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UniProtKB - Q01518 (CAP1_HUMAN)

Entry version 203 (02 Jun 2021)
Sequence version 5 (05 Oct 2010)
Previous versions | rss
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Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01518

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-428890, Role of ABL in ROBO-SLIT signaling
R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAP1
Synonyms:CAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20040, CAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617801, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01518

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131236.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10487

Open Targets

More...OpenTargetsi		ENSG00000131236

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA399

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01518, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153681

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056962 – 475Adenylyl cyclase-associated protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei287N6-methyllysineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-325
CPTAC-326

Encyclopedia of Proteome Dynamics

More...EPDi		Q01518

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01518

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01518

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q01518

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01518

PeptideAtlas

More...PeptideAtlasi		Q01518

PRoteomics IDEntifications database

More...PRIDEi		Q01518

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57962 [Q01518-1]
57963 [Q01518-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q01518

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00639931

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q01518

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q01518, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01518

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q01518

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01518

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01518

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131236, Expressed in caudate nucleus and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01518, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01518, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131236, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds actin monomers.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115750, 81 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q01518

Database of interacting proteins

More...DIPi		DIP-62063N

Protein interaction database and analysis system

More...IntActi		Q01518, 31 interactors

Molecular INTeraction database

More...MINTi		Q01518

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361883

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01518, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01518

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q01518

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 453C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni216 – 237DisorderedSequence analysisAdd BLAST22
Regioni278 – 319DisorderedSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2675, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015780_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01518

Identification of Orthologs from Complete Genome Data

More...OMAi		ELEGNKW

Database of Orthologous Groups

More...OrthoDBi		1098760at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01518

TreeFam database of animal gene trees

More...TreeFami		TF313791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.330, 1 hit
2.160.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001837, Adenylate_cyclase-assoc_CAP
IPR013912, Adenylate_cyclase-assoc_CAP_C
IPR013992, Adenylate_cyclase-assoc_CAP_N
IPR017901, C-CAP_CF_C-like
IPR016098, CAP/MinC_C
IPR028415, CAP1
IPR036223, CAP_C_sf
IPR028417, CAP_CS_C
IPR018106, CAP_CS_N
IPR036222, CAP_N_sf
IPR006599, CARP_motif

The PANTHER Classification System

More...PANTHERi		PTHR10652, PTHR10652, 1 hit
PTHR10652:SF1, PTHR10652:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08603, CAP_C, 1 hit
PF01213, CAP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00673, CARP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101278, SSF101278, 1 hit
SSF69340, SSF69340, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51329, C_CAP_COFACTOR_C, 1 hit
PS01088, CAP_1, 1 hit
PS01089, CAP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL 
        60         70         80         90        100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK 
       110        120        130        140        150
LSDLLAPISE QIKEVITFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP 
       160        170        180        190        200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF 
       210        220        230        240        250
HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP PVSTISCSYE 
       260        270        280        290        300
SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF 
       310        320        330        340        350
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV 
       360        370        380        390        400
AYIYKCVNTT LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ 
       410        420        430        440        450
VMGKVPTISI NKTDGCHAYL SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE 
       460        470 
FPVPEQFKTL WNGQKLVTTV TEIAG
Length:475
Mass (Da):51,901
Last modified:October 5, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7789D1FAC0D1AB7B
GO
Isoform 2 (identifier: Q01518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:474
Mass (Da):51,830
Checksum:iE0CD26F4975A39A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0R9Q5T0R9_HUMAN
Adenylyl cyclase-associated protein...
CAP1
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0S3Q5T0S3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R2Q5T0R2_HUMAN
Adenylyl cyclase-associated protein...
CAP1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R1Q5T0R1_HUMAN
Adenylyl cyclase-associated protein...
CAP1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R3Q5T0R3_HUMAN
Adenylyl cyclase-associated protein...
CAP1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R6Q5T0R6_HUMAN
Adenylyl cyclase-associated protein...
CAP1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R7Q5T0R7_HUMAN
Adenylyl cyclase-associated protein...
CAP1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R4Q5T0R4_HUMAN
Adenylyl cyclase-associated protein...
CAP1
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R5Q5T0R5_HUMAN
Adenylyl cyclase-associated protein...
CAP1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0R8Q5T0R8_HUMAN
Adenylyl cyclase-associated protein...
CAP1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti374N → S in BAD96233 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028419229C → G6 PublicationsCorresponds to variant dbSNP:rs11207440Ensembl.1
Natural variantiVAR_028420236C → G6 PublicationsCorresponds to variant dbSNP:rs6665926Ensembl.1
Natural variantiVAR_028421245I → S6 PublicationsCorresponds to variant dbSNP:rs6665933Ensembl.1
Natural variantiVAR_028422247C → G6 PublicationsCorresponds to variant dbSNP:rs6665936Ensembl.1
Natural variantiVAR_028423249Y → D6 PublicationsCorresponds to variant dbSNP:rs6665937Ensembl.1
Natural variantiVAR_028424256S → A6 PublicationsCorresponds to variant dbSNP:rs6665944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03603838Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A48120

NCBI Reference Sequences

More...RefSeqi		NP_001099000.1, NM_001105530.1 [Q01518-1]
NP_006358.1, NM_006367.3 [Q01518-1]
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10487

UCSC genome browser

More...UCSCi		uc001cey.5, human [Q01518-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98474 mRNA Translation: AAA35648.1
L12168 mRNA Translation: AAA35507.1
BT007152 mRNA Translation: AAP35816.1
CR457409 mRNA Translation: CAG33690.1
AK222513 mRNA Translation: BAD96233.1
AL512599 Genomic DNA No translation available.
BC013963 mRNA Translation: AAH13963.1
BC095440 mRNA Translation: AAH95440.1
CCDSiCCDS41309.1 [Q01518-1]
CCDS81304.1 [Q01518-2]
PIRiA48120
RefSeqiNP_001099000.1, NM_001105530.1 [Q01518-1]
NP_006358.1, NM_006367.3 [Q01518-1]
XP_005270425.1, XM_005270368.1
XP_011538811.1, XM_011540509.1
XP_011538812.1, XM_011540510.1 [Q01518-1]
XP_011538813.1, XM_011540511.1
XP_011538814.1, XM_011540512.1
XP_011538815.1, XM_011540513.2
XP_011538816.1, XM_011540514.1
XP_011538817.1, XM_011540515.1 [Q01518-2]
XP_016855556.1, XM_017000067.1
XP_016855557.1, XM_017000068.1
XP_016855558.1, XM_017000069.1 [Q01518-1]
XP_016855559.1, XM_017000070.1
XP_016855560.1, XM_017000071.1
XP_016855561.1, XM_017000072.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8FX-ray2.80A/B/C/D319-475[»]
SMRiQ01518
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115750, 81 interactors
CORUMiQ01518
DIPiDIP-62063N
IntActiQ01518, 31 interactors
MINTiQ01518
STRINGi9606.ENSP00000361883

PTM databases

CarbonylDBiQ01518
GlyGeniQ01518, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ01518
MetOSiteiQ01518
PhosphoSitePlusiQ01518
SwissPalmiQ01518

Genetic variation databases

BioMutaiCAP1
DMDMi308153681

2D gel databases

OGPiQ01518
REPRODUCTION-2DPAGEiIPI00639931

Proteomic databases

CPTACiCPTAC-325
CPTAC-326
EPDiQ01518
jPOSTiQ01518
MassIVEiQ01518
MaxQBiQ01518
PaxDbiQ01518
PeptideAtlasiQ01518
PRIDEiQ01518
ProteomicsDBi57962 [Q01518-1]
57963 [Q01518-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32000, 202 antibodies

The DNASU plasmid repository

More...DNASUi		10487

Genome annotation databases

EnsembliENST00000340450; ENSP00000344832; ENSG00000131236 [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236 [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236 [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236 [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236 [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236 [Q01518-1]
GeneIDi10487
KEGGihsa:10487
UCSCiuc001cey.5, human [Q01518-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10487
DisGeNETi10487

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAP1
HGNCiHGNC:20040, CAP1
HPAiENSG00000131236, Tissue enhanced (blood)
MIMi617801, gene
neXtProtiNX_Q01518
OpenTargetsiENSG00000131236
PharmGKBiPA399
VEuPathDBiHostDB:ENSG00000131236.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2675, Eukaryota
GeneTreeiENSGT00390000017955
HOGENOMiCLU_015780_1_1_1
InParanoidiQ01518
OMAiELEGNKW
OrthoDBi1098760at2759
PhylomeDBiQ01518
TreeFamiTF313791

Enzyme and pathway databases

PathwayCommonsiQ01518
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-428890, Role of ABL in ROBO-SLIT signaling
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10487, 290 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAP1, human
EvolutionaryTraceiQ01518

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10487
PharosiQ01518, Tbio

Protein Ontology

More...PROi		PR:Q01518
RNActiQ01518, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131236, Expressed in caudate nucleus and 244 other tissues
ExpressionAtlasiQ01518, baseline and differential
GenevisibleiQ01518, HS

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837, Adenylate_cyclase-assoc_CAP
IPR013912, Adenylate_cyclase-assoc_CAP_C
IPR013992, Adenylate_cyclase-assoc_CAP_N
IPR017901, C-CAP_CF_C-like
IPR016098, CAP/MinC_C
IPR028415, CAP1
IPR036223, CAP_C_sf
IPR028417, CAP_CS_C
IPR018106, CAP_CS_N
IPR036222, CAP_N_sf
IPR006599, CARP_motif
PANTHERiPTHR10652, PTHR10652, 1 hit
PTHR10652:SF1, PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603, CAP_C, 1 hit
PF01213, CAP_N, 1 hit
SMARTiView protein in SMART
SM00673, CARP, 2 hits
SUPFAMiSSF101278, SSF101278, 1 hit
SSF69340, SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329, C_CAP_COFACTOR_C, 1 hit
PS01088, CAP_1, 1 hit
PS01089, CAP_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01518
Secondary accession number(s): Q53HR7
, Q5T0S1, Q5T0S2, Q6I9U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 5, 2010
Last modified: June 2, 2021
This is version 203 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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