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Entry version 198 (16 Oct 2019)
Sequence version 2 (24 Jan 2001)
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Protein

Large neutral amino acids transporter small subunit 1

Gene

SLC7A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).By similarity1 Publication13 Publications

Miscellaneous

The uptake of leucine, tyrosine and tryptophan is inhibited by the different iodothyronines, in particular T3. Leucine transport is also inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine and cysteine) and by glutamine and asparagine. The uptake of T3 is almost completely blocked by coincubation with leucine, tryptophan, tyrosine, and phenylalanine, or 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH). Methionine uptake was inhibited by the L-system substrates L-leucine, BCH, L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. Tyrosine uptake in fibroblasts was inhibited by D-methionine, and methyl-aminoisobutyric acid (MeAIB).

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.9 µM for T4 (in the presence of choline chloride)5 Publications
  2. KM=0.8 µM for T3 (in the presence of choline chloride)5 Publications
  3. KM=12.5 µM for reverse triiodothyronine (rT3) (in the presence of choline chloride)5 Publications
  4. KM=7.9 µM for 3,3'-diiodothyronine (in the presence of choline chloride)5 Publications
  5. KM=46 µM for leucine (in the presence of choline chloride)5 Publications
  6. KM=19 µM for tryptophan (in the presence of choline chloride)5 Publications
  7. KM=32 µM for L-leucine5 Publications
  8. KM=10 mM for L-alanine5 Publications
  9. KM=2.2 mM for L-glutamine5 Publications
  10. KM=35 µM for L-histidine5 Publications
  11. KM=740 µM for L-phenylalanine5 Publications
  12. KM=98 µM for MeHg-L-cysteine5 Publications
  13. KM=99 µM for methionine5 Publications
  14. KM=55.2 µM for phenylalanine (in T24 human bladder carcinoma cells)5 Publications
  15. KM=60.4 µM for tyrosine (in T24 human bladder carcinoma cells)5 Publications
  16. KM=16.4 µM for tyrosine (in human fibroblasts)5 Publications
  17. KM=138 µM for Dopa (in T24 human bladder carcinoma cells)5 Publications
  18. KM=96.5 µM for 3-O-methyldopa (in T24 human bladder carcinoma cells)5 Publications
  19. KM=153 µM for alpha-methyltyrosine (in T24 human bladder carcinoma cells)5 Publications
  20. KM=216 µM for alpha-methyldopa (in T24 human bladder carcinoma cells)5 Publications
  21. KM=191 µM for gabapentin (in T24 human bladder carcinoma cells)5 Publications
  22. KM=7.3 µM for triiodothyronine (in T24 human bladder carcinoma cells)5 Publications
  23. KM=162 µM for thyroxine (in T24 human bladder carcinoma cells)5 Publications
  24. KM=75.3 µM for melphanan (in T24 human bladder carcinoma cells)5 Publications
  25. KM=156 µM for BCH (in T24 human bladder carcinoma cells)5 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000103257-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-210991 Basigin interactions
    R-HSA-352230 Amino acid transport across the plasma membrane
    R-HSA-71240 Tryptophan catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q01650

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.3.8.25 the amino acid-polyamine-organocation (apc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Large neutral amino acids transporter small subunit 1
    Alternative name(s):
    4F2 light chain
    Short name:
    4F2 LC
    Short name:
    4F2LC
    CD98 light chain
    Integral membrane protein E161 Publication
    Short name:
    E161 Publication
    L-type amino acid transporter 11 Publication
    Short name:
    hLAT11 Publication
    Solute carrier family 7 member 5
    y+ system cationic amino acid transporter
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC7A5
    Synonyms:CD98LC, LAT12 Publications, MPE16
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11063 SLC7A5

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600182 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q01650

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicCuratedAdd BLAST49
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70Helical1 PublicationAdd BLAST21
    Topological domaini71 – 83ExtracellularCuratedAdd BLAST13
    Transmembranei84 – 104Helical1 PublicationAdd BLAST21
    Topological domaini105 – 126CytoplasmicCuratedAdd BLAST22
    Transmembranei127 – 147Helical1 PublicationAdd BLAST21
    Topological domaini148 – 169ExtracellularCuratedAdd BLAST22
    Transmembranei170 – 190Helical1 PublicationAdd BLAST21
    Topological domaini191 – 192CytoplasmicCurated2
    Transmembranei193 – 214Helical1 PublicationAdd BLAST22
    Topological domaini215 – 242ExtracellularCuratedAdd BLAST28
    Transmembranei243 – 263Helical1 PublicationAdd BLAST21
    Topological domaini264 – 276CytoplasmicCuratedAdd BLAST13
    Transmembranei277 – 297Helical1 PublicationAdd BLAST21
    Topological domaini298 – 324ExtracellularCuratedAdd BLAST27
    Transmembranei325 – 345Helical1 PublicationAdd BLAST21
    Topological domaini346 – 369CytoplasmicCuratedAdd BLAST24
    Transmembranei370 – 390Helical1 PublicationAdd BLAST21
    Topological domaini391 – 395ExtracellularCurated5
    Transmembranei396 – 416Helical1 PublicationAdd BLAST21
    Topological domaini417 – 430CytoplasmicCuratedAdd BLAST14
    Transmembranei431 – 451Helical1 PublicationAdd BLAST21
    Topological domaini452 – 457ExtracellularCurated6
    Transmembranei458 – 478Helical1 PublicationAdd BLAST21
    Topological domaini479 – 507CytoplasmicCuratedAdd BLAST29

    Keywords - Cellular componenti

    Cell membrane, Lysosome, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi117Y → A: Strongly decreased transport activity. 1 Publication1
    Mutagenesisi246A → V: Nearly abolishes transport activity. 1 Publication1
    Mutagenesisi252F → A: Nearly abolishes transport activity. 1 Publication1
    Mutagenesisi257W → A: Nearly abolishes transport activity. 1 Publication1
    Mutagenesisi258N → A: Decreased transport activity. 1 Publication1
    Mutagenesisi258N → D: Nearly abolishes transport activity. 1 Publication1
    Mutagenesisi259Y → A: Strongly decreased transport activity. 1 Publication1
    Mutagenesisi303E → K: Decreased transport activity. 1 Publication1
    Mutagenesisi375P → L: Nearly abolishes transport activity. 1 Publication1
    Mutagenesisi483 – 507Missing : Nearly abolishes transport activity. 1 PublicationAdd BLAST25

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8140

    Open Targets

    More...
    OpenTargetsi
    ENSG00000103257

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35923

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q01650

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4459

    Drug and drug target database

    More...
    DrugBanki
    DB01746 D-Leucine
    DB02556 D-Phenylalanine
    DB00509 Dextrothyroxine
    DB01235 Levodopa
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01042 Melphalan
    DB00230 Pregabalin
    DB02750 S-(Methylmercury)-L-Cysteine

    DrugCentral

    More...
    DrugCentrali
    Q01650

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC7A5

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    12643412

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542701 – 507Large neutral amino acids transporter small subunit 1Add BLAST507

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
    Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineCombined sources1
    Modified residuei35PhosphoserineCombined sources1
    Modified residuei45PhosphothreonineCombined sources1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi164Interchain (with C-210 in SLC3A2)1 Publication

    Keywords - PTMi

    Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q01650

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q01650

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q01650

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q01650

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q01650

    PeptideAtlas

    More...
    PeptideAtlasi
    Q01650

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q01650

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    57978

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q01650

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q01650

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q01650

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q01650

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.9 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000103257 Expressed in 224 organ(s), highest expression level in pigmented layer of retina

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q01650 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q01650 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA052673
    HPA056077

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:9751058, PubMed:25998567, PubMed:30867591).

    Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

    13 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    SLC3A2P081952EBI-6138761,EBI-702356

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    113801, 40 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q01650, 34 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q01650

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000261622

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q01650

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1507
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q01650

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1287 Eukaryota
    COG0531 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155581

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000098892

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q01650

    KEGG Orthology (KO)

    More...
    KOi
    K13780

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HKAFGIH

    Database of Orthologous Groups

    More...
    OrthoDBi
    621852at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q01650

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313355

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002293 AA/rel_permease1
    IPR004760 L_AA_transporter

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13520 AA_permease_2, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF006060 AA_transporter, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00911 2A0308, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q01650-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI
    60 70 80 90 100
    TLLNGVAIIV GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA
    110 120 130 140 150
    LCYAELGTTI SKSGGDYAYM LEVYGSLPAF LKLWIELLII RPSSQYIVAL
    160 170 180 190 200
    VFATYLLKPL FPTCPVPEEA AKLVACLCVL LLTAVNCYSV KAATRVQDAF
    210 220 230 240 250
    AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV GNIVLALYSG
    260 270 280 290 300
    LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL
    310 320 330 340 350
    STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF
    360 370 380 390 400
    FVGSREGHLP SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF
    410 420 430 440 450
    SFFNWLCVAL AIIGMIWLRH RKPELERPIK VNLALPVFFI LACLFLIAVS
    460 470 480 490 500
    FWKTPVECGI GFTIILSGLP VYFFGVWWKN KPKWLLQGIF STTVLCQKLM

    QVVPQET
    Length:507
    Mass (Da):55,010
    Last modified:January 24, 2001 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i767F3C60B62C0F02
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0C4DGL4A0A0C4DGL4_HUMAN
    Large neutral amino acids transport...
    SLC7A5 hCG_1789357
    241Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15A → V in BAA75746 (Ref. 5) Curated1
    Sequence conflicti29 – 31AKS → SKR in BAA75746 (Ref. 5) Curated3
    Sequence conflicti35S → A in BAA75746 (Ref. 5) Curated1
    Sequence conflicti62T → A in BAA75746 (Ref. 5) Curated1
    Sequence conflicti88V → M in BAA75746 (Ref. 5) Curated1
    Sequence conflicti154T → A in BAA75746 (Ref. 5) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070119223D → V1 PublicationCorresponds to variant dbSNP:rs17853937Ensembl.1
    Natural variantiVAR_048157230N → K1 PublicationCorresponds to variant dbSNP:rs1060250Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF077866 mRNA Translation: AAC61479.1
    AF104032 mRNA Translation: AAD20464.1
    AB018542 mRNA Translation: BAA33851.1
    AB018009 mRNA Translation: BAA84648.1
    AB017908 mRNA Translation: BAA75746.1
    BC039692 mRNA Translation: AAH39692.1
    BC042600 mRNA Translation: AAH42600.1
    M80244 mRNA Translation: AAA35780.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10964.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JG0165

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_003477.4, NM_003486.6

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000261622; ENSP00000261622; ENSG00000103257

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8140

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8140

    UCSC genome browser

    More...
    UCSCi
    uc002fkm.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF077866 mRNA Translation: AAC61479.1
    AF104032 mRNA Translation: AAD20464.1
    AB018542 mRNA Translation: BAA33851.1
    AB018009 mRNA Translation: BAA84648.1
    AB017908 mRNA Translation: BAA75746.1
    BC039692 mRNA Translation: AAH39692.1
    BC042600 mRNA Translation: AAH42600.1
    M80244 mRNA Translation: AAA35780.1
    CCDSiCCDS10964.1
    PIRiJG0165
    RefSeqiNP_003477.4, NM_003486.6

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6IRSelectron microscopy3.30B2-507[»]
    6IRTelectron microscopy3.50B2-507[»]
    6JMQelectron microscopy3.31A1-507[»]
    SMRiQ01650
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi113801, 40 interactors
    IntActiQ01650, 34 interactors
    MINTiQ01650
    STRINGi9606.ENSP00000261622

    Chemistry databases

    BindingDBiQ01650
    ChEMBLiCHEMBL4459
    DrugBankiDB01746 D-Leucine
    DB02556 D-Phenylalanine
    DB00509 Dextrothyroxine
    DB01235 Levodopa
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01042 Melphalan
    DB00230 Pregabalin
    DB02750 S-(Methylmercury)-L-Cysteine
    DrugCentraliQ01650

    Protein family/group databases

    TCDBi2.A.3.8.25 the amino acid-polyamine-organocation (apc) family

    PTM databases

    iPTMnetiQ01650
    PhosphoSitePlusiQ01650
    SwissPalmiQ01650

    Polymorphism and mutation databases

    BioMutaiSLC7A5
    DMDMi12643412

    Proteomic databases

    EPDiQ01650
    jPOSTiQ01650
    MassIVEiQ01650
    MaxQBiQ01650
    PaxDbiQ01650
    PeptideAtlasiQ01650
    PRIDEiQ01650
    ProteomicsDBi57978
    TopDownProteomicsiQ01650

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    8140

    Genome annotation databases

    EnsembliENST00000261622; ENSP00000261622; ENSG00000103257
    GeneIDi8140
    KEGGihsa:8140
    UCSCiuc002fkm.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8140
    DisGeNETi8140

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC7A5
    HGNCiHGNC:11063 SLC7A5
    HPAiHPA052673
    HPA056077
    MIMi600182 gene
    neXtProtiNX_Q01650
    OpenTargetsiENSG00000103257
    PharmGKBiPA35923

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1287 Eukaryota
    COG0531 LUCA
    GeneTreeiENSGT00940000155581
    HOGENOMiHOG000098892
    InParanoidiQ01650
    KOiK13780
    OMAiHKAFGIH
    OrthoDBi621852at2759
    PhylomeDBiQ01650
    TreeFamiTF313355

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000103257-MONOMER
    ReactomeiR-HSA-210991 Basigin interactions
    R-HSA-352230 Amino acid transport across the plasma membrane
    R-HSA-71240 Tryptophan catabolism
    SABIO-RKiQ01650

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC7A5 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC7A5

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8140
    PharosiQ01650

    Protein Ontology

    More...
    PROi
    PR:Q01650

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000103257 Expressed in 224 organ(s), highest expression level in pigmented layer of retina
    ExpressionAtlasiQ01650 baseline and differential
    GenevisibleiQ01650 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002293 AA/rel_permease1
    IPR004760 L_AA_transporter
    PfamiView protein in Pfam
    PF13520 AA_permease_2, 1 hit
    PIRSFiPIRSF006060 AA_transporter, 1 hit
    TIGRFAMsiTIGR00911 2A0308, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAT1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01650
    Secondary accession number(s): Q8IV97
    , Q9UBN8, Q9UP15, Q9UQC0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 24, 2001
    Last modified: October 16, 2019
    This is version 198 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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