UniProtKB - Q01780 (EXOSX_HUMAN)

BLAST

>sp|Q01780|EXOSX_HUMAN Exosome component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2
MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY
DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI
LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI
IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF
IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL
NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA
IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ
LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK
FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI
AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE
RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL
FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI
SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR
ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF
DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR

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History
Entry version 199 (07 Nov 2018)
Sequence version 2 (01 Dec 2000)
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Protein

Exosome component 10

Gene

EXOSC10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.By similarity8 Publications

GO - Molecular functionⁱ

3'-5'-exoribonuclease activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 26950371
exoribonuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17174896
nucleotide binding Source: InterPro
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
telomerase RNA binding
Source: BHF-UCL
Inferred by curatorⁱ
- 26950371

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

CUT catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19056938
dosage compensation by inactivation of X chromosome Source: Ensembl
histone mRNA catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18172165
maturation of 5.8S rRNA
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17412707
- 20368444
negative regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 26950371
nuclear mRNA surveillance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17545563
nuclear polyadenylation-dependent rRNA catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16455498
nuclear retention of unspliced pre-mRNA at the site of transcription
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20699273
nuclear-transcribed mRNA catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17545563
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
regulation of telomerase RNA localization to Cajal body
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 26950371
rRNA processing Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Exonuclease, Hydrolase, Nuclease, RNA-binding
Biological process	Nonsense-mediated mRNA decay, rRNA processing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Exosome component 10Curated (EC:3.1.13.-) Alternative name(s): Autoantigen PM/Scl 2 P100 polymyositis-scleroderma overlap syndrome-associated autoantigen Polymyositis/scleroderma autoantigen 100 kDa Short name: PM/Scl-100 Polymyositis/scleroderma autoantigen 2
Gene namesⁱ	Name:EXOSC10Imported Synonyms:PMSCL, PMSCL2, RRP61 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171824.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9138 EXOSC10
MIMⁱ	605960 gene
neXtProtⁱ	NX_Q01780

Keywords - Cellular componentⁱ

Cytoplasm, Exosome, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5394
Open Targets More...OpenTargetsⁱ	ENSG00000171824
PharmGKBⁱ	PA33464

Polymorphism and mutation databases

BioMutaⁱ	EXOSC10
DMDMⁱ	8928564

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087133	1 – 885	Exosome component 10Add BLAST		885

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	19	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	583	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	583	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	710	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	821	PhosphoserineCombined sources	1
Cross-linkⁱ	826	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	833	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	859	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	873	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q01780
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01780
PaxDbⁱ	Q01780
PeptideAtlas More...PeptideAtlasⁱ	Q01780
PRIDEⁱ	Q01780
ProteomicsDBⁱ	57986 57987 [Q01780-2]

2D gel databases

SWISS-2DPAGEⁱ	Q01780

SWISS-2DPAGEⁱ

Q01780

PTM databases

iPTMnetⁱ	Q01780
PhosphoSitePlusⁱ	Q01780
SwissPalmⁱ	Q01780

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171824 Expressed in 229 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_EXOSC10
ExpressionAtlasⁱ	Q01780 baseline and differential
Genevisibleⁱ	Q01780 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037141 HPA028470 HPA028484

HPAⁱ

CAB037141
HPA028470
HPA028484

Interactionⁱ

Subunit structureⁱ

Component of the RNA exosome complex (PubMed:20531389, PubMed:26166824). The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (PubMed:20531389). Interacts with C1D and MPHOSPH6 (PubMed:17412707). Interacts with ALYREF/THOC4 (PubMed:17234882). Interacts with MTREX; the interaction mediates the association of MTREX with nuclear RNA exosomes (PubMed:26166824). Interacts with DHX36; this interaction occurs in a RNase-insensitive manner (PubMed:14731398).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
C1D	Q13901	5	EBI-358236,EBI-3844053
DDX5	P17844	3	EBI-358236,EBI-351962
DIS3	Q9Y2L1	4	EBI-358236,EBI-373539
EXOSC4	Q9NPD3	4	EBI-358236,EBI-371823
EXOSC5	Q9NQT4	3	EBI-358236,EBI-371876
MPHOSPH6	Q99547	4	EBI-358236,EBI-373187

Protein-protein interaction databases

BioGridⁱ	111403, 79 interactors
ComplexPortalⁱ	CPX-476 Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591 Nucleolar exosome complex, EXOSC10 variant CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
CORUMⁱ	Q01780
Database of interacting proteins More...DIPⁱ	DIP-31249N
IntActⁱ	Q01780, 61 interactors
Molecular INTeraction database More...MINTⁱ	Q01780
STRINGⁱ	9606.ENSP00000366135

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	183 – 186	Combined sources	4
Beta strandⁱ	194 – 196	Combined sources	3
Helixⁱ	214 – 216	Combined sources	3
Helixⁱ	218 – 220	Combined sources	3
Beta strandⁱ	253 – 255	Combined sources	3
Helixⁱ	259 – 263	Combined sources	5
Helixⁱ	269 – 272	Combined sources	4
Helixⁱ	283 – 285	Combined sources	3
Beta strandⁱ	288 – 291	Combined sources	4
Helixⁱ	294 – 304	Combined sources	11
Beta strandⁱ	308 – 317	Combined sources	10
Beta strandⁱ	325 – 332	Combined sources	8
Beta strandⁱ	337 – 341	Combined sources	5
Turnⁱ	342 – 345	Combined sources	4
Helixⁱ	346 – 352	Combined sources	7
Helixⁱ	353 – 356	Combined sources	4
Beta strandⁱ	361 – 367	Combined sources	7
Helixⁱ	369 – 379	Combined sources	11
Beta strandⁱ	384 – 388	Combined sources	5
Helixⁱ	389 – 395	Combined sources	7
Helixⁱ	403 – 411	Combined sources	9
Turnⁱ	418 – 421	Combined sources	4
Helixⁱ	431 – 442	Combined sources	12
Helixⁱ	444 – 458	Combined sources	15
Beta strandⁱ	461 – 463	Combined sources	3
Helixⁱ	464 – 476	Combined sources	13
Helixⁱ	490 – 492	Combined sources	3
Helixⁱ	493 – 496	Combined sources	4
Beta strandⁱ	497 – 500	Combined sources	4
Helixⁱ	504 – 524	Combined sources	21
Helixⁱ	528 – 531	Combined sources	4
Helixⁱ	534 – 543	Combined sources	10
Helixⁱ	548 – 552	Combined sources	5
Beta strandⁱ	555 – 557	Combined sources	3
Helixⁱ	560 – 564	Combined sources	5
Helixⁱ	566 – 577	Combined sources	12
Helixⁱ	583 – 586	Combined sources	4
Beta strandⁱ	636 – 638	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q01780
SMRⁱ	Q01780
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q01780

EvolutionaryTraceⁱ

Q01780

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	503 – 583	HRDCPROSITE-ProRule annotationAdd BLAST		81

Phylogenomic databases

eggNOGⁱ	KOG2206 Eukaryota COG0349 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015408
HOGENOMⁱ	HOG000001579
HOVERGENⁱ	HBG051524
InParanoidⁱ	Q01780
KEGG Orthology (KO) More...KOⁱ	K12591
OMAⁱ	NMFDTHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03BH
PhylomeDBⁱ	Q01780
TreeFamⁱ	TF105991

Family and domain databases

InterProⁱ	View protein in InterPro IPR002562 3'-5'_exonuclease_dom IPR012588 Exosome-assoc_fac_Rrp6_N IPR010997 HRDC-like_sf IPR002121 HRDC_dom IPR012337 RNaseH-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01612 DNA_pol_A_exo1, 1 hit PF00570 HRDC, 1 hit PF08066 PMC2NT, 1 hit
SMARTⁱ	View protein in SMART SM00474 35EXOc, 1 hit SM00341 HRDC, 1 hit
SUPFAMⁱ	SSF47819 SSF47819, 1 hit SSF53098 SSF53098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50967 HRDC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q01780-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS 
        60         70         80         90        100
GGLPQFGDEY DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR 
       110        120        130        140        150
SKVTELEDKF DLLVDANDVI LERVGILLDE ASGVNKNQQP VLPAGLQVPK 
       160        170        180        190        200
TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI IRPQLKFREK IDNSNTPFLP 
       210        220        230        240        250
KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE 
       260        270        280        290        300
QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL 
       310        320        330        340        350
NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY 
       360        370        380        390        400
ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR 
       410        420        430        440        450
HSLDHLLKLY CNVDSNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDK 
       460        470        480        490        500
MRLEMWERGN GQPVQLQVVW QRSRDICLKK FIKPIFTDES YLELYRKQKK 
       510        520        530        540        550
HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG 
       560        570        580        590        600
IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE 
       610        620        630        640        650
RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT 
       660        670        680        690        700
CLIATAVITL FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMFLPSLG 
       710        720        730        740        750
HRAPVSQAAK FDPSTKIYEI SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR 
       760        770        780        790        800
EQAKEACKAA AEQAISVRQQ VVLENAAKKR ERATSDPRTT EQKQEKKRLK 
       810        820        830        840        850
ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF DPNKQTPSGK 
       860        870        880 
KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR

Length:885

Mass (Da):100,831

Last modified:December 1, 2000 - v2

Checksum:ⁱA37BDC8F49BF2E57

Isoform 2 (identifier: Q01780-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
695-719: Missing.

« Hide

        10         20         30         40         50
MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS 
        60         70         80         90        100
GGLPQFGDEY DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR 
       110        120        130        140        150
SKVTELEDKF DLLVDANDVI LERVGILLDE ASGVNKNQQP VLPAGLQVPK 
       160        170        180        190        200
TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI IRPQLKFREK IDNSNTPFLP 
       210        220        230        240        250
KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE 
       260        270        280        290        300
QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL 
       310        320        330        340        350
NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY 
       360        370        380        390        400
ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR 
       410        420        430        440        450
HSLDHLLKLY CNVDSNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDK 
       460        470        480        490        500
MRLEMWERGN GQPVQLQVVW QRSRDICLKK FIKPIFTDES YLELYRKQKK 
       510        520        530        540        550
HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG 
       560        570        580        590        600
IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE 
       610        620        630        640        650
RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT 
       660        670        680        690        700
CLIATAVITL FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMISNRWK 
       710        720        730        740        750
LAQVQVQKDS KEAVKKKAAE QTAAREQAKE ACKAAAEQAI SVRQQVVLEN 
       760        770        780        790        800
AAKKRERATS DPRTTEQKQE KKRLKISKKP KDPEPPEKEF TPYDYSQSDF 
       810        820        830        840        850
KAFAGNSKSK VSSQFDPNKQ TPSGKKCIAA KKIKQSVGNK SMSFPTGKSD 
       860
RGFRYNWPQR

Note: No experimental confirmation available.

Show »

Length:860

Mass (Da):98,089

Checksum:ⁱB7FBE8B15F28BFE2

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EJ37	K7EJ37_HUMAN		Exosome component 10 Exosome component 10	EXOSC10	124	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004362	695 – 719	Missing in isoform 2. 1 PublicationAdd BLAST		25

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66113 mRNA Translation: CAA46904.1 L01457 mRNA Translation: AAB59352.1 AJ300188 Genomic DNA Translation: CAC15569.1 AL109811 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71679.1 BC039901 mRNA Translation: AAH39901.1 BC073788 mRNA Translation: AAH73788.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS126.1 [Q01780-2] CCDS30584.1 [Q01780-1]
PIRⁱ	A43920 JH0796
NCBI Reference Sequences More...RefSeqⁱ	NP_001001998.1, NM_001001998.2 [Q01780-1] NP_002676.1, NM_002685.3 [Q01780-2]
UniGeneⁱ	Hs.632368

Genome annotation databases

Ensemblⁱ	ENST00000304457; ENSP00000307307; ENSG00000171824 [Q01780-2] ENST00000376936; ENSP00000366135; ENSG00000171824 [Q01780-1]
GeneIDⁱ	5394
KEGGⁱ	hsa:5394
UCSC genome browser More...UCSCⁱ	uc001asa.4 human [Q01780-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01780	Uncharacterized protein		MACFA		908	UniRef90_Q01780
Uncharacterized protein		MACNE		884
Uncharacterized protein		PONAB		905
Uncharacterized protein		NOMLE		893
Exosome component 10 isoform 1		CALJA		890
+64
Q01780-2	Uncharacterized protein		MACFA		887	UniRef90_Q01780-2
Uncharacterized protein		COLAP		869
Uncharacterized protein		CERAT		860
Uncharacterized protein		MANLE		860
Uncharacterized protein		CALJA		860
+19

Protein	Similar proteins		Species	Score	Length	Source
Q01780	Exosome component 10		MOUSE		887	UniRef50_Q01780
Uncharacterized protein		MACFA		908
Uncharacterized protein		MACNE		884
Uncharacterized protein		PONAB		905
Uncharacterized protein		NOMLE		893
+333

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66113 mRNA Translation: CAA46904.1 L01457 mRNA Translation: AAB59352.1 AJ300188 Genomic DNA Translation: CAC15569.1 AL109811 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71679.1 BC039901 mRNA Translation: AAH39901.1 BC073788 mRNA Translation: AAH73788.1
CCDSⁱ	CCDS126.1 [Q01780-2] CCDS30584.1 [Q01780-1]
PIRⁱ	A43920 JH0796
RefSeqⁱ	NP_001001998.1, NM_001001998.2 [Q01780-1] NP_002676.1, NM_002685.3 [Q01780-2]
UniGeneⁱ	Hs.632368

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CPR	NMR	-	A	483-593	[»]
	3SAF	X-ray	2.50	A/B	180-606	[»]
	3SAG	X-ray	2.70	A/B	180-606	[»]
	3SAH	X-ray	2.65	A/B	180-606	[»]
	6D6Q	electron microscopy	3.45	J	1-648	[»]
				J	705-804	[»]
	6D6R	electron microscopy	3.45	J	1-648	[»]
				J	705-804	[»]
ProteinModelPortalⁱ	Q01780
SMRⁱ	Q01780
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111403, 79 interactors
ComplexPortalⁱ	CPX-476 Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591 Nucleolar exosome complex, EXOSC10 variant CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
CORUMⁱ	Q01780
DIPⁱ	DIP-31249N
IntActⁱ	Q01780, 61 interactors
MINTⁱ	Q01780
STRINGⁱ	9606.ENSP00000366135

PTM databases

iPTMnetⁱ	Q01780
PhosphoSitePlusⁱ	Q01780
SwissPalmⁱ	Q01780

Polymorphism and mutation databases

BioMutaⁱ	EXOSC10
DMDMⁱ	8928564

2D gel databases

SWISS-2DPAGEⁱ	Q01780

SWISS-2DPAGEⁱ

Q01780

Proteomic databases

EPDⁱ	Q01780
MaxQBⁱ	Q01780
PaxDbⁱ	Q01780
PeptideAtlasⁱ	Q01780
PRIDEⁱ	Q01780
ProteomicsDBⁱ	57986 57987 [Q01780-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5394
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304457; ENSP00000307307; ENSG00000171824 [Q01780-2] ENST00000376936; ENSP00000366135; ENSG00000171824 [Q01780-1]
GeneIDⁱ	5394
KEGGⁱ	hsa:5394
UCSCⁱ	uc001asa.4 human [Q01780-1]

Organism-specific databases

CTDⁱ	5394
DisGeNETⁱ	5394
EuPathDBⁱ	HostDB:ENSG00000171824.13
GeneCardsⁱ	EXOSC10
HGNCⁱ	HGNC:9138 EXOSC10
HPAⁱ	CAB037141 HPA028470 HPA028484
MIMⁱ	605960 gene
neXtProtⁱ	NX_Q01780
OpenTargetsⁱ	ENSG00000171824
PharmGKBⁱ	PA33464
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2206 Eukaryota COG0349 LUCA
GeneTreeⁱ	ENSGT00390000015408
HOGENOMⁱ	HOG000001579
HOVERGENⁱ	HBG051524
InParanoidⁱ	Q01780
KOⁱ	K12591
OMAⁱ	NMFDTHR
OrthoDBⁱ	EOG091G03BH
PhylomeDBⁱ	Q01780
TreeFamⁱ	TF105991

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	EXOSC10 human
EvolutionaryTraceⁱ	Q01780
GeneWikiⁱ	Exosome_component_10
GenomeRNAiⁱ	5394
Protein Ontology More...PROⁱ	PR:Q01780
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171824 Expressed in 229 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_EXOSC10
ExpressionAtlasⁱ	Q01780 baseline and differential
Genevisibleⁱ	Q01780 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002562 3'-5'_exonuclease_dom IPR012588 Exosome-assoc_fac_Rrp6_N IPR010997 HRDC-like_sf IPR002121 HRDC_dom IPR012337 RNaseH-like_sf
Pfamⁱ	View protein in Pfam PF01612 DNA_pol_A_exo1, 1 hit PF00570 HRDC, 1 hit PF08066 PMC2NT, 1 hit
SMARTⁱ	View protein in SMART SM00474 35EXOc, 1 hit SM00341 HRDC, 1 hit
SUPFAMⁱ	SSF47819 SSF47819, 1 hit SSF53098 SSF53098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50967 HRDC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EXOSX_HUMAN
Accessionⁱ	Q01780Primary (citable) accession number: Q01780 Secondary accession number(s): B1AKQ0, B1AKQ1, Q15158
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q01780 (EXOSX_HUMAN)

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Exosome component 10

EXOSC10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Keywords - Cellular componenti

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

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Alternative sequence

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Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

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2D gel databases

Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ