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Entry version 189 (05 Jun 2019)
Sequence version 5 (05 Oct 2010)
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Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: GO_Central
  • adenylate cyclase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAP1
Synonyms:CAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20040 CAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617801 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01518

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10487

Open Targets

More...
OpenTargetsi
ENSG00000131236

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA399

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153681

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056962 – 475Adenylyl cyclase-associated protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei287N6-methyllysineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01518

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01518

MaxQB - The MaxQuant DataBase

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MaxQBi
Q01518

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01518

PeptideAtlas

More...
PeptideAtlasi
Q01518

PRoteomics IDEntifications database

More...
PRIDEi
Q01518

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57962
57963 [Q01518-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q01518

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00639931

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q01518

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01518

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01518

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q01518

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131236 Expressed in 230 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01518 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01518 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030124

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds actin monomers.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115750, 66 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q01518

Database of interacting proteins

More...
DIPi
DIP-62063N

Protein interaction database and analysis system

More...
IntActi
Q01518, 10 interactors

Molecular INTeraction database

More...
MINTi
Q01518

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361883

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01518

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q01518

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 453C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 256Ala/Pro/Ser-richAdd BLAST39
Compositional biasi230 – 241Poly-ProAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2675 Eukaryota
ENOG410XPXJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000206192

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01518

KEGG Orthology (KO)

More...
KOi
K17261

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELEGNKW

Database of Orthologous Groups

More...
OrthoDBi
1098760at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01518

TreeFam database of animal gene trees

More...
TreeFami
TF313791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.330, 1 hit
2.160.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif

The PANTHER Classification System

More...
PANTHERi
PTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00673 CARP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL
60 70 80 90 100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK
110 120 130 140 150
LSDLLAPISE QIKEVITFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP
160 170 180 190 200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF
210 220 230 240 250
HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP PVSTISCSYE
260 270 280 290 300
SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF
310 320 330 340 350
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV
360 370 380 390 400
AYIYKCVNTT LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ
410 420 430 440 450
VMGKVPTISI NKTDGCHAYL SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE
460 470
FPVPEQFKTL WNGQKLVTTV TEIAG
Length:475
Mass (Da):51,901
Last modified:October 5, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7789D1FAC0D1AB7B
GO
Isoform 2 (identifier: Q01518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:474
Mass (Da):51,830
Checksum:iE0CD26F4975A39A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0R9Q5T0R9_HUMAN
Adenylyl cyclase-associated protein...
CAP1
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0S3Q5T0S3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R2Q5T0R2_HUMAN
Adenylyl cyclase-associated protein...
CAP1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R1Q5T0R1_HUMAN
Adenylyl cyclase-associated protein...
CAP1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R7Q5T0R7_HUMAN
Adenylyl cyclase-associated protein...
CAP1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R3Q5T0R3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R6Q5T0R6_HUMAN
Adenylyl cyclase-associated protein...
CAP1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R5Q5T0R5_HUMAN
Adenylyl cyclase-associated protein...
CAP1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R4Q5T0R4_HUMAN
Adenylyl cyclase-associated protein...
CAP1
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R8Q5T0R8_HUMAN
Adenylyl cyclase-associated protein...
CAP1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti374N → S in BAD96233 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028419229C → G6 PublicationsCorresponds to variant dbSNP:rs11207440Ensembl.1
Natural variantiVAR_028420236C → G6 PublicationsCorresponds to variant dbSNP:rs6665926Ensembl.1
Natural variantiVAR_028421245I → S6 PublicationsCorresponds to variant dbSNP:rs6665933Ensembl.1
Natural variantiVAR_028422247C → G6 PublicationsCorresponds to variant dbSNP:rs6665936Ensembl.1
Natural variantiVAR_028423249Y → D6 PublicationsCorresponds to variant dbSNP:rs6665937Ensembl.1
Natural variantiVAR_028424256S → A6 PublicationsCorresponds to variant dbSNP:rs6665944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03603838Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]

Protein sequence database of the Protein Information Resource

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PIRi
A48120

NCBI Reference Sequences

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RefSeqi
NP_001099000.1, NM_001105530.1
NP_006358.1, NM_006367.3
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10487

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10487

UCSC genome browser

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UCSCi
uc001cey.5 human [Q01518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1
CCDSiCCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]
PIRiA48120
RefSeqiNP_001099000.1, NM_001105530.1
NP_006358.1, NM_006367.3
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8FX-ray2.80A/B/C/D319-475[»]
SMRiQ01518
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115750, 66 interactors
CORUMiQ01518
DIPiDIP-62063N
IntActiQ01518, 10 interactors
MINTiQ01518
STRINGi9606.ENSP00000361883

PTM databases

CarbonylDBiQ01518
iPTMnetiQ01518
PhosphoSitePlusiQ01518
SwissPalmiQ01518

Polymorphism and mutation databases

BioMutaiCAP1
DMDMi308153681

2D gel databases

OGPiQ01518
REPRODUCTION-2DPAGEiIPI00639931

Proteomic databases

EPDiQ01518
jPOSTiQ01518
MaxQBiQ01518
PaxDbiQ01518
PeptideAtlasiQ01518
PRIDEiQ01518
ProteomicsDBi57962
57963 [Q01518-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]
GeneIDi10487
KEGGihsa:10487
UCSCiuc001cey.5 human [Q01518-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10487
DisGeNETi10487

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAP1
HGNCiHGNC:20040 CAP1
HPAiHPA030124
MIMi617801 gene
neXtProtiNX_Q01518
OpenTargetsiENSG00000131236
PharmGKBiPA399

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
InParanoidiQ01518
KOiK17261
OMAiELEGNKW
OrthoDBi1098760at2759
PhylomeDBiQ01518
TreeFamiTF313791

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAP1 human
EvolutionaryTraceiQ01518

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10487

Protein Ontology

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PROi
PR:Q01518

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131236 Expressed in 230 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ01518 baseline and differential
GenevisibleiQ01518 HS

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01518
Secondary accession number(s): Q53HR7
, Q5T0S1, Q5T0S2, Q6I9U6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 5, 2010
Last modified: June 5, 2019
This is version 189 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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