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UniProtKB - Q01628 (IFM3_HUMAN)

Entry version 172 (02 Jun 2021)
Sequence version 2 (16 Apr 2002)
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Protein

Interferon-induced transmembrane protein 3

Gene

IFITM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33270927).

Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927).

Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436).

IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).

Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927).

10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01628

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-909733, Interferon alpha/beta signaling

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.58.1.3, the dispanin (dispanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-induced transmembrane protein 3Curated
Alternative name(s):
Dispanin subfamily A member 2b
Short name:
DSPA2b
Interferon-inducible protein 1-8U
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFITM3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5414, IFITM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605579, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01628

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142089.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 107CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 133ExtracellularSequence analysis5

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20Y → A: Loss of phosphorylation. Accumulates at the plasma membrane. Increases anti-HCV properties. Loss of anti-SARS-CoV-2 activity by enhancing Spike-mediated cell-to-cell fusion. 2 Publications1
Mutagenesisi23L → Q: Accumulates at the plasma membrane. Loss of anti-SARS-CoV-2 activity by enhancing Spike-mediated cell-to-cell fusion. 1 Publication1
Mutagenesisi59 – 68Missing : Slightly enhances infection by SARS-CoV-2. 1 Publication10
Mutagenesisi61 – 65SLFNT → ALFAA: Decreases anti-SARS-CoV-2 activity. 1 Publication5
Mutagenesisi71 – 72CC → AA: Loss of anti-HCV activity. Only localizes at the lysosome. No effect on SARS-CoV-2 infection; when associated with A-105. Loss of anti-influenza A virus activity; when associated with A-105. 2 Publications2
Mutagenesisi105C → A: Loss of anti-HCV activity. Only localizes at the lysosome. No effect on SARS-CoV-2 infection; when associated with 71-A-A-72. Loss of anti-influenza A virus activity; when associated with 71-A-A-72. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		10410

MalaCards human disease database

More...MalaCardsi		IFITM3
MIMi614680, phenotype

Open Targets

More...OpenTargetsi		ENSG00000142089

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29655

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01628, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IFITM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		20178301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001537291 – 133Interferon-induced transmembrane protein 3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20Phosphotyrosine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi71S-palmitoyl cysteine1 Publication1
Lipidationi72S-palmitoyl cysteine1 Publication1
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Lipidationi105S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus and hepatitis C virus (HCV). Has no effect on anti-SARS-CoV-2 activity.4 Publications
Not glycosylated.
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.1 Publication
Phosphorylation at Tyr-20 is required for endosomal and lysosomal location.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q01628

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01628

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01628

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01628

PeptideAtlas

More...PeptideAtlasi		Q01628

PRoteomics IDEntifications database

More...PRIDEi		Q01628

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57973

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q01628

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01628

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01628

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01628

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFN-alpha and IFNG/IFN-gamma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142089, Expressed in ectocervix and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01628, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01628, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142089, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP6V0B (By similarity).

Interacts with CD81 (By similarity).

Interacts with SPP1; the interaction reduces OPN expression (PubMed:19901966).

Interacts with VAPA (PubMed:23601107).

Interacts with BRI3 (isoforms 1 and 2); the interaction with isoform 2 is weaker than with isoform 1 (PubMed:30983867).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115681, 108 interactors

Protein interaction database and analysis system

More...IntActi		Q01628, 29 interactors

Molecular INTeraction database

More...MINTi		Q01628

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382707

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01628, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 93Interaction with SPP11 PublicationAdd BLAST34
Regioni108 – 133Interaction with VAPA1 PublicationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9XK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182857

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01628

Identification of Orthologs from Complete Genome Data

More...OMAi		TLYLNFC

Database of Orthologous Groups

More...OrthoDBi		1555189at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01628

TreeFam database of animal gene trees

More...TreeFami		TF334894

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007593, CD225/Dispanin_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04505, CD225, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q01628-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS 
        60         70         80         90        100
ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA 
       110        120        130 
STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYG
Length:133
Mass (Da):14,632
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FFB2E4623F7A1DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS44E9PS44_HUMAN
Interferon-induced transmembrane pr...
IFITM3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNG9R4GNG9_HUMAN
Interferon-induced transmembrane pr...
IFITM3
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8W2A0A7P0T8W2_HUMAN
Interferon-induced transmembrane pr...
IFITM3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9S7A0A7P0T9S7_HUMAN
Interferon-induced transmembrane pr...
IFITM3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9U8A0A7P0T9U8_HUMAN
Interferon-induced transmembrane pr...
IFITM3
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TB46A0A7P0TB46_HUMAN
Interferon-induced transmembrane pr...
IFITM3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TB91A0A7P0TB91_HUMAN
Interferon-induced transmembrane pr...
IFITM3
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBF9A0A7P0TBF9_HUMAN
Interferon-induced transmembrane pr...
IFITM3
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2N → S in CAA40626 (PubMed:1906403).Curated1
Sequence conflicti34A → G in CAA40626 (PubMed:1906403).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIMi:614680].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0538103H → Q1 PublicationCorresponds to variant dbSNP:rs1136853Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X57352 mRNA Translation: CAA40626.1
JQ610571 Genomic DNA Translation: AFF60305.1
JQ610572 Genomic DNA Translation: AFF60306.1
JQ610573 Genomic DNA Translation: AFF60307.1
JQ610574 Genomic DNA Translation: AFF60308.1
JQ610575 Genomic DNA Translation: AFF60309.1
JQ610576 Genomic DNA Translation: AFF60310.1
JQ610577 Genomic DNA Translation: AFF60311.1
JQ610578 Genomic DNA Translation: AFF60312.1
JQ610579 Genomic DNA Translation: AFF60313.1
JQ610580 Genomic DNA Translation: AFF60314.1
JQ610581 Genomic DNA Translation: AFF60315.1
JQ610582 Genomic DNA Translation: AFF60316.1
JQ610583 Genomic DNA Translation: AFF60317.1
JQ610585 Genomic DNA Translation: AFF60319.1
JQ610586 Genomic DNA Translation: AFF60320.1
JQ610587 Genomic DNA Translation: AFF60321.1
JQ610588 Genomic DNA Translation: AFF60322.1
JQ610589 Genomic DNA Translation: AFF60323.1
JQ610590 Genomic DNA Translation: AFF60324.1
JQ610591 Genomic DNA Translation: AFF60325.1
JQ610592 Genomic DNA Translation: AFF60326.1
JQ610593 Genomic DNA Translation: AFF60327.1
JQ610594 Genomic DNA Translation: AFF60328.1
JQ610595 Genomic DNA Translation: AFF60329.1
JQ610596 Genomic DNA Translation: AFF60330.1
JQ610597 Genomic DNA Translation: AFF60331.1
JQ610598 Genomic DNA Translation: AFF60332.1
JQ610599 Genomic DNA Translation: AFF60333.1
JQ610600 Genomic DNA Translation: AFF60334.1
JQ610601 Genomic DNA Translation: AFF60335.1
JQ610602 Genomic DNA Translation: AFF60336.1
JQ610603 Genomic DNA Translation: AFF60337.1
JQ610604 Genomic DNA Translation: AFF60338.1
JQ610605 Genomic DNA Translation: AFF60339.1
JQ610606 Genomic DNA Translation: AFF60340.1
JQ610607 Genomic DNA Translation: AFF60341.1
JQ610608 Genomic DNA Translation: AFF60342.1
JQ610609 Genomic DNA Translation: AFF60343.1
JQ610610 Genomic DNA Translation: AFF60344.1
JQ610611 Genomic DNA Translation: AFF60345.1
JQ610613 Genomic DNA Translation: AFF60347.1
JQ610614 Genomic DNA Translation: AFF60348.1
JQ610615 Genomic DNA Translation: AFF60349.1
JQ610616 Genomic DNA Translation: AFF60350.1
JQ610617 Genomic DNA Translation: AFF60351.1
JQ610618 Genomic DNA Translation: AFF60352.1
JQ610620 Genomic DNA Translation: AFF60354.1
JQ610621 Genomic DNA Translation: AFF60355.1
BT006892 mRNA Translation: AAP35538.1
AK292173 mRNA Translation: BAF84862.1
AC136475 Genomic DNA No translation available.
CH891444 Genomic DNA Translation: EAW50866.1
BC006794 mRNA Translation: AAH06794.1
BC008417 mRNA Translation: AAH08417.1
BC022439 mRNA Translation: AAH22439.1
BC070243 mRNA Translation: AAH70243.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41585.1

Protein sequence database of the Protein Information Resource

More...PIRi		S17182

NCBI Reference Sequences

More...RefSeqi		NP_066362.2, NM_021034.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399808; ENSP00000382707; ENSG00000142089

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10410

UCSC genome browser

More...UCSCi		uc001lpa.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57352 mRNA Translation: CAA40626.1
JQ610571 Genomic DNA Translation: AFF60305.1
JQ610572 Genomic DNA Translation: AFF60306.1
JQ610573 Genomic DNA Translation: AFF60307.1
JQ610574 Genomic DNA Translation: AFF60308.1
JQ610575 Genomic DNA Translation: AFF60309.1
JQ610576 Genomic DNA Translation: AFF60310.1
JQ610577 Genomic DNA Translation: AFF60311.1
JQ610578 Genomic DNA Translation: AFF60312.1
JQ610579 Genomic DNA Translation: AFF60313.1
JQ610580 Genomic DNA Translation: AFF60314.1
JQ610581 Genomic DNA Translation: AFF60315.1
JQ610582 Genomic DNA Translation: AFF60316.1
JQ610583 Genomic DNA Translation: AFF60317.1
JQ610585 Genomic DNA Translation: AFF60319.1
JQ610586 Genomic DNA Translation: AFF60320.1
JQ610587 Genomic DNA Translation: AFF60321.1
JQ610588 Genomic DNA Translation: AFF60322.1
JQ610589 Genomic DNA Translation: AFF60323.1
JQ610590 Genomic DNA Translation: AFF60324.1
JQ610591 Genomic DNA Translation: AFF60325.1
JQ610592 Genomic DNA Translation: AFF60326.1
JQ610593 Genomic DNA Translation: AFF60327.1
JQ610594 Genomic DNA Translation: AFF60328.1
JQ610595 Genomic DNA Translation: AFF60329.1
JQ610596 Genomic DNA Translation: AFF60330.1
JQ610597 Genomic DNA Translation: AFF60331.1
JQ610598 Genomic DNA Translation: AFF60332.1
JQ610599 Genomic DNA Translation: AFF60333.1
JQ610600 Genomic DNA Translation: AFF60334.1
JQ610601 Genomic DNA Translation: AFF60335.1
JQ610602 Genomic DNA Translation: AFF60336.1
JQ610603 Genomic DNA Translation: AFF60337.1
JQ610604 Genomic DNA Translation: AFF60338.1
JQ610605 Genomic DNA Translation: AFF60339.1
JQ610606 Genomic DNA Translation: AFF60340.1
JQ610607 Genomic DNA Translation: AFF60341.1
JQ610608 Genomic DNA Translation: AFF60342.1
JQ610609 Genomic DNA Translation: AFF60343.1
JQ610610 Genomic DNA Translation: AFF60344.1
JQ610611 Genomic DNA Translation: AFF60345.1
JQ610613 Genomic DNA Translation: AFF60347.1
JQ610614 Genomic DNA Translation: AFF60348.1
JQ610615 Genomic DNA Translation: AFF60349.1
JQ610616 Genomic DNA Translation: AFF60350.1
JQ610617 Genomic DNA Translation: AFF60351.1
JQ610618 Genomic DNA Translation: AFF60352.1
JQ610620 Genomic DNA Translation: AFF60354.1
JQ610621 Genomic DNA Translation: AFF60355.1
BT006892 mRNA Translation: AAP35538.1
AK292173 mRNA Translation: BAF84862.1
AC136475 Genomic DNA No translation available.
CH891444 Genomic DNA Translation: EAW50866.1
BC006794 mRNA Translation: AAH06794.1
BC008417 mRNA Translation: AAH08417.1
BC022439 mRNA Translation: AAH22439.1
BC070243 mRNA Translation: AAH70243.1
CCDSiCCDS41585.1
PIRiS17182
RefSeqiNP_066362.2, NM_021034.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115681, 108 interactors
IntActiQ01628, 29 interactors
MINTiQ01628
STRINGi9606.ENSP00000382707

Protein family/group databases

TCDBi8.A.58.1.3, the dispanin (dispanin) family

PTM databases

iPTMnetiQ01628
PhosphoSitePlusiQ01628
SwissPalmiQ01628

Genetic variation databases

BioMutaiIFITM3
DMDMi20178301

Proteomic databases

EPDiQ01628
jPOSTiQ01628
MassIVEiQ01628
PaxDbiQ01628
PeptideAtlasiQ01628
PRIDEiQ01628
ProteomicsDBi57973
TopDownProteomicsiQ01628

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1023, 342 antibodies

The DNASU plasmid repository

More...DNASUi		10410

Genome annotation databases

EnsembliENST00000399808; ENSP00000382707; ENSG00000142089
GeneIDi10410
KEGGihsa:10410
UCSCiuc001lpa.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10410
DisGeNETi10410

GeneCards: human genes, protein and diseases

More...GeneCardsi		IFITM3
HGNCiHGNC:5414, IFITM3
HPAiENSG00000142089, Low tissue specificity
MalaCardsiIFITM3
MIMi605579, gene
614680, phenotype
neXtProtiNX_Q01628
OpenTargetsiENSG00000142089
PharmGKBiPA29655
VEuPathDBiHostDB:ENSG00000142089.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9XK, Eukaryota
GeneTreeiENSGT00950000182857
InParanoidiQ01628
OMAiTLYLNFC
OrthoDBi1555189at2759
PhylomeDBiQ01628
TreeFamiTF334894

Enzyme and pathway databases

PathwayCommonsiQ01628
ReactomeiR-HSA-909733, Interferon alpha/beta signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10410, 645 hits in 962 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IFITM3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IFITM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10410
PharosiQ01628, Tbio

Protein Ontology

More...PROi		PR:Q01628
RNActiQ01628, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142089, Expressed in ectocervix and 243 other tissues
ExpressionAtlasiQ01628, baseline and differential
GenevisibleiQ01628, HS

Family and domain databases

InterProiView protein in InterPro
IPR007593, CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505, CD225, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01628
Secondary accession number(s): Q53Y76, Q96HK8, Q96J15
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 16, 2002
Last modified: June 2, 2021
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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