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UniProtKB - Q01679 (LAC1_PHLRA)
Protein
Laccase
Gene
LAC
Organism
Phlebia radiata (White-rot fungus)
Status
Functioni
Lignin degradation and detoxification of lignin-derived products.
By similarityCatalytic activityi
- EC:1.10.3.2By similarity
Cofactori
Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 85 | Copper 1; type 2By similarity | 1 | |
Metal bindingi | 87 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 130 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 132 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 418 | Copper 4; type 1By similarity | 1 | |
Metal bindingi | 421 | Copper 1; type 2By similarity | 1 | |
Metal bindingi | 423 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 473 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 474 | Copper 4; type 1By similarity | 1 | |
Metal bindingi | 475 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 479 | Copper 4; type 1By similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
GO - Biological processi
- lignin catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lignin degradation |
Ligand | Copper, Metal-binding |
Protein family/group databases
CAZyi | AA1, Auxiliary Activities 1 |
Names & Taxonomyi
Protein namesi | Recommended name: Laccase (EC:1.10.3.2By similarity)Alternative name(s): Benzenediol:oxygen oxidoreductase Diphenol oxidase Ligninolytic phenoloxidase Urishiol oxidase |
Gene namesi | Name:LAC |
Organismi | Phlebia radiata (White-rot fungus) |
Taxonomic identifieri | 5308 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Polyporales › Meruliaceae › Phlebia |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000002928 | 22 – 520 | LaccaseAdd BLAST | 499 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 509 | By similarity | ||
Disulfide bondi | 138 ↔ 227 | By similarity | ||
Glycosylationi | 352 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 148 | Plastocyanin-like 1Add BLAST | 127 | |
Domaini | 160 – 304 | Plastocyanin-like 2Add BLAST | 145 | |
Domaini | 373 – 496 | Plastocyanin-like 3Add BLAST | 124 |
Sequence similaritiesi
Belongs to the multicopper oxidase family.Curated
Keywords - Domaini
Repeat, SignalFamily and domain databases
Gene3Di | 2.60.40.420, 3 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin |
PANTHERi | PTHR11709, PTHR11709, 1 hit |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
PROSITEi | View protein in PROSITE PS00079, MULTICOPPER_OXIDASE1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q01679-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHTFLRSTAL VVAGLSARAL ASIGPVTDFH IVNAAVSPDG FSRQAVLAEG
60 70 80 90 100
VFPGPLIAGN KGDNFQINVI DELTNATMLK TTTIHWHGFF QHGTNWADGP
110 120 130 140 150
AFINQCPIAS GDSFLYNFQV PDQAGTFWYH SHLSTQYCDG LRGPFVVYDP
160 170 180 190 200
ADPYLDQYDV DDDSTVITLA DWYHTAARLG SPFPAADTTL INGLGRCGEA
210 220 230 240 250
GCPVSDLAVI SVTKGKRYRF RLVSISCDSF FTFSIDGHSL NVIEVDATNH
260 270 280 290 300
QPLTVDELTI YAGQRYSFIL TADQDVDNYW IRANPGIGIT TGFAGGINSA
310 320 330 340 350
ILRYDGADVV EPTTTQATSP VVLSESNLAP LTNAAAPGLP EVGGVDLALN
360 370 380 390 400
FNLTFDGPSL KFQINGVTFV PPTVPVLLQI LSGAQSAADL LPSGSVYALP
410 420 430 440 450
SNATIELSLP AGALGGPHPF HLHGHTFSVV RPAGSTTYNY VNPVQRDVVS
460 470 480 490 500
IGNTGDNVTI RFDTNNPGPW FLHCHIDWHL EAGFAVVFAE DIPDVASINP
510 520
VPQDWSNLCP IYNALDASDH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52134 Genomic DNA Translation: CAA36379.2 |
PIRi | S18746 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52134 Genomic DNA Translation: CAA36379.2 |
PIRi | S18746 |
3D structure databases
SMRi | Q01679 |
ModBasei | Search... |
Protein family/group databases
CAZyi | AA1, Auxiliary Activities 1 |
Family and domain databases
Gene3Di | 2.60.40.420, 3 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin |
PANTHERi | PTHR11709, PTHR11709, 1 hit |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
PROSITEi | View protein in PROSITE PS00079, MULTICOPPER_OXIDASE1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAC1_PHLRA | |
Accessioni | Q01679Primary (citable) accession number: Q01679 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 23, 2022 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families