UniProtKB - Q01518 (CAP1_HUMAN)
Protein
Adenylyl cyclase-associated protein 1
Gene
CAP1
Organism
Homo sapiens (Human)
Status
Functioni
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
GO - Molecular functioni
- actin binding Source: GO_Central
- adenylate cyclase binding Source: GO_Central
GO - Biological processi
- actin polymerization or depolymerization Source: GO_Central
- activation of adenylate cyclase activity Source: ProtInc
- ameboidal-type cell migration Source: Ensembl
- cell morphogenesis Source: GO_Central
- establishment or maintenance of cell polarity Source: GO_Central
- neutrophil degranulation Source: Reactome
- receptor-mediated endocytosis Source: Ensembl
- regulation of adenylate cyclase activity Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q01518 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-428890, Role of ABL in ROBO-SLIT signaling R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylyl cyclase-associated protein 1Short name: CAP 1 |
Gene namesi | Name:CAP1 Synonyms:CAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20040, CAP1 |
MIMi | 617801, gene |
neXtProti | NX_Q01518 |
VEuPathDBi | HostDB:ENSG00000131236.16 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Lysosome
- azurophil granule lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10487 |
OpenTargetsi | ENSG00000131236 |
PharmGKBi | PA399 |
Miscellaneous databases
Pharosi | Q01518, Tbio |
Genetic variation databases
BioMutai | CAP1 |
DMDMi | 308153681 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000205696 | 2 – 475 | Adenylyl cyclase-associated protein 1Add BLAST | 474 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 31 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 287 | N6-methyllysineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 301 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 308 | PhosphoserineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 | |
Cross-linki | 348 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-325 CPTAC-326 |
EPDi | Q01518 |
jPOSTi | Q01518 |
MassIVEi | Q01518 |
MaxQBi | Q01518 |
PaxDbi | Q01518 |
PeptideAtlasi | Q01518 |
PRIDEi | Q01518 |
ProteomicsDBi | 57962 [Q01518-1] 57963 [Q01518-2] |
2D gel databases
OGPi | Q01518 |
REPRODUCTION-2DPAGEi | IPI00639931 |
PTM databases
CarbonylDBi | Q01518 |
GlyGeni | Q01518, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q01518 |
MetOSitei | Q01518 |
PhosphoSitePlusi | Q01518 |
SwissPalmi | Q01518 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131236, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | Q01518, baseline and differential |
Genevisiblei | Q01518, HS |
Organism-specific databases
HPAi | ENSG00000131236, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Homodimer. Binds actin monomers.
GO - Molecular functioni
- actin binding Source: GO_Central
- adenylate cyclase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 115750, 77 interactors |
CORUMi | Q01518 |
DIPi | DIP-62063N |
IntActi | Q01518, 29 interactors |
MINTi | Q01518 |
STRINGi | 9606.ENSP00000361883 |
Miscellaneous databases
RNActi | Q01518, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q01518 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01518 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 319 – 453 | C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST | 135 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 218 – 256 | Ala/Pro/Ser-richAdd BLAST | 39 | |
Compositional biasi | 230 – 241 | Poly-ProAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the CAP family.Curated
Phylogenomic databases
eggNOGi | KOG2675, Eukaryota |
GeneTreei | ENSGT00390000017955 |
HOGENOMi | CLU_015780_1_1_1 |
InParanoidi | Q01518 |
OMAi | ELEGNKW |
OrthoDBi | 1098760at2759 |
PhylomeDBi | Q01518 |
TreeFami | TF313791 |
Family and domain databases
Gene3Di | 1.25.40.330, 1 hit 2.160.20.70, 1 hit |
InterProi | View protein in InterPro IPR001837, Adenylate_cyclase-assoc_CAP IPR013912, Adenylate_cyclase-assoc_CAP_C IPR013992, Adenylate_cyclase-assoc_CAP_N IPR017901, C-CAP_CF_C-like IPR016098, CAP/MinC_C IPR028415, CAP1 IPR036223, CAP_C_sf IPR028417, CAP_CS_C IPR018106, CAP_CS_N IPR036222, CAP_N_sf IPR006599, CARP_motif |
PANTHERi | PTHR10652, PTHR10652, 1 hit PTHR10652:SF1, PTHR10652:SF1, 1 hit |
Pfami | View protein in Pfam PF08603, CAP_C, 1 hit PF01213, CAP_N, 1 hit |
SMARTi | View protein in SMART SM00673, CARP, 2 hits |
SUPFAMi | SSF101278, SSF101278, 1 hit SSF69340, SSF69340, 1 hit |
PROSITEi | View protein in PROSITE PS51329, C_CAP_COFACTOR_C, 1 hit PS01088, CAP_1, 1 hit PS01089, CAP_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q01518-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL
60 70 80 90 100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK
110 120 130 140 150
LSDLLAPISE QIKEVITFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP
160 170 180 190 200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF
210 220 230 240 250
HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP PVSTISCSYE
260 270 280 290 300
SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF
310 320 330 340 350
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV
360 370 380 390 400
AYIYKCVNTT LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ
410 420 430 440 450
VMGKVPTISI NKTDGCHAYL SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE
460 470
FPVPEQFKTL WNGQKLVTTV TEIAG
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T0R9 | Q5T0R9_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 262 | Annotation score: | ||
Q5T0S3 | Q5T0S3_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 145 | Annotation score: | ||
Q5T0R2 | Q5T0R2_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 208 | Annotation score: | ||
Q5T0R1 | Q5T0R1_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 215 | Annotation score: | ||
Q5T0R3 | Q5T0R3_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 203 | Annotation score: | ||
Q5T0R6 | Q5T0R6_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 176 | Annotation score: | ||
Q5T0R7 | Q5T0R7_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 174 | Annotation score: | ||
Q5T0R4 | Q5T0R4_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 201 | Annotation score: | ||
Q5T0R5 | Q5T0R5_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 179 | Annotation score: | ||
Q5T0R8 | Q5T0R8_HUMAN | Adenylyl cyclase-associated protein... | CAP1 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 | N → S in BAD96233 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028419 | 229 | C → G6 PublicationsCorresponds to variant dbSNP:rs11207440Ensembl. | 1 | |
Natural variantiVAR_028420 | 236 | C → G6 PublicationsCorresponds to variant dbSNP:rs6665926Ensembl. | 1 | |
Natural variantiVAR_028421 | 245 | I → S6 PublicationsCorresponds to variant dbSNP:rs6665933Ensembl. | 1 | |
Natural variantiVAR_028422 | 247 | C → G6 PublicationsCorresponds to variant dbSNP:rs6665936Ensembl. | 1 | |
Natural variantiVAR_028423 | 249 | Y → D6 PublicationsCorresponds to variant dbSNP:rs6665937Ensembl. | 1 | |
Natural variantiVAR_028424 | 256 | S → A6 PublicationsCorresponds to variant dbSNP:rs6665944Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036038 | 38 | Missing in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M98474 mRNA Translation: AAA35648.1 L12168 mRNA Translation: AAA35507.1 BT007152 mRNA Translation: AAP35816.1 CR457409 mRNA Translation: CAG33690.1 AK222513 mRNA Translation: BAD96233.1 AL512599 Genomic DNA No translation available. BC013963 mRNA Translation: AAH13963.1 BC095440 mRNA Translation: AAH95440.1 |
CCDSi | CCDS41309.1 [Q01518-1] CCDS81304.1 [Q01518-2] |
PIRi | A48120 |
RefSeqi | NP_001099000.1, NM_001105530.1 [Q01518-1] NP_006358.1, NM_006367.3 [Q01518-1] XP_005270425.1, XM_005270368.1 XP_011538811.1, XM_011540509.1 XP_011538812.1, XM_011540510.1 [Q01518-1] XP_011538813.1, XM_011540511.1 XP_011538814.1, XM_011540512.1 XP_011538815.1, XM_011540513.2 XP_011538816.1, XM_011540514.1 XP_011538817.1, XM_011540515.1 [Q01518-2] XP_016855556.1, XM_017000067.1 XP_016855557.1, XM_017000068.1 XP_016855558.1, XM_017000069.1 [Q01518-1] XP_016855559.1, XM_017000070.1 XP_016855560.1, XM_017000071.1 XP_016855561.1, XM_017000072.1 |
Genome annotation databases
Ensembli | ENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2] ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1] ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1] ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2] ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2] ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1] |
GeneIDi | 10487 |
KEGGi | hsa:10487 |
UCSCi | uc001cey.5, human [Q01518-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M98474 mRNA Translation: AAA35648.1 L12168 mRNA Translation: AAA35507.1 BT007152 mRNA Translation: AAP35816.1 CR457409 mRNA Translation: CAG33690.1 AK222513 mRNA Translation: BAD96233.1 AL512599 Genomic DNA No translation available. BC013963 mRNA Translation: AAH13963.1 BC095440 mRNA Translation: AAH95440.1 |
CCDSi | CCDS41309.1 [Q01518-1] CCDS81304.1 [Q01518-2] |
PIRi | A48120 |
RefSeqi | NP_001099000.1, NM_001105530.1 [Q01518-1] NP_006358.1, NM_006367.3 [Q01518-1] XP_005270425.1, XM_005270368.1 XP_011538811.1, XM_011540509.1 XP_011538812.1, XM_011540510.1 [Q01518-1] XP_011538813.1, XM_011540511.1 XP_011538814.1, XM_011540512.1 XP_011538815.1, XM_011540513.2 XP_011538816.1, XM_011540514.1 XP_011538817.1, XM_011540515.1 [Q01518-2] XP_016855556.1, XM_017000067.1 XP_016855557.1, XM_017000068.1 XP_016855558.1, XM_017000069.1 [Q01518-1] XP_016855559.1, XM_017000070.1 XP_016855560.1, XM_017000071.1 XP_016855561.1, XM_017000072.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K8F | X-ray | 2.80 | A/B/C/D | 319-475 | [»] | |
SMRi | Q01518 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115750, 77 interactors |
CORUMi | Q01518 |
DIPi | DIP-62063N |
IntActi | Q01518, 29 interactors |
MINTi | Q01518 |
STRINGi | 9606.ENSP00000361883 |
PTM databases
CarbonylDBi | Q01518 |
GlyGeni | Q01518, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q01518 |
MetOSitei | Q01518 |
PhosphoSitePlusi | Q01518 |
SwissPalmi | Q01518 |
Genetic variation databases
BioMutai | CAP1 |
DMDMi | 308153681 |
2D gel databases
OGPi | Q01518 |
REPRODUCTION-2DPAGEi | IPI00639931 |
Proteomic databases
CPTACi | CPTAC-325 CPTAC-326 |
EPDi | Q01518 |
jPOSTi | Q01518 |
MassIVEi | Q01518 |
MaxQBi | Q01518 |
PaxDbi | Q01518 |
PeptideAtlasi | Q01518 |
PRIDEi | Q01518 |
ProteomicsDBi | 57962 [Q01518-1] 57963 [Q01518-2] |
Protocols and materials databases
Antibodypediai | 32000, 196 antibodies |
Genome annotation databases
Ensembli | ENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2] ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1] ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1] ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2] ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2] ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1] |
GeneIDi | 10487 |
KEGGi | hsa:10487 |
UCSCi | uc001cey.5, human [Q01518-1] |
Organism-specific databases
CTDi | 10487 |
DisGeNETi | 10487 |
GeneCardsi | CAP1 |
HGNCi | HGNC:20040, CAP1 |
HPAi | ENSG00000131236, Tissue enhanced (blood) |
MIMi | 617801, gene |
neXtProti | NX_Q01518 |
OpenTargetsi | ENSG00000131236 |
PharmGKBi | PA399 |
VEuPathDBi | HostDB:ENSG00000131236.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2675, Eukaryota |
GeneTreei | ENSGT00390000017955 |
HOGENOMi | CLU_015780_1_1_1 |
InParanoidi | Q01518 |
OMAi | ELEGNKW |
OrthoDBi | 1098760at2759 |
PhylomeDBi | Q01518 |
TreeFami | TF313791 |
Enzyme and pathway databases
PathwayCommonsi | Q01518 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-428890, Role of ABL in ROBO-SLIT signaling R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 10487, 281 hits in 873 CRISPR screens |
ChiTaRSi | CAP1, human |
EvolutionaryTracei | Q01518 |
GeneWikii | CAP1 |
GenomeRNAii | 10487 |
Pharosi | Q01518, Tbio |
PROi | PR:Q01518 |
RNActi | Q01518, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131236, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | Q01518, baseline and differential |
Genevisiblei | Q01518, HS |
Family and domain databases
Gene3Di | 1.25.40.330, 1 hit 2.160.20.70, 1 hit |
InterProi | View protein in InterPro IPR001837, Adenylate_cyclase-assoc_CAP IPR013912, Adenylate_cyclase-assoc_CAP_C IPR013992, Adenylate_cyclase-assoc_CAP_N IPR017901, C-CAP_CF_C-like IPR016098, CAP/MinC_C IPR028415, CAP1 IPR036223, CAP_C_sf IPR028417, CAP_CS_C IPR018106, CAP_CS_N IPR036222, CAP_N_sf IPR006599, CARP_motif |
PANTHERi | PTHR10652, PTHR10652, 1 hit PTHR10652:SF1, PTHR10652:SF1, 1 hit |
Pfami | View protein in Pfam PF08603, CAP_C, 1 hit PF01213, CAP_N, 1 hit |
SMARTi | View protein in SMART SM00673, CARP, 2 hits |
SUPFAMi | SSF101278, SSF101278, 1 hit SSF69340, SSF69340, 1 hit |
PROSITEi | View protein in PROSITE PS51329, C_CAP_COFACTOR_C, 1 hit PS01088, CAP_1, 1 hit PS01089, CAP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAP1_HUMAN | |
Accessioni | Q01518Primary (citable) accession number: Q01518 Secondary accession number(s): Q53HR7 Q6I9U6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 10, 2021 | |
This is version 201 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families