UniProtKB - Q01629 (IFM2_HUMAN)
Protein
Interferon-induced transmembrane protein 2
Gene
IFITM2
Organism
Homo sapiens (Human)
Status
Functioni
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.7 Publications
GO - Biological processi
- defense response to virus Source: GO_Central
- immune response Source: ProtInc
- negative regulation of viral entry into host cell Source: UniProtKB
- negative regulation of viral genome replication Source: UniProtKB
- response to interferon-alpha Source: UniProtKB
- response to interferon-beta Source: UniProtKB
- response to interferon-gamma Source: UniProtKB
- response to virus Source: UniProtKB
- type I interferon signaling pathway Source: GO_Central
Keywordsi
Biological process | Antiviral defense, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q01629 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling |
Protein family/group databases
TCDBi | 8.A.58.1.2, the dispanin (dispanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-induced transmembrane protein 2Alternative name(s): Dispanin subfamily A member 2c Short name: DSPA2c Interferon-inducible protein 1-8D |
Gene namesi | Name:IFITM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5413, IFITM2 |
MIMi | 605578, gene |
neXtProti | NX_Q01629 |
VEuPathDBi | HostDB:ENSG00000185201.16 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | CytoplasmicSequence analysisAdd BLAST | 56 | |
Intramembranei | 57 – 77 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 78 – 106 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 132 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10581 |
OpenTargetsi | ENSG00000185201 |
PharmGKBi | PA29654 |
Miscellaneous databases
Pharosi | Q01629, Tbio |
Genetic variation databases
BioMutai | IFITM2 |
DMDMi | 290457648 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153728 | 1 – 132 | Interferon-induced transmembrane protein 2Add BLAST | 132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Lipidationi | 70 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 71 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 104 | S-palmitoyl cysteineBy similarity | 1 |
Post-translational modificationi
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity
Keywords - PTMi
Acetylation, Lipoprotein, PalmitateProteomic databases
EPDi | Q01629 |
jPOSTi | Q01629 |
MassIVEi | Q01629 |
MaxQBi | Q01629 |
PaxDbi | Q01629 |
PeptideAtlasi | Q01629 |
PRIDEi | Q01629 |
ProteomicsDBi | 57974 |
PTM databases
iPTMneti | Q01629 |
PhosphoSitePlusi | Q01629 |
SwissPalmi | Q01629 |
Expressioni
Inductioni
By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53.1 Publication
Gene expression databases
Bgeei | ENSG00000185201, Expressed in blood and 243 other tissues |
ExpressionAtlasi | Q01629, baseline and differential |
Genevisiblei | Q01629, HS |
Organism-specific databases
HPAi | ENSG00000185201, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Interacts with CD81.
By similarityProtein-protein interaction databases
BioGRIDi | 115832, 5 interactors |
IntActi | Q01629, 6 interactors |
STRINGi | 9606.ENSP00000484689 |
Miscellaneous databases
RNActi | Q01629, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CD225/Dispanin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S9XK, Eukaryota |
GeneTreei | ENSGT00950000182857 |
InParanoidi | Q01629 |
OMAi | RTPHSGF |
OrthoDBi | 1555189at2759 |
PhylomeDBi | Q01629 |
TreeFami | TF334894 |
Family and domain databases
InterProi | View protein in InterPro IPR007593, CD225/Dispanin_fam |
Pfami | View protein in Pfam PF04505, CD225, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q01629-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE
60 70 80 90 100
TSVPDHVVWS LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS
110 120 130
TAKCLNIWAL ILGIFMTILL IIIPVLVVQA QR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BYV1 | H7BYV1_HUMAN | Interferon-induced transmembrane pr... | IFITM2 | 74 | Annotation score: | ||
E9PQN9 | E9PQN9_HUMAN | Interferon-induced transmembrane pr... | IFITM2 | 112 | Annotation score: | ||
H0YCL2 | H0YCL2_HUMAN | Interferon-induced transmembrane pr... | IFITM2 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | V → G in CAA40625 (PubMed:1906403).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062677 | 33 | V → A2 PublicationsCorresponds to variant dbSNP:rs1058900Ensembl. | 1 | |
Natural variantiVAR_014848 | 41 | M → T2 PublicationsCorresponds to variant dbSNP:rs14408Ensembl. | 1 | |
Natural variantiVAR_060470 | 121 | I → V2 PublicationsCorresponds to variant dbSNP:rs1059091Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57351 mRNA Translation: CAA40625.1 CR541874 mRNA Translation: CAG46672.1 AC136475 Genomic DNA No translation available. BC009696 mRNA Translation: AAH09696.1 |
CCDSi | CCDS41583.1 |
PIRi | S17183 |
RefSeqi | NP_006426.2, NM_006435.2 |
Genome annotation databases
Ensembli | ENST00000399817; ENSP00000382714; ENSG00000185201 ENST00000616316; ENSP00000484689; ENSG00000185201 |
GeneIDi | 10581 |
KEGGi | hsa:10581 |
UCSCi | uc001lox.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57351 mRNA Translation: CAA40625.1 CR541874 mRNA Translation: CAG46672.1 AC136475 Genomic DNA No translation available. BC009696 mRNA Translation: AAH09696.1 |
CCDSi | CCDS41583.1 |
PIRi | S17183 |
RefSeqi | NP_006426.2, NM_006435.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115832, 5 interactors |
IntActi | Q01629, 6 interactors |
STRINGi | 9606.ENSP00000484689 |
Protein family/group databases
TCDBi | 8.A.58.1.2, the dispanin (dispanin) family |
PTM databases
iPTMneti | Q01629 |
PhosphoSitePlusi | Q01629 |
SwissPalmi | Q01629 |
Genetic variation databases
BioMutai | IFITM2 |
DMDMi | 290457648 |
Proteomic databases
EPDi | Q01629 |
jPOSTi | Q01629 |
MassIVEi | Q01629 |
MaxQBi | Q01629 |
PaxDbi | Q01629 |
PeptideAtlasi | Q01629 |
PRIDEi | Q01629 |
ProteomicsDBi | 57974 |
Protocols and materials databases
Antibodypediai | 22433, 252 antibodies |
DNASUi | 10581 |
Genome annotation databases
Ensembli | ENST00000399817; ENSP00000382714; ENSG00000185201 ENST00000616316; ENSP00000484689; ENSG00000185201 |
GeneIDi | 10581 |
KEGGi | hsa:10581 |
UCSCi | uc001lox.5, human |
Organism-specific databases
CTDi | 10581 |
DisGeNETi | 10581 |
GeneCardsi | IFITM2 |
HGNCi | HGNC:5413, IFITM2 |
HPAi | ENSG00000185201, Tissue enhanced (blood) |
MIMi | 605578, gene |
neXtProti | NX_Q01629 |
OpenTargetsi | ENSG00000185201 |
PharmGKBi | PA29654 |
VEuPathDBi | HostDB:ENSG00000185201.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9XK, Eukaryota |
GeneTreei | ENSGT00950000182857 |
InParanoidi | Q01629 |
OMAi | RTPHSGF |
OrthoDBi | 1555189at2759 |
PhylomeDBi | Q01629 |
TreeFami | TF334894 |
Enzyme and pathway databases
PathwayCommonsi | Q01629 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling |
Miscellaneous databases
BioGRID-ORCSi | 10581, 316 hits in 957 CRISPR screens |
ChiTaRSi | IFITM2, human |
GenomeRNAii | 10581 |
Pharosi | Q01629, Tbio |
PROi | PR:Q01629 |
RNActi | Q01629, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185201, Expressed in blood and 243 other tissues |
ExpressionAtlasi | Q01629, baseline and differential |
Genevisiblei | Q01629, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007593, CD225/Dispanin_fam |
Pfami | View protein in Pfam PF04505, CD225, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFM2_HUMAN | |
Accessioni | Q01629Primary (citable) accession number: Q01629 Secondary accession number(s): Q6FH82, Q96DA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | March 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families