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Protein

Myelin transcription factor 1

Gene

MYT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri433 – 476CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri477 – 520CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri791 – 834CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri835 – 878CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri884 – 927CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri937 – 980CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Myelin transcription factor I
Short name:
MyTI
PLPB1
Proteolipid protein-binding protein
Gene namesi
Name:MYT1
Synonyms:KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000196132.11
HGNCiHGNC:7622 MYT1
MIMi600379 gene
neXtProtiNX_Q01538

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4661
OpenTargetsiENSG00000196132
PharmGKBiPA31426

Chemistry databases

ChEMBLiCHEMBL2331044

Polymorphism and mutation databases

BioMutaiMYT1
DMDMi13638422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966761 – 1121Myelin transcription factor 1Add BLAST1121

Proteomic databases

MaxQBiQ01538
PaxDbiQ01538
PeptideAtlasiQ01538
PRIDEiQ01538
ProteomicsDBi57968

PTM databases

iPTMnetiQ01538
PhosphoSitePlusiQ01538

Expressioni

Tissue specificityi

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.1 Publication

Gene expression databases

BgeeiENSG00000196132 Expressed in 94 organ(s), highest expression level in forebrain
CleanExiHS_MTF1
HS_MYT1
ExpressionAtlasiQ01538 baseline and differential
GenevisibleiQ01538 HS

Organism-specific databases

HPAiHPA006303

Interactioni

Subunit structurei

Interacts with STEAP3.1 Publication

Protein-protein interaction databases

BioGridi110744, 6 interactors
IntActiQ01538, 1 interactor
STRINGi9606.ENSP00000327465

Chemistry databases

BindingDBiQ01538

Structurei

3D structure databases

ProteinModelPortaliQ01538
SMRiQ01538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 306Glu-richAdd BLAST107
Compositional biasi685 – 723Ser-richAdd BLAST39

Domaini

Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri433 – 476CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri477 – 520CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri791 – 834CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri835 – 878CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri884 – 927CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri937 – 980CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4P Eukaryota
ENOG4111XF7 LUCA
GeneTreeiENSGT00440000038465
HOGENOMiHOG000234099
HOVERGENiHBG006433
InParanoidiQ01538
OMAiQDEWDGP
OrthoDBiEOG091G0135
PhylomeDBiQ01538
TreeFamiTF317299

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf
PfamiView protein in Pfam
PF08474 MYT1, 2 hits
PF01530 zf-C2HC, 7 hits
SUPFAMiSSF103637 SSF103637, 7 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 7 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01538-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS
60 70 80 90 100
LQSCPLAKKR KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK
110 120 130 140 150
DASVSDESEG TLEGAEAETS GQDEIHRPET AEGRSPVKSH FGSNPIGSAT
160 170 180 190 200
ASSKGSYSSY QGIIATSLLN LGQIAEETLV EEDLGQAAKP GPGIVHLLQE
210 220 230 240 250
AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL EDAASEESSK
260 270 280 290 300
QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE
310 320 330 340 350
EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD
360 370 380 390 400
DKDEDTHSRK STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC
410 420 430 440 450
PPAEQSQLGL GEPGKAAKPL DTVRKSYYSK DPSRAEKREI KCPTPGCDGT
460 470 480 490 500
GHVTGLYPHH RSLSGCPHKD RIPPEILAMH ENVLKCPTPG CTGQGHVNSN
510 520 530 540 550
RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD RILRPMCFVK
560 570 580 590 600
QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML
610 620 630 640 650
APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK
660 670 680 690 700
PQDLPSKSVD IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA
710 720 730 740 750
SQRHSSTSAP SSSMTSPQSS QASRQDEWDR PLDYTKPSRL REEEPEESEP
760 770 780 790 800
AAHSFASSEA DDQEVSEENF EERKYPGEVT LTNFKLKFLS KDIKKELLTC
810 820 830 840 850
PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA DLKCPTPGCD
860 870 880 890 900
GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG
910 920 930 940 950
LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG
960 970 980 990 1000
CDGSGHANGS FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN
1010 1020 1030 1040 1050
DEEIKQLNQE IRDLNESNSE MEAAMVQLQS QISSMEKNLK NIEEENKLIE
1060 1070 1080 1090 1100
EQNEALFLEL SGLSQALIQS LANIRLPHME PICEQNFDAY VSTLTDMYSN
1110 1120
QDPENKDLLE SIKQAVRGIQ V
Length:1,121
Mass (Da):122,329
Last modified:April 27, 2001 - v2
Checksum:iD4AF1F8C7D4EC01E
GO
Isoform 2 (identifier: Q01538-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: C → SKPFPKASSPRHSPSSSYVRSTSSSSAG

Show »
Length:1,148
Mass (Da):125,075
Checksum:i53CCE237F8356742
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P6D5Q6P6D5_HUMAN
MYT1 protein
MYT1
591Annotation score:
A0A2R8Y3S5A0A2R8Y3S5_HUMAN
Myelin transcription factor 1
MYT1
40Annotation score:

Sequence cautioni

The sequence BAA74858 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti567 – 574ATPRANLA → RHTQGQLG in AAA59897 (PubMed:1280325).Curated8
Sequence conflicti837A → T in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti943G → D in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti957 – 958AN → TI in AAA59897 (PubMed:1280325).Curated2
Sequence conflicti1075R → H in AAA59897 (PubMed:1280325).Curated1
Sequence conflicti1088 – 1089DA → VP in AAA59897 (PubMed:1280325).Curated2
Sequence conflicti1102D → A in AAA59897 (PubMed:1280325).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054313616C → SKPFPKASSPRHSPSSSYVR STSSSSAG in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020642 mRNA Translation: BAA74858.2 Different initiation.
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75155.1
CH471077 Genomic DNA Translation: EAW75157.1
CH471077 Genomic DNA Translation: EAW75158.1
AB028973 mRNA Translation: BAA83002.1
BC053638 mRNA Translation: AAH53638.1
M96980 mRNA Translation: AAA59897.1
CCDSiCCDS13558.1 [Q01538-1]
RefSeqiNP_004526.1, NM_004535.2 [Q01538-1]
UniGeneiHs.279562

Genome annotation databases

EnsembliENST00000328439; ENSP00000327465; ENSG00000196132 [Q01538-1]
ENST00000536311; ENSP00000442412; ENSG00000196132 [Q01538-2]
ENST00000613234; ENSP00000477771; ENSG00000276876 [Q01538-1]
ENST00000616648; ENSP00000483021; ENSG00000276876 [Q01538-2]
GeneIDi4661
KEGGihsa:4661
UCSCiuc002yii.3 human [Q01538-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020642 mRNA Translation: BAA74858.2 Different initiation.
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75155.1
CH471077 Genomic DNA Translation: EAW75157.1
CH471077 Genomic DNA Translation: EAW75158.1
AB028973 mRNA Translation: BAA83002.1
BC053638 mRNA Translation: AAH53638.1
M96980 mRNA Translation: AAA59897.1
CCDSiCCDS13558.1 [Q01538-1]
RefSeqiNP_004526.1, NM_004535.2 [Q01538-1]
UniGeneiHs.279562

3D structure databases

ProteinModelPortaliQ01538
SMRiQ01538
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110744, 6 interactors
IntActiQ01538, 1 interactor
STRINGi9606.ENSP00000327465

Chemistry databases

BindingDBiQ01538
ChEMBLiCHEMBL2331044

PTM databases

iPTMnetiQ01538
PhosphoSitePlusiQ01538

Polymorphism and mutation databases

BioMutaiMYT1
DMDMi13638422

Proteomic databases

MaxQBiQ01538
PaxDbiQ01538
PeptideAtlasiQ01538
PRIDEiQ01538
ProteomicsDBi57968

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328439; ENSP00000327465; ENSG00000196132 [Q01538-1]
ENST00000536311; ENSP00000442412; ENSG00000196132 [Q01538-2]
ENST00000613234; ENSP00000477771; ENSG00000276876 [Q01538-1]
ENST00000616648; ENSP00000483021; ENSG00000276876 [Q01538-2]
GeneIDi4661
KEGGihsa:4661
UCSCiuc002yii.3 human [Q01538-1]

Organism-specific databases

CTDi4661
DisGeNETi4661
EuPathDBiHostDB:ENSG00000196132.11
GeneCardsiMYT1
H-InvDBiHIX0080185
HGNCiHGNC:7622 MYT1
HPAiHPA006303
MIMi600379 gene
neXtProtiNX_Q01538
OpenTargetsiENSG00000196132
PharmGKBiPA31426
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ4P Eukaryota
ENOG4111XF7 LUCA
GeneTreeiENSGT00440000038465
HOGENOMiHOG000234099
HOVERGENiHBG006433
InParanoidiQ01538
OMAiQDEWDGP
OrthoDBiEOG091G0135
PhylomeDBiQ01538
TreeFamiTF317299

Miscellaneous databases

GeneWikiiMYT1
GenomeRNAii4661
PROiPR:Q01538
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196132 Expressed in 94 organ(s), highest expression level in forebrain
CleanExiHS_MTF1
HS_MYT1
ExpressionAtlasiQ01538 baseline and differential
GenevisibleiQ01538 HS

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf
PfamiView protein in Pfam
PF08474 MYT1, 2 hits
PF01530 zf-C2HC, 7 hits
SUPFAMiSSF103637 SSF103637, 7 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYT1_HUMAN
AccessioniPrimary (citable) accession number: Q01538
Secondary accession number(s): E1P5H0
, F5H7M8, O94922, Q7Z5W2, Q9UPV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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