UniProtKB - Q01780 (EXOSX_HUMAN)
Exosome component 10
EXOSC10
Functioni
GO - Molecular functioni
- 3'-5'-exoribonuclease activity Source: BHF-UCL
- exoribonuclease activity Source: UniProtKB
- nucleotide binding Source: InterPro
- RNA binding Source: UniProtKB
- single-stranded RNA binding Source: GO_Central
- telomerase RNA binding Source: BHF-UCL
GO - Biological processi
- CUT catabolic process Source: UniProtKB
- dosage compensation by inactivation of X chromosome Source: Ensembl
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- histone mRNA catabolic process Source: UniProtKB
- maturation of 5.8S rRNA Source: UniProtKB
- negative regulation of telomere maintenance via telomerase Source: BHF-UCL
- nuclear mRNA surveillance Source: UniProtKB
- nuclear polyadenylation-dependent antisense transcript catabolic process Source: GO_Central
- nuclear polyadenylation-dependent CUT catabolic process Source: GO_Central
- nuclear polyadenylation-dependent rRNA catabolic process Source: UniProtKB
- nuclear polyadenylation-dependent snoRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent snRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent tRNA catabolic process Source: GO_Central
- nuclear retention of unspliced pre-mRNA at the site of transcription Source: UniProtKB
- nuclear-transcribed mRNA catabolic process Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
- polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
- regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
- rRNA processing Source: Reactome
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease, RNA-binding |
Biological process | Nonsense-mediated mRNA decay, rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q01780 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q01780 |
Names & Taxonomyi
Protein namesi | Recommended name: Exosome component 10Curated (EC:3.1.13.-)Alternative name(s): Autoantigen PM/Scl 2 P100 polymyositis-scleroderma overlap syndrome-associated autoantigen Polymyositis/scleroderma autoantigen 100 kDa Short name: PM/Scl-100 Polymyositis/scleroderma autoantigen 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171824.13 |
HGNCi | HGNC:9138, EXOSC10 |
MIMi | 605960, gene |
neXtProti | NX_Q01780 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear exosome (RNase complex) Source: UniProtKB
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- exosome (RNase complex) Source: UniProtKB
- membrane Source: UniProtKB
- transcriptionally active chromatin Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Exosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5394 |
OpenTargetsi | ENSG00000171824 |
PharmGKBi | PA33464 |
Miscellaneous databases
Pharosi | Q01780, Tbio |
Polymorphism and mutation databases
BioMutai | EXOSC10 |
DMDMi | 8928564 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087133 | 1 – 885 | Exosome component 10Add BLAST | 885 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 19 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 583 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 583 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 710 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 821 | PhosphoserineCombined sources | 1 | |
Cross-linki | 826 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 833 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 859 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 873 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q01780 |
jPOSTi | Q01780 |
MassIVEi | Q01780 |
MaxQBi | Q01780 |
PaxDbi | Q01780 |
PeptideAtlasi | Q01780 |
PRIDEi | Q01780 |
ProteomicsDBi | 57986 [Q01780-1] 57987 [Q01780-2] |
2D gel databases
SWISS-2DPAGEi | Q01780 |
PTM databases
iPTMneti | Q01780 |
MetOSitei | Q01780 |
PhosphoSitePlusi | Q01780 |
SwissPalmi | Q01780 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171824, Expressed in right hemisphere of cerebellum and 239 other tissues |
ExpressionAtlasi | Q01780, baseline and differential |
Genevisiblei | Q01780, HS |
Organism-specific databases
HPAi | ENSG00000171824, Low tissue specificity |
Interactioni
Subunit structurei
Component of the RNA exosome complex (PubMed:20531389, PubMed:26166824, PubMed:29906447). The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (PubMed:20531389).
Interacts with C1D and MPHOSPH6 (PubMed:17412707).
Interacts with ALYREF/THOC4 (PubMed:17234882).
Interacts with MTREX; the interaction mediates the association of MTREX with nuclear RNA exosomes (PubMed:26166824).
Interacts with DHX36; this interaction occurs in a RNase-insensitive manner (PubMed:14731398).
6 PublicationsBinary interactionsi
Hide detailsQ01780
Protein-protein interaction databases
BioGRIDi | 111403, 106 interactors |
ComplexPortali | CPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591, Nucleolar exosome complex, EXOSC10 variant CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant |
CORUMi | Q01780 |
DIPi | DIP-31249N |
IntActi | Q01780, 70 interactors |
MINTi | Q01780 |
STRINGi | 9606.ENSP00000366135 |
Miscellaneous databases
RNActi | Q01780, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q01780 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01780 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 503 – 583 | HRDCPROSITE-ProRule annotationAdd BLAST | 81 |
Phylogenomic databases
eggNOGi | KOG2206, Eukaryota |
GeneTreei | ENSGT00390000015408 |
HOGENOMi | CLU_010129_1_1_1 |
InParanoidi | Q01780 |
OMAi | GFKAKNR |
OrthoDBi | 677201at2759 |
PhylomeDBi | Q01780 |
TreeFami | TF105991 |
Family and domain databases
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR012588, Exosome-assoc_fac_Rrp6_N IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit PF08066, PMC2NT, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS
60 70 80 90 100
GGLPQFGDEY DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR
110 120 130 140 150
SKVTELEDKF DLLVDANDVI LERVGILLDE ASGVNKNQQP VLPAGLQVPK
160 170 180 190 200
TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI IRPQLKFREK IDNSNTPFLP
210 220 230 240 250
KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE
260 270 280 290 300
QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL
310 320 330 340 350
NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY
360 370 380 390 400
ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR
410 420 430 440 450
HSLDHLLKLY CNVDSNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDK
460 470 480 490 500
MRLEMWERGN GQPVQLQVVW QRSRDICLKK FIKPIFTDES YLELYRKQKK
510 520 530 540 550
HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG
560 570 580 590 600
IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE
610 620 630 640 650
RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT
660 670 680 690 700
CLIATAVITL FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMFLPSLG
710 720 730 740 750
HRAPVSQAAK FDPSTKIYEI SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR
760 770 780 790 800
EQAKEACKAA AEQAISVRQQ VVLENAAKKR ERATSDPRTT EQKQEKKRLK
810 820 830 840 850
ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF DPNKQTPSGK
860 870 880
KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EJ37 | K7EJ37_HUMAN | Exosome component 10 | EXOSC10 | 124 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004362 | 695 – 719 | Missing in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66113 mRNA Translation: CAA46904.1 L01457 mRNA Translation: AAB59352.1 AJ300188 Genomic DNA Translation: CAC15569.1 AL109811 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71679.1 BC039901 mRNA Translation: AAH39901.1 BC073788 mRNA Translation: AAH73788.1 |
CCDSi | CCDS126.1 [Q01780-2] CCDS30584.1 [Q01780-1] |
PIRi | A43920 JH0796 |
RefSeqi | NP_001001998.1, NM_001001998.2 [Q01780-1] NP_002676.1, NM_002685.3 [Q01780-2] |
Genome annotation databases
Ensembli | ENST00000304457; ENSP00000307307; ENSG00000171824 [Q01780-2] ENST00000376936; ENSP00000366135; ENSG00000171824 [Q01780-1] |
GeneIDi | 5394 |
KEGGi | hsa:5394 |
UCSCi | uc001asa.4, human [Q01780-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66113 mRNA Translation: CAA46904.1 L01457 mRNA Translation: AAB59352.1 AJ300188 Genomic DNA Translation: CAC15569.1 AL109811 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71679.1 BC039901 mRNA Translation: AAH39901.1 BC073788 mRNA Translation: AAH73788.1 |
CCDSi | CCDS126.1 [Q01780-2] CCDS30584.1 [Q01780-1] |
PIRi | A43920 JH0796 |
RefSeqi | NP_001001998.1, NM_001001998.2 [Q01780-1] NP_002676.1, NM_002685.3 [Q01780-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CPR | NMR | - | A | 483-593 | [»] | |
3SAF | X-ray | 2.50 | A/B | 180-606 | [»] | |
3SAG | X-ray | 2.70 | A/B | 180-606 | [»] | |
3SAH | X-ray | 2.65 | A/B | 180-606 | [»] | |
6D6Q | electron microscopy | 3.45 | J | 1-648 | [»] | |
J | 705-804 | [»] | ||||
6D6R | electron microscopy | 3.45 | J | 1-648 | [»] | |
J | 705-804 | [»] | ||||
SMRi | Q01780 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111403, 106 interactors |
ComplexPortali | CPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591, Nucleolar exosome complex, EXOSC10 variant CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant |
CORUMi | Q01780 |
DIPi | DIP-31249N |
IntActi | Q01780, 70 interactors |
MINTi | Q01780 |
STRINGi | 9606.ENSP00000366135 |
PTM databases
iPTMneti | Q01780 |
MetOSitei | Q01780 |
PhosphoSitePlusi | Q01780 |
SwissPalmi | Q01780 |
Polymorphism and mutation databases
BioMutai | EXOSC10 |
DMDMi | 8928564 |
2D gel databases
SWISS-2DPAGEi | Q01780 |
Proteomic databases
EPDi | Q01780 |
jPOSTi | Q01780 |
MassIVEi | Q01780 |
MaxQBi | Q01780 |
PaxDbi | Q01780 |
PeptideAtlasi | Q01780 |
PRIDEi | Q01780 |
ProteomicsDBi | 57986 [Q01780-1] 57987 [Q01780-2] |
Protocols and materials databases
Antibodypediai | 13683, 176 antibodies |
DNASUi | 5394 |
Genome annotation databases
Ensembli | ENST00000304457; ENSP00000307307; ENSG00000171824 [Q01780-2] ENST00000376936; ENSP00000366135; ENSG00000171824 [Q01780-1] |
GeneIDi | 5394 |
KEGGi | hsa:5394 |
UCSCi | uc001asa.4, human [Q01780-1] |
Organism-specific databases
CTDi | 5394 |
DisGeNETi | 5394 |
EuPathDBi | HostDB:ENSG00000171824.13 |
GeneCardsi | EXOSC10 |
HGNCi | HGNC:9138, EXOSC10 |
HPAi | ENSG00000171824, Low tissue specificity |
MIMi | 605960, gene |
neXtProti | NX_Q01780 |
OpenTargetsi | ENSG00000171824 |
PharmGKBi | PA33464 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2206, Eukaryota |
GeneTreei | ENSGT00390000015408 |
HOGENOMi | CLU_010129_1_1_1 |
InParanoidi | Q01780 |
OMAi | GFKAKNR |
OrthoDBi | 677201at2759 |
PhylomeDBi | Q01780 |
TreeFami | TF105991 |
Enzyme and pathway databases
PathwayCommonsi | Q01780 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q01780 |
Miscellaneous databases
BioGRID-ORCSi | 5394, 455 hits in 851 CRISPR screens |
ChiTaRSi | EXOSC10, human |
EvolutionaryTracei | Q01780 |
GeneWikii | Exosome_component_10 |
GenomeRNAii | 5394 |
Pharosi | Q01780, Tbio |
PROi | PR:Q01780 |
RNActi | Q01780, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171824, Expressed in right hemisphere of cerebellum and 239 other tissues |
ExpressionAtlasi | Q01780, baseline and differential |
Genevisiblei | Q01780, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR012588, Exosome-assoc_fac_Rrp6_N IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit PF08066, PMC2NT, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXOSX_HUMAN | |
Accessioni | Q01780Primary (citable) accession number: Q01780 Secondary accession number(s): B1AKQ0, B1AKQ1, Q15158 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 215 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM