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Protein

Defensin-6

Gene

DEFA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Protein family/group databases

TCDBi1.C.19.1.7 the defensin (defensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-6
Alternative name(s):
Defensin, alpha 6
Gene namesi
Name:DEFA6
Synonyms:DEF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164822.4
HGNCiHGNC:2765 DEFA6
MIMi600471 gene
neXtProtiNX_Q01524

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1671
OpenTargetsiENSG00000164822
PharmGKBiPA27242

Polymorphism and mutation databases

BioMutaiDEFA6
DMDMi399354

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000679020 – ?68Sequence analysisAdd BLAST49
PeptideiPRO_0000006791?69 – 100Defensin-6Add BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 991 Publication
Disulfide bondi74 ↔ 881 Publication
Disulfide bondi78 ↔ 981 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ01524
PeptideAtlasiQ01524
PRIDEiQ01524
ProteomicsDBi57965

PTM databases

iPTMnetiQ01524
PhosphoSitePlusiQ01524

Expressioni

Tissue specificityi

Paneth cells of the small intestine.

Gene expression databases

BgeeiENSG00000164822 Expressed in 71 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_DEF6
HS_DEFA6
GenevisibleiQ01524 HS

Organism-specific databases

HPAiHPA019462

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108035, 18 interactors
IntActiQ01524, 3 interactors
STRINGi9606.ENSP00000297436

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01524
SMRiQ01524
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01524

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ01524
KOiK05230
OMAiNCRRSCY
OrthoDBiEOG091G12GE
PhylomeDBiQ01524
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01524-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA
60 70 80 90 100
VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL
Length:100
Mass (Da):10,975
Last modified:July 1, 1993 - v1
Checksum:iEDF77E033DDCE2D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98331 mRNA Translation: AAB59357.1
U33317 Genomic DNA Translation: AAC50382.1 Sequence problems.
AF200455 Genomic DNA Translation: AAT68876.1
CH471153 Genomic DNA Translation: EAW80484.1
BC069667 mRNA Translation: AAH69667.1
BC069710 mRNA Translation: AAH69710.1
BC069728 mRNA Translation: AAH69728.1
BC069769 mRNA Translation: AAH69769.1
BC093951 mRNA Translation: AAH93951.1
BC093953 mRNA Translation: AAH93953.1
CCDSiCCDS5960.1
PIRiS27016
RefSeqiNP_001917.1, NM_001926.3
UniGeneiHs.711

Genome annotation databases

EnsembliENST00000297436; ENSP00000297436; ENSG00000164822
ENST00000646187; ENSP00000494361; ENSG00000285136
GeneIDi1671
KEGGihsa:1671
UCSCiuc003wqt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98331 mRNA Translation: AAB59357.1
U33317 Genomic DNA Translation: AAC50382.1 Sequence problems.
AF200455 Genomic DNA Translation: AAT68876.1
CH471153 Genomic DNA Translation: EAW80484.1
BC069667 mRNA Translation: AAH69667.1
BC069710 mRNA Translation: AAH69710.1
BC069728 mRNA Translation: AAH69728.1
BC069769 mRNA Translation: AAH69769.1
BC093951 mRNA Translation: AAH93951.1
BC093953 mRNA Translation: AAH93953.1
CCDSiCCDS5960.1
PIRiS27016
RefSeqiNP_001917.1, NM_001926.3
UniGeneiHs.711

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZMQX-ray2.10A/B/C/D69-100[»]
3QTEX-ray1.95A/B/C/D69-100[»]
ProteinModelPortaliQ01524
SMRiQ01524
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108035, 18 interactors
IntActiQ01524, 3 interactors
STRINGi9606.ENSP00000297436

Protein family/group databases

TCDBi1.C.19.1.7 the defensin (defensin) family

PTM databases

iPTMnetiQ01524
PhosphoSitePlusiQ01524

Polymorphism and mutation databases

BioMutaiDEFA6
DMDMi399354

Proteomic databases

PaxDbiQ01524
PeptideAtlasiQ01524
PRIDEiQ01524
ProteomicsDBi57965

Protocols and materials databases

DNASUi1671
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297436; ENSP00000297436; ENSG00000164822
ENST00000646187; ENSP00000494361; ENSG00000285136
GeneIDi1671
KEGGihsa:1671
UCSCiuc003wqt.4 human

Organism-specific databases

CTDi1671
DisGeNETi1671
EuPathDBiHostDB:ENSG00000164822.4
GeneCardsiDEFA6
HGNCiHGNC:2765 DEFA6
HPAiHPA019462
MIMi600471 gene
neXtProtiNX_Q01524
OpenTargetsiENSG00000164822
PharmGKBiPA27242
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ01524
KOiK05230
OMAiNCRRSCY
OrthoDBiEOG091G12GE
PhylomeDBiQ01524
TreeFamiTF338414

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Miscellaneous databases

ChiTaRSiDEFA6 human
EvolutionaryTraceiQ01524
GeneWikiiDEFA6
GenomeRNAii1671
PROiPR:Q01524
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164822 Expressed in 71 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_DEF6
HS_DEFA6
GenevisibleiQ01524 HS

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEF6_HUMAN
AccessioniPrimary (citable) accession number: Q01524
Secondary accession number(s): Q6EZF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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