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Entry version 197 (22 Apr 2020)
Sequence version 4 (17 Oct 2006)
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Protein

Interleukin-1 receptor-like 1

Gene

IL1RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.1 Publication1 Publication
Inhibits IL-33 signaling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei461PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Receptor
LigandNAD

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling [Q01638-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor-like 1 (EC:3.2.2.6PROSITE-ProRule annotation)
Alternative name(s):
Protein ST2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL1RL1
Synonyms:DER4, ST2, T1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5998 IL1RL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601203 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01638

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 328ExtracellularSequence analysisAdd BLAST310
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 556CytoplasmicSequence analysisAdd BLAST207

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9173

Open Targets

More...
OpenTargetsi
ENSG00000115602

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29814

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q01638 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL1RL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242527

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001544219 – 556Interleukin-1 receptor-like 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 87PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 151PROSITE-ProRule annotation1 Publication
Disulfide bondi133 ↔ 181PROSITE-ProRule annotation1 Publication
Glycosylationi140N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 303PROSITE-ProRule annotation1 Publication
Disulfide bondi238 ↔ 282PROSITE-ProRule annotation1 Publication
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01638

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q01638

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01638

PeptideAtlas

More...
PeptideAtlasi
Q01638

PRoteomics IDEntifications database

More...
PRIDEi
Q01638

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57975 [Q01638-1]
57976 [Q01638-2]
57977 [Q01638-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q01638-2 [Q01638-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1948

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01638

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01638

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115602 Expressed in right lung and 138 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01638 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01638 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000115602 Group enriched (kidney, lung, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry.

Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.

By similarity1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114613, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q01638

Database of interacting proteins

More...
DIPi
DIP-37861N

Protein interaction database and analysis system

More...
IntActi
Q01638, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233954

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q01638 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01638

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 103Ig-like C2-type 1Add BLAST85
Domaini114 – 197Ig-like C2-type 2Add BLAST84
Domaini212 – 319Ig-like C2-type 3Add BLAST108
Domaini375 – 535TIRPROSITE-ProRule annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni198 – 211Flexible linkerAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPTT Eukaryota
ENOG4110Z8K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198494

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025552_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01638

KEGG Orthology (KO)

More...
KOi
K05171

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVANKRS

Database of Orthologous Groups

More...
OrthoDBi
1109920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01638

TreeFam database of animal gene trees

More...
TreeFami
TF325519

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11890 PTHR11890, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF01582 TIR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01536 INTRLKN1R12F

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q01638-1) [UniParc]FASTAAdd to basket
Also known as: ST2L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY
60 70 80 90 100
SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA
110 120 130 140 150
NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN
160 170 180 190 200
CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF
210 220 230 240 250
TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL
260 270 280 290 300
WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
310 320 330 340 350
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL
360 370 380 390 400
KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF
410 420 430 440 450
VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP
460 470 480 490 500
QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL
510 520 530 540 550
QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP

LAAQKQ
Length:556
Mass (Da):63,358
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB3E444A2DD477B5
GO
Isoform B (identifier: Q01638-2) [UniParc]FASTAAdd to basket
Also known as: ST2S

The sequence of this isoform differs from the canonical sequence as follows:
     324-328: IDHHS → SKECF
     329-556: Missing.

Show »
Length:328
Mass (Da):36,993
Checksum:iF91C46FE2D7FEAD1
GO
Isoform C (identifier: Q01638-3) [UniParc]FASTAAdd to basket
Also known as: ST2V

The sequence of this isoform differs from the canonical sequence as follows:
     204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
     260-556: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:259
Mass (Da):29,951
Checksum:iC349EC8B232EA231
GO
Isoform 4 (identifier: Q01638-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     324-328: IDHHS → SKECF
     329-556: Missing.

Show »
Length:211
Mass (Da):23,723
Checksum:i6AAFBE28B3FD0428
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC41E9PC41_HUMAN
Interleukin-1 receptor-like 1
IL1RL1
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSY6C9JSY6_HUMAN
Interleukin-1 receptor-like 1
IL1RL1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70Q → R in BAA85894 (PubMed:10527832).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02374978A → E3 PublicationsCorresponds to variant dbSNP:rs1041973Ensembl.1
Natural variantiVAR_053373433A → T1 PublicationCorresponds to variant dbSNP:rs4988956Ensembl.1
Natural variantiVAR_053374501Q → K. Corresponds to variant dbSNP:rs10192036Ensembl.1
Natural variantiVAR_053375501Q → R. Corresponds to variant dbSNP:rs10204137Ensembl.1
Natural variantiVAR_053376549T → I. Corresponds to variant dbSNP:rs10192157Ensembl.1
Natural variantiVAR_053377551L → S. Corresponds to variant dbSNP:rs10206753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0549331 – 117Missing in isoform 4. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_002664204 – 259DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_002665260 – 556Missing in isoform C. 1 PublicationAdd BLAST297
Alternative sequenceiVSP_002666324 – 328IDHHS → SKECF in isoform B and isoform 4. 3 Publications5
Alternative sequenceiVSP_002667329 – 556Missing in isoform B and isoform 4. 3 PublicationsAdd BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D12763 mRNA Translation: BAA02233.1
D12764 Genomic DNA Translation: BAA20539.1
AB029084 mRNA Translation: BAA85894.1
AB012701 mRNA Translation: BAA82405.2
AK291578 mRNA Translation: BAF84267.1
AK303389 mRNA Translation: BAG64445.1
AC007248 Genomic DNA Translation: AAY15047.1
CH471127 Genomic DNA Translation: EAX01795.1
BC030975 mRNA Translation: AAH30975.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2057.1 [Q01638-1]
CCDS2058.1 [Q01638-2]
CCDS74548.1 [Q01638-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7109
S30444

NCBI Reference Sequences

More...
RefSeqi
NP_001269337.1, NM_001282408.1 [Q01638-4]
NP_003847.2, NM_003856.3 [Q01638-2]
NP_057316.3, NM_016232.4 [Q01638-1]
XP_006712902.1, XM_006712839.3 [Q01638-1]
XP_011510453.1, XM_011512151.1 [Q01638-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9173

UCSC genome browser

More...
UCSCi
uc002tbu.1 human [Q01638-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA Translation: BAA02233.1
D12764 Genomic DNA Translation: BAA20539.1
AB029084 mRNA Translation: BAA85894.1
AB012701 mRNA Translation: BAA82405.2
AK291578 mRNA Translation: BAF84267.1
AK303389 mRNA Translation: BAG64445.1
AC007248 Genomic DNA Translation: AAY15047.1
CH471127 Genomic DNA Translation: EAX01795.1
BC030975 mRNA Translation: AAH30975.1
CCDSiCCDS2057.1 [Q01638-1]
CCDS2058.1 [Q01638-2]
CCDS74548.1 [Q01638-4]
PIRiJC7109
S30444
RefSeqiNP_001269337.1, NM_001282408.1 [Q01638-4]
NP_003847.2, NM_003856.3 [Q01638-2]
NP_057316.3, NM_016232.4 [Q01638-1]
XP_006712902.1, XM_006712839.3 [Q01638-1]
XP_011510453.1, XM_011512151.1 [Q01638-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KC3X-ray3.27B19-321[»]
SMRiQ01638
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114613, 9 interactors
CORUMiQ01638
DIPiDIP-37861N
IntActiQ01638, 16 interactors
STRINGi9606.ENSP00000233954

PTM databases

GlyConnecti1948
iPTMnetiQ01638
PhosphoSitePlusiQ01638

Polymorphism and mutation databases

BioMutaiIL1RL1
DMDMi116242527

Proteomic databases

EPDiQ01638
MassIVEiQ01638
PaxDbiQ01638
PeptideAtlasiQ01638
PRIDEiQ01638
ProteomicsDBi57975 [Q01638-1]
57976 [Q01638-2]
57977 [Q01638-3]
TopDownProteomicsiQ01638-2 [Q01638-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q01638

Antibodypedia a portal for validated antibodies

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Antibodypediai
2362 545 antibodies

The DNASU plasmid repository

More...
DNASUi
9173

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3]
GeneIDi9173
KEGGihsa:9173
UCSCiuc002tbu.1 human [Q01638-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9173
DisGeNETi9173

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL1RL1
HGNCiHGNC:5998 IL1RL1
HPAiENSG00000115602 Group enriched (kidney, lung, placenta)
MIMi601203 gene
neXtProtiNX_Q01638
OpenTargetsiENSG00000115602
PharmGKBiPA29814

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00980000198494
HOGENOMiCLU_025552_3_1_1
InParanoidiQ01638
KOiK05171
OMAiHVANKRS
OrthoDBi1109920at2759
PhylomeDBiQ01638
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling [Q01638-2]

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IL1RL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9173
PharosiQ01638 Tbio

Protein Ontology

More...
PROi
PR:Q01638
RNActiQ01638 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115602 Expressed in right lung and 138 other tissues
ExpressionAtlasiQ01638 baseline and differential
GenevisibleiQ01638 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiILRL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01638
Secondary accession number(s): A8K6B3
, B4E0I3, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 17, 2006
Last modified: April 22, 2020
This is version 197 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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