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Protein

Melanocyte-stimulating hormone receptor

Gene

MC1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: BHF-UCL
  • melanocortin receptor activity Source: ProtInc
  • melanocyte-stimulating hormone receptor activity Source: BHF-UCL
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiQ01726

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:MC1R
Synonyms:MSHR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000258839.2
HGNCiHGNC:6929 MC1R
MIMi155555 gene
neXtProtiNX_Q01726

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 63Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 118ExtracellularSequence analysisAdd BLAST25
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 163CytoplasmicSequence analysisAdd BLAST23
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 191ExtracellularSequence analysis8
Transmembranei192 – 211Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 266Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini267 – 279ExtracellularSequence analysisAdd BLAST13
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 317CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Melanoma, cutaneous malignant 5 (CMM5)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
See also OMIM:613099
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05901838V → M in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant dbSNP:rs200050206EnsemblClinVar.1
Natural variantiVAR_05901941S → F in CMM5; complete absence of functional coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 2 Publications1
Natural variantiVAR_05902051V → A in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant dbSNP:rs766080391Ensembl.1
Natural variantiVAR_059022128M → T in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 2 PublicationsCorresponds to variant dbSNP:rs374235260Ensembl.1
Natural variantiVAR_059025289C → R in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 1 PublicationCorresponds to variant dbSNP:rs369542041Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65K → R: Only minor effect on internalization rate and protein half-life; when associated with R-226; R-238 and R-310. 1 Publication1
Mutagenesisi226K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-238 and R-310. 1 Publication1
Mutagenesisi238K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-226 and R-310. 1 Publication1
Mutagenesisi310K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-226 and R-238. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4157
MalaCardsiMC1R
MIMi266300 phenotype
613098 phenotype
613099 phenotype
OpenTargetsiENSG00000258839
Orphaneti618 Familial melanoma
626 Large congenital melanocytic nevus
79432 Oculocutaneous albinism type 2
PharmGKBiPA30673

Chemistry databases

ChEMBLiCHEMBL3795
DrugBankiDB04931 Afamelanotide
DB05479 CZEN 002
GuidetoPHARMACOLOGYi282

Polymorphism and mutation databases

BioMutaiMC1R
DMDMi12644376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698181 – 317Melanocyte-stimulating hormone receptorAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi315S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ01726
PeptideAtlasiQ01726
PRIDEiQ01726
ProteomicsDBi57984

PTM databases

iPTMnetiQ01726
PhosphoSitePlusiQ01726
SwissPalmiQ01726

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiENSG00000258839 Expressed in 132 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ01726 baseline and differential
GenevisibleiQ01726 HS

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MRAPQ8TCY52EBI-9538513,EBI-9538727

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110327, 12 interactors
DIPiDIP-48789N
IntActiQ01726, 2 interactors
STRINGi9606.ENSP00000451605

Chemistry databases

BindingDBiQ01726

Structurei

3D structure databases

ProteinModelPortaliQ01726
SMRiQ01726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119061
HOVERGENiHBG108148
InParanoidiQ01726
KOiK04199
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
IPR000761 MSH_rcpt
PANTHERiPTHR22750:SF2 PTHR22750:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00536 MELNOCYTESHR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01726-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL
60 70 80 90 100
VSLVENALVV ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL
110 120 130 140 150
LEAGALVARA AVLQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL
160 170 180 190 200
RYHSIVTLPR ARRAVAAIWV ASVVFSTLFI AYYDHVAVLL CLVVFFLAML
210 220 230 240 250
VLMAVLYVHM LARACQHAQG IARLHKRQRP VHQGFGLKGA VTLTILLGIF
260 270 280 290 300
FLCWGPFFLH LTLIVLCPEH PTCGCIFKNF NLFLALIICN AIIDPLIYAF
310
HSQELRRTLK EVLTCSW
Length:317
Mass (Da):34,706
Last modified:December 1, 2000 - v2
Checksum:iCB67405A562C29B2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4F0G3V4F0_HUMAN
Melanocyte-stimulating hormone rece...
MC1R
382Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90S → T (PubMed:1325670).Curated1
Sequence conflicti90S → T (PubMed:8463333).Curated1
Sequence conflicti164A → R (PubMed:1516719).Curated1
Sequence conflicti222A → T in AAQ62976 (Ref. 9) Curated1

Polymorphismi

Genetic variants in MC1R define the skin/hair/eye pigmentation variation locus 2 (SHEP2) [MIMi:266300]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator, with type I skin being the most lightly pigmented and type IV the most dark pigmented. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. Partial loss-of-function mutations are associated with fair skin, poor tanning and increased skin cancer risk.
MC1R variants associated with red hair and fair skin, determine female-specific increased analgesia from kappa-opioid receptor agonist [MIMi:613098].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05901838V → M in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant dbSNP:rs200050206EnsemblClinVar.1
Natural variantiVAR_01361140I → T Associated with fair hair and light skin; partial loss-of-function. 1 PublicationCorresponds to variant dbSNP:rs748138541Ensembl.1
Natural variantiVAR_05901941S → F in CMM5; complete absence of functional coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 2 Publications1
Natural variantiVAR_05902051V → A in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant dbSNP:rs766080391Ensembl.1
Natural variantiVAR_01361260V → L Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation. 5 PublicationsCorresponds to variant dbSNP:rs1805005EnsemblClinVar.1
Natural variantiVAR_00952267R → Q Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a decreased responses to low concentrations of NDP-MSH stimulation. 2 PublicationsCorresponds to variant dbSNP:rs34090186EnsemblClinVar.1
Natural variantiVAR_00350784D → E May be associated with a risk for developing melanoma; reduced expression at the cell surface. 4 PublicationsCorresponds to variant dbSNP:rs1805006EnsemblClinVar.1
Natural variantiVAR_04265489G → R. Corresponds to variant dbSNP:rs34540312EnsemblClinVar.1
Natural variantiVAR_00350892V → M Associated with a risk for developing melanoma; predominantly found in type I skin; shows a moderate and not significant decreased of cAMP production to NDP-MSH stimulation. 7 PublicationsCorresponds to variant dbSNP:rs2228479EnsemblClinVar.1
Natural variantiVAR_05902193L → R Loss-of-function mutation abolishing agonist binding. 1 Publication1
Natural variantiVAR_04265595T → M. Corresponds to variant dbSNP:rs34158934Ensembl.1
Natural variantiVAR_042656104G → S. Corresponds to variant dbSNP:rs2229617Ensembl.1
Natural variantiVAR_042657120I → T Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows decreased responses to low concentrations of NDP-MSH stimulation. 1 PublicationCorresponds to variant dbSNP:rs33932559EnsemblClinVar.1
Natural variantiVAR_013613122V → M Associated with fair hair and light skin; partial loss-of-function. 1 PublicationCorresponds to variant dbSNP:rs201192930EnsemblClinVar.1
Natural variantiVAR_059022128M → T in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 2 PublicationsCorresponds to variant dbSNP:rs374235260Ensembl.1
Natural variantiVAR_059023142R → H2 PublicationsCorresponds to variant dbSNP:rs11547464EnsemblClinVar.1
Natural variantiVAR_042658147Missing Associated with UV induced susceptibility to skin damage; unresponsive to NDP-MSH stimulation. 1 Publication1
Natural variantiVAR_008522151R → C Associated with red hair and light skin of type I; binds to alpha-MSH but cannot be stimulated to produce cAMP; reduced expression at the cell surface. 9 PublicationsCorresponds to variant dbSNP:rs1805007EnsemblClinVar.1
Natural variantiVAR_013614155I → T Associated with a risk for developing melanoma; reduced expression at the cell surface. 4 PublicationsCorresponds to variant dbSNP:rs1110400EnsemblClinVar.1
Natural variantiVAR_013615156V → L1 PublicationCorresponds to variant dbSNP:rs3212365EnsemblClinVar.1
Natural variantiVAR_042659157T → I Associated with UV induced susceptibility to skin damage; shows a dramatically decreased cAMP production to NDP-MSH stimulation. 1 PublicationCorresponds to variant dbSNP:rs104894524EnsemblClinVar.1
Natural variantiVAR_042660159P → T Associated with UV induced susceptibility to skin damage; shows a strong decreased cAMP production to NDP-MSH stimulation. 1 PublicationCorresponds to variant dbSNP:rs104894523EnsemblClinVar.1
Natural variantiVAR_008523160R → W Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation; reduced expression at the cell surface. 6 PublicationsCorresponds to variant dbSNP:rs1805008EnsemblClinVar.1
Natural variantiVAR_013632162R → P1 Publication1
Natural variantiVAR_009523163R → Q Associated with a risk for developing melanoma; shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a not significant decrease in cAMP production at any concentrations of NDP-MSH stimulation. 4 PublicationsCorresponds to variant dbSNP:rs885479EnsemblClinVar.1
Natural variantiVAR_042661166A → G Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a not significant decrease in cAMP production at any concentrations of NDP-MSH stimulation. 1 PublicationCorresponds to variant dbSNP:rs35040147EnsemblClinVar.1
Natural variantiVAR_042662171A → S. Corresponds to variant dbSNP:rs35784916Ensembl.1
Natural variantiVAR_013616196F → L1 PublicationCorresponds to variant dbSNP:rs3212366EnsemblClinVar.1
Natural variantiVAR_059024281N → S Functionally silent polymorphism; does not affect receptor surface expression, agonist binding and agonist-induced signaling. 2 PublicationsCorresponds to variant dbSNP:rs141177570Ensembl.1
Natural variantiVAR_059025289C → R in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 1 PublicationCorresponds to variant dbSNP:rs369542041Ensembl.1
Natural variantiVAR_008524294D → H Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation. 4 PublicationsCorresponds to variant dbSNP:rs1805009EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65634 Genomic DNA Translation: CAA46588.1
X67594 mRNA Translation: CAA47865.1
AF153431 Genomic DNA Translation: AAD41349.1
AF153432 Genomic DNA Translation: AAD41350.1
AF153433 Genomic DNA Translation: AAD41351.1
AF153434 Genomic DNA Translation: AAD41352.1
AF153435 Genomic DNA Translation: AAD41353.1
AF153436 Genomic DNA Translation: AAD41354.1
AF153437 Genomic DNA Translation: AAD41355.1
AF326275 Genomic DNA Translation: AAK01121.1
AF263461 Genomic DNA Translation: AAK58525.1
AY046528 Genomic DNA Translation: AAL05887.1
AY046529 Genomic DNA Translation: AAL05888.1
AB241548 Genomic DNA Translation: BAE94314.1
AY363626 Genomic DNA Translation: AAQ62976.1
AY225228 Genomic DNA Translation: AAO67713.1
AF514787 Genomic DNA Translation: AAM44861.1
BC007856 mRNA Translation: AAH07856.1
BC080622 mRNA Translation: AAH80622.1
CCDSiCCDS56011.1
PIRiS29204
RefSeqiNP_002377.4, NM_002386.3
UniGeneiHs.513829
Hs.734194

Genome annotation databases

EnsembliENST00000555147; ENSP00000451605; ENSG00000258839
ENST00000639847; ENSP00000492011; ENSG00000258839
GeneIDi4157
KEGGihsa:4157

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65634 Genomic DNA Translation: CAA46588.1
X67594 mRNA Translation: CAA47865.1
AF153431 Genomic DNA Translation: AAD41349.1
AF153432 Genomic DNA Translation: AAD41350.1
AF153433 Genomic DNA Translation: AAD41351.1
AF153434 Genomic DNA Translation: AAD41352.1
AF153435 Genomic DNA Translation: AAD41353.1
AF153436 Genomic DNA Translation: AAD41354.1
AF153437 Genomic DNA Translation: AAD41355.1
AF326275 Genomic DNA Translation: AAK01121.1
AF263461 Genomic DNA Translation: AAK58525.1
AY046528 Genomic DNA Translation: AAL05887.1
AY046529 Genomic DNA Translation: AAL05888.1
AB241548 Genomic DNA Translation: BAE94314.1
AY363626 Genomic DNA Translation: AAQ62976.1
AY225228 Genomic DNA Translation: AAO67713.1
AF514787 Genomic DNA Translation: AAM44861.1
BC007856 mRNA Translation: AAH07856.1
BC080622 mRNA Translation: AAH80622.1
CCDSiCCDS56011.1
PIRiS29204
RefSeqiNP_002377.4, NM_002386.3
UniGeneiHs.513829
Hs.734194

3D structure databases

ProteinModelPortaliQ01726
SMRiQ01726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110327, 12 interactors
DIPiDIP-48789N
IntActiQ01726, 2 interactors
STRINGi9606.ENSP00000451605

Chemistry databases

BindingDBiQ01726
ChEMBLiCHEMBL3795
DrugBankiDB04931 Afamelanotide
DB05479 CZEN 002
GuidetoPHARMACOLOGYi282

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ01726
PhosphoSitePlusiQ01726
SwissPalmiQ01726

Polymorphism and mutation databases

BioMutaiMC1R
DMDMi12644376

Proteomic databases

PaxDbiQ01726
PeptideAtlasiQ01726
PRIDEiQ01726
ProteomicsDBi57984

Protocols and materials databases

DNASUi4157
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555147; ENSP00000451605; ENSG00000258839
ENST00000639847; ENSP00000492011; ENSG00000258839
GeneIDi4157
KEGGihsa:4157

Organism-specific databases

CTDi4157
DisGeNETi4157
EuPathDBiHostDB:ENSG00000258839.2
GeneCardsiMC1R
HGNCiHGNC:6929 MC1R
MalaCardsiMC1R
MIMi155555 gene
266300 phenotype
613098 phenotype
613099 phenotype
neXtProtiNX_Q01726
OpenTargetsiENSG00000258839
Orphaneti618 Familial melanoma
626 Large congenital melanocytic nevus
79432 Oculocutaneous albinism type 2
PharmGKBiPA30673
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119061
HOVERGENiHBG108148
InParanoidiQ01726
KOiK04199
TreeFamiTF332646

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiQ01726

Miscellaneous databases

ChiTaRSiMC1R human
GeneWikiiMelanocortin_1_receptor
GenomeRNAii4157
PROiPR:Q01726
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000258839 Expressed in 132 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ01726 baseline and differential
GenevisibleiQ01726 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
IPR000761 MSH_rcpt
PANTHERiPTHR22750:SF2 PTHR22750:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00536 MELNOCYTESHR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSHR_HUMAN
AccessioniPrimary (citable) accession number: Q01726
Secondary accession number(s): Q66K38
, Q6UR93, Q8WWX6, Q8WWX7, Q96I33, Q96RU4, Q9UBF7, Q9UN58, Q9UN59, Q9UN60, Q9UN61, Q9UN62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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