Transcription factor AP-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression."
    Cui Y., Narayanan C.S., Zhou J., Kumar A.
    Gene 224:97-107(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCLInferred from direct assayⁱ
  • "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro."
    Mermod N., Williams T.J., Tjian R.
    Nature 332:557-561(1988) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro."
    Mermod N., Williams T.J., Tjian R.
    Nature 332:557-561(1988) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: UniProtKBInferred from direct assayⁱ
  • "Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements."
    Aranburu A., Carlsson R., Persson C., Leanderson T.
    Biochem J 354:431-438(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene."
    Cheng C.K., Hoo R.L., Chow B.K., Leung P.C.
    Mol Endocrinol 17:1175-1191(2003) [PubMed] [Europe PMC] [Abstract]
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function."
    Ou S.H., Garcia-Martinez L.F., Paulssen E.J., Gaynor R.B.
    J. Virol. 68:7188-7199(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• histone deacetylase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J Biol Chem 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • Ref.4

    "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-338, PARTIAL PROTEIN SEQUENCE.
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-338, PARTIAL PROTEIN SEQUENCE.
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA."
    Glahder J.A., Hansen C.N., Vinther J., Madsen B.S., Norrild B.
    J Gen Virol 84:3429-3441(2003) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J Biol Chem 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to dexamethasone stimulus Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKBInferred from direct assayⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral transcription Source: UniProtKBInferred from direct assayⁱ
  • "A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA."
    Glahder J.A., Hansen C.N., Vinther J., Madsen B.S., Norrild B.
    J Gen Virol 84:3429-3441(2003) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J Biol Chem 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle arrest Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKBInferred from direct assayⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J Biol Chem 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function."
    Ou S.H., Garcia-Martinez L.F., Paulssen E.J., Gaynor R.B.
    J. Virol. 68:7188-7199(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
  • "Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression."
    Cui Y., Narayanan C.S., Zhou J., Kumar A.
    Gene 224:97-107(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation by host of viral transcription Source: UniProtKBInferred from direct assayⁱ
  • "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro."
    Mermod N., Williams T.J., Tjian R.
    Nature 332:557-561(1988) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene."
    Cheng C.K., Hoo R.L., Chow B.K., Leung P.C.
    Mol Endocrinol 17:1175-1191(2003) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: UniProtKBInferred from direct assayⁱ
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle phase transition Source: UniProtKBInferred from direct assayⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc Natl Acad Sci U S A 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J Biol Chem 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • Ref.4

    "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-338, PARTIAL PROTEIN SEQUENCE.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR 
        60         70         80         90        100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE 
       110        120        130        140        150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED 
       160        170        180        190        200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ 
       210        220        230        240        250
QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV 
       260        270        280        290        300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP 
       310        320        330 
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP              

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 16
   Human chromosome 16: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot