UniProtKB - Q01664 (TFAP4_HUMAN)
Protein
Transcription factor AP-4
Gene
TFAP4
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- E-box binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- cellular response to dexamethasone stimulus Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
- negative regulation by host of viral transcription Source: UniProtKB
- negative regulation of cell cycle arrest Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation by host of viral transcription Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- regulation of mitotic cell cycle phase transition Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q01664 |
SIGNORi | Q01664 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-4Alternative name(s): Activating enhancer-binding protein 4 Class C basic helix-loop-helix protein 41 Short name: bHLHc41 |
Gene namesi | Name:TFAP4 Synonyms:BHLHC41 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11745, TFAP4 |
MIMi | 600743, gene |
neXtProti | NX_Q01664 |
VEuPathDBi | HostDB:ENSG00000090447.11 |
Subcellular locationi
Nucleus
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7023 |
OpenTargetsi | ENSG00000090447 |
PharmGKBi | PA36462 |
Miscellaneous databases
Pharosi | Q01664, Tbio |
Genetic variation databases
BioMutai | TFAP4 |
DMDMi | 1729833 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127458 | 1 – 338 | Transcription factor AP-4Add BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Cross-linki | 147 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 187 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 189 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 285 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q01664 |
jPOSTi | Q01664 |
MassIVEi | Q01664 |
MaxQBi | Q01664 |
PaxDbi | Q01664 |
PeptideAtlasi | Q01664 |
PRIDEi | Q01664 |
ProteomicsDBi | 57980 |
PTM databases
iPTMneti | Q01664 |
PhosphoSitePlusi | Q01664 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090447, Expressed in cingulate cortex and 222 other tissues |
ExpressionAtlasi | Q01664, baseline and differential |
Genevisiblei | Q01664, HS |
Organism-specific databases
HPAi | ENSG00000090447, Low tissue specificity |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.
Binary interactionsi
Hide detailsQ01664
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112881, 133 interactors |
DIPi | DIP-53627N |
IntActi | Q01664, 44 interactors |
MINTi | Q01664 |
STRINGi | 9606.ENSP00000204517 |
Miscellaneous databases
RNActi | Q01664, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 99 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 120 | Leucine-zipper 1Add BLAST | 21 | |
Regioni | 151 – 179 | Leucine-zipper 2Add BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 193 – 222 | Gln-richAdd BLAST | 30 | |
Compositional biasi | 225 – 244 | Pro-richAdd BLAST | 20 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0561, Eukaryota |
GeneTreei | ENSGT00390000015189 |
HOGENOMi | CLU_064747_0_0_1 |
InParanoidi | Q01664 |
OMAi | RGCPEAH |
OrthoDBi | 1565841at2759 |
PhylomeDBi | Q01664 |
TreeFami | TF316489 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q01664-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR
60 70 80 90 100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE
110 120 130 140 150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED
160 170 180 190 200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ
210 220 230 240 250
QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV
260 270 280 290 300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP
310 320 330
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L254 | I3L254_HUMAN | Transcription factor AP-4 | TFAP4 | 115 | Annotation score: | ||
I3L301 | I3L301_HUMAN | Transcription factor AP-4 | TFAP4 | 167 | Annotation score: | ||
I3L4L6 | I3L4L6_HUMAN | Transcription factor AP-4 | TFAP4 | 44 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059346 | 218 | Q → H1 PublicationCorresponds to variant dbSNP:rs251732Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S73885 mRNA Translation: AAB32235.1 AC004653 Genomic DNA Translation: AAC17116.1 BC010576 mRNA Translation: AAH10576.1 X57435 mRNA Translation: CAA40683.1 |
CCDSi | CCDS10510.1 |
PIRi | I56893 |
RefSeqi | NP_003214.1, NM_003223.2 |
Genome annotation databases
Ensembli | ENST00000204517; ENSP00000204517; ENSG00000090447 |
GeneIDi | 7023 |
KEGGi | hsa:7023 |
UCSCi | uc010uxg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S73885 mRNA Translation: AAB32235.1 AC004653 Genomic DNA Translation: AAC17116.1 BC010576 mRNA Translation: AAH10576.1 X57435 mRNA Translation: CAA40683.1 |
CCDSi | CCDS10510.1 |
PIRi | I56893 |
RefSeqi | NP_003214.1, NM_003223.2 |
3D structure databases
SMRi | Q01664 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112881, 133 interactors |
DIPi | DIP-53627N |
IntActi | Q01664, 44 interactors |
MINTi | Q01664 |
STRINGi | 9606.ENSP00000204517 |
PTM databases
iPTMneti | Q01664 |
PhosphoSitePlusi | Q01664 |
Genetic variation databases
BioMutai | TFAP4 |
DMDMi | 1729833 |
Proteomic databases
EPDi | Q01664 |
jPOSTi | Q01664 |
MassIVEi | Q01664 |
MaxQBi | Q01664 |
PaxDbi | Q01664 |
PeptideAtlasi | Q01664 |
PRIDEi | Q01664 |
ProteomicsDBi | 57980 |
Protocols and materials databases
Antibodypediai | 894, 306 antibodies |
DNASUi | 7023 |
Genome annotation databases
Ensembli | ENST00000204517; ENSP00000204517; ENSG00000090447 |
GeneIDi | 7023 |
KEGGi | hsa:7023 |
UCSCi | uc010uxg.3, human |
Organism-specific databases
CTDi | 7023 |
DisGeNETi | 7023 |
GeneCardsi | TFAP4 |
HGNCi | HGNC:11745, TFAP4 |
HPAi | ENSG00000090447, Low tissue specificity |
MIMi | 600743, gene |
neXtProti | NX_Q01664 |
OpenTargetsi | ENSG00000090447 |
PharmGKBi | PA36462 |
VEuPathDBi | HostDB:ENSG00000090447.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0561, Eukaryota |
GeneTreei | ENSGT00390000015189 |
HOGENOMi | CLU_064747_0_0_1 |
InParanoidi | Q01664 |
OMAi | RGCPEAH |
OrthoDBi | 1565841at2759 |
PhylomeDBi | Q01664 |
TreeFami | TF316489 |
Enzyme and pathway databases
PathwayCommonsi | Q01664 |
SIGNORi | Q01664 |
Miscellaneous databases
BioGRID-ORCSi | 7023, 162 hits in 1032 CRISPR screens |
GeneWikii | TFAP4 |
GenomeRNAii | 7023 |
Pharosi | Q01664, Tbio |
PROi | PR:Q01664 |
RNActi | Q01664, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090447, Expressed in cingulate cortex and 222 other tissues |
ExpressionAtlasi | Q01664, baseline and differential |
Genevisiblei | Q01664, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TFAP4_HUMAN | |
Accessioni | Q01664Primary (citable) accession number: Q01664 Secondary accession number(s): O60409 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot