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Protein

Cytochrome c oxidase subunit 6B

Gene

COX12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • oxidative phosphorylation Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YLR038C-MONOMER
YEAST:YLR038C-MONOMER
UniPathwayi
UPA00705

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX12
Ordered Locus Names:YLR038C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR038C
SGDiS000004028 COX12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001949252 – 83Cytochrome c oxidase subunit 6BAdd BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 59PROSITE-ProRule annotation
Disulfide bondi37 ↔ 48PROSITE-ProRule annotation
Modified residuei82PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ01519
PaxDbiQ01519
PRIDEiQ01519

2D gel databases

UCD-2DPAGEiQ01519

PTM databases

iPTMnetiQ01519

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31314, 289 interactors
ComplexPortaliCPX-1721 Mitochondrial respiratory chain complex IV variant 1
CPX-1722 Mitochondrial electron transport complex IV variant 2
DIPiDIP-4520N
IntActiQ01519, 11 interactors
STRINGi4932.YLR038C

Structurei

3D structure databases

ProteinModelPortaliQ01519
SMRiQ01519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 67CHCHPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 37Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi48 – 59Cx10C motifPROSITE-ProRule annotationAdd BLAST12

Domaini

The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000001191
HOGENOMiHOG000165128
InParanoidiQ01519
KOiK02267
OMAiAPCKQFK
OrthoDBiEOG092C5PUX

Family and domain databases

CDDicd00926 Cyt_c_Oxidase_VIb, 1 hit
Gene3Di1.10.10.140, 1 hit
InterProiView protein in InterPro
IPR003213 Cyt_c_oxidase_su6B
IPR036549 Cyt_c_oxidase_su6B_sf
PANTHERiPTHR11387 PTHR11387, 1 hit
PfamiView protein in Pfam
PF02297 COX6B, 1 hit
PIRSFiPIRSF000278 Cyt_c_oxidase_6B, 1 hit
SUPFAMiSSF47694 SSF47694, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01519-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQENSPLH TVGFDARFPQ QNQTKHCWQS YVDYHKCVNM KGEDFAPCKV
60 70 80
FWKTYNALCP LDWIEKWDDQ REKGIFAGDI NSD
Length:83
Mass (Da):9,788
Last modified:January 23, 2007 - v2
Checksum:i57A8FAD93756577E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98332 Genomic DNA Translation: AAA34510.1
Z73210 Genomic DNA Translation: CAA97566.1
AY557925 Genomic DNA Translation: AAS56251.1
BK006945 Genomic DNA Translation: DAA09357.1
PIRiS31256
RefSeqiNP_013139.1, NM_001181925.1

Genome annotation databases

EnsemblFungiiYLR038C; YLR038C; YLR038C
GeneIDi850727
KEGGisce:YLR038C

Similar proteinsi

Entry informationi

Entry nameiCOX12_YEAST
AccessioniPrimary (citable) accession number: Q01519
Secondary accession number(s): D6VY41, Q9URA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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