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Entry version 210 (29 Sep 2021)
Sequence version 2 (24 Jan 2001)
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Protein

Large neutral amino acids transporter small subunit 1

Gene

SLC7A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).

Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591).

May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).

May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).

Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).

When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).

Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).

Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).

By similarity1 Publication13 Publications

(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.

1 Publication

Miscellaneous

The uptake of leucine, tyrosine and tryptophan is inhibited by the different iodothyronines, in particular T3. Leucine transport is also inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine and cysteine) and by glutamine and asparagine. The uptake of T3 is almost completely blocked by coincubation with leucine, tryptophan, tyrosine, and phenylalanine, or 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH). Methionine uptake was inhibited by the L-system substrates L-leucine, BCH, L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. Tyrosine uptake in fibroblasts was inhibited by D-methionine, and methyl-aminoisobutyric acid (MeAIB).

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.9 µM for T4 (in the presence of choline chloride)5 Publications
  2. KM=0.8 µM for T3 (in the presence of choline chloride)5 Publications
  3. KM=12.5 µM for reverse triiodothyronine (rT3) (in the presence of choline chloride)5 Publications
  4. KM=7.9 µM for 3,3'-diiodothyronine (in the presence of choline chloride)5 Publications
  5. KM=46 µM for leucine (in the presence of choline chloride)5 Publications
  6. KM=19 µM for tryptophan (in the presence of choline chloride)5 Publications
  7. KM=32 µM for L-leucine5 Publications
  8. KM=10 mM for L-alanine5 Publications
  9. KM=2.2 mM for L-glutamine5 Publications
  10. KM=35 µM for L-histidine5 Publications
  11. KM=740 µM for L-phenylalanine5 Publications
  12. KM=98 µM for MeHg-L-cysteine5 Publications
  13. KM=99 µM for methionine5 Publications
  14. KM=55.2 µM for phenylalanine (in T24 human bladder carcinoma cells)5 Publications
  15. KM=60.4 µM for tyrosine (in T24 human bladder carcinoma cells)5 Publications
  16. KM=16.4 µM for tyrosine (in human fibroblasts)5 Publications
  17. KM=138 µM for Dopa (in T24 human bladder carcinoma cells)5 Publications
  18. KM=96.5 µM for 3-O-methyldopa (in T24 human bladder carcinoma cells)5 Publications
  19. KM=153 µM for alpha-methyltyrosine (in T24 human bladder carcinoma cells)5 Publications
  20. KM=216 µM for alpha-methyldopa (in T24 human bladder carcinoma cells)5 Publications
  21. KM=191 µM for gabapentin (in T24 human bladder carcinoma cells)5 Publications
  22. KM=7.3 µM for triiodothyronine (in T24 human bladder carcinoma cells)5 Publications
  23. KM=162 µM for thyroxine (in T24 human bladder carcinoma cells)5 Publications
  24. KM=75.3 µM for melphanan (in T24 human bladder carcinoma cells)5 Publications
  25. KM=156 µM for BCH (in T24 human bladder carcinoma cells)5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000103257-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q01650

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210991, Basigin interactions
R-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-71240, Tryptophan catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q01650

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.8.25, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 1
Alternative name(s):
4F2 light chain
Short name:
4F2 LC
Short name:
4F2LC
CD98 light chain
Integral membrane protein E161 Publication
Short name:
E161 Publication
L-type amino acid transporter 11 Publication
Short name:
hLAT11 Publication
Solute carrier family 7 member 5
y+ system cationic amino acid transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC7A5
Synonyms:CD98LC, LAT12 Publications, MPE16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11063, SLC7A5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600182, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01650

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000103257

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicCuratedAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70Helical1 PublicationAdd BLAST21
Topological domaini71 – 83ExtracellularCuratedAdd BLAST13
Transmembranei84 – 104Helical1 PublicationAdd BLAST21
Topological domaini105 – 126CytoplasmicCuratedAdd BLAST22
Transmembranei127 – 147Helical1 PublicationAdd BLAST21
Topological domaini148 – 169ExtracellularCuratedAdd BLAST22
Transmembranei170 – 190Helical1 PublicationAdd BLAST21
Topological domaini191 – 192CytoplasmicCurated2
Transmembranei193 – 214Helical1 PublicationAdd BLAST22
Topological domaini215 – 242ExtracellularCuratedAdd BLAST28
Transmembranei243 – 263Helical1 PublicationAdd BLAST21
Topological domaini264 – 276CytoplasmicCuratedAdd BLAST13
Transmembranei277 – 297Helical1 PublicationAdd BLAST21
Topological domaini298 – 324ExtracellularCuratedAdd BLAST27
Transmembranei325 – 345Helical1 PublicationAdd BLAST21
Topological domaini346 – 369CytoplasmicCuratedAdd BLAST24
Transmembranei370 – 390Helical1 PublicationAdd BLAST21
Topological domaini391 – 395ExtracellularCurated5
Transmembranei396 – 416Helical1 PublicationAdd BLAST21
Topological domaini417 – 430CytoplasmicCuratedAdd BLAST14
Transmembranei431 – 451Helical1 PublicationAdd BLAST21
Topological domaini452 – 457ExtracellularCurated6
Transmembranei458 – 478Helical1 PublicationAdd BLAST21
Topological domaini479 – 507CytoplasmicCuratedAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi117Y → A: Strongly decreased transport activity. 1 Publication1
Mutagenesisi246A → V: Nearly abolishes transport activity. 1 Publication1
Mutagenesisi252F → A: Nearly abolishes transport activity. 1 Publication1
Mutagenesisi257W → A: Nearly abolishes transport activity. 1 Publication1
Mutagenesisi258N → A: Decreased transport activity. 1 Publication1
Mutagenesisi258N → D: Nearly abolishes transport activity. 1 Publication1
Mutagenesisi259Y → A: Strongly decreased transport activity. 1 Publication1
Mutagenesisi303E → K: Decreased transport activity. 1 Publication1
Mutagenesisi375P → L: Nearly abolishes transport activity. 1 Publication1
Mutagenesisi483 – 507Missing : Nearly abolishes transport activity. 1 PublicationAdd BLAST25

Organism-specific databases

DisGeNET

More...
DisGeNETi
8140

Open Targets

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OpenTargetsi
ENSG00000103257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35923

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q01650, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4459

Drug and drug target database

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DrugBanki
DB01746, D-Leucine
DB02556, D-Phenylalanine
DB00509, Dextrothyroxine
DB00996, Gabapentin
DB00130, L-Glutamine
DB01235, Levodopa
DB00451, Levothyroxine
DB00279, Liothyronine
DB01042, Melphalan
DB00230, Pregabalin
DB02750, S-(Methylmercury)-L-Cysteine
DB09100, Thyroid, porcine

DrugCentral

More...
DrugCentrali
Q01650

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC7A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542701 – 507Large neutral amino acids transporter small subunit 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi164Interchain (with C-210 in SLC3A2)1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01650

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q01650

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q01650

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q01650

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01650

PeptideAtlas

More...
PeptideAtlasi
Q01650

PRoteomics IDEntifications database

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PRIDEi
Q01650

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57978

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q01650

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q01650, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q01650

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01650

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q01650

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.9 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

(Microbial infection) Up-regulation of the complex formed by SLC3A2 and SLC7A5/LAT1 upon hepatitis C virus/HCV infection.1 Publication
Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103257, Expressed in pigmented layer of retina and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01650, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q01650, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000103257, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:9751058, PubMed:25998567, PubMed:30867591).

Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113801, 80 interactors

Protein interaction database and analysis system

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IntActi
Q01650, 44 interactors

Molecular INTeraction database

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MINTi
Q01650

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261622

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q01650

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q01650, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01650

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 28Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1287, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155581

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_007946_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q01650

Identification of Orthologs from Complete Genome Data

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OMAi
TTALCQK

Database of Orthologous Groups

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OrthoDBi
621852at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q01650

TreeFam database of animal gene trees

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TreeFami
TF313355

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002293, AA/rel_permease1
IPR004760, L_AA_transporter

Pfam protein domain database

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Pfami
View protein in Pfam
PF13520, AA_permease_2, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00911, 2A0308, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01650-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI
60 70 80 90 100
TLLNGVAIIV GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA
110 120 130 140 150
LCYAELGTTI SKSGGDYAYM LEVYGSLPAF LKLWIELLII RPSSQYIVAL
160 170 180 190 200
VFATYLLKPL FPTCPVPEEA AKLVACLCVL LLTAVNCYSV KAATRVQDAF
210 220 230 240 250
AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV GNIVLALYSG
260 270 280 290 300
LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL
310 320 330 340 350
STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF
360 370 380 390 400
FVGSREGHLP SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF
410 420 430 440 450
SFFNWLCVAL AIIGMIWLRH RKPELERPIK VNLALPVFFI LACLFLIAVS
460 470 480 490 500
FWKTPVECGI GFTIILSGLP VYFFGVWWKN KPKWLLQGIF STTVLCQKLM

QVVPQET
Length:507
Mass (Da):55,010
Last modified:January 24, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i767F3C60B62C0F02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGL4A0A0C4DGL4_HUMAN
Large neutral amino acids transport...
SLC7A5 hCG_1789357
241Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15A → V in BAA75746 (Ref. 5) Curated1
Sequence conflicti29 – 31AKS → SKR in BAA75746 (Ref. 5) Curated3
Sequence conflicti35S → A in BAA75746 (Ref. 5) Curated1
Sequence conflicti62T → A in BAA75746 (Ref. 5) Curated1
Sequence conflicti88V → M in BAA75746 (Ref. 5) Curated1
Sequence conflicti154T → A in BAA75746 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070119223D → V1 PublicationCorresponds to variant dbSNP:rs17853937EnsemblClinVar.1
Natural variantiVAR_048157230N → K1 PublicationCorresponds to variant dbSNP:rs1060250EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF077866 mRNA Translation: AAC61479.1
AF104032 mRNA Translation: AAD20464.1
AB018542 mRNA Translation: BAA33851.1
AB018009 mRNA Translation: BAA84648.1
AB017908 mRNA Translation: BAA75746.1
BC039692 mRNA Translation: AAH39692.1
BC042600 mRNA Translation: AAH42600.1
M80244 mRNA Translation: AAA35780.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10964.1

Protein sequence database of the Protein Information Resource

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PIRi
JG0165

NCBI Reference Sequences

More...
RefSeqi
NP_003477.4, NM_003486.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261622; ENSP00000261622; ENSG00000103257

Database of genes from NCBI RefSeq genomes

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GeneIDi
8140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8140

UCSC genome browser

More...
UCSCi
uc002fkm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077866 mRNA Translation: AAC61479.1
AF104032 mRNA Translation: AAD20464.1
AB018542 mRNA Translation: BAA33851.1
AB018009 mRNA Translation: BAA84648.1
AB017908 mRNA Translation: BAA75746.1
BC039692 mRNA Translation: AAH39692.1
BC042600 mRNA Translation: AAH42600.1
M80244 mRNA Translation: AAA35780.1
CCDSiCCDS10964.1
PIRiJG0165
RefSeqiNP_003477.4, NM_003486.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6IRSelectron microscopy3.30B2-507[»]
6IRTelectron microscopy3.50B2-507[»]
6JMQelectron microscopy3.31A1-507[»]
7DSKelectron microscopy2.90B2-507[»]
7DSLelectron microscopy2.90B2-507[»]
7DSNelectron microscopy3.10B2-507[»]
7DSQelectron microscopy3.40B2-507[»]
SMRiQ01650
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113801, 80 interactors
IntActiQ01650, 44 interactors
MINTiQ01650
STRINGi9606.ENSP00000261622

Chemistry databases

BindingDBiQ01650
ChEMBLiCHEMBL4459
DrugBankiDB01746, D-Leucine
DB02556, D-Phenylalanine
DB00509, Dextrothyroxine
DB00996, Gabapentin
DB00130, L-Glutamine
DB01235, Levodopa
DB00451, Levothyroxine
DB00279, Liothyronine
DB01042, Melphalan
DB00230, Pregabalin
DB02750, S-(Methylmercury)-L-Cysteine
DB09100, Thyroid, porcine
DrugCentraliQ01650

Protein family/group databases

TCDBi2.A.3.8.25, the amino acid-polyamine-organocation (apc) family

PTM databases

GlyGeniQ01650, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ01650
PhosphoSitePlusiQ01650
SwissPalmiQ01650

Genetic variation databases

BioMutaiSLC7A5
DMDMi12643412

Proteomic databases

EPDiQ01650
jPOSTiQ01650
MassIVEiQ01650
MaxQBiQ01650
PaxDbiQ01650
PeptideAtlasiQ01650
PRIDEiQ01650
ProteomicsDBi57978
TopDownProteomicsiQ01650

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
17241, 401 antibodies

The DNASU plasmid repository

More...
DNASUi
8140

Genome annotation databases

EnsembliENST00000261622; ENSP00000261622; ENSG00000103257
GeneIDi8140
KEGGihsa:8140
UCSCiuc002fkm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8140
DisGeNETi8140

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC7A5
HGNCiHGNC:11063, SLC7A5
HPAiENSG00000103257, Tissue enhanced (bone)
MIMi600182, gene
neXtProtiNX_Q01650
OpenTargetsiENSG00000103257
PharmGKBiPA35923
VEuPathDBiHostDB:ENSG00000103257

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1287, Eukaryota
GeneTreeiENSGT00940000155581
HOGENOMiCLU_007946_3_0_1
InParanoidiQ01650
OMAiTTALCQK
OrthoDBi621852at2759
PhylomeDBiQ01650
TreeFamiTF313355

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000103257-MONOMER
PathwayCommonsiQ01650
ReactomeiR-HSA-210991, Basigin interactions
R-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-71240, Tryptophan catabolism
SABIO-RKiQ01650

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8140, 277 hits in 1031 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC7A5, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC7A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8140
PharosiQ01650, Tbio

Protein Ontology

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PROi
PR:Q01650
RNActiQ01650, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103257, Expressed in pigmented layer of retina and 236 other tissues
ExpressionAtlasiQ01650, baseline and differential
GenevisibleiQ01650, HS

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
IPR004760, L_AA_transporter
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit
TIGRFAMsiTIGR00911, 2A0308, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01650
Secondary accession number(s): Q8IV97
, Q9UBN8, Q9UP15, Q9UQC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 24, 2001
Last modified: September 29, 2021
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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