UniProtKB - Q01556 (COX2_TRIRU)
Cytochrome c oxidase subunit 2
COX2
Functioni
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
By similarityCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 176 | Copper A1By similarity | 1 | |
Metal bindingi | 211 | Copper A1By similarity | 1 | |
Metal bindingi | 211 | Copper A2By similarity | 1 | |
Metal bindingi | 213 | Copper A2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 213 | Magnesium; shared with subunit 1By similarity | 1 | |
Metal bindingi | 215 | Copper A1By similarity | 1 | |
Metal bindingi | 215 | Copper A2By similarity | 1 | |
Metal bindingi | 219 | Copper A2By similarity | 1 | |
Metal bindingi | 222 | Copper A1By similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- cytochrome-c oxidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Copper, Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 2 (EC:7.1.1.9)Alternative name(s): Cytochrome c oxidase polypeptide II |
Gene namesi | Name:COX2 |
Encoded oni | Mitochondrion |
Organismi | Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
Taxonomic identifieri | 5551 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Trichophyton |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | Mitochondrial intermembraneSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 52 – 67 | Mitochondrial matrixSequence analysisAdd BLAST | 16 | |
Transmembranei | 68 – 94 | HelicalSequence analysisAdd BLAST | 27 | |
Topological domaini | 95 – 237 | Mitochondrial intermembraneSequence analysisAdd BLAST | 143 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183706 | 1 – 237 | Cytochrome c oxidase subunit 2Add BLAST | 237 |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
By similarityFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd13912, CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR045187, CcO_II IPR002429, CcO_II-like_C IPR034210, CcO_II_C IPR001505, Copper_CuA IPR008972, Cupredoxin IPR011759, Cyt_c_oxidase_su2_TM_dom IPR036257, Cyt_c_oxidase_su2_TM_sf |
PANTHERi | PTHR22888, PTHR22888, 1 hit |
Pfami | View protein in Pfam PF00116, COX2, 1 hit PF02790, COX2_TM, 1 hit |
SUPFAMi | SSF49503, SSF49503, 1 hit SSF81464, SSF81464, 1 hit |
PROSITEi | View protein in PROSITE PS00078, COX2, 1 hit PS50857, COX2_CUA, 1 hit PS50999, COX2_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MNLVAPTPWG LFFQDSATPQ MEGIEELHNN IMFYLTIILF SVTWMMITII
60 70 80 90 100
KSFVNTKSPI SHKYMNHGTL IELIWTITPA VILILIAFPS FKLLYLMDEV
110 120 130 140 150
MDPSLVIYGE GHQWYWSYQY PDFTNADGEF VEFDSYIVPE SDLEEGTLRM
160 170 180 190 200
LEVDNRVIIP ELTHTRFVIS AADVIHSFAC PSLGIKCDAY PGRLNQSSVY
210 220 230
LNRQGTYFGQ CSEICGILHS SMPIVIQSVS LKNFYYD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65223 Genomic DNA Translation: CAA46327.1 |
PIRi | S26949 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65223 Genomic DNA Translation: CAA46327.1 |
PIRi | S26949 |
3D structure databases
AlphaFoldDBi | Q01556 |
SMRi | Q01556 |
ModBasei | Search... |
Family and domain databases
CDDi | cd13912, CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR045187, CcO_II IPR002429, CcO_II-like_C IPR034210, CcO_II_C IPR001505, Copper_CuA IPR008972, Cupredoxin IPR011759, Cyt_c_oxidase_su2_TM_dom IPR036257, Cyt_c_oxidase_su2_TM_sf |
PANTHERi | PTHR22888, PTHR22888, 1 hit |
Pfami | View protein in Pfam PF00116, COX2, 1 hit PF02790, COX2_TM, 1 hit |
SUPFAMi | SSF49503, SSF49503, 1 hit SSF81464, SSF81464, 1 hit |
PROSITEi | View protein in PROSITE PS00078, COX2, 1 hit PS50857, COX2_CUA, 1 hit PS50999, COX2_TM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COX2_TRIRU | |
Accessioni | Q01556Primary (citable) accession number: Q01556 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |