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Protein

Ras suppressor protein 1

Gene

Rsu1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of neural precursor cell proliferation Source: MGI
  • Ras protein signal transduction Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ras suppressor protein 1
Short name:
RSP-1
Short name:
Rsu-1
Gene namesi
Name:Rsu1
Synonyms:Rsp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103040 Rsu1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000975002 – 277Ras suppressor protein 1Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ01730
MaxQBiQ01730
PaxDbiQ01730
PeptideAtlasiQ01730
PRIDEiQ01730
TopDownProteomicsiQ01730

PTM databases

iPTMnetiQ01730
PhosphoSitePlusiQ01730

Expressioni

Gene expression databases

CleanExiMM_RSU1

Interactioni

Protein-protein interaction databases

IntActiQ01730, 1 interactor
STRINGi10090.ENSMUSP00000028059

Structurei

3D structure databases

ProteinModelPortaliQ01730
SMRiQ01730
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 63LRR 1Add BLAST23
Repeati64 – 85LRR 2Add BLAST22
Repeati87 – 108LRR 3Add BLAST22
Repeati110 – 133LRR 4Add BLAST24
Repeati135 – 156LRR 5Add BLAST22
Repeati158 – 179LRR 6Add BLAST22
Repeati181 – 202LRR 7Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0617 Eukaryota
COG4886 LUCA
HOGENOMiHOG000116557
HOVERGENiHBG002478
InParanoidiQ01730
PhylomeDBiQ01730

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q01730-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSLKKLVE ESREKNQPEV DMSDRGISSM LDVNGLFSLA HITQLVLSHN
60 70 80 90 100
KLTTVPPNVA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT
110 120 130 140 150
LPRGFGSSRL LEVLELTYNN LNEHSLPGNF FYLTTLRALY LSDNDFEILP
160 170 180 190 200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG
210 220 230 240 250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM
260 270
QANPEPPKKN NDKSKKISRK PLAAKNK
Length:277
Mass (Da):31,550
Last modified:January 23, 2007 - v3
Checksum:i0D12705A39872F2E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D031Q9D031_MOUSE
Ras suppressor protein 1
Rsu1 mCG_15700
277Annotation score:
A2AUR7A2AUR7_MOUSE
Ras suppressor protein 1
Rsu1 mCG_15700
260Annotation score:
B1AYQ0B1AYQ0_MOUSE
Ras suppressor protein 1
Rsu1
112Annotation score:
E0CXG5E0CXG5_MOUSE
Ras suppressor protein 1
Rsu1
56Annotation score:
A0A0A6YWZ2A0A0A6YWZ2_MOUSE
Ras suppressor protein 1
Rsu1
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63039 mRNA Translation: CAA44765.1
CCDSiCCDS15693.1
PIRiS25770
UniGeneiMm.905

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63039 mRNA Translation: CAA44765.1
CCDSiCCDS15693.1
PIRiS25770
UniGeneiMm.905

3D structure databases

ProteinModelPortaliQ01730
SMRiQ01730
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01730, 1 interactor
STRINGi10090.ENSMUSP00000028059

PTM databases

iPTMnetiQ01730
PhosphoSitePlusiQ01730

Proteomic databases

EPDiQ01730
MaxQBiQ01730
PaxDbiQ01730
PeptideAtlasiQ01730
PRIDEiQ01730
TopDownProteomicsiQ01730

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103040 Rsu1

Phylogenomic databases

eggNOGiKOG0617 Eukaryota
COG4886 LUCA
HOGENOMiHOG000116557
HOVERGENiHBG002478
InParanoidiQ01730
PhylomeDBiQ01730

Miscellaneous databases

ChiTaRSiRsu1 mouse
PROiPR:Q01730
SOURCEiSearch...

Gene expression databases

CleanExiMM_RSU1

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRSU1_MOUSE
AccessioniPrimary (citable) accession number: Q01730
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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