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Protein

T-complex protein 11

Gene

Tcp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the process of sperm capacitation and acrosome reactions (PubMed:9322250, PubMed:9820206). Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway (PubMed:9322250, PubMed:9820206).2 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 11
Alternative name(s):
Testis-specific protein PBS13
Gene namesi
Name:Tcp11
Synonyms:Tcp-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98544 Tcp11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei393 – 412HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasmic vesicle, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656501 – 566T-complex protein 11Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineBy similarity1

Post-translational modificationi

Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa (PubMed:27105888). Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway (PubMed:27105888).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01755
PaxDbiQ01755
PRIDEiQ01755

PTM databases

iPTMnetiQ01755
PhosphoSitePlusiQ01755

Expressioni

Tissue specificityi

Testis-specific (PubMed:1893875). Expressed in mature epididymal spermatozoa (at protein level) (PubMed:9322250).2 Publications

Developmental stagei

First expressed in the pachytene spermatocyte stage (PubMed:1893875).

Gene expression databases

CleanExiMM_TCP11

Interactioni

Subunit structurei

Found in a complex at least composed of MROH2B isoform 2, PRKACA isoform 2 and TCP11 (PubMed:27105888). Interacts with MROH2B isoform 2 (PubMed:27105888). Interacts with PRKACA isoform 2 (PubMed:27105888). Interacts with ODF1 (via leucine zipper motif) (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038590

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi138 – 143Poly-Ser6

Sequence similaritiesi

Belongs to the TCP11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1981 Eukaryota
ENOG410ZDEH LUCA
HOGENOMiHOG000231350
HOVERGENiHBG008348
InParanoidiQ01755

Family and domain databases

InterProiView protein in InterPro
IPR008862 Tcp11
PANTHERiPTHR12832 PTHR12832, 1 hit
PfamiView protein in Pfam
PF05794 Tcp11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q01755-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDVKERAAR KEPGAAESAS RESRGGNTRE SASSARGTDR VGSTVARARP
60 70 80 90 100
PSPQGPRRGA VKTAPRGPVG HGGLRTGPTS RCPQPSARAK LPSVTRGAPL
110 120 130 140 150
PPSPGKGHLG GTPSSHRLGM TERVHDASKL DCQLEERSLS SSSLKGKVKD
160 170 180 190 200
TMPSDFWEHL NEQLSAVPPD FSCALELLKE IKEILLSLLL PRQSRLKNEI
210 220 230 240 250
EEALDMEFLQ QQADRGDLNV SYLSKYILNM MVLLCAPIRD EAVQRLENIS
260 270 280 290 300
DPVRLLRGIF QVLGQMKMDM VNYTIQSLQP QLQEHSVQFE RAQFQERLNK
310 320 330 340 350
EPRLLNHTTK WLTQAATQLI APSASSSDLQ DCSSSAGPSP SDVAVPEPLS
360 370 380 390 400
PAMVLSQGFL NLLTWDPENE EFPETLVADR PRLQELESQQ SQLTILASVL
410 420 430 440 450
LVASSFSDSG LFSSPQFVDK LKQITKSLVE DFNSRPEEVM QSVSEQVVEE
460 470 480 490 500
VHQGLESMGL AALSSENTAS LVGQLQNIAK KENCVRSVID QRIHLFLKCC
510 520 530 540 550
FVLGVQRSLL DLPGGLTLIE AELAELGQKF VSLTHHNQQV FAPYYTEILK
560
TLISPAQTLA TKGGSL
Length:566
Mass (Da):61,970
Last modified:November 1, 1995 - v1
Checksum:i2FA8F83AF1015C49
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2KF25B2KF25_MOUSE
T-complex protein 11
Tcp11
567Annotation score:
Q5FWA2Q5FWA2_MOUSE
T-complex protein 11
Tcp11
488Annotation score:
B2KF24B2KF24_MOUSE
T-complex protein 11
Tcp11
237Annotation score:
B2KF23B2KF23_MOUSE
T-complex protein 11
Tcp11
183Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52128 mRNA Translation: CAA36374.1
PIRiS22933
UniGeneiMm.29758

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52128 mRNA Translation: CAA36374.1
PIRiS22933
UniGeneiMm.29758

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038590

PTM databases

iPTMnetiQ01755
PhosphoSitePlusiQ01755

Proteomic databases

MaxQBiQ01755
PaxDbiQ01755
PRIDEiQ01755

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98544 Tcp11

Phylogenomic databases

eggNOGiKOG1981 Eukaryota
ENOG410ZDEH LUCA
HOGENOMiHOG000231350
HOVERGENiHBG008348
InParanoidiQ01755

Miscellaneous databases

ChiTaRSiTcp11 mouse
PROiPR:Q01755
SOURCEiSearch...

Gene expression databases

CleanExiMM_TCP11

Family and domain databases

InterProiView protein in InterPro
IPR008862 Tcp11
PANTHERiPTHR12832 PTHR12832, 1 hit
PfamiView protein in Pfam
PF05794 Tcp11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCP11_MOUSE
AccessioniPrimary (citable) accession number: Q01755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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