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Protein

Defensin-5

Gene

DEFA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.3 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-5
Alternative name(s):
Defensin, alpha 5
HD5(20-94)
Cleaved into the following 4 chains:
Gene namesi
Name:DEFA5
Synonyms:DEF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164816.7
HGNCiHGNC:2764 DEFA5
MIMi600472 gene
neXtProtiNX_Q01523

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1670
OpenTargetsiENSG00000164816
PharmGKBiPA27241

Polymorphism and mutation databases

BioMutaiDEFA5
DMDMi399353

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
PeptideiPRO_000000678720 – 94Defensin-5Add BLAST75
PeptideiPRO_000041738723 – 94HD5(23-94)Add BLAST72
PeptideiPRO_000041738829 – 94HD5(29-94)Add BLAST66
PeptideiPRO_000041738956 – 94HD5(56-94)Add BLAST39
PeptideiPRO_000041739063 – 94HD5(63-94)Add BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 931 Publication
Disulfide bondi67 ↔ 821 Publication
Disulfide bondi72 ↔ 921 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01523
PeptideAtlasiQ01523
PRIDEiQ01523
ProteomicsDBi57964

Miscellaneous databases

PMAP-CutDBiQ01523

Expressioni

Tissue specificityi

Paneth cells of the small intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000164816 Expressed in 76 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_DEFA5
GenevisibleiQ01523 HS

Organism-specific databases

HPAiCAB069919
HPA015775

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108034, 65 interactors
IntActiQ01523, 2 interactors
STRINGi9606.ENSP00000329890

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01523
SMRiQ01523
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01523

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ01523
KOiK05230
OMAiQARSTCY
OrthoDBiEOG091G12GE
PhylomeDBiQ01523
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01523-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTIAILAAI LLVALQAQAE SLQERADEAT TQKQSGEDNQ DLAISFAGNG
60 70 80 90
LSALRTSGSQ ARATCYCRTG RCATRESLSG VCEISGRLYR LCCR
Length:94
Mass (Da):10,071
Last modified:July 1, 1993 - v1
Checksum:i19B5B00B6BAF90DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05924571R → H. Corresponds to variant dbSNP:rs7839771Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97925 Genomic DNA Translation: AAA35754.1
AF238378 Genomic DNA Translation: AAT68886.1
CH471153 Genomic DNA Translation: EAW80489.1
BC069690 mRNA Translation: AAH69690.1
BC107079 mRNA Translation: AAI07080.1
CCDSiCCDS5963.1
PIRiA44454
RefSeqiNP_066290.1, NM_021010.2
UniGeneiHs.655233

Genome annotation databases

EnsembliENST00000330590; ENSP00000329890; ENSG00000164816
ENST00000647159; ENSP00000494799; ENSG00000285251
GeneIDi1670
KEGGihsa:1670
UCSCiuc003wra.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97925 Genomic DNA Translation: AAA35754.1
AF238378 Genomic DNA Translation: AAT68886.1
CH471153 Genomic DNA Translation: EAW80489.1
BC069690 mRNA Translation: AAH69690.1
BC107079 mRNA Translation: AAI07080.1
CCDSiCCDS5963.1
PIRiA44454
RefSeqiNP_066290.1, NM_021010.2
UniGeneiHs.655233

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZMPX-ray1.65A/B/C/D63-94[»]
2LXZNMR-A63-94[»]
2MITNMR-A/B63-94[»]
3I5WX-ray1.63A/B63-94[»]
4E82X-ray1.70A/B63-94[»]
4E83X-ray1.90A/B63-94[»]
4E86X-ray2.75A/B/C/D/E/F/G/H/L63-94[»]
4RBWX-ray1.50A/B/C/D63-94[»]
4RBXX-ray1.10A63-94[»]
5CUIX-ray2.40A/B/C/D/E/F63-94[»]
5CUJX-ray2.08A/B/C/D/E/F63-94[»]
5CUMX-ray1.75A/B/C63-94[»]
ProteinModelPortaliQ01523
SMRiQ01523
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108034, 65 interactors
IntActiQ01523, 2 interactors
STRINGi9606.ENSP00000329890

Polymorphism and mutation databases

BioMutaiDEFA5
DMDMi399353

Proteomic databases

PaxDbiQ01523
PeptideAtlasiQ01523
PRIDEiQ01523
ProteomicsDBi57964

Protocols and materials databases

DNASUi1670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330590; ENSP00000329890; ENSG00000164816
ENST00000647159; ENSP00000494799; ENSG00000285251
GeneIDi1670
KEGGihsa:1670
UCSCiuc003wra.2 human

Organism-specific databases

CTDi1670
DisGeNETi1670
EuPathDBiHostDB:ENSG00000164816.7
GeneCardsiDEFA5
HGNCiHGNC:2764 DEFA5
HPAiCAB069919
HPA015775
MIMi600472 gene
neXtProtiNX_Q01523
OpenTargetsiENSG00000164816
PharmGKBiPA27241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ01523
KOiK05230
OMAiQARSTCY
OrthoDBiEOG091G12GE
PhylomeDBiQ01523
TreeFamiTF338414

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Miscellaneous databases

ChiTaRSiDEFA5 human
EvolutionaryTraceiQ01523
GeneWikiiDEFA5
GenomeRNAii1670
PMAP-CutDBiQ01523
PROiPR:Q01523
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164816 Expressed in 76 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_DEFA5
GenevisibleiQ01523 HS

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEF5_HUMAN
AccessioniPrimary (citable) accession number: Q01523
Secondary accession number(s): A0JDY6, Q3KNV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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