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UniProtKB - Q01613 (SHRM1_XENLA)

Entry version 76 (02 Dec 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Protein Shroom1

Gene

shroom1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces gamma-tubulin accumulation at cell-cell junctions and may direct the assembly of robust microtubule arrays during cell elongation. May regulate the surface expression of amiloride-sensitive sodium channel.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom1
Alternative name(s):
APX
Apical protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shroom1
Synonyms:apx
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-6254041, shroom1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646511 – 1420Protein Shroom1Add BLAST1420

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Kidney, proximal intestine, oocytes, and to a lesser extent in the distal intestine, stomach and eye. Epithelial cells of the cement gland.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (By similarity).

Interacts with scnn1a.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01613

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini518 – 620ASD1PROSITE-ProRule annotationAdd BLAST103
Domaini1150 – 1419ASD2PROSITE-ProRule annotationAdd BLAST270

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 114Poly-Ser4
Compositional biasi559 – 564Poly-Ser6
Compositional biasi1048 – 1051Poly-Thr4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		29607at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR027685, Shroom_fam

The PANTHER Classification System

More...PANTHERi		PTHR15012, PTHR15012, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01613-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFGNTIER WNIKSTGVIA GLGHSERISP VRSMTTLVDS AYSSFSGSSY 
        60         70         80         90        100
VPEYQNSFQH DGCHYNDEQL SYMDSEYVRA IYNPSLLDKD GVYNDIVSEH 
       110        120        130        140        150
GSSKVALSGR SSSSLCSDNT TSVHRTSPAK LDNYVTNLDS EKNIYGDPIN 
       160        170        180        190        200
MKHKQNRPNH KAYGLQRNSP TGINSLQEKE NQLYNPSNFM EIKDNYFGRS 
       210        220        230        240        250
LDVLQADGDI MTQDSYTQNA LYFPQNQPDQ YRNTQYPGAN RMSKEQFKVN 
       260        270        280        290        300
DVQKSNEENT ERDGPYLTKD GQFVQGQYAS DVRTSFKNIR RSLKKSASGK 
       310        320        330        340        350
IVAHDSQGSC WIMKPGKDTP SFNSEGTITD MDYDNREQWD IRKSRLSTRA 
       360        370        380        390        400
SQSLYYESNE DVSGPPLKAM NSKNEVDQTL SFQKDATVKS IPLLSQQLQQ 
       410        420        430        440        450
EKCKSHPLSD LNCEKITKAS TPMLYHLAGG RHSAFIAPVH NTNPAQQEKL 
       460        470        480        490        500
KLESKTLERM NNISVLQLSE PRPDNHKLPK NKSLTQLADL HDSVEGGNSG 
       510        520        530        540        550
NLNSSAEESL MNDYIEKLKV AQKKVLRETS FKRKDLQMSL PCRFKLNPPK 
       560        570        580        590        600
RPTIDHFRSY SSSSANEESA YLQTKNSADS SYKKDDTEKV AVTRIGGRKR 
       610        620        630        640        650
ITKEQKKLCY SEPEKLDHLG IQKSNFAWKE EPTFANRREM SDSDISANRI 
       660        670        680        690        700
KYLESKERTN SSSNLSKTEL KQIQHNALVQ YMERKTNQRP NSNPQVQMER 
       710        720        730        740        750
TSLGLPNYNE WSIYSSETSS SDASQKYLRR RSAGASSSYD ATVTWNDRFG 
       760        770        780        790        800
KTSPLGRSAA EKTAGVQRKT FSDQRTLDGS QEHLEGSSPS LSQKTSKSTH 
       810        820        830        840        850
NEQVSYVNME FLPSSHSKNH MYNDRLTVPG DGTSAESGRM FVSKSRGKSM 
       860        870        880        890        900
EEIGTTDIVK LAELSHSSDQ LYHIKGPVIS SRLENTRTTA ASHQDRLLAS 
       910        920        930        940        950
TQIETGNLPR QTHQESVVGP CRSDLANLGQ EAHSWPLRAS DVSPGTDNPC 
       960        970        980        990       1000
SSSPSAEVQP GAPEPLHCLQ TEDEVFTPAS TARNEEPNST AFSYLLSTGK 
      1010       1020       1030       1040       1050
PVSQGEATAL SFTFLPEQDR LEHPIVSETT PSSESDENVS DAAAEKETTT 
      1060       1070       1080       1090       1100
TQLPETSNVN KPLGFTVDNQ EVEGDGEPMQ PEFIDSSKQL ELSSLPSSQV 
      1110       1120       1130       1140       1150
NIMQTAEPYL GDKNIGNEQK TEDLEQKSKN PEEDDLPKVK LKSPEDEILE 
      1160       1170       1180       1190       1200
ELVKEIVAKD KSLLNCLQPV SVRESAMDLM KSLFPMDVTA AEKSRTRGLL 
      1210       1220       1230       1240       1250
GKDKGETLKK NNSDLESSSK LPSKITGMLQ KRPDGESLDD ITLKKMELLS 
      1260       1270       1280       1290       1300
KIGSKLEDLC EQREFLLSDI SKNTTNGNNM QTMVKELCKP NEFERYMMFI 
      1310       1320       1330       1340       1350
GDLEKVVSLL FSLSTRLTRV ENSLSKVDEN TDAEEMQSLK ERHNLLSSQR 
      1360       1370       1380       1390       1400
EDAKDLKANL DRREQVVTGI LVKYLNEEQL QDYKHFVRLK TSLLIEQKNL 
      1410       1420
EEKIKVYEEQ FESIHNSLPP
Length:1,420
Mass (Da):159,468
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DD8B5C11413FFBC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z14997 mRNA Translation: CAA78718.1

Protein sequence database of the Protein Information Resource

More...PIRi		A44361

NCBI Reference Sequences

More...RefSeqi		NP_001084156.1, NM_001090687.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		399339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:399339

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14997 mRNA Translation: CAA78718.1
PIRiA44361
RefSeqiNP_001084156.1, NM_001090687.1

3D structure databases

SMRiQ01613
ModBaseiSearch...

Genome annotation databases

GeneIDi399339
KEGGixla:399339

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		399339
XenbaseiXB-GENE-6254041, shroom1.L

Phylogenomic databases

OrthoDBi29607at2759

Family and domain databases

InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 1 hit
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01613
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 2, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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