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UniProtKB - Q01658 (NC2B_HUMAN)

Entry version 194 (02 Jun 2021)
Sequence version 1 (01 Jul 1993)
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Protein

Protein Dr1

Gene

DR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01658

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01658

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Dr1
Alternative name(s):
Down-regulator of transcription 1
Negative cofactor 2-beta
Short name:
NC2-beta
TATA-binding protein-associated phosphoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3017, DR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601482, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01658

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117505.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1810

Open Targets

More...OpenTargetsi		ENSG00000117505

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01658, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		401162

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724402 – 176Protein Dr1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q01658

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01658

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01658

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01658

PeptideAtlas

More...PeptideAtlasi		Q01658

PRoteomics IDEntifications database

More...PRIDEi		Q01658

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57979

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01658

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117505, Expressed in choroid plexus epithelium and 258 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01658, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01658, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117505, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer.

Interacts with NFIL3.

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q01658
With#Exp.IntAct
ANXA8 [P13928]3EBI-750300,EBI-2556915
APP [P05067]3EBI-750300,EBI-77613
ASCL4 [Q6XD76]3EBI-750300,EBI-10254793
AUNIP [Q9H7T9]3EBI-750300,EBI-10693257
BAG6 - isoform 2 [P46379-2]3EBI-750300,EBI-10988864
BAHD1 [Q8TBE0]3EBI-750300,EBI-742750
C14orf93 - isoform 2 [Q9H972-2]3EBI-750300,EBI-11524174
C8orf48 [Q96LL4]3EBI-750300,EBI-751596
CBLB [Q13191]3EBI-750300,EBI-744027
CFAP100 - isoform 2 [Q494V2-2]3EBI-750300,EBI-11953200
CSNK1D - isoform 2 [P48730-2]3EBI-750300,EBI-9087876
DCAF8 - isoform 2 [Q5TAQ9-2]3EBI-750300,EBI-25842815
DPF1 - isoform 2 [Q92782-2]3EBI-750300,EBI-23669343
DPP9 - isoform 2 [Q86TI2-2]3EBI-750300,EBI-21529239
DRAP1 [Q14919]32EBI-750300,EBI-712941
EMILIN1 - isoform 2 [Q9Y6C2-2]3EBI-750300,EBI-11748557
FAM117B [Q6P1L5]3EBI-750300,EBI-3893327
FAM98C [Q17RN3]3EBI-750300,EBI-5461838
FAM9A [Q8IZU1]3EBI-750300,EBI-8468186
GMPPA [Q96IJ6]3EBI-750300,EBI-750953
GOLGA2P5 [Q9HBQ8]3EBI-750300,EBI-22000587
GPSM3 [Q9Y4H4]3EBI-750300,EBI-347538
H3-5 [Q6NXT2]3EBI-750300,EBI-2868501
HES4 [Q9HCC6]3EBI-750300,EBI-2680288
IK [Q13123]3EBI-750300,EBI-713456
JADE3 [Q92613]3EBI-750300,EBI-10278909
KLF15 [Q9UIH9]3EBI-750300,EBI-2796400
LARP4B [Q92615]3EBI-750300,EBI-1052558
LOC401296 [A2RU56]3EBI-750300,EBI-9088215
LPIN1 [Q14693]3EBI-750300,EBI-5278370
MAGEC3 - isoform 2 [Q8TD91-2]3EBI-750300,EBI-10694180
MKRN2 [Q9H000]3EBI-750300,EBI-2341005
MLC1 [Q15049]3EBI-750300,EBI-8475277
MPC2 [O95563]3EBI-750300,EBI-719403
MYC [P01106]3EBI-750300,EBI-447544
NFYC - isoform 1 [Q13952-2]3EBI-750300,EBI-11956831
NVL - isoform 5 [O15381-5]3EBI-750300,EBI-18577082
PBX4 [Q9BYU1]3EBI-750300,EBI-10302990
PHF19 [Q5T6S3]3EBI-750300,EBI-2339674
POLE3 [Q9NRF9]7EBI-750300,EBI-744901
POLR2E [P19388]3EBI-750300,EBI-395189
PRMT1 - isoform 2 [Q99873-2]3EBI-750300,EBI-16399024
RAI2 [Q9Y5P3]3EBI-750300,EBI-746228
RNF183 [Q96D59]3EBI-750300,EBI-743938
RNF34 [Q969K3]3EBI-750300,EBI-2340642
RPP25 [Q9BUL9]3EBI-750300,EBI-366570
RPS4X [P62701]3EBI-750300,EBI-354303
RUSC1 [Q9BVN2]3EBI-750300,EBI-6257312
RYBP [Q8N488]3EBI-750300,EBI-752324
SAP30 [O75446]3EBI-750300,EBI-632609
SEM1 [P60896]3EBI-750300,EBI-79819
SPATA22 [Q8NHS9]3EBI-750300,EBI-7067260
SPPL2B - isoform 2 [Q8TCT7-2]3EBI-750300,EBI-8345366
STRN4 [Q9NRL3]3EBI-750300,EBI-717245
SYNCRIP - isoform 4 [O60506-4]3EBI-750300,EBI-11123832
TACO1 [Q9BSH4]3EBI-750300,EBI-747797
TBP [Q32MN6]3EBI-750300,EBI-10239991
THEG [Q9P2T0]3EBI-750300,EBI-751020
TIMM44 [O43615]3EBI-750300,EBI-861737
USP2 - isoform 3 [O75604-3]3EBI-750300,EBI-10696113
VHL - isoform 2 [P40337-2]3EBI-750300,EBI-12157263
VSX2 [P58304]3EBI-750300,EBI-6427899
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-750300,EBI-14104088
ZNF219 [Q9P2Y4]3EBI-750300,EBI-3937106
ZNF488 - isoform 2 [Q96MN9-2]3EBI-750300,EBI-25831733
ZNF581 [Q9P0T4]3EBI-750300,EBI-745520
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-750300,EBI-18036029
ZSCAN1 - isoform 2 [Q8NBB4-2]3EBI-750300,EBI-12021938
ZSCAN22 [P10073]3EBI-750300,EBI-10178224
A0A384ME253EBI-750300,EBI-10211777
Q9H6693EBI-750300,EBI-10307430

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108144, 50 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q01658

Protein interaction database and analysis system

More...IntActi		Q01658, 82 interactors

Molecular INTeraction database

More...MINTi		Q01658

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359295

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01658, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01658

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q01658

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 75Histone-foldSequence analysisAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 176DisorderedSequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi100 – 103Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 166Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NC2 beta/DR1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0871, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_066247_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01658

Identification of Orthologs from Complete Genome Data

More...OMAi		ANSGMSM

Database of Orthologous Groups

More...OrthoDBi		1465912at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01658

TreeFam database of animal gene trees

More...TreeFami		TF317588

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00206

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003958, CBFA_NFYB_domain
IPR009072, Histone-fold
IPR042225, Ncb2

The PANTHER Classification System

More...PANTHERi		PTHR46138, PTHR46138, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00808, CBFD_NFYB_HMF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q01658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI 
        60         70         80         90        100
SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK 
       110        120        130        140        150
RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ 
       160        170 
AQLAAASASA SNQAGSSQDE EDDDDI
Length:176
Mass (Da):19,444
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36E7E59F2FD6CAB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034506171E → D. Corresponds to variant dbSNP:rs3088371Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M97388 mRNA Translation: AAA58442.1
BT006972 mRNA Translation: AAP35618.1
AL137159 Genomic DNA No translation available.
BC002809 mRNA Translation: AAH02809.1
BC035507 mRNA Translation: AAH35507.1
BC068553 mRNA Translation: AAH68553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS744.1

Protein sequence database of the Protein Information Resource

More...PIRi		A43320

NCBI Reference Sequences

More...RefSeqi		NP_001929.1, NM_001938.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370267; ENSP00000359290; ENSG00000117505
ENST00000370272; ENSP00000359295; ENSG00000117505

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1810

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97388 mRNA Translation: AAA58442.1
BT006972 mRNA Translation: AAP35618.1
AL137159 Genomic DNA No translation available.
BC002809 mRNA Translation: AAH02809.1
BC035507 mRNA Translation: AAH35507.1
BC068553 mRNA Translation: AAH68553.1
CCDSiCCDS744.1
PIRiA43320
RefSeqiNP_001929.1, NM_001938.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JFIX-ray2.62B1-176[»]
SMRiQ01658
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108144, 50 interactors
ComplexPortaliCPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex
CORUMiQ01658
IntActiQ01658, 82 interactors
MINTiQ01658
STRINGi9606.ENSP00000359295

PTM databases

iPTMnetiQ01658
PhosphoSitePlusiQ01658

Genetic variation databases

BioMutaiDR1
DMDMi401162

Proteomic databases

EPDiQ01658
jPOSTiQ01658
MassIVEiQ01658
PaxDbiQ01658
PeptideAtlasiQ01658
PRIDEiQ01658
ProteomicsDBi57979

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19942, 200 antibodies

The DNASU plasmid repository

More...DNASUi		1810

Genome annotation databases

EnsembliENST00000370267; ENSP00000359290; ENSG00000117505
ENST00000370272; ENSP00000359295; ENSG00000117505
GeneIDi1810
KEGGihsa:1810

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1810
DisGeNETi1810

GeneCards: human genes, protein and diseases

More...GeneCardsi		DR1
HGNCiHGNC:3017, DR1
HPAiENSG00000117505, Low tissue specificity
MIMi601482, gene
neXtProtiNX_Q01658
OpenTargetsiENSG00000117505
PharmGKBiPA27475
VEuPathDBiHostDB:ENSG00000117505.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0871, Eukaryota
GeneTreeiENSGT00550000075010
HOGENOMiCLU_066247_11_1_1
InParanoidiQ01658
OMAiANSGMSM
OrthoDBi1465912at2759
PhylomeDBiQ01658
TreeFamiTF317588

Enzyme and pathway databases

PathwayCommonsiQ01658
ReactomeiR-HSA-3214847, HATs acetylate histones
SIGNORiQ01658

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1810, 559 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DR1, human
EvolutionaryTraceiQ01658

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DR1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1810
PharosiQ01658, Tbio

Protein Ontology

More...PROi		PR:Q01658
RNActiQ01658, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117505, Expressed in choroid plexus epithelium and 258 other tissues
ExpressionAtlasiQ01658, baseline and differential
GenevisibleiQ01658, HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
IDEALiIID00206
InterProiView protein in InterPro
IPR003958, CBFA_NFYB_domain
IPR009072, Histone-fold
IPR042225, Ncb2
PANTHERiPTHR46138, PTHR46138, 1 hit
PfamiView protein in Pfam
PF00808, CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNC2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01658
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 2, 2021
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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