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Entry version 123 (07 Apr 2021)
Sequence version 1 (01 Jul 1993)
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Protein

Genome polyprotein

Gene
N/A
Organism
Plum pox potyvirus (strain El amar) (PPV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
has helicase activity. It may be involved in replication.
has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei471For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei506For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei576For nuclear inclusion protein A activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C04.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 6 chains:
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-A
Short name:
NIA
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
Nuclear inclusion protein B
Short name:
NI-B
Short name:
NIB
Alternative name(s):
RNA-directed RNA polymerase (EC:2.7.7.48)
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlum pox potyvirus (strain El amar) (PPV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31738 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPrunus armeniaca (Apricot) (Armeniaca vulgaris) [TaxID: 36596]
Prunus cerasifera (cherry plum) [TaxID: 36595]
Prunus domestica (Garden plum) [TaxID: 3758]
Prunus glandulosa [TaxID: 105665]
Prunus persica (Peach) (Amygdalus persica) [TaxID: 3760]
Prunus salicina [TaxID: 88123]
Prunus spinosa (Blackthorn) (Prunus domestica var. spinosa) [TaxID: 114937]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000040325‹1 – 179Cytoplasmic inclusion proteinBy similarityAdd BLAST›179
ChainiPRO_00004200061 – 1518Genome polyproteinAdd BLAST1518
ChainiPRO_0000040326180 – 2326 kDa protein 2By similarityAdd BLAST53
ChainiPRO_0000040327233 – 425Viral genome-linked proteinBy similarityAdd BLAST193
ChainiPRO_0000040328426 – 668Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_0000040329669 – 1186Nuclear inclusion protein BBy similarityAdd BLAST518
ChainiPRO_00000403301187 – 1518Capsid proteinBy similarityAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei179 – 180Cleavage; by NIa-proBy similarity2
Sitei232 – 233Cleavage; by NIa-proBy similarity2
Sitei425 – 426Cleavage; by NIa-proBy similarity2
Sitei668 – 669Cleavage; by NIa-proBy similarity2
Sitei1186 – 1187Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini426 – 644Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini910 – 1034RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi273 – 280Nuclear localization signalSequence analysis8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00863, Peptidase_C4, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q01681-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LNKLAIPNAN VCGWMSVRDY KRQGCNLDLD DNIRVPFYVK DLPETLHEKI
60 70 80 90 100
WQTVEAHKAD AGFGRICSSS ACKIAYTLQT DIHSIPRTVK ILDALLEQER
110 120 130 140 150
TKQAHFRSMT SQSCSSSNFS LSSITSAIRS KYAKDHTEEN IGVLQMAKAQ
160 170 180 190 200
LLEFKNLNID PSYPELVRNF GALECVHHQT KEGVSKALRL KGHWNKQLVT
210 220 230 240 250
RDATLMLGVL GGGAWMIFSY LRDSFKEEVV HQGFNRRQRQ KLKFRQARDN
260 270 280 290 300
RMAREVYGDD STMEDYFGSA YSKKGKSKGR TRGMGTKTRK FVNMYGYDPT
310 320 330 340 350
DYNFVRFVDP LTGHTLDENP LMDINLVQEH FSQVRNDYLG DDKITMQHIM
360 370 380 390 400
SNPGIVAYYI KDATQKALKV DLTPHNPLRV CDKTATIAGF PEREFELRQT
410 420 430 440 450
GQPVLVEPNA IPQINEEGDE EVGHESKSLF RGLRDYNPIA SSICHLTNAS
460 470 480 490 500
GTRQSEIYGL GFGGLIVTNQ HLFKRNDGEL TIRSHHGEFV VKDTKTLKLL
510 520 530 540 550
PCKGRDIIII RLPKDFPPFP RRLQFRTPTA EDRVCLIGSN FQTKSVSSTM
560 570 580 590 600
SETSATYPVD NSHFWKHWIS TKDGHCGLPI VSTRDGSILG LHSLANSTNT
610 620 630 640 650
QNFYAAFPDN FETTYLANQD NDNWIKQWRY NPDEVCWGSL QLKRDVPQSP
660 670 680 690 700
FTICKLLTDL DGEFVYNQAK TTHWLRDKLE GNLKAVGACP GQLVTKHVVK
710 720 730 740 750
GKCTLFETYL LTHPEEREFF QPLMGAYQKS ALNKDAYVKD LMKYSKSIVV
760 770 780 790 800
GAVDCEQFER AVDVVISMLI SKGFSECSYV TDPEEIFSAL NMKAAVGALY
810 820 830 840 850
SGKKRDYFKD TSELEKEEFV RASCKRLFMG KKGVWNGSLK AELRPKEKVE
860 870 880 890 900
ANKTRSFTAA PIDTLLGGKV CVDDFNNQFY SLNLHCPWSV GMTKFRGGWD
910 920 930 940 950
KLLRALPDGW IYCDADGSQF DSSLSPYLIN AVLNIRLAFM EEWDIGEQML
960 970 980 990 1000
SNLYTEIVYT PIATPDGTIV KKFKGNNSGQ PSTVVDNTLM VILAMTYSLL
1010 1020 1030 1040 1050
KLGYHPDTHE CICRYFVNGD DLVLAVHPAY ESIYDELQHH FSQLGLNYTF
1060 1070 1080 1090 1100
TTKTENKEDL WFMSHKGIMC EGMYIPKLEP ERIVSILEWD RSSEPIHRLE
1110 1120 1130 1140 1150
AICASMVEAW GYKELLREIR KFYSWVLEQA PYNALSKDGK APYIAETALK
1160 1170 1180 1190 1200
KLYTDTEASE TEIERYLEAF YSNLTDEDES NVVVHQADEK EDDEEEVDAG
1210 1220 1230 1240 1250
RPLVTTTQQP IVTTTTQQTP ITSTTLQATQ AMFNPIFTPA TTEPTTRTVP
1260 1270 1280 1290 1300
HTTTTTPPSF GVIGNEDTAP NASNAVVRTG RDRDVDAGSI GTFTVPRLKA
1310 1320 1330 1340 1350
MTSKLSLPKV KGKAIMNLNH LAFYSPAQVD LSNTRAPQSC FQTWYEGVRR
1360 1370 1380 1390 1400
DYDVTDDEMS IILNGLMVWC IENGTSPNIN GMWVMMDGET QVEYPIKPLL
1410 1420 1430 1440 1450
DHAKPTFRQI MAHFSNVAEA YIEKRNYEKA YMPRYGIQRN LTDYSLARYA
1460 1470 1480 1490 1500
FDFYEMTSTT PVRAREAHIQ MKAAALRNAQ NRLFGLDGNV GTQEEDTERH
1510
TAGDVNRNMH NLLGMRGV
Length:1,518
Mass (Da):172,033
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1268F972F5B247C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56258 mRNA Translation: CAA39698.1

Protein sequence database of the Protein Information Resource

More...
PIRi
PQ0221

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56258 mRNA Translation: CAA39698.1
PIRiPQ0221

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC04.001

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00863, Peptidase_C4, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_PPVEA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01681
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 7, 2021
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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