Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

FMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi61 – 62FADBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • monooxygenase activity Source: MGI
  • N,N-dimethylaniline monooxygenase activity Source: BHF-UCL
  • NADP binding Source: InterPro

GO - Biological processi

  • drug metabolic process Source: Ensembl
  • NADPH oxidation Source: BHF-UCL
  • organic acid metabolic process Source: BHF-UCL
  • response to lipopolysaccharide Source: Ensembl
  • response to osmotic stress Source: Ensembl
  • toxin metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 2681
ReactomeiR-HSA-217271 FMO oxidises nucleophiles
SABIO-RKiQ01740

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Fetal hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:FMO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000010932.15
HGNCiHGNC:3769 FMO1
MIMi136130 gene
neXtProtiNX_Q01740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi2326
OpenTargetsiENSG00000010932
PharmGKBiPA165

Chemistry databases

ChEMBLiCHEMBL3430872
DrugBankiDB00185 Cevimeline
DB00501 Cimetidine
DB04871 Lorcaserin
DB00675 Tamoxifen
DB05294 Vandetanib
DB00582 Voriconazole

Polymorphism and mutation databases

DMDMi399505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001476392 – 532Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ01740
PeptideAtlasiQ01740
PRIDEiQ01740
ProteomicsDBi57985

PTM databases

iPTMnetiQ01740
PhosphoSitePlusiQ01740

Expressioni

Tissue specificityi

Expressed mainly in fetal and adult liver.1 Publication

Gene expression databases

BgeeiENSG00000010932
CleanExiHS_FMO1
ExpressionAtlasiQ01740 baseline and differential
GenevisibleiQ01740 HS

Organism-specific databases

HPAiHPA023680

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-23EBI-12701460,EBI-625022

Protein-protein interaction databases

BioGridi108613, 2 interactors
IntActiQ01740, 6 interactors
STRINGi9606.ENSP00000346901

Structurei

3D structure databases

ProteinModelPortaliQ01740
SMRiQ01740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiQ01740
KOiK00485
OMAiDWEVYVW
OrthoDBiEOG091G0465
PhylomeDBiQ01740
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002253 Flavin_mOase_1
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01121 FMOXYGENASE1
SUPFAMiSSF51905 SSF51905, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL
110 120 130 140 150
LKHIQFKTKV CSVTKCSDSA VSGQWEVVTM HEEKQESAIF DAVMVCTGFL
160 170 180 190 200
TNPYLPLDSF PGINAFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA
210 220 230 240 250
VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ NMLRNSLPTP
260 270 280 290 300
IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR
310 320 330 340 350
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP
410 420 430 440 450
PPSVMIEEIN ARKENKPSWF GLCYCKALQS DYITYIDELL TYINAKPNLF
460 470 480 490 500
SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK WEGARNAIMT QWDRTFKVIK
510 520 530
ARVVQESPSP FESFLKVFSF LALLVAIFLI FL
Length:532
Mass (Da):60,311
Last modified:January 23, 2007 - v3
Checksum:i627B855F38C2EB6D
GO
Isoform 2 (identifier: Q01740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-107: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):52,813
Checksum:iFC2C46683FE78025
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01535897H → Q1 PublicationCorresponds to variant dbSNP:rs56841822Ensembl.1
Natural variantiVAR_022204223R → Q1 PublicationCorresponds to variant dbSNP:rs16864310Ensembl.1
Natural variantiVAR_022205227S → T1 Publication1
Natural variantiVAR_015359303I → T1 PublicationCorresponds to variant dbSNP:rs28360418Ensembl.1
Natural variantiVAR_015360303I → V2 PublicationsCorresponds to variant dbSNP:rs16864314Ensembl.1
Natural variantiVAR_022206322I → V1 PublicationCorresponds to variant dbSNP:rs28360419Ensembl.1
Natural variantiVAR_022207327F → L1 PublicationCorresponds to variant dbSNP:rs28360420Ensembl.1
Natural variantiVAR_022208373K → R1 PublicationCorresponds to variant dbSNP:rs28360421Ensembl.1
Natural variantiVAR_022209474R → H1 PublicationCorresponds to variant dbSNP:rs28360433Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05454345 – 107Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64082 mRNA Translation: AAA52457.1
AY879266 Genomic DNA Translation: AAW56076.1
AK290113 mRNA Translation: BAF82802.1
AK296198 mRNA Translation: BAH12280.1
AL021026 Genomic DNA No translation available.
AL445673 Genomic DNA No translation available.
AL031274 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90892.1
BC047129 mRNA Translation: AAH47129.1
CCDSiCCDS1294.1 [Q01740-1]
CCDS60351.1 [Q01740-2]
PIRiA40876
RefSeqiNP_001269621.1, NM_001282692.1
NP_001269622.1, NM_001282693.1 [Q01740-1]
NP_001269623.1, NM_001282694.1 [Q01740-2]
NP_002012.1, NM_002021.2 [Q01740-1]
UniGeneiHs.1424

Genome annotation databases

EnsembliENST00000354841; ENSP00000346901; ENSG00000010932 [Q01740-1]
ENST00000367750; ENSP00000356724; ENSG00000010932 [Q01740-1]
ENST00000402921; ENSP00000385543; ENSG00000010932 [Q01740-2]
ENST00000617670; ENSP00000481732; ENSG00000010932 [Q01740-1]
GeneIDi2326
KEGGihsa:2326
UCSCiuc001ghl.5 human [Q01740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFMO1_HUMAN
AccessioniPrimary (citable) accession number: Q01740
Secondary accession number(s): A8K248
, B7Z3P4, Q5QPT2, Q9UJC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health