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Protein

Bacterial leucyl aminopeptidase

Gene
N/A
Organism
Vibrio proteolyticus (Aeromonas proteolytica)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Zn2+4 PublicationsNote: Binds 2 Zn2+ ions per subunit.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi203Zinc 1Combined sources4 Publications1
Metal bindingi223Zinc 1Combined sources4 Publications1
Metal bindingi223Zinc 2; catalyticCombined sources4 Publications1
Metal bindingi258Zinc 2; catalyticCombined sources4 Publications1
Metal bindingi285Zinc 1Combined sources4 Publications1
Metal bindingi362Zinc 2; via tele nitrogen; catalyticCombined sources4 Publications1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.11.10 167
SABIO-RKiQ01693

Protein family/group databases

MEROPSiM28.002

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial leucyl aminopeptidase (EC:3.4.11.10)
OrganismiVibrio proteolyticus (Aeromonas proteolytica)
Taxonomic identifieri671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3750
DrugBankiDB02664 1-Butane Boronic Acid
DB02386 Leucine Phosphonic Acid
DB01980 Para-Iodo-D-Phenylalanine Hydroxamic Acid
DB03424 Ubenimex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002684922 – 1062 PublicationsAdd BLAST85
ChainiPRO_0000026850107 – 405Bacterial leucyl aminopeptidaseAdd BLAST299
PropeptideiPRO_0000026851406 – 504Removed in mature form1 PublicationAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi329 ↔ 333Combined sources4 Publications

Keywords - PTMi

Disulfide bond, Zymogen

Miscellaneous databases

PMAP-CutDBiQ01693

Interactioni

Chemistry databases

BindingDBiQ01693

Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01693
SMRiQ01693
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01693

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family. M28E subfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR012189 Pept_M28E_Ap1
IPR007280 Peptidase_C_arc/bac
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit
PF04151 PPC, 1 hit
PIRSFiPIRSF036685 BacLeuNPeptidase, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01693-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYTKTLLAM VLSATFCQAY AEDKVWISIG ADANQTVMKS GAESILPNSV
60 70 80 90 100
ASSGQVWVGQ VDVAQLAELS HNMHEEHNRC GGYMVHPSAQ SAMAASAMPT
110 120 130 140 150
TLASFVMPPI TQQATVTAWL PQVDASQITG TISSLESFTN RFYTTTSGAQ
160 170 180 190 200
ASDWIASEWQ ALSASLPNAS VKQVSHSGYN QKSVVMTITG SEAPDEWIVI
210 220 230 240 250
GGHLDSTIGS HTNEQSVAPG ADDDASGIAA VTEVIRVLSE NNFQPKRSIA
260 270 280 290 300
FMAYAAEEVG LRGSQDLANQ YKSEGKNVVS ALQLDMTNYK GSAQDVVFIT
310 320 330 340 350
DYTDSNFTQY LTQLMDEYLP SLTYGFDTCG YACSDHASWH NAGYPAAMPF
360 370 380 390 400
ESKFNDYNPR IHTTQDTLAN SDPTGSHAKK FTQLGLAYAI EMGSATGDTP
410 420 430 440 450
TPGNQLEDGV PVTDLSGSRG SNVWYTFELE TQKNLQITTS GGYGDLDLYV
460 470 480 490 500
KFGSKASKQN WDCRPYLSGN NEVCTFNNAS PGTYSVMLTG YSNYSGASLK

ASTF
Length:504
Mass (Da):54,232
Last modified:July 1, 1993 - v1
Checksum:i7B33317EF6153B48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303 – 304TD → DT AA sequence (PubMed:1627651).Curated2
Sequence conflicti306N → D AA sequence (PubMed:1627651).Curated1
Sequence conflicti312 – 314TQL → QT AA sequence (PubMed:1627651).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11993 Genomic DNA Translation: CAA78039.1
M85159 Genomic DNA Translation: AAA21940.1
PIRiS24314

Similar proteinsi

Entry informationi

Entry nameiAMPX_VIBPR
AccessioniPrimary (citable) accession number: Q01693
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 15, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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