UniProtKB - Q01613 (SHRM1_XENLA)
Protein
Protein Shroom1
Gene
shroom1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Induces gamma-tubulin accumulation at cell-cell junctions and may direct the assembly of robust microtubule arrays during cell elongation. May regulate the surface expression of amiloride-sensitive sodium channel.3 Publications
GO - Molecular functioni
- actin filament binding Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Shroom1Alternative name(s): APX Apical protein |
Gene namesi | Name:shroom1 Synonyms:apx |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6254041, shroom1.L |
Subcellular locationi
Plasma membrane
- Apicolateral cell membrane 1 Publication
- Apical cell membrane 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- microtubule Source: UniProtKB-KW
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- apicolateral plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Membrane, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064651 | 1 – 1420 | Protein Shroom1Add BLAST | 1420 |
Expressioni
Tissue specificityi
Kidney, proximal intestine, oocytes, and to a lesser extent in the distal intestine, stomach and eye. Epithelial cells of the cement gland.1 Publication
Interactioni
Subunit structurei
Interacts with F-actin (By similarity).
Interacts with scnn1a.
By similarity1 PublicationGO - Molecular functioni
- actin filament binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 518 – 620 | ASD1PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 1150 – 1419 | ASD2PROSITE-ProRule annotationAdd BLAST | 270 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 114 | Poly-Ser | 4 | |
Compositional biasi | 559 – 564 | Poly-Ser | 6 | |
Compositional biasi | 1048 – 1051 | Poly-Thr | 4 |
Domaini
The ASD1 domain mediates F-actin binding.By similarity
Sequence similaritiesi
Belongs to the shroom family.Curated
Phylogenomic databases
OrthoDBi | 29607at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 1 hit |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q01613-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAFGNTIER WNIKSTGVIA GLGHSERISP VRSMTTLVDS AYSSFSGSSY
60 70 80 90 100
VPEYQNSFQH DGCHYNDEQL SYMDSEYVRA IYNPSLLDKD GVYNDIVSEH
110 120 130 140 150
GSSKVALSGR SSSSLCSDNT TSVHRTSPAK LDNYVTNLDS EKNIYGDPIN
160 170 180 190 200
MKHKQNRPNH KAYGLQRNSP TGINSLQEKE NQLYNPSNFM EIKDNYFGRS
210 220 230 240 250
LDVLQADGDI MTQDSYTQNA LYFPQNQPDQ YRNTQYPGAN RMSKEQFKVN
260 270 280 290 300
DVQKSNEENT ERDGPYLTKD GQFVQGQYAS DVRTSFKNIR RSLKKSASGK
310 320 330 340 350
IVAHDSQGSC WIMKPGKDTP SFNSEGTITD MDYDNREQWD IRKSRLSTRA
360 370 380 390 400
SQSLYYESNE DVSGPPLKAM NSKNEVDQTL SFQKDATVKS IPLLSQQLQQ
410 420 430 440 450
EKCKSHPLSD LNCEKITKAS TPMLYHLAGG RHSAFIAPVH NTNPAQQEKL
460 470 480 490 500
KLESKTLERM NNISVLQLSE PRPDNHKLPK NKSLTQLADL HDSVEGGNSG
510 520 530 540 550
NLNSSAEESL MNDYIEKLKV AQKKVLRETS FKRKDLQMSL PCRFKLNPPK
560 570 580 590 600
RPTIDHFRSY SSSSANEESA YLQTKNSADS SYKKDDTEKV AVTRIGGRKR
610 620 630 640 650
ITKEQKKLCY SEPEKLDHLG IQKSNFAWKE EPTFANRREM SDSDISANRI
660 670 680 690 700
KYLESKERTN SSSNLSKTEL KQIQHNALVQ YMERKTNQRP NSNPQVQMER
710 720 730 740 750
TSLGLPNYNE WSIYSSETSS SDASQKYLRR RSAGASSSYD ATVTWNDRFG
760 770 780 790 800
KTSPLGRSAA EKTAGVQRKT FSDQRTLDGS QEHLEGSSPS LSQKTSKSTH
810 820 830 840 850
NEQVSYVNME FLPSSHSKNH MYNDRLTVPG DGTSAESGRM FVSKSRGKSM
860 870 880 890 900
EEIGTTDIVK LAELSHSSDQ LYHIKGPVIS SRLENTRTTA ASHQDRLLAS
910 920 930 940 950
TQIETGNLPR QTHQESVVGP CRSDLANLGQ EAHSWPLRAS DVSPGTDNPC
960 970 980 990 1000
SSSPSAEVQP GAPEPLHCLQ TEDEVFTPAS TARNEEPNST AFSYLLSTGK
1010 1020 1030 1040 1050
PVSQGEATAL SFTFLPEQDR LEHPIVSETT PSSESDENVS DAAAEKETTT
1060 1070 1080 1090 1100
TQLPETSNVN KPLGFTVDNQ EVEGDGEPMQ PEFIDSSKQL ELSSLPSSQV
1110 1120 1130 1140 1150
NIMQTAEPYL GDKNIGNEQK TEDLEQKSKN PEEDDLPKVK LKSPEDEILE
1160 1170 1180 1190 1200
ELVKEIVAKD KSLLNCLQPV SVRESAMDLM KSLFPMDVTA AEKSRTRGLL
1210 1220 1230 1240 1250
GKDKGETLKK NNSDLESSSK LPSKITGMLQ KRPDGESLDD ITLKKMELLS
1260 1270 1280 1290 1300
KIGSKLEDLC EQREFLLSDI SKNTTNGNNM QTMVKELCKP NEFERYMMFI
1310 1320 1330 1340 1350
GDLEKVVSLL FSLSTRLTRV ENSLSKVDEN TDAEEMQSLK ERHNLLSSQR
1360 1370 1380 1390 1400
EDAKDLKANL DRREQVVTGI LVKYLNEEQL QDYKHFVRLK TSLLIEQKNL
1410 1420
EEKIKVYEEQ FESIHNSLPP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z14997 mRNA Translation: CAA78718.1 |
PIRi | A44361 |
RefSeqi | NP_001084156.1, NM_001090687.1 |
Genome annotation databases
GeneIDi | 399339 |
KEGGi | xla:399339 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z14997 mRNA Translation: CAA78718.1 |
PIRi | A44361 |
RefSeqi | NP_001084156.1, NM_001090687.1 |
3D structure databases
SMRi | Q01613 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 399339 |
KEGGi | xla:399339 |
Organism-specific databases
CTDi | 399339 |
Xenbasei | XB-GENE-6254041, shroom1.L |
Phylogenomic databases
OrthoDBi | 29607at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 1 hit |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHRM1_XENLA | |
Accessioni | Q01613Primary (citable) accession number: Q01613 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |