505024).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96647 mRNA Translation: AAA28424.1
X68701 mRNA Translation: CAA48652.1
AE014296 Genomic DNA Translation: AAF47952.3 Different initiation.
AY119518 mRNA Translation: AAM50172.1 Different initiation.
PIRiA43318
A49121
RefSeqiNP_001246635.1, NM_001259706.2
NP_523930.3, NM_079206.5
UniGeneiDm.2557

Genome annotation databases

EnsemblMetazoaiFBtr0073375; FBpp0073231; FBgn0005775
GeneIDi38590
KEGGidme:Dmel_CG7503
UCSCiCG7503-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCONN_DROME
AccessioniPrimary (citable) accession number: Q01819
Secondary accession number(s): Q8MRN1, Q9VZ74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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