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Protein

Acyclic carotenoid 1,2-hydratase

Gene

crtC

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids spheroidene and spirilloxanthin. Catalyzes the hydration of neurosporene to the corresponding hydroxylated carotenoids 1-HO-neurosporene and that of lycopene to 1-HO-lycopene (By similarity).By similarity

Catalytic activityi

1-hydroxy-1,2-dihydrolycopene = lycopene + H2O.
1-hydroxy-1,2-dihydroneurosporene = neurosporene + H2O.

Pathwayi: spheroidene biosynthesis

This protein is involved in the pathway spheroidene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway spheroidene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarotenoid biosynthesis, Chlorophyll biosynthesis, Photosynthesis

Enzyme and pathway databases

UniPathwayiUPA00683

Names & Taxonomyi

Protein namesi
Recommended name:
Acyclic carotenoid 1,2-hydratase (EC:4.2.1.131)
Alternative name(s):
Hydroxyneurosporene synthase
Lycopene hydratase
Neurosporene hydratase
Gene namesi
Name:crtC
Synonyms:ctrC
Ordered Locus Names:RHOS4_18730
ORF Names:RSP_0267
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793661 – 279Acyclic carotenoid 1,2-hydrataseAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0267

Family & Domainsi

Sequence similaritiesi

Belongs to the CrtC hydratase family.Curated

Phylogenomic databases

eggNOGiENOG4108PZJ Bacteria
ENOG410XPMM LUCA
HOGENOMiHOG000230364
KOiK09844
OrthoDBiPOG091H1KB0

Sequencei

Sequence statusi: Complete.

Q01670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGFIGSVFS PWYRWSGRKE PQNHCCLNVA TYGPGGRFTM TDRGRAALRQ
60 70 80 90 100
SPDTLTVGPS RMHWTGTQLI VEVNEISSPP LVSPVKGRIV LTPTGITDVE
110 120 130 140 150
VTLKDDGSHI WRPFAPTARI EVDLTQGHRW HGHGYFDANF GTAALEADFR
160 170 180 190 200
FWTWGRYPVA DGAACFYDAT RRDGSRLELG LHVAADGRAR LIQPPPEARF
210 220 230 240 250
ARSRWLVERH TPADPGTRPR QVMSMLDAPF YSRAMVETTV FGQKTVGVHE
260 270
ALDLRRFRSP LLMPMLAVRV PRRPGWSFS
Length:279
Mass (Da):31,356
Last modified:January 24, 2006 - v3
Checksum:iC9065F7A5AC30C11
GO

Sequence cautioni

The sequence ABA79441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 45RGR → AA in CAB38742 (PubMed:7721699).Curated3
Sequence conflicti44G → A in CAA44887 (PubMed:1612412).Curated1
Sequence conflicti232S → A in CAB38742 (PubMed:7721699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010302 Genomic DNA Translation: CAB38742.1
X63204 Genomic DNA Translation: CAA44887.1
CP000143 Genomic DNA Translation: ABA79441.2 Different initiation.
PIRiS49623
RefSeqiYP_353342.2, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA79441; ABA79441; RSP_0267
GeneIDi3719277
KEGGirsp:RSP_0267
PATRICifig|272943.9.peg.2211

Similar proteinsi

Entry informationi

Entry nameiCRTC_RHOS4
AccessioniPrimary (citable) accession number: Q01670
Secondary accession number(s): Q3J193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 24, 2006
Last modified: October 25, 2017
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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