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Protein

Protein Dr1

Gene

DR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ01658

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Dr1
Alternative name(s):
Down-regulator of transcription 1
Negative cofactor 2-beta
Short name:
NC2-beta
TATA-binding protein-associated phosphoprotein
Gene namesi
Name:DR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117505.12
HGNCiHGNC:3017 DR1
MIMi601482 gene
neXtProtiNX_Q01658

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1810
OpenTargetsiENSG00000117505
PharmGKBiPA27475

Polymorphism and mutation databases

BioMutaiDR1
DMDMi401162

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000724402 – 176Protein Dr1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01658
PaxDbiQ01658
PeptideAtlasiQ01658
PRIDEiQ01658
ProteomicsDBi57979

PTM databases

iPTMnetiQ01658
PhosphoSitePlusiQ01658

Expressioni

Gene expression databases

BgeeiENSG00000117505 Expressed in 246 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_DR1
ExpressionAtlasiQ01658 baseline and differential
GenevisibleiQ01658 HS

Organism-specific databases

HPAiHPA050785
HPA055308

Interactioni

Subunit structurei

Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLE3Q9NRF93EBI-750300,EBI-744901

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108144, 47 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ01658
IntActiQ01658, 10 interactors
MINTiQ01658
STRINGi9606.ENSP00000359290

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01658
SMRiQ01658
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01658

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 75Histone-foldSequence analysisAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi100 – 103Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 168Ala/Gln-richAdd BLAST48

Sequence similaritiesi

Belongs to the NC2 beta/DR1 family.Curated

Phylogenomic databases

eggNOGiKOG0871 Eukaryota
COG5150 LUCA
GeneTreeiENSGT00550000075010
HOGENOMiHOG000178641
HOVERGENiHBG002051
InParanoidiQ01658
KOiK21751
OMAiTIACDHI
OrthoDBiEOG091G0ZDR
PhylomeDBiQ01658
TreeFamiTF317588

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI
60 70 80 90 100
SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK
110 120 130 140 150
RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ
160 170
AQLAAASASA SNQAGSSQDE EDDDDI
Length:176
Mass (Da):19,444
Last modified:July 1, 1993 - v1
Checksum:i36E7E59F2FD6CAB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034506171E → D. Corresponds to variant dbSNP:rs3088371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97388 mRNA Translation: AAA58442.1
BT006972 mRNA Translation: AAP35618.1
AL137159 Genomic DNA No translation available.
BC002809 mRNA Translation: AAH02809.1
BC035507 mRNA Translation: AAH35507.1
BC068553 mRNA Translation: AAH68553.1
CCDSiCCDS744.1
PIRiA43320
RefSeqiNP_001929.1, NM_001938.2
UniGeneiHs.348418

Genome annotation databases

EnsembliENST00000370267; ENSP00000359290; ENSG00000117505
ENST00000370272; ENSP00000359295; ENSG00000117505
GeneIDi1810
KEGGihsa:1810

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97388 mRNA Translation: AAA58442.1
BT006972 mRNA Translation: AAP35618.1
AL137159 Genomic DNA No translation available.
BC002809 mRNA Translation: AAH02809.1
BC035507 mRNA Translation: AAH35507.1
BC068553 mRNA Translation: AAH68553.1
CCDSiCCDS744.1
PIRiA43320
RefSeqiNP_001929.1, NM_001938.2
UniGeneiHs.348418

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JFIX-ray2.62B1-176[»]
ProteinModelPortaliQ01658
SMRiQ01658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108144, 47 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ01658
IntActiQ01658, 10 interactors
MINTiQ01658
STRINGi9606.ENSP00000359290

PTM databases

iPTMnetiQ01658
PhosphoSitePlusiQ01658

Polymorphism and mutation databases

BioMutaiDR1
DMDMi401162

Proteomic databases

EPDiQ01658
PaxDbiQ01658
PeptideAtlasiQ01658
PRIDEiQ01658
ProteomicsDBi57979

Protocols and materials databases

DNASUi1810
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370267; ENSP00000359290; ENSG00000117505
ENST00000370272; ENSP00000359295; ENSG00000117505
GeneIDi1810
KEGGihsa:1810

Organism-specific databases

CTDi1810
DisGeNETi1810
EuPathDBiHostDB:ENSG00000117505.12
GeneCardsiDR1
HGNCiHGNC:3017 DR1
HPAiHPA050785
HPA055308
MIMi601482 gene
neXtProtiNX_Q01658
OpenTargetsiENSG00000117505
PharmGKBiPA27475
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0871 Eukaryota
COG5150 LUCA
GeneTreeiENSGT00550000075010
HOGENOMiHOG000178641
HOVERGENiHBG002051
InParanoidiQ01658
KOiK21751
OMAiTIACDHI
OrthoDBiEOG091G0ZDR
PhylomeDBiQ01658
TreeFamiTF317588

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ01658

Miscellaneous databases

ChiTaRSiDR1 human
EvolutionaryTraceiQ01658
GeneWikiiDR1_(gene)
GenomeRNAii1810
PROiPR:Q01658
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117505 Expressed in 246 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_DR1
ExpressionAtlasiQ01658 baseline and differential
GenevisibleiQ01658 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNC2B_HUMAN
AccessioniPrimary (citable) accession number: Q01658
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 12, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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