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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

FMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi61 – 62FADBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.13.8 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-217271 FMO oxidises nucleophiles

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q01740

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Fetal hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FMO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000010932.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3769 FMO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136130 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01740

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei511 – 531HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2326

Open Targets

More...
OpenTargetsi
ENSG00000010932

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430872

Drug and drug target database

More...
DrugBanki
DB00185 Cevimeline
DB00501 Cimetidine
DB04871 Lorcaserin
DB00675 Tamoxifen
DB05294 Vandetanib
DB00582 Voriconazole

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FMO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
399505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476392 – 532Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01740

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01740

PeptideAtlas

More...
PeptideAtlasi
Q01740

PRoteomics IDEntifications database

More...
PRIDEi
Q01740

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57985

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01740

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01740

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in fetal and adult liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000010932 Expressed in 135 organ(s), highest expression level in nephron tubule

CleanEx database of gene expression profiles

More...
CleanExi
HS_FMO1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01740 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01740 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023680

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-23EBI-12701460,EBI-625022

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108613, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q01740, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346901

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q01740

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1399 Eukaryota
COG2072 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160945

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000076537

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002037

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01740

KEGG Orthology (KO)

More...
KOi
K00485

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWEVYVW

Database of Orthologous Groups

More...
OrthoDBi
405736at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01740

TreeFam database of animal gene trees

More...
TreeFami
TF105285

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002253 Flavin_mOase_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00743 FMO-like, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000332 FMO, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00370 FMOXYGENASE
PR01121 FMOXYGENASE1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL
110 120 130 140 150
LKHIQFKTKV CSVTKCSDSA VSGQWEVVTM HEEKQESAIF DAVMVCTGFL
160 170 180 190 200
TNPYLPLDSF PGINAFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA
210 220 230 240 250
VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ NMLRNSLPTP
260 270 280 290 300
IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR
310 320 330 340 350
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP
410 420 430 440 450
PPSVMIEEIN ARKENKPSWF GLCYCKALQS DYITYIDELL TYINAKPNLF
460 470 480 490 500
SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK WEGARNAIMT QWDRTFKVIK
510 520 530
ARVVQESPSP FESFLKVFSF LALLVAIFLI FL
Length:532
Mass (Da):60,311
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i627B855F38C2EB6D
GO
Isoform 2 (identifier: Q01740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-107: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):52,813
Checksum:iFC2C46683FE78025
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PNR8A0A1W2PNR8_HUMAN
Flavin-containing monooxygenase
FMO1
126Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01535897H → Q1 PublicationCorresponds to variant dbSNP:rs56841822Ensembl.1
Natural variantiVAR_022204223R → Q1 PublicationCorresponds to variant dbSNP:rs16864310Ensembl.1
Natural variantiVAR_022205227S → T1 Publication1
Natural variantiVAR_015359303I → T1 PublicationCorresponds to variant dbSNP:rs28360418Ensembl.1
Natural variantiVAR_015360303I → V2 PublicationsCorresponds to variant dbSNP:rs16864314Ensembl.1
Natural variantiVAR_022206322I → V1 PublicationCorresponds to variant dbSNP:rs28360419Ensembl.1
Natural variantiVAR_022207327F → L1 PublicationCorresponds to variant dbSNP:rs28360420Ensembl.1
Natural variantiVAR_022208373K → R1 PublicationCorresponds to variant dbSNP:rs28360421Ensembl.1
Natural variantiVAR_022209474R → H1 PublicationCorresponds to variant dbSNP:rs28360433Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05454345 – 107Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M64082 mRNA Translation: AAA52457.1
AY879266 Genomic DNA Translation: AAW56076.1
AK290113 mRNA Translation: BAF82802.1
AK296198 mRNA Translation: BAH12280.1
AL021026 Genomic DNA No translation available.
AL445673 Genomic DNA No translation available.
AL031274 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90892.1
BC047129 mRNA Translation: AAH47129.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1294.1 [Q01740-1]
CCDS60351.1 [Q01740-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A40876

NCBI Reference Sequences

More...
RefSeqi
NP_001269621.1, NM_001282692.1
NP_001269622.1, NM_001282693.1 [Q01740-1]
NP_001269623.1, NM_001282694.1 [Q01740-2]
NP_002012.1, NM_002021.2 [Q01740-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1424

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354841; ENSP00000346901; ENSG00000010932 [Q01740-1]
ENST00000367750; ENSP00000356724; ENSG00000010932 [Q01740-1]
ENST00000402921; ENSP00000385543; ENSG00000010932 [Q01740-2]
ENST00000617670; ENSP00000481732; ENSG00000010932 [Q01740-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2326

UCSC genome browser

More...
UCSCi
uc001ghl.5 human [Q01740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64082 mRNA Translation: AAA52457.1
AY879266 Genomic DNA Translation: AAW56076.1
AK290113 mRNA Translation: BAF82802.1
AK296198 mRNA Translation: BAH12280.1
AL021026 Genomic DNA No translation available.
AL445673 Genomic DNA No translation available.
AL031274 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90892.1
BC047129 mRNA Translation: AAH47129.1
CCDSiCCDS1294.1 [Q01740-1]
CCDS60351.1 [Q01740-2]
PIRiA40876
RefSeqiNP_001269621.1, NM_001282692.1
NP_001269622.1, NM_001282693.1 [Q01740-1]
NP_001269623.1, NM_001282694.1 [Q01740-2]
NP_002012.1, NM_002021.2 [Q01740-1]
UniGeneiHs.1424

3D structure databases

ProteinModelPortaliQ01740
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108613, 2 interactors
IntActiQ01740, 6 interactors
STRINGi9606.ENSP00000346901

Chemistry databases

ChEMBLiCHEMBL3430872
DrugBankiDB00185 Cevimeline
DB00501 Cimetidine
DB04871 Lorcaserin
DB00675 Tamoxifen
DB05294 Vandetanib
DB00582 Voriconazole

PTM databases

iPTMnetiQ01740
PhosphoSitePlusiQ01740

Polymorphism and mutation databases

BioMutaiFMO1
DMDMi399505

Proteomic databases

jPOSTiQ01740
PaxDbiQ01740
PeptideAtlasiQ01740
PRIDEiQ01740
ProteomicsDBi57985

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2326
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354841; ENSP00000346901; ENSG00000010932 [Q01740-1]
ENST00000367750; ENSP00000356724; ENSG00000010932 [Q01740-1]
ENST00000402921; ENSP00000385543; ENSG00000010932 [Q01740-2]
ENST00000617670; ENSP00000481732; ENSG00000010932 [Q01740-1]
GeneIDi2326
KEGGihsa:2326
UCSCiuc001ghl.5 human [Q01740-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2326
DisGeNETi2326
EuPathDBiHostDB:ENSG00000010932.15

GeneCards: human genes, protein and diseases

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GeneCardsi
FMO1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028548
HGNCiHGNC:3769 FMO1
HPAiHPA023680
MIMi136130 gene
neXtProtiNX_Q01740
OpenTargetsiENSG00000010932
PharmGKBiPA165

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00940000160945
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiQ01740
KOiK00485
OMAiDWEVYVW
OrthoDBi405736at2759
PhylomeDBiQ01740
TreeFamiTF105285

Enzyme and pathway databases

BRENDAi1.14.13.8 2681
ReactomeiR-HSA-217271 FMO oxidises nucleophiles
SABIO-RKiQ01740

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Flavin_containing_monooxygenase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2326

Protein Ontology

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PROi
PR:Q01740

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000010932 Expressed in 135 organ(s), highest expression level in nephron tubule
CleanExiHS_FMO1
ExpressionAtlasiQ01740 baseline and differential
GenevisibleiQ01740 HS

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002253 Flavin_mOase_1
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01121 FMOXYGENASE1
SUPFAMiSSF51905 SSF51905, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01740
Secondary accession number(s): A8K248
, B7Z3P4, Q5QPT2, Q9UJC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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