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Protein

Growth arrest-specific protein 1

Gene

Gas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Enzyme and pathway databases

ReactomeiR-MMU-5632681 Ligand-receptor interactions
R-MMU-5635838 Activation of SMO

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 1
Short name:
GAS-1
Gene namesi
Name:Gas1
Synonyms:Gas-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:95655 Gas1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000002132039 – 315Growth arrest-specific protein 1Add BLAST277
PropeptideiPRO_0000021321316 – 343Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi315GPI-anchor amidated serineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ01721
PaxDbiQ01721
PeptideAtlasiQ01721
PRIDEiQ01721

PTM databases

iPTMnetiQ01721
PhosphoSitePlusiQ01721

Expressioni

Gene expression databases

CleanExiMM_GAS1
ExpressionAtlasiQ01721 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi199832, 1 interactor
DIPiDIP-59801N
IntActiQ01721, 1 interactor
STRINGi10090.ENSMUSP00000064555

Structurei

3D structure databases

ProteinModelPortaliQ01721
SMRiQ01721
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi281 – 284Poly-Asp4
Compositional biasi293 – 296Poly-Ala4
Compositional biasi310 – 315Poly-Ser6
Compositional biasi331 – 339Poly-Leu9

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW52 Eukaryota
ENOG4111JS0 LUCA
GeneTreeiENSGT00390000001195
HOGENOMiHOG000233688
HOVERGENiHBG005804
InParanoidiQ01721
KOiK06232
OMAiPECSYAY
PhylomeDBiQ01721
TreeFamiTF329660

Family and domain databases

InterProiView protein in InterPro
IPR039596 GAS1
IPR016017 GDNF/GAS1
PANTHERiPTHR16840 PTHR16840, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 1 hit
SMARTiView protein in SMART
SM00907 GDNF, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01721-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAALLGGAG ARTGTLPGAL LCLMALLQLL CSAPRGSGLA HGRRLICWQA
60 70 80 90 100
LLQCQGEPDC SYAYSQYAEA CAPVLAQRGG ADAPGPAGAF PASAASSPRW
110 120 130 140 150
RCPSHCISAL IQLNHTRRGP ALEDCDCAQD EHCRSTKRAI EPCLPRTSSV
160 170 180 190 200
GPGAGAGSVM GCTEARRRCD RDSRCNLALS RYLAYCGKLF NGLRCTDECR
210 220 230 240 250
AVIEDMLAVP KAALLNDCVC DGLERPICES VKENMARLCF GPDASNGPGS
260 270 280 290 300
SGSDGGLDDY YDEEYDDEQR AGAAGGEQPL DDDDGLARPG GGAAAAGGRG
310 320 330 340
DLPHGPGRRS SSSGSGGHWA NRSAWTPFAC LLLLLLLLLG SHL
Length:343
Mass (Da):35,694
Last modified:May 16, 2003 - v2
Checksum:iF85D393F248B8895
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YD87A0A286YD87_MOUSE
Growth arrest-specific protein 1
Gas1
384Annotation score:

Sequence cautioni

The sequence CAA46256 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65128 mRNA Translation: CAA46256.1 Different initiation.
BC058628 mRNA Translation: AAH58628.1
PIRiS25771
RefSeqiNP_032112.1, NM_008086.2
UniGeneiMm.22701

Genome annotation databases

EnsembliENSMUST00000065086; ENSMUSP00000064555; ENSMUSG00000052957
GeneIDi14451
KEGGimmu:14451
UCSCiuc007qvi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65128 mRNA Translation: CAA46256.1 Different initiation.
BC058628 mRNA Translation: AAH58628.1
PIRiS25771
RefSeqiNP_032112.1, NM_008086.2
UniGeneiMm.22701

3D structure databases

ProteinModelPortaliQ01721
SMRiQ01721
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199832, 1 interactor
DIPiDIP-59801N
IntActiQ01721, 1 interactor
STRINGi10090.ENSMUSP00000064555

PTM databases

iPTMnetiQ01721
PhosphoSitePlusiQ01721

Proteomic databases

MaxQBiQ01721
PaxDbiQ01721
PeptideAtlasiQ01721
PRIDEiQ01721

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065086; ENSMUSP00000064555; ENSMUSG00000052957
GeneIDi14451
KEGGimmu:14451
UCSCiuc007qvi.2 mouse

Organism-specific databases

CTDi2619
MGIiMGI:95655 Gas1

Phylogenomic databases

eggNOGiENOG410IW52 Eukaryota
ENOG4111JS0 LUCA
GeneTreeiENSGT00390000001195
HOGENOMiHOG000233688
HOVERGENiHBG005804
InParanoidiQ01721
KOiK06232
OMAiPECSYAY
PhylomeDBiQ01721
TreeFamiTF329660

Enzyme and pathway databases

ReactomeiR-MMU-5632681 Ligand-receptor interactions
R-MMU-5635838 Activation of SMO

Miscellaneous databases

PROiPR:Q01721
SOURCEiSearch...

Gene expression databases

CleanExiMM_GAS1
ExpressionAtlasiQ01721 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039596 GAS1
IPR016017 GDNF/GAS1
PANTHERiPTHR16840 PTHR16840, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 1 hit
SMARTiView protein in SMART
SM00907 GDNF, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGAS1_MOUSE
AccessioniPrimary (citable) accession number: Q01721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 16, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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