UniProtKB - Q01638 (ILRL1_HUMAN)
Interleukin-1 receptor-like 1
IL1RL1
Functioni
Catalytic activityi
- EC:3.2.2.6PROSITE-ProRule annotationThis reaction proceeds in the forwardPROSITE-ProRule annotation direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 461 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cytokine receptor activity Source: UniProtKB
- interleukin-1 receptor activity Source: InterPro
- interleukin-33 binding Source: GO_Central
- interleukin-33 receptor activity Source: GO_Central
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
GO - Biological processi
- immune response Source: UniProtKB
- interleukin-33-mediated signaling pathway Source: Reactome
- negative regulation of interferon-gamma production Source: Ensembl
- negative regulation of T-helper 1 type immune response Source: Ensembl
- positive regulation of chemokine secretion Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of interleukin-5 production Source: Ensembl
- positive regulation of macrophage activation Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Receptor |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q01638 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9014843, Interleukin-33 signaling [Q01638-2] |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-1 receptor-like 1 (EC:3.2.2.6PROSITE-ProRule annotation)Alternative name(s): Protein ST2 |
Gene namesi | Name:IL1RL1 Synonyms:DER4, ST2, T1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000115602.16 |
HGNCi | HGNC:5998, IL1RL1 |
MIMi | 601203, gene |
neXtProti | NX_Q01638 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- focal adhesion Source: HPA
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 328 | ExtracellularSequence analysisAdd BLAST | 310 | |
Transmembranei | 329 – 349 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 350 – 556 | CytoplasmicSequence analysisAdd BLAST | 207 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 9173 |
OpenTargetsi | ENSG00000115602 |
PharmGKBi | PA29814 |
Miscellaneous databases
Pharosi | Q01638, Tbio |
Polymorphism and mutation databases
BioMutai | IL1RL1 |
DMDMi | 116242527 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000015442 | 19 – 556 | Interleukin-1 receptor-like 1Add BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 87 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 111 ↔ 151 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 133 ↔ 181 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 140 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 191 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 235 ↔ 303 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 238 ↔ 282 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q01638 |
jPOSTi | Q01638 |
MassIVEi | Q01638 |
PaxDbi | Q01638 |
PeptideAtlasi | Q01638 |
PRIDEi | Q01638 |
ProteomicsDBi | 57975 [Q01638-1] 57976 [Q01638-2] 57977 [Q01638-3] |
TopDownProteomicsi | Q01638-2 [Q01638-2] |
PTM databases
GlyConnecti | 1948, 10 N-Linked glycans (5 sites) |
GlyGeni | Q01638, 10 sites |
iPTMneti | Q01638 |
PhosphoSitePlusi | Q01638 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115602, Expressed in right lung and 156 other tissues |
ExpressionAtlasi | Q01638, baseline and differential |
Genevisiblei | Q01638, HS |
Organism-specific databases
HPAi | ENSG00000115602, Group enriched (kidney, lung, placenta) |
Interactioni
Subunit structurei
Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry.
Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.
By similarity1 Publication2 PublicationsBinary interactionsi
Hide detailsQ01638
With | #Exp. | IntAct |
---|---|---|
CLEC7A [Q9BXN2] | 3 | EBI-993762,EBI-3939278 |
IL33 [O95760] | 2 | EBI-993762,EBI-724057 |
Isoform B [Q01638-2]
GO - Molecular functioni
- interleukin-33 binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114613, 20 interactors |
CORUMi | Q01638 |
DIPi | DIP-37861N |
IntActi | Q01638, 16 interactors |
STRINGi | 9606.ENSP00000233954 |
Miscellaneous databases
RNActi | Q01638, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q01638 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 103 | Ig-like C2-type 1Add BLAST | 85 | |
Domaini | 114 – 197 | Ig-like C2-type 2Add BLAST | 84 | |
Domaini | 212 – 319 | Ig-like C2-type 3Add BLAST | 108 | |
Domaini | 375 – 535 | TIRPROSITE-ProRule annotationAdd BLAST | 161 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 211 | Flexible linkerAdd BLAST | 14 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU6H, Eukaryota |
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_1_1 |
InParanoidi | Q01638 |
OMAi | HVRYHMP |
OrthoDBi | 1109920at2759 |
PhylomeDBi | Q01638 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR015621, IL-1_rcpt_fam IPR004074, IL-1_rcpt_I/II-typ IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 2 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS50104, TIR, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY
60 70 80 90 100
SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA
110 120 130 140 150
NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN
160 170 180 190 200
CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF
210 220 230 240 250
TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL
260 270 280 290 300
WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
310 320 330 340 350
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL
360 370 380 390 400
KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF
410 420 430 440 450
VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP
460 470 480 490 500
QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL
510 520 530 540 550
QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP
LAAQKQ
The sequence of this isoform differs from the canonical sequence as follows:
204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
260-556: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC41 | E9PC41_HUMAN | Interleukin-1 receptor-like 1 | IL1RL1 | 314 | Annotation score: | ||
C9JSY6 | C9JSY6_HUMAN | Interleukin-1 receptor-like 1 | IL1RL1 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | Q → R in BAA85894 (PubMed:10527832).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023749 | 78 | A → E3 PublicationsCorresponds to variant dbSNP:rs1041973Ensembl. | 1 | |
Natural variantiVAR_053373 | 433 | A → T1 PublicationCorresponds to variant dbSNP:rs4988956Ensembl. | 1 | |
Natural variantiVAR_053374 | 501 | Q → K. Corresponds to variant dbSNP:rs10192036Ensembl. | 1 | |
Natural variantiVAR_053375 | 501 | Q → R. Corresponds to variant dbSNP:rs10204137Ensembl. | 1 | |
Natural variantiVAR_053376 | 549 | T → I. Corresponds to variant dbSNP:rs10192157Ensembl. | 1 | |
Natural variantiVAR_053377 | 551 | L → S. Corresponds to variant dbSNP:rs10206753Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054933 | 1 – 117 | Missing in isoform 4. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_002664 | 204 – 259 | DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_002665 | 260 – 556 | Missing in isoform C. 1 PublicationAdd BLAST | 297 | |
Alternative sequenceiVSP_002666 | 324 – 328 | IDHHS → SKECF in isoform B and isoform 4. 3 Publications | 5 | |
Alternative sequenceiVSP_002667 | 329 – 556 | Missing in isoform B and isoform 4. 3 PublicationsAdd BLAST | 228 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12763 mRNA Translation: BAA02233.1 D12764 Genomic DNA Translation: BAA20539.1 AB029084 mRNA Translation: BAA85894.1 AB012701 mRNA Translation: BAA82405.2 AK291578 mRNA Translation: BAF84267.1 AK303389 mRNA Translation: BAG64445.1 AC007248 Genomic DNA Translation: AAY15047.1 CH471127 Genomic DNA Translation: EAX01795.1 BC030975 mRNA Translation: AAH30975.1 |
CCDSi | CCDS2057.1 [Q01638-1] CCDS2058.1 [Q01638-2] CCDS74548.1 [Q01638-4] |
PIRi | JC7109 S30444 |
RefSeqi | NP_001269337.1, NM_001282408.1 [Q01638-4] NP_003847.2, NM_003856.3 [Q01638-2] NP_057316.3, NM_016232.4 [Q01638-1] XP_006712902.1, XM_006712839.3 [Q01638-1] XP_011510453.1, XM_011512151.1 [Q01638-2] |
Genome annotation databases
Ensembli | ENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1] ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2] ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4] ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3] |
GeneIDi | 9173 |
KEGGi | hsa:9173 |
UCSCi | uc002tbu.1, human [Q01638-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12763 mRNA Translation: BAA02233.1 D12764 Genomic DNA Translation: BAA20539.1 AB029084 mRNA Translation: BAA85894.1 AB012701 mRNA Translation: BAA82405.2 AK291578 mRNA Translation: BAF84267.1 AK303389 mRNA Translation: BAG64445.1 AC007248 Genomic DNA Translation: AAY15047.1 CH471127 Genomic DNA Translation: EAX01795.1 BC030975 mRNA Translation: AAH30975.1 |
CCDSi | CCDS2057.1 [Q01638-1] CCDS2058.1 [Q01638-2] CCDS74548.1 [Q01638-4] |
PIRi | JC7109 S30444 |
RefSeqi | NP_001269337.1, NM_001282408.1 [Q01638-4] NP_003847.2, NM_003856.3 [Q01638-2] NP_057316.3, NM_016232.4 [Q01638-1] XP_006712902.1, XM_006712839.3 [Q01638-1] XP_011510453.1, XM_011512151.1 [Q01638-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4KC3 | X-ray | 3.27 | B | 19-321 | [»] | |
SMRi | Q01638 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114613, 20 interactors |
CORUMi | Q01638 |
DIPi | DIP-37861N |
IntActi | Q01638, 16 interactors |
STRINGi | 9606.ENSP00000233954 |
PTM databases
GlyConnecti | 1948, 10 N-Linked glycans (5 sites) |
GlyGeni | Q01638, 10 sites |
iPTMneti | Q01638 |
PhosphoSitePlusi | Q01638 |
Polymorphism and mutation databases
BioMutai | IL1RL1 |
DMDMi | 116242527 |
Proteomic databases
EPDi | Q01638 |
jPOSTi | Q01638 |
MassIVEi | Q01638 |
PaxDbi | Q01638 |
PeptideAtlasi | Q01638 |
PRIDEi | Q01638 |
ProteomicsDBi | 57975 [Q01638-1] 57976 [Q01638-2] 57977 [Q01638-3] |
TopDownProteomicsi | Q01638-2 [Q01638-2] |
Protocols and materials databases
ABCDi | Q01638, 14 sequenced antibodies |
Antibodypediai | 2362, 559 antibodies |
DNASUi | 9173 |
Genome annotation databases
Ensembli | ENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1] ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2] ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4] ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3] |
GeneIDi | 9173 |
KEGGi | hsa:9173 |
UCSCi | uc002tbu.1, human [Q01638-1] |
Organism-specific databases
CTDi | 9173 |
DisGeNETi | 9173 |
EuPathDBi | HostDB:ENSG00000115602.16 |
GeneCardsi | IL1RL1 |
HGNCi | HGNC:5998, IL1RL1 |
HPAi | ENSG00000115602, Group enriched (kidney, lung, placenta) |
MIMi | 601203, gene |
neXtProti | NX_Q01638 |
OpenTargetsi | ENSG00000115602 |
PharmGKBi | PA29814 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU6H, Eukaryota |
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_1_1 |
InParanoidi | Q01638 |
OMAi | HVRYHMP |
OrthoDBi | 1109920at2759 |
PhylomeDBi | Q01638 |
TreeFami | TF325519 |
Enzyme and pathway databases
PathwayCommonsi | Q01638 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9014843, Interleukin-33 signaling [Q01638-2] |
Miscellaneous databases
BioGRID-ORCSi | 9173, 2 hits in 845 CRISPR screens |
GeneWikii | IL1RL1 |
GenomeRNAii | 9173 |
Pharosi | Q01638, Tbio |
PROi | PR:Q01638 |
RNActi | Q01638, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115602, Expressed in right lung and 156 other tissues |
ExpressionAtlasi | Q01638, baseline and differential |
Genevisiblei | Q01638, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR015621, IL-1_rcpt_fam IPR004074, IL-1_rcpt_I/II-typ IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 2 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ILRL1_HUMAN | |
Accessioni | Q01638Primary (citable) accession number: Q01638 Secondary accession number(s): A8K6B3 Q9UQ44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations