UniProtKB - Q01727 (MSHR_MOUSE)
Protein
Melanocyte-stimulating hormone receptor
Gene
Mc1r
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).By similarity1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- hormone binding Source: MGI
- melanocortin receptor activity Source: BHF-UCL
- melanocyte-stimulating hormone receptor activity Source: MGI
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- intracellular signal transduction Source: BHF-UCL
- melanin biosynthetic process Source: MGI
- negative regulation of tumor necrosis factor production Source: MGI
- pigmentation Source: MGI
- positive regulation of feeding behavior Source: MGI
- positive regulation of protein kinase A signaling Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: BHF-UCL
- positive regulation of protein kinase C signaling Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of feeding behavior Source: MGI
- regulation of metabolic process Source: GO_Central
- sensory perception of pain Source: MGI
- UV-damage excision repair Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocyte-stimulating hormone receptorShort name: MSH-R Alternative name(s): Melanocortin receptor 1 Short name: MC1-R |
Gene namesi | Name:Mc1r Synonyms:Msh-r |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99456, Mc1r |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 61 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 62 – 70 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 71 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 116 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 117 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 139 – 161 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 162 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 182 – 189 | ExtracellularSequence analysis | 8 | |
Transmembranei | 190 – 209 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 210 – 238 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 239 – 264 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 265 – 277 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 278 – 298 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 315 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069834 | 1 – 315 | Melanocyte-stimulating hormone receptorAdd BLAST | 315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 313 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q01727 |
PRIDEi | Q01727 |
PTM databases
GlyGeni | Q01727, 2 sites |
PhosphoSitePlusi | Q01727 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000074037, Expressed in hair follicle and 41 other tissues |
ExpressionAtlasi | Q01727, baseline and differential |
Genevisiblei | Q01727, MM |
Interactioni
Subunit structurei
Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.
Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
By similarityGO - Molecular functioni
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201338, 2 interactors |
STRINGi | 10090.ENSMUSP00000095929 |
Chemistry databases
BindingDBi | Q01727 |
Miscellaneous databases
RNActi | Q01727, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | Q01727 |
OMAi | IDVMICS |
OrthoDBi | 981062at2759 |
TreeFami | TF332646 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001671, Melcrt_ACTH_rcpt IPR000761, MSH_rcpt |
PANTHERi | PTHR22750:SF2, PTHR22750:SF2, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00536, MELNOCYTESHR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q01727-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS
60 70 80 90 100
LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE
110 120 130 140 150
AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY
160 170 180 190 200
HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL
210 220 230 240 250
MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL
260 270 280 290 300
CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS
310
QELRMTLKEV LLCSW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 101 | A → V in CAA46589 (PubMed:1325670).Curated | 1 | |
Sequence conflicti | 216 | A → V in CAA46589 (PubMed:1325670).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65635 mRNA Translation: CAA46589.1 AB177607 Genomic DNA Translation: BAD16659.1 AB177608 Genomic DNA Translation: BAD16660.1 AB306322 Genomic DNA Translation: BAG85190.1 CH466525 Genomic DNA Translation: EDL11741.1 BC119294 mRNA Translation: AAI19295.1 BC119296 mRNA Translation: AAI19297.1 |
CCDSi | CCDS22756.1 |
PIRi | S25581 |
RefSeqi | NP_032585.2, NM_008559.2 |
Genome annotation databases
Ensembli | ENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037 |
GeneIDi | 17199 |
KEGGi | mmu:17199 |
UCSCi | uc009nvs.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65635 mRNA Translation: CAA46589.1 AB177607 Genomic DNA Translation: BAD16659.1 AB177608 Genomic DNA Translation: BAD16660.1 AB306322 Genomic DNA Translation: BAG85190.1 CH466525 Genomic DNA Translation: EDL11741.1 BC119294 mRNA Translation: AAI19295.1 BC119296 mRNA Translation: AAI19297.1 |
CCDSi | CCDS22756.1 |
PIRi | S25581 |
RefSeqi | NP_032585.2, NM_008559.2 |
3D structure databases
SMRi | Q01727 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201338, 2 interactors |
STRINGi | 10090.ENSMUSP00000095929 |
Chemistry databases
BindingDBi | Q01727 |
ChEMBLi | CHEMBL4077 |
GuidetoPHARMACOLOGYi | 282 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q01727, 2 sites |
PhosphoSitePlusi | Q01727 |
Proteomic databases
PaxDbi | Q01727 |
PRIDEi | Q01727 |
Protocols and materials databases
Antibodypediai | 54873, 342 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037 |
GeneIDi | 17199 |
KEGGi | mmu:17199 |
UCSCi | uc009nvs.2, mouse |
Organism-specific databases
CTDi | 4157 |
MGIi | MGI:99456, Mc1r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | Q01727 |
OMAi | IDVMICS |
OrthoDBi | 981062at2759 |
TreeFami | TF332646 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 17199, 1 hit in 18 CRISPR screens |
ChiTaRSi | Mc1r, mouse |
PROi | PR:Q01727 |
RNActi | Q01727, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074037, Expressed in hair follicle and 41 other tissues |
ExpressionAtlasi | Q01727, baseline and differential |
Genevisiblei | Q01727, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001671, Melcrt_ACTH_rcpt IPR000761, MSH_rcpt |
PANTHERi | PTHR22750:SF2, PTHR22750:SF2, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00536, MELNOCYTESHR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSHR_MOUSE | |
Accessioni | Q01727Primary (citable) accession number: Q01727 Secondary accession number(s): Q75NA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries