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Entry version 204 (13 Feb 2019)
Sequence version 1 (01 Jul 1993)
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Protein

Friend leukemia integration 1 transcription factor

Gene

FLI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.3 Publications

Miscellaneous

Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi281 – 361ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q01543

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Friend leukemia integration 1 transcription factor
Alternative name(s):
Proto-oncogene Fli-1
Transcription factor ERGB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151702.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3749 FLI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
193067 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ewing sarcoma (ES)2 Publications
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.2 Publications
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
See also OMIM:612219
Bleeding disorder, platelet-type 21 (BDPLT21)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
See also OMIM:617443
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078929324R → W in BDPLT21; decreased function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs773148506EnsemblClinVar.1
Natural variantiVAR_078930337R → Q in BDPLT21; loss of function in positive regulation of DNA-templated transcription; decreased localization to nucleus; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs1064797086Ensembl.1
Natural variantiVAR_078931337R → W in BDPLT21; loss of function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs1064797083Ensembl.1
Natural variantiVAR_078932343Y → C in BDPLT21; loss of function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs1064797084Ensembl.1
Natural variantiVAR_078933345K → E in BDPLT21; loss of function in positive regulation of DNA-templated transcription; decreased localization to nucleus; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs1064797087Ensembl.1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
2313

MalaCards human disease database

More...
MalaCardsi
FLI1
MIMi612219 phenotype
617443 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151702

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
248340 Isolated delta-storage pool disease
2308 Jacobsen syndrome
851 Paris-Trousseau thrombocytopenia
370348 Peripheral primitive neuroectodermal tumor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28170

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FLI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
399496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041241 – 452Friend leukemia integration 1 transcription factorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01543

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01543

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q01543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01543

PeptideAtlas

More...
PeptideAtlasi
Q01543

PRoteomics IDEntifications database

More...
PRIDEi
Q01543

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57969
57970 [Q01543-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01543

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q01543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151702 Expressed in 188 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01543 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01543 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA073099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers or heterodimers with ETV6/TEL1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108602, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q01543

Protein interaction database and analysis system

More...
IntActi
Q01543, 7 interactors

Molecular INTeraction database

More...
MINTi
Q01543

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399985

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLINMR-A276-373[»]
1X66NMR-A114-198[»]
2YTUNMR-A100-220[»]
5E8GX-ray2.70A/B/C/D276-399[»]
5E8IX-ray3.45A/D/G/J276-399[»]
5JVTX-ray3.10A/D/G276-375[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q01543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01543

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q01543

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 198PNTPROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158261

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000290658

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001553

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01543

KEGG Orthology (KO)

More...
KOi
K09436

Identification of Orthologs from Complete Genome Data

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OMAi
NPDYGQP

Database of Orthologous Groups

More...
OrthoDBi
1568974at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01543

TreeFam database of animal gene trees

More...
TreeFami
TF350537

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08541 SAM_PNT-FLI-1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR035575 Fli-1
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR035573 SAM_PNT-FLI-1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11849:SF161 PTHR11849:SF161, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP
60 70 80 90 100
LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM
110 120 130 140 150
NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS
160 170 180 190 200
LMEIDTSFFQ NMDGKELCKM NKEDFLRATT LYNTEVLLSH LSYLRESSLL
210 220 230 240 250
AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK SPPLGGAQTI
260 270 280 290 300
SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
310 320 330 340 350
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK
360 370 380 390 400
VHGKRYAYKF DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF
410 420 430 440 450
VPPHPSSMPV TSSSFFGAAS QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS

YY
Length:452
Mass (Da):50,982
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C2AAEEAF683F3FA
GO
Isoform 2 (identifier: Q01543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MDGTIKEALS...KREYDHMNGS → MEGGLAGERA

Show »
Length:386
Mass (Da):43,649
Checksum:iBEA132F4038A230C
GO
Isoform 3 (identifier: Q01543-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):47,576
Checksum:i44928649B0BC6840
GO
Isoform 4 (identifier: Q01543-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: MDGTIKEALS...LSHLSYLRES → MDPG

Show »
Length:259
Mass (Da):29,084
Checksum:i4070E5F30894C473
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GY62V9GY62_HUMAN
Friend leukemia integration 1 trans...
FLI1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSR4A0A0A0MSR4_HUMAN
Friend leukemia integration 1 trans...
FLI1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ02V9GZ02_HUMAN
Friend leukemia integration 1 trans...
FLI1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69E → V in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti77Missing in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti130P → A in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti130P → A in AAA58480 (PubMed:8439553).Curated1
Sequence conflicti133W → V in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti133W → V in AAA58480 (PubMed:8439553).Curated1
Sequence conflicti294S → N in BAG61938 (PubMed:14702039).Curated1
Sequence conflicti323E → Q in AAB23637 (PubMed:1394211).Curated1
Sequence conflicti323E → Q in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti323E → Q in AAA58480 (PubMed:8439553).Curated1
Sequence conflicti426Missing in AAA58479 (PubMed:8439553).Curated1
Sequence conflicti426Missing in AAA58480 (PubMed:8439553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078929324R → W in BDPLT21; decreased function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs773148506EnsemblClinVar.1
Natural variantiVAR_078930337R → Q in BDPLT21; loss of function in positive regulation of DNA-templated transcription; decreased localization to nucleus; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs1064797086Ensembl.1
Natural variantiVAR_078931337R → W in BDPLT21; loss of function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs1064797083Ensembl.1
Natural variantiVAR_078932343Y → C in BDPLT21; loss of function in positive regulation of DNA-templated transcription. 1 PublicationCorresponds to variant dbSNP:rs1064797084Ensembl.1
Natural variantiVAR_078933345K → E in BDPLT21; loss of function in positive regulation of DNA-templated transcription; decreased localization to nucleus; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs1064797087Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469431 – 197MDGTI…YLRES → MDPG in isoform 4. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_0014781 – 76MDGTI…HMNGS → MEGGLAGERA in isoform 2. 2 PublicationsAdd BLAST76
Alternative sequenceiVSP_0452761 – 33Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67001 mRNA Translation: CAA47399.1
M98833 mRNA Translation: AAA35812.2
S45205 mRNA Translation: AAB23637.1
M93255 mRNA Translation: AAA58479.1
M93255 mRNA Translation: AAA58480.1
AY029368 mRNA Translation: AAK50443.1
AK294279 mRNA Translation: BAG57565.1
AK300153 mRNA Translation: BAG61938.1
AK313370 mRNA Translation: BAG36169.1
AP001122 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67715.1
CH471065 Genomic DNA Translation: EAW67718.1
BC001670 mRNA Translation: AAH01670.1
BC010115 mRNA Translation: AAH10115.1
Y17293 Genomic DNA Translation: CAA76731.1
D38408 Genomic DNA Translation: BAA07463.1 Different termination.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44768.1 [Q01543-1]
CCDS53725.1 [Q01543-3]
CCDS59230.1 [Q01543-4]
CCDS59231.1 [Q01543-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37565
S29844

NCBI Reference Sequences

More...
RefSeqi
NP_001161153.1, NM_001167681.2 [Q01543-3]
NP_001257939.1, NM_001271010.1 [Q01543-2]
NP_001257941.1, NM_001271012.1 [Q01543-4]
NP_002008.2, NM_002017.4 [Q01543-1]
XP_011541003.1, XM_011542701.2 [Q01543-3]
XP_016872894.1, XM_017017405.1 [Q01543-3]
XP_016872895.1, XM_017017406.1 [Q01543-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.504281

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281428; ENSP00000281428; ENSG00000151702 [Q01543-2]
ENST00000344954; ENSP00000339627; ENSG00000151702 [Q01543-4]
ENST00000527786; ENSP00000433488; ENSG00000151702 [Q01543-1]
ENST00000534087; ENSP00000432950; ENSG00000151702 [Q01543-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2313

UCSC genome browser

More...
UCSCi
uc009zci.4 human [Q01543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67001 mRNA Translation: CAA47399.1
M98833 mRNA Translation: AAA35812.2
S45205 mRNA Translation: AAB23637.1
M93255 mRNA Translation: AAA58479.1
M93255 mRNA Translation: AAA58480.1
AY029368 mRNA Translation: AAK50443.1
AK294279 mRNA Translation: BAG57565.1
AK300153 mRNA Translation: BAG61938.1
AK313370 mRNA Translation: BAG36169.1
AP001122 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67715.1
CH471065 Genomic DNA Translation: EAW67718.1
BC001670 mRNA Translation: AAH01670.1
BC010115 mRNA Translation: AAH10115.1
Y17293 Genomic DNA Translation: CAA76731.1
D38408 Genomic DNA Translation: BAA07463.1 Different termination.
CCDSiCCDS44768.1 [Q01543-1]
CCDS53725.1 [Q01543-3]
CCDS59230.1 [Q01543-4]
CCDS59231.1 [Q01543-2]
PIRiI37565
S29844
RefSeqiNP_001161153.1, NM_001167681.2 [Q01543-3]
NP_001257939.1, NM_001271010.1 [Q01543-2]
NP_001257941.1, NM_001271012.1 [Q01543-4]
NP_002008.2, NM_002017.4 [Q01543-1]
XP_011541003.1, XM_011542701.2 [Q01543-3]
XP_016872894.1, XM_017017405.1 [Q01543-3]
XP_016872895.1, XM_017017406.1 [Q01543-3]
UniGeneiHs.504281

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLINMR-A276-373[»]
1X66NMR-A114-198[»]
2YTUNMR-A100-220[»]
5E8GX-ray2.70A/B/C/D276-399[»]
5E8IX-ray3.45A/D/G/J276-399[»]
5JVTX-ray3.10A/D/G276-375[»]
ProteinModelPortaliQ01543
SMRiQ01543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108602, 17 interactors
CORUMiQ01543
IntActiQ01543, 7 interactors
MINTiQ01543
STRINGi9606.ENSP00000399985

PTM databases

iPTMnetiQ01543
PhosphoSitePlusiQ01543

Polymorphism and mutation databases

BioMutaiFLI1
DMDMi399496

Proteomic databases

EPDiQ01543
jPOSTiQ01543
MaxQBiQ01543
PaxDbiQ01543
PeptideAtlasiQ01543
PRIDEiQ01543
ProteomicsDBi57969
57970 [Q01543-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2313
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281428; ENSP00000281428; ENSG00000151702 [Q01543-2]
ENST00000344954; ENSP00000339627; ENSG00000151702 [Q01543-4]
ENST00000527786; ENSP00000433488; ENSG00000151702 [Q01543-1]
ENST00000534087; ENSP00000432950; ENSG00000151702 [Q01543-3]
GeneIDi2313
KEGGihsa:2313
UCSCiuc009zci.4 human [Q01543-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2313
DisGeNETi2313
EuPathDBiHostDB:ENSG00000151702.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FLI1
HGNCiHGNC:3749 FLI1
HPAiHPA073099
MalaCardsiFLI1
MIMi193067 gene
612219 phenotype
617443 phenotype
neXtProtiNX_Q01543
OpenTargetsiENSG00000151702
Orphaneti319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
248340 Isolated delta-storage pool disease
2308 Jacobsen syndrome
851 Paris-Trousseau thrombocytopenia
370348 Peripheral primitive neuroectodermal tumor
PharmGKBiPA28170

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000158261
HOGENOMiHOG000290658
HOVERGENiHBG001553
InParanoidiQ01543
KOiK09436
OMAiNPDYGQP
OrthoDBi1568974at2759
PhylomeDBiQ01543
TreeFamiTF350537

Enzyme and pathway databases

SIGNORiQ01543

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FLI1 human
EvolutionaryTraceiQ01543

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FLI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2313
PMAP-CutDBiQ01543

Protein Ontology

More...
PROi
PR:Q01543

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151702 Expressed in 188 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ01543 baseline and differential
GenevisibleiQ01543 HS

Family and domain databases

CDDicd08541 SAM_PNT-FLI-1, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR035575 Fli-1
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR035573 SAM_PNT-FLI-1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF161 PTHR11849:SF161, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01543
Secondary accession number(s): B2R8H2
, B4DFV4, B4DTC6, G3V183, Q14319, Q92480, Q9UE07
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 13, 2019
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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