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Protein

Interleukin-1 receptor-like 1

Gene

IL1RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.1 Publication1 Publication
Isoform B: Inhibits IL-33 signaling.By similarity

GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB
  • interleukin-1 receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Protein ST2
Gene namesi
Name:IL1RL1
Synonyms:DER4, ST2, T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115602.16
HGNCiHGNC:5998 IL1RL1
MIMi601203 gene
neXtProtiNX_Q01638

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 328ExtracellularSequence analysisAdd BLAST310
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 556CytoplasmicSequence analysisAdd BLAST207

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9173
OpenTargetsiENSG00000115602
PharmGKBiPA29814

Polymorphism and mutation databases

BioMutaiIL1RL1
DMDMi116242527

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001544219 – 556Interleukin-1 receptor-like 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 87PROSITE-ProRule annotation1 Publication
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 151PROSITE-ProRule annotation1 Publication
Disulfide bondi133 ↔ 181PROSITE-ProRule annotation1 Publication
Glycosylationi140N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 303PROSITE-ProRule annotation1 Publication
Disulfide bondi238 ↔ 282PROSITE-ProRule annotation1 Publication
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ01638
PaxDbiQ01638
PeptideAtlasiQ01638
PRIDEiQ01638
ProteomicsDBi57975
57976 [Q01638-2]
57977 [Q01638-3]
TopDownProteomicsiQ01638-2 [Q01638-2]

PTM databases

iPTMnetiQ01638
PhosphoSitePlusiQ01638

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.2 Publications

Gene expression databases

BgeeiENSG00000115602 Expressed in 139 organ(s), highest expression level in right lung
CleanExiHS_IL1RL1
ExpressionAtlasiQ01638 baseline and differential
GenevisibleiQ01638 HS

Organism-specific databases

HPAiHPA007406
HPA007917

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.By similarity1 Publication2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114613, 8 interactors
DIPiDIP-37861N
IntActiQ01638, 15 interactors
STRINGi9606.ENSP00000233954

Structurei

Secondary structure

1556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01638
SMRiQ01638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 103Ig-like C2-type 1Add BLAST85
Domaini114 – 197Ig-like C2-type 2Add BLAST84
Domaini212 – 319Ig-like C2-type 3Add BLAST108
Domaini375 – 538TIRPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 211Flexible linkerAdd BLAST14

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113054
HOVERGENiHBG098401
InParanoidiQ01638
KOiK05171
OMAiVQGTIKW
OrthoDBiEOG091G0GXW
PhylomeDBiQ01638
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q01638-1) [UniParc]FASTAAdd to basket
Also known as: ST2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY
60 70 80 90 100
SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA
110 120 130 140 150
NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN
160 170 180 190 200
CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF
210 220 230 240 250
TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL
260 270 280 290 300
WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
310 320 330 340 350
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL
360 370 380 390 400
KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF
410 420 430 440 450
VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP
460 470 480 490 500
QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL
510 520 530 540 550
QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP

LAAQKQ
Length:556
Mass (Da):63,358
Last modified:October 17, 2006 - v4
Checksum:iCB3E444A2DD477B5
GO
Isoform B (identifier: Q01638-2) [UniParc]FASTAAdd to basket
Also known as: ST2S

The sequence of this isoform differs from the canonical sequence as follows:
     324-328: IDHHS → SKECF
     329-556: Missing.

Show »
Length:328
Mass (Da):36,993
Checksum:iF91C46FE2D7FEAD1
GO
Isoform C (identifier: Q01638-3) [UniParc]FASTAAdd to basket
Also known as: ST2V

The sequence of this isoform differs from the canonical sequence as follows:
     204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
     260-556: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:259
Mass (Da):29,951
Checksum:iC349EC8B232EA231
GO
Isoform 4 (identifier: Q01638-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     324-328: IDHHS → SKECF
     329-556: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):23,723
Checksum:i6AAFBE28B3FD0428
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC41E9PC41_HUMAN
Interleukin-1 receptor-like 1
IL1RL1
314Annotation score:
C9JSY6C9JSY6_HUMAN
Interleukin-1 receptor-like 1
IL1RL1
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Q → R in BAA85894 (PubMed:10527832).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02374978A → E3 PublicationsCorresponds to variant dbSNP:rs1041973Ensembl.1
Natural variantiVAR_053373433A → T1 PublicationCorresponds to variant dbSNP:rs4988956Ensembl.1
Natural variantiVAR_053374501Q → K. Corresponds to variant dbSNP:rs10192036Ensembl.1
Natural variantiVAR_053375501Q → R. Corresponds to variant dbSNP:rs10204137Ensembl.1
Natural variantiVAR_053376549T → I. Corresponds to variant dbSNP:rs10192157Ensembl.1
Natural variantiVAR_053377551L → S. Corresponds to variant dbSNP:rs10206753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0549331 – 117Missing in isoform 4. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_002664204 – 259DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_002665260 – 556Missing in isoform C. 1 PublicationAdd BLAST297
Alternative sequenceiVSP_002666324 – 328IDHHS → SKECF in isoform B and isoform 4. 3 Publications5
Alternative sequenceiVSP_002667329 – 556Missing in isoform B and isoform 4. 3 PublicationsAdd BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA Translation: BAA02233.1
D12764 Genomic DNA Translation: BAA20539.1
AB029084 mRNA Translation: BAA85894.1
AB012701 mRNA Translation: BAA82405.2
AK291578 mRNA Translation: BAF84267.1
AK303389 mRNA Translation: BAG64445.1
AC007248 Genomic DNA Translation: AAY15047.1
CH471127 Genomic DNA Translation: EAX01795.1
BC030975 mRNA Translation: AAH30975.1
CCDSiCCDS2057.1 [Q01638-1]
CCDS2058.1 [Q01638-2]
CCDS74548.1 [Q01638-4]
PIRiJC7109
S30444
RefSeqiNP_001269337.1, NM_001282408.1 [Q01638-4]
NP_003847.2, NM_003856.3 [Q01638-2]
NP_057316.3, NM_016232.4 [Q01638-1]
XP_006712902.1, XM_006712839.3 [Q01638-1]
XP_011510453.1, XM_011512151.1 [Q01638-2]
UniGeneiHs.66
Hs.731651

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3]
GeneIDi9173
KEGGihsa:9173
UCSCiuc002tbu.1 human [Q01638-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA Translation: BAA02233.1
D12764 Genomic DNA Translation: BAA20539.1
AB029084 mRNA Translation: BAA85894.1
AB012701 mRNA Translation: BAA82405.2
AK291578 mRNA Translation: BAF84267.1
AK303389 mRNA Translation: BAG64445.1
AC007248 Genomic DNA Translation: AAY15047.1
CH471127 Genomic DNA Translation: EAX01795.1
BC030975 mRNA Translation: AAH30975.1
CCDSiCCDS2057.1 [Q01638-1]
CCDS2058.1 [Q01638-2]
CCDS74548.1 [Q01638-4]
PIRiJC7109
S30444
RefSeqiNP_001269337.1, NM_001282408.1 [Q01638-4]
NP_003847.2, NM_003856.3 [Q01638-2]
NP_057316.3, NM_016232.4 [Q01638-1]
XP_006712902.1, XM_006712839.3 [Q01638-1]
XP_011510453.1, XM_011512151.1 [Q01638-2]
UniGeneiHs.66
Hs.731651

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KC3X-ray3.27B19-321[»]
ProteinModelPortaliQ01638
SMRiQ01638
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114613, 8 interactors
DIPiDIP-37861N
IntActiQ01638, 15 interactors
STRINGi9606.ENSP00000233954

PTM databases

iPTMnetiQ01638
PhosphoSitePlusiQ01638

Polymorphism and mutation databases

BioMutaiIL1RL1
DMDMi116242527

Proteomic databases

EPDiQ01638
PaxDbiQ01638
PeptideAtlasiQ01638
PRIDEiQ01638
ProteomicsDBi57975
57976 [Q01638-2]
57977 [Q01638-3]
TopDownProteomicsiQ01638-2 [Q01638-2]

Protocols and materials databases

DNASUi9173
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602 [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602 [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602 [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602 [Q01638-3]
GeneIDi9173
KEGGihsa:9173
UCSCiuc002tbu.1 human [Q01638-1]

Organism-specific databases

CTDi9173
DisGeNETi9173
EuPathDBiHostDB:ENSG00000115602.16
GeneCardsiIL1RL1
HGNCiHGNC:5998 IL1RL1
HPAiHPA007406
HPA007917
MIMi601203 gene
neXtProtiNX_Q01638
OpenTargetsiENSG00000115602
PharmGKBiPA29814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113054
HOVERGENiHBG098401
InParanoidiQ01638
KOiK05171
OMAiVQGTIKW
OrthoDBiEOG091G0GXW
PhylomeDBiQ01638
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling

Miscellaneous databases

GeneWikiiIL1RL1
GenomeRNAii9173
PROiPR:Q01638
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115602 Expressed in 139 organ(s), highest expression level in right lung
CleanExiHS_IL1RL1
ExpressionAtlasiQ01638 baseline and differential
GenevisibleiQ01638 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiILRL1_HUMAN
AccessioniPrimary (citable) accession number: Q01638
Secondary accession number(s): A8K6B3
, B4E0I3, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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