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Entry version 180 (31 Jul 2019)
Sequence version 2 (27 Apr 2001)
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Protein

Myelin transcription factor 1

Gene

MYT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri433 – 476CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri477 – 520CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri791 – 834CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri835 – 878CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri884 – 927CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri937 – 980CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Myelin transcription factor I
Short name:
MyTI
PLPB1
Proteolipid protein-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYT1
Synonyms:KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7622 MYT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600379 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01538

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4661

Open Targets

More...
OpenTargetsi
ENSG00000196132

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31426

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2331044

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13638422

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966761 – 1121Myelin transcription factor 1Add BLAST1121

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01538

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q01538

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01538

PeptideAtlas

More...
PeptideAtlasi
Q01538

PRoteomics IDEntifications database

More...
PRIDEi
Q01538

ProteomicsDB human proteome resource

More...
ProteomicsDBi
27533
57968 [Q01538-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01538

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01538

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196132 Expressed in 94 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01538 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q01538 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006303

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STEAP3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110744, 6 interactors

Protein interaction database and analysis system

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IntActi
Q01538, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327465

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q01538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01538

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi200 – 306Glu-richAdd BLAST107
Compositional biasi685 – 723Ser-richAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri433 – 476CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri477 – 520CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri791 – 834CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri835 – 878CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri884 – 927CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri937 – 980CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ4P Eukaryota
ENOG4111XF7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01538

KEGG Orthology (KO)

More...
KOi
K23192

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDEWDGP

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01538

TreeFam database of animal gene trees

More...
TreeFami
TF317299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474 MYT1, 2 hits
PF01530 zf-C2HC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637 SSF103637, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802 ZF_CCHHC, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01538-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS
60 70 80 90 100
LQSCPLAKKR KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK
110 120 130 140 150
DASVSDESEG TLEGAEAETS GQDEIHRPET AEGRSPVKSH FGSNPIGSAT
160 170 180 190 200
ASSKGSYSSY QGIIATSLLN LGQIAEETLV EEDLGQAAKP GPGIVHLLQE
210 220 230 240 250
AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL EDAASEESSK
260 270 280 290 300
QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE
310 320 330 340 350
EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD
360 370 380 390 400
DKDEDTHSRK STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC
410 420 430 440 450
PPAEQSQLGL GEPGKAAKPL DTVRKSYYSK DPSRAEKREI KCPTPGCDGT
460 470 480 490 500
GHVTGLYPHH RSLSGCPHKD RIPPEILAMH ENVLKCPTPG CTGQGHVNSN
510 520 530 540 550
RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD RILRPMCFVK
560 570 580 590 600
QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML
610 620 630 640 650
APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK
660 670 680 690 700
PQDLPSKSVD IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA
710 720 730 740 750
SQRHSSTSAP SSSMTSPQSS QASRQDEWDR PLDYTKPSRL REEEPEESEP
760 770 780 790 800
AAHSFASSEA DDQEVSEENF EERKYPGEVT LTNFKLKFLS KDIKKELLTC
810 820 830 840 850
PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA DLKCPTPGCD
860 870 880 890 900
GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG
910 920 930 940 950
LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG
960 970 980 990 1000
CDGSGHANGS FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN
1010 1020 1030 1040 1050
DEEIKQLNQE IRDLNESNSE MEAAMVQLQS QISSMEKNLK NIEEENKLIE
1060 1070 1080 1090 1100
EQNEALFLEL SGLSQALIQS LANIRLPHME PICEQNFDAY VSTLTDMYSN
1110 1120
QDPENKDLLE SIKQAVRGIQ V
Length:1,121
Mass (Da):122,329
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4AF1F8C7D4EC01E
GO
Isoform 2 (identifier: Q01538-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: C → SKPFPKASSPRHSPSSSYVRSTSSSSAG

Show »
Length:1,148
Mass (Da):125,075
Checksum:i53CCE237F8356742
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P6D5Q6P6D5_HUMAN
MYT1 protein
MYT1
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y3S5A0A2R8Y3S5_HUMAN
Myelin transcription factor 1
MYT1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74858 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti567 – 574ATPRANLA → RHTQGQLG in AAA59897 (PubMed:1280325).Curated8
Sequence conflicti837A → T in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti943G → D in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti957 – 958AN → TI in AAA59897 (PubMed:1280325).Curated2
Sequence conflicti1075R → H in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti1088 – 1089DA → VP in AAA59897 (PubMed:1280325).Curated2
Sequence conflicti1102D → A in AAA59897 (PubMed:1280325).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054313616C → SKPFPKASSPRHSPSSSYVR STSSSSAG in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020642 mRNA Translation: BAA74858.2 Different initiation.
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75155.1
CH471077 Genomic DNA Translation: EAW75157.1
CH471077 Genomic DNA Translation: EAW75158.1
AB028973 mRNA Translation: BAA83002.1
BC053638 mRNA Translation: AAH53638.1
M96980 mRNA Translation: AAA59897.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13558.1 [Q01538-1]

NCBI Reference Sequences

More...
RefSeqi
NP_004526.1, NM_004535.2 [Q01538-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328439; ENSP00000327465; ENSG00000196132 [Q01538-1]
ENST00000536311; ENSP00000442412; ENSG00000196132 [Q01538-2]
ENST00000613234; ENSP00000477771; ENSG00000276876 [Q01538-1]
ENST00000616648; ENSP00000483021; ENSG00000276876 [Q01538-2]
ENST00000650655; ENSP00000498616; ENSG00000196132 [Q01538-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4661

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4661

UCSC genome browser

More...
UCSCi
uc002yii.3 human [Q01538-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020642 mRNA Translation: BAA74858.2 Different initiation.
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75155.1
CH471077 Genomic DNA Translation: EAW75157.1
CH471077 Genomic DNA Translation: EAW75158.1
AB028973 mRNA Translation: BAA83002.1
BC053638 mRNA Translation: AAH53638.1
M96980 mRNA Translation: AAA59897.1
CCDSiCCDS13558.1 [Q01538-1]
RefSeqiNP_004526.1, NM_004535.2 [Q01538-1]

3D structure databases

SMRiQ01538
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110744, 6 interactors
IntActiQ01538, 3 interactors
STRINGi9606.ENSP00000327465

Chemistry databases

BindingDBiQ01538
ChEMBLiCHEMBL2331044

PTM databases

iPTMnetiQ01538
PhosphoSitePlusiQ01538

Polymorphism and mutation databases

BioMutaiMYT1
DMDMi13638422

Proteomic databases

jPOSTiQ01538
MaxQBiQ01538
PaxDbiQ01538
PeptideAtlasiQ01538
PRIDEiQ01538
ProteomicsDBi27533
57968 [Q01538-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328439; ENSP00000327465; ENSG00000196132 [Q01538-1]
ENST00000536311; ENSP00000442412; ENSG00000196132 [Q01538-2]
ENST00000613234; ENSP00000477771; ENSG00000276876 [Q01538-1]
ENST00000616648; ENSP00000483021; ENSG00000276876 [Q01538-2]
ENST00000650655; ENSP00000498616; ENSG00000196132 [Q01538-1]
GeneIDi4661
KEGGihsa:4661
UCSCiuc002yii.3 human [Q01538-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4661
DisGeNETi4661

GeneCards: human genes, protein and diseases

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GeneCardsi
MYT1
HGNCiHGNC:7622 MYT1
HPAiHPA006303
MIMi600379 gene
neXtProtiNX_Q01538
OpenTargetsiENSG00000196132
PharmGKBiPA31426

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQ4P Eukaryota
ENOG4111XF7 LUCA
GeneTreeiENSGT00940000156364
HOGENOMiHOG000234099
InParanoidiQ01538
KOiK23192
OMAiQDEWDGP
OrthoDBi116799at2759
PhylomeDBiQ01538
TreeFamiTF317299

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4661

Protein Ontology

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PROi
PR:Q01538

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196132 Expressed in 94 organ(s), highest expression level in forebrain
ExpressionAtlasiQ01538 baseline and differential
GenevisibleiQ01538 HS

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474 MYT1, 2 hits
PF01530 zf-C2HC, 7 hits
SUPFAMiSSF103637 SSF103637, 7 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01538
Secondary accession number(s): E1P5H0
, F5H7M8, O94922, Q7Z5W2, Q9UPV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: July 31, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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