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Protein

Glutathione S-transferase theta-1

Gene

Gstt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

SABIO-RKiQ01579

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST 5-5
GST class-theta-1
Glutathione S-transferase 5
Gene namesi
Name:Gstt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2765 Gstt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2423

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001859422 – 240Glutathione S-transferase theta-1Add BLAST239

Proteomic databases

PaxDbiQ01579
PRIDEiQ01579

PTM databases

iPTMnetiQ01579
PhosphoSitePlusiQ01579

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. In lung, expressed mainly in Clara cells of the bronchiolar epithelium and, at low levels, in type II alveolar cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000049771 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ01579 baseline and differential
GenevisibleiQ01579 RN

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001669

Chemistry databases

BindingDBiQ01579

Structurei

3D structure databases

ProteinModelPortaliQ01579
SMRiQ01579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 223GST C-terminalAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
HOGENOMiHOG000125747
HOVERGENiHBG051854
InParanoidiQ01579
KOiK00799
OMAiDYWYPQD
OrthoDBiEOG091G0PCG
PhylomeDBiQ01579

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01579-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLELYLDLL SQPCRAIYIF AKKNNIPFQM HTVELRKGEH LSDAFAQVNP
60 70 80 90 100
MKKVPAMKDG GFTLCESVAI LLYLAHKYKV PDHWYPQDLQ ARARVDEYLA
110 120 130 140 150
WQHTTLRRSC LRTLWHKVMF PVFLGEQIRP EMLAATLADL DVNVQVLEDQ
160 170 180 190 200
FLQDKDFLVG PHISLADVVA ITELMHPVGG GCPVFEGRPR LAAWYRRVEA
210 220 230 240
AVGKDLFLEA HEVILKVRDC PPADPVIKQK LMPRVLTMIQ
Length:240
Mass (Da):27,468
Last modified:January 23, 2007 - v2
Checksum:i09583ACF9C85DF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67654 mRNA Translation: CAA47896.1
BC086426 mRNA Translation: AAH86426.1
PIRiS27161
RefSeqiNP_445745.1, NM_053293.2
UniGeneiRn.11122

Genome annotation databases

EnsembliENSRNOT00000001669; ENSRNOP00000001669; ENSRNOG00000049771
GeneIDi25260
KEGGirno:25260
UCSCiRGD:2765 rat

Similar proteinsi

Entry informationi

Entry nameiGSTT1_RAT
AccessioniPrimary (citable) accession number: Q01579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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