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UniProtKB - Q01518 (CAP1_HUMAN)

Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

GO - Molecular functioni

  • actin binding Source: GO_Central
  • adenylate cyclase binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:CAP1
Synonyms:CAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000131236.16
HGNCiHGNC:20040 CAP1
MIMi617801 gene
neXtProtiNX_Q01518

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10487
OpenTargetsiENSG00000131236
PharmGKBiPA399

Polymorphism and mutation databases

BioMutaiCAP1
DMDMi308153681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002056962 – 475Adenylyl cyclase-associated protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei287N6-methyllysineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ01518
MaxQBiQ01518
PaxDbiQ01518
PeptideAtlasiQ01518
PRIDEiQ01518
ProteomicsDBi57962
57963 [Q01518-2]

2D gel databases

OGPiQ01518
REPRODUCTION-2DPAGEiIPI00639931

PTM databases

CarbonylDBiQ01518
iPTMnetiQ01518
PhosphoSitePlusiQ01518
SwissPalmiQ01518

Expressioni

Gene expression databases

BgeeiENSG00000131236 Expressed in 230 organ(s), highest expression level in caudate nucleus
CleanExiHS_CAP1
ExpressionAtlasiQ01518 baseline and differential
GenevisibleiQ01518 HS

Organism-specific databases

HPAiHPA030124

Interactioni

Subunit structurei

Homodimer. Binds actin monomers.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi115750, 58 interactors
CORUMiQ01518
DIPiDIP-62063N
IntActiQ01518, 9 interactors
MINTiQ01518
STRINGi9606.ENSP00000361878

Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01518
SMRiQ01518
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01518

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 453C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 256Ala/Pro/Ser-richAdd BLAST39
Compositional biasi230 – 241Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiQ01518
KOiK17261
OMAiELEGNKW
OrthoDBiEOG091G0DLX
PhylomeDBiQ01518
TreeFamiTF313791

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL 
        60         70         80         90        100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK 
       110        120        130        140        150
LSDLLAPISE QIKEVITFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP 
       160        170        180        190        200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF 
       210        220        230        240        250
HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP PVSTISCSYE 
       260        270        280        290        300
SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF 
       310        320        330        340        350
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV 
       360        370        380        390        400
AYIYKCVNTT LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ 
       410        420        430        440        450
VMGKVPTISI NKTDGCHAYL SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE 
       460        470 
FPVPEQFKTL WNGQKLVTTV TEIAG
Length:475
Mass (Da):51,901
Last modified:October 5, 2010 - v5
Checksum:i7789D1FAC0D1AB7B
GO
Isoform 2 (identifier: Q01518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:474
Mass (Da):51,830
Checksum:iE0CD26F4975A39A0
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0R9Q5T0R9_HUMAN
Adenylyl cyclase-associated protein...
CAP1
262Annotation score:
Q5T0R1Q5T0R1_HUMAN
Adenylyl cyclase-associated protein...
CAP1
215Annotation score:
Q5T0R7Q5T0R7_HUMAN
Adenylyl cyclase-associated protein...
CAP1
174Annotation score:
Q5T0R2Q5T0R2_HUMAN
Adenylyl cyclase-associated protein...
CAP1
208Annotation score:
Q5T0R6Q5T0R6_HUMAN
Adenylyl cyclase-associated protein...
CAP1
176Annotation score:
Q5T0R3Q5T0R3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
203Annotation score:
Q5T0R5Q5T0R5_HUMAN
Adenylyl cyclase-associated protein...
CAP1
179Annotation score:
Q5T0S3Q5T0S3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
145Annotation score:
Q5T0R4Q5T0R4_HUMAN
Adenylyl cyclase-associated protein...
CAP1
201Annotation score:
Q5T0R8Q5T0R8_HUMAN
Adenylyl cyclase-associated protein...
CAP1
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374N → S in BAD96233 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028419229C → G6 PublicationsCorresponds to variant dbSNP:rs11207440Ensembl.1
Natural variantiVAR_028420236C → G6 PublicationsCorresponds to variant dbSNP:rs6665926Ensembl.1
Natural variantiVAR_028421245I → S6 PublicationsCorresponds to variant dbSNP:rs6665933Ensembl.1
Natural variantiVAR_028422247C → G6 PublicationsCorresponds to variant dbSNP:rs6665936Ensembl.1
Natural variantiVAR_028423249Y → D6 PublicationsCorresponds to variant dbSNP:rs6665937Ensembl.1
Natural variantiVAR_028424256S → A6 PublicationsCorresponds to variant dbSNP:rs6665944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03603838Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1
CCDSiCCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]
PIRiA48120
RefSeqiNP_001099000.1, NM_001105530.1
NP_006358.1, NM_006367.3
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1
UniGeneiHs.370581
Hs.733189

Genome annotation databases

EnsembliENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]
GeneIDi10487
KEGGihsa:10487
UCSCiuc001cey.5 human [Q01518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1
CCDSiCCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]
PIRiA48120
RefSeqiNP_001099000.1, NM_001105530.1
NP_006358.1, NM_006367.3
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1
UniGeneiHs.370581
Hs.733189

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8FX-ray2.80A/B/C/D319-475[»]
ProteinModelPortaliQ01518
SMRiQ01518
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115750, 58 interactors
CORUMiQ01518
DIPiDIP-62063N
IntActiQ01518, 9 interactors
MINTiQ01518
STRINGi9606.ENSP00000361878

PTM databases

CarbonylDBiQ01518
iPTMnetiQ01518
PhosphoSitePlusiQ01518
SwissPalmiQ01518

Polymorphism and mutation databases

BioMutaiCAP1
DMDMi308153681

2D gel databases

OGPiQ01518
REPRODUCTION-2DPAGEiIPI00639931

Proteomic databases

EPDiQ01518
MaxQBiQ01518
PaxDbiQ01518
PeptideAtlasiQ01518
PRIDEiQ01518
ProteomicsDBi57962
57963 [Q01518-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]
GeneIDi10487
KEGGihsa:10487
UCSCiuc001cey.5 human [Q01518-1]

Organism-specific databases

CTDi10487
DisGeNETi10487
EuPathDBiHostDB:ENSG00000131236.16
GeneCardsiCAP1
HGNCiHGNC:20040 CAP1
HPAiHPA030124
MIMi617801 gene
neXtProtiNX_Q01518
OpenTargetsiENSG00000131236
PharmGKBiPA399
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiQ01518
KOiK17261
OMAiELEGNKW
OrthoDBiEOG091G0DLX
PhylomeDBiQ01518
TreeFamiTF313791

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCAP1 human
EvolutionaryTraceiQ01518
GeneWikiiCAP1
GenomeRNAii10487
PROiPR:Q01518
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131236 Expressed in 230 organ(s), highest expression level in caudate nucleus
CleanExiHS_CAP1
ExpressionAtlasiQ01518 baseline and differential
GenevisibleiQ01518 HS

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAP1_HUMAN
AccessioniPrimary (citable) accession number: Q01518
Secondary accession number(s): Q53HR7
, Q5T0S1, Q5T0S2, Q6I9U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 183 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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