UniProtKB - Q01499 (POLG_BVDVS)
Genome polyprotein
Functioni
Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.
By similarityPackages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Plays also a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
By similarityInitial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans.
By similarityE1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.
By similarityE1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.
By similarityPlays an essential role in the virus replication cycle by acting as a viroporin (By similarity).
Forms ion conductive pores, which alters the cell permeability allowing the transport of ions and other small molecules (By similarity).
Forms a leader sequence to properly orient NS2 in the membrane.
By similarityUncleaved NS2-3 is required for production of infectious virus.
Plays a role in the regulation of viral RNA replication.
By similarityMultifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and viral genome replication. The chymotrypsin-like serine protease activity utilizes NS4A as an essential cofactor and catalyzes the cleavage of the polyprotein leading to the release of NS4A, NS4B, NS5A, and NS5B. Interacts with NS5B to enhance RNA-dependent RNA polymerase activity.
By similarityActs as a cofactor for the NS3 protease activity.
By similarityInduces a specific membrane alteration that serves as a scaffold for the virus replication complex.
By similarityReplicates the viral (+) and (-) genome.
Miscellaneous
Catalytic activityi
- Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites. EC:3.4.21.113
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 49 | For N-terminal protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 69 | For N-terminal protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1447 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1461 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1512 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1658 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1695 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1752 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- cysteine-type endopeptidase activity Source: InterPro
- ion channel activity Source: UniProtKB-KW
- ribonuclease T2 activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- serine-type endopeptidase activity Source: InterPro
- serine-type exopeptidase activity Source: InterPro
GO - Biological processi
- clathrin-dependent endocytosis of virus by host cell Source: UniProtKB-KW
- fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- pore formation by virus in membrane of host cell Source: UniProtKB-KW
- protein complex oligomerization Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-KW
- viral protein processing Source: InterPro
- viral RNA genome replication Source: InterPro
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Enzyme and pathway databases
BRENDAi | 3.4.21.113, 925 |
Protein family/group databases
MEROPSi | S31.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinCleaved into the following 13 chains: Alternative name(s): Autoprotease p20 Alternative name(s): gp44/48 Alternative name(s): gp33 Alternative name(s): gp55 Viroporin p7By similarity Alternative name(s): Non-structural protein 2 Serine protease NS3 (EC:3.4.21.113, EC:3.6.1.15, EC:3.6.4.13) Alternative name(s): Non-structural protein 3 Alternative name(s): NS5B |
Organismi | Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus) |
Taxonomic identifieri | 31656 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Flasuviricetes › Amarillovirales › Flaviviridae › Pestivirus › |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
Subcellular locationi
- Virion By similarity
- Host membrane ; Peripheral membrane protein
- Virion membrane ; Peripheral membrane protein Curated Note: The C-terminus membrane anchor of Erns represents an amphipathic helix embedded in plane into the membrane.Curated
- Host cell surface By similarity
- Virion membrane By similarity
- Host membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
- Host cytoplasm By similarity
- Host cytoplasm By similarity
- Host cytoplasm By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1144 – 1164 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1189 – 1209 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1217 – 1237 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1247 – 1267 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1281 – 1301 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1360 – 1380 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1568 – 1588 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Host cytoplasm, Host membrane, Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000450892 | 1 – 3898 | Genome polyproteinAdd BLAST | 3898 | |
ChainiPRO_0000038037 | 1 – 168 | N-terminal proteaseBy similarityAdd BLAST | 168 | |
ChainiPRO_0000038038 | 169 – 270 | Capsid protein CBy similarityAdd BLAST | 102 | |
ChainiPRO_0000038039 | 271 – 497 | E(rns) glycoproteinBy similarityAdd BLAST | 227 | |
ChainiPRO_0000038040 | 498 – 659 | Envelope glycoprotein E1By similarityAdd BLAST | 162 | |
ChainiPRO_0000038041 | 660 – 1066 | Envelope glycoprotein E2By similarityAdd BLAST | 407 | |
ChainiPRO_0000038042 | 1067 – 1136 | Viroporin p7By similarityAdd BLAST | 70 | |
ChainiPRO_0000038043 | 1137 – 2272 | Non-structural protein 2-3By similarityAdd BLAST | 1136 | |
ChainiPRO_0000038044 | 1137 – 1589 | Cysteine protease NS2PROSITE-ProRule annotationAdd BLAST | 453 | |
ChainiPRO_0000038045 | 1590 – 2272 | Serine protease NS3By similarityAdd BLAST | 683 | |
ChainiPRO_0000038046 | 2273 – 2336 | Non-structural protein 4ABy similarityAdd BLAST | 64 | |
ChainiPRO_0000038047 | 2337 – 2683 | Non-structural protein 4BBy similarityAdd BLAST | 347 | |
ChainiPRO_0000038048 | 2684 – 3179 | Non-structural protein 5ABy similarityAdd BLAST | 496 | |
ChainiPRO_0000038049 | 3180 – 3898 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 719 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 272 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 281 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 335 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 365 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 370 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 413 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 487 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 597 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 809 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 878 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 922 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 990 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1357 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1419 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1451 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1713 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2134 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2217 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2494 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2682 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2751 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2891 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2988 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3688 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3777 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3793 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 168 – 169 | Cleavage; by autolysisPROSITE-ProRule annotation | 2 | |
Sitei | 270 – 271 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 497 – 498 | CleavageBy similarity | 2 | |
Sitei | 659 – 660 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 1066 – 1067 | Cleavage; by host signal peptidase; partialBy similarity | 2 | |
Sitei | 1136 – 1137 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 1589 – 1590 | Cleavage; partial; cysteine protease NS2PROSITE-ProRule annotation | 2 | |
Sitei | 2272 – 2273 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 2336 – 2337 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 2683 – 2684 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 3179 – 3180 | Cleavage; by serine protease NS3By similarity | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q01499 |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity). Heterodimer with E1; disulfide-linked (By similarity).
By similarityHomodimer; disulfide-linked (By similarity). Heterodimer with E1; disulfide-linked (By similarity).
By similarityStructurei
Secondary structure
3D structure databases
SMRi | Q01499 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 168 | Peptidase C53PROSITE-ProRule annotationAdd BLAST | 168 | |
Domaini | 1441 – 1589 | Peptidase C74PROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 1590 – 1763 | Peptidase S31PROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 1802 – 1960 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 159 | |
Domaini | 1978 – 2143 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 3518 – 3641 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 72 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 172 – 209 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 223 – 245 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 172 – 208 | Basic and acidic residuesSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.30.140.40, 1 hit 2.60.320.20, 1 hit 2.60.40.3000, 1 hit 2.60.40.4200, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 2 hits 3.90.730.10, 1 hit |
InterProi | View protein in InterPro IPR021824, Capsid-C_pestivirus IPR011492, DEAD_Flavivir IPR043502, DNA/RNA_pol_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR022120, NS2 IPR030399, NS2_C74 IPR027417, P-loop_NTPase IPR008751, Peptidase_C53 IPR042542, Peptidase_C53_interaction IPR032521, Pestivirus_E2 IPR042309, Pestivirus_E2_A IPR042310, Pestivirus_E2_B IPR042311, Pestivirus_E2_D IPR000280, Pestivirus_NS3_S31 IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV IPR036430, RNase_T2-like_sf IPR033130, RNase_T2_His_AS_2 |
Pfami | View protein in Pfam PF11889, DUF3409, 1 hit PF07652, Flavi_DEAD, 1 hit PF00271, Helicase_C, 1 hit PF05550, Peptidase_C53, 1 hit PF12387, Peptidase_C74, 1 hit PF05578, Peptidase_S31, 1 hit PF16329, Pestivirus_E2, 1 hit PF00998, RdRP_3, 1 hit |
PRINTSi | PR00729, CDVENDOPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55895, SSF55895, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51692, PESTIVIRUS_NS2_PRO, 1 hit PS51535, PESTIVIRUS_NS3PRO, 1 hit PS51876, PV_NPRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS00531, RNASE_T2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MELITNELLY KTYKQKPVGV EEPVYDQAGN PLFGERGAIH PQSTLKLPHK
60 70 80 90 100
RGERNVPTSL ASLPKRGDCR SGNSKGPVSG IYLKPGPLFY QDYKGPVYHR
110 120 130 140 150
APLELFEEGS MCETTKRIGR VTGSDGKLYH IYICIDGCIT VKSATRSHQR
160 170 180 190 200
VLRWVHNRLD CPLWVTSCSD TKEEGATKKK QQKPDRLEKG RMKIVPKESE
210 220 230 240 250
KDSKTKPPDA TIVVDGVKYQ VKKKGKVKSK NTQDGLYHNK NKPPESRKKL
260 270 280 290 300
EKALLAWAIL AVVLIEVTMG ENITQWNLQD NGTEGIQRAM FQRGVNRSLH
310 320 330 340 350
GIWPEKICTG VPSHLATDVE LKTIHGMMDA SEKTNYTCCR LQRHEWNKHG
360 370 380 390 400
WCNWYNIEPW ILIMNRTQAN LTEGQPPREC AVTCRYDRDS DLNVVTQARD
410 420 430 440 450
SPTPLTGCKK GKNFSFAGVL TRGPCNFEIA ASDVLFKEHE CTGVFQDTAH
460 470 480 490 500
YLVDGVTNSL ESARQGTAKL TTWLGKQLGI LGKKLENKSK TWFGAYAASP
510 520 530 540 550
YCDVDRKIGY IWFTKNCTPA CLPKNTKIIG PGKFDTNAED GKILHEMGGH
560 570 580 590 600
LSEVLLLSLV VLSDFAPETA SAMYLILHFS IPQSHVDITD CDKTQLNLTI
610 620 630 640 650
ELTTADVIPG SVWNLGKYVC IRPDWWPYET AAVLAFEEVG QVVKIVLRAL
660 670 680 690 700
RDLTRIWNAA TTTAFLVCLI KMVRGQVVQG ILWLLLITGV QGHLDCKPEY
710 720 730 740 750
SYAIAKNDRV GPLGAEGLTT VWKDYSHEMK LEDTMVIAWC KGGKFTYLSR
760 770 780 790 800
CTRETRYLAI LHSRALPTSV VFKKLFEGQK QEDTVEMDDD FEFGLCPCDA
810 820 830 840 850
KPIVRGKFNT TLLNGPAFQM VCPIGWTGTV SCMLANRDTL DTAVVRTYRR
860 870 880 890 900
SVPFPYRQGC ITQKTLGEDL YDCALGGNWT CVTGDQSRYT GGLIESCKWC
910 920 930 940 950
GYKFQKSEGL PHYPIGKCRL NNETGYRLVD DTSCDREGVA IVPHGLVKCK
960 970 980 990 1000
IGDTTVQVIA TDTKLGPMPC KPHEIISSEG PIEKTACTFN YTRTLKNKYF
1010 1020 1030 1040 1050
EPRDSYFQQY MLKGDYQYWF DLEVTDHHRD YFAESILVVV VALLGGRYVL
1060 1070 1080 1090 1100
WLLVTYMVLS EQKASGAQYG AGEVVMMGNL LTHDNVEVVT YFFLLYLLLR
1110 1120 1130 1140 1150
EESVKKWVLL LYHILVAHPL KSVIVILLMI GDVVKADPGG QGYLGQIDVC
1160 1170 1180 1190 1200
FTMVVIIIIG LIIARRDPTI VPLITIVASL RVTGLTYSPG VDAAMAVITI
1210 1220 1230 1240 1250
TLLMVSYVTD YFRYKRWLQC ILSLVSGVFL IRCLIHLGRI ETPEVTIPNW
1260 1270 1280 1290 1300
RPLTLILFYL ISTTVVTMWK IDLAGLLLQG VPILLLITTL WADFLTLILI
1310 1320 1330 1340 1350
LPTYELVKLY YLKTIKTDIE KSWLGGLDYK RVDSIYDVDE SGEGVYLFPS
1360 1370 1380 1390 1400
RQKAQKNFSM LLPLVRATLI SCVSSKWQLI YMAYLSVDFM YYMHRKVIEE
1410 1420 1430 1440 1450
ISGGTNMISR IVAALIELNW SMEEEESKGL KKFYLLSGRL RNLIIKHKVR
1460 1470 1480 1490 1500
NETVAGWYGE EEVYGMPKIM TIIKASTLNK NKHCIICTVC EGRKWKGGTC
1510 1520 1530 1540 1550
PKCGRHGKPI TCGMSLADFE ERHYKRIFIR EGNFEGPFRQ EYNGFIQYTA
1560 1570 1580 1590 1600
RGQLFLRNLP ILATKVKMLM VGNLGEEVGD LEHLGWILRG PAVCKKITEH
1610 1620 1630 1640 1650
ERCHINILDK LTAFFGIMPR GTTPRAPVRF PTSLLKVRRG LETGWAYTHQ
1660 1670 1680 1690 1700
GGISSVDHVT AGKDLLVCDS MGRTRVVCQS NNKLTDETEY GVKTDSGCPD
1710 1720 1730 1740 1750
GARCYVLNPE AVNISGSKGA VVHLQKTGGE FTCVTASGTP AFFDLKNLKG
1760 1770 1780 1790 1800
WSGLPIFEAS SGRVVGRVKV GKNEESKPTK IMSGIQTVSK NTADLTEMVK
1810 1820 1830 1840 1850
KITSMNRGDF KQITLATGAG KTTELPKAVI EEIGRHKRVL VLIPLRAAAE
1860 1870 1880 1890 1900
SVYQYMRLKH PSISFNLRIG DMKEGDMATG ITYASYGYFC QMPQPKLRAA
1910 1920 1930 1940 1950
MVEYSYIFLD EYHCATPEQL AIIGKIHRFS ESIRVVAMTA TPAGSVTTTG
1960 1970 1980 1990 2000
QKHPIEEFIA PEVMEGEDLG SQFLDIAGLK IPVDEMKGNM LVFVPTRNMA
2010 2020 2030 2040 2050
VEVAKKLKAK GYNSGYYYSG EDPANLRVVT SQSPYVIVAT NAIESGVTLP
2060 2070 2080 2090 2100
DLDTVVDTGL KCEKRVRVSS KIPFIVTGLK RMAVTVGEQA QRRGRVGRVK
2110 2120 2130 2140 2150
PGRYYRSQET ATGSKDYHYD LLQAQRYGIE DGINVTKSFR EMNYDWSLYE
2160 2170 2180 2190 2200
EDSLLITQLE ILNNLLISED LPAAVKNIMA RTDHPEPIQL AYNSYEVQVP
2210 2220 2230 2240 2250
VLFPKIRNGE VTDTYENYSF LNARKLGEDV PVYIYATEDE DLAVDLLGLD
2260 2270 2280 2290 2300
WPDPGNQQVV ETGKALKQVA GLSSAENALL VALFGYVGYQ ALSKRHVPMI
2310 2320 2330 2340 2350
TDIYTIEDQR LEDTTHLQYA PNAIKTEGTE TELKELASGD VEKIMGAISD
2360 2370 2380 2390 2400
YAAGGLDFVK SQAEKIKTAP LFKENVEAAR GYVQKLIDSL IEDKDVIIRY
2410 2420 2430 2440 2450
GLWGTHTALY KSIAARLGHE TAFATLVLKW LAFGGETVSD HIRQAAVDLV
2460 2470 2480 2490 2500
VYYVMNKPSF PGDTETQQEG RRFVASLFIS ALATYTYKTW NYNNLSKVVE
2510 2520 2530 2540 2550
PALAYLPYAT SALKMFTPTR LESVVILSTT IYKTYLSIRK GKSDGLLGTG
2560 2570 2580 2590 2600
ISAAMEILSQ NPVSVGISVM LGVGAIAAHN AIESSEQKRT LLMKVFVKNF
2610 2620 2630 2640 2650
LDQAATDELV KENPEKIIMA LFEAVQTIGN PLRLIYHLYG VYYKGWEAKE
2660 2670 2680 2690 2700
LSERTAGRNL FTLIMFEAFE LLGMDSEGKI RNLSGNYILD LIHGLHKQIN
2710 2720 2730 2740 2750
RGLKKIVLGW APAPFSCDWT PSDERIRLPT DSYLRVETKC PCGYEMKALK
2760 2770 2780 2790 2800
NVSGKLTKVE ESGPFLCRNR PGRGPVNYRV TKYYDDNLRE IRPVAKLEGQ
2810 2820 2830 2840 2850
VEHYYKGVTA RIDYSKGKTL LATDKWEVEH GTLTRLTKRY TGVGFRGAYL
2860 2870 2880 2890 2900
GDEPNHRDLV ERDCATITKN TVQFLKMKKG CAFTYDLTIS NLTRLIELVH
2910 2920 2930 2940 2950
RNNLEEKEIP TATVTTWLAY TFVNEDVGTI KPVLGERVIP DPVVDINLQP
2960 2970 2980 2990 3000
EVQVDTSEVG ITIIGKEAVM TTGVTPVMEK VEPDTDNNQS SVKIGLDEGN
3010 3020 3030 3040 3050
YPGPGVQTHT LVEEIHNKDA RPFIMVLGSK SSMSNRAKTA RNINLYTGND
3060 3070 3080 3090 3100
PREIRDLMAE GRILVVALRD IDPDLSELVD FKGTFLDREA LEALSLGQPK
3110 3120 3130 3140 3150
PKQVTKAAIR DLLKEERQVE IPDWFTSDDP VFLDIAMKKD KYHLIGDVVE
3160 3170 3180 3190 3200
VKDQAKALGA TDQTRIVKEV GSRTYTMKLS SWFLQASSKQ MSLTPLFEEL
3210 3220 3230 3240 3250
LLRCPPATKS NKGHMASAYQ LAQGNWEPLG CGVHLGTVPA RRVKMHPYEA
3260 3270 3280 3290 3300
YLKLKDLVEE EEKKPRIRDT VIREHNKWIL KKIKFQGNLN TKKMLNPGKL
3310 3320 3330 3340 3350
SEQLDREGHK RNIYNNQIST VMSSAGIRLE KLPIVRAQTD TKSFHEAIRD
3360 3370 3380 3390 3400
KIDKNENRQN PELHNKLLEI FHTIADPSLK HTYGEVTWEQ LEAGINRKGA
3410 3420 3430 3440 3450
AGFLEKKNIG EVLDSEKHLV EQLVRDLKAG RKIRYYETAI PKNEKRDVSD
3460 3470 3480 3490 3500
DWQAGDLVDE KKPRVIQYPE AKTRLAITKV MYNWVKQQPV VIPGYEGKTP
3510 3520 3530 3540 3550
LFNIFNKVRK EWDLFNEPVA VSFDTKAWDT QVTSRDLHLI GEIQKYYYRK
3560 3570 3580 3590 3600
EWHKFIDTIT DHMVEVPVIT ADGEVYIRNG QRGSGQPDTS AGNSMLNVLT
3610 3620 3630 3640 3650
MIYAFCESTG VPYKSFNRVA KIHVCGDDGF LITEKGLGLK FSNKGMQILH
3660 3670 3680 3690 3700
EAGKPQKLTE GEKMKVAYKF EDIEFCSHTP VPVRWSDNTS SYMAGRDTAV
3710 3720 3730 3740 3750
ILSKMATRLD SSGERGTTAY EKAVAFSFLL MYSWNPLVRR ICLLVLSQRP
3760 3770 3780 3790 3800
ETAPSTQTTY YYKGDPIGAY KDVIGRNLSE LKRTGFEKLA NLNLSLSTLG
3810 3820 3830 3840 3850
IWTKHTSKRI IQDCVAIGKE EGNWLVNADR LISSKTGHLY IPDKGFTLQG
3860 3870 3880 3890
KHYEQLQLGA ETNPVMGVGT ERYKLGPIVN LLLRRLKVLL MAAVGASS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96751 Genomic RNA Translation: AAA42860.1 |
PIRi | A44217 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96751 Genomic RNA Translation: AAA42860.1 |
PIRi | A44217 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YQ2 | X-ray | 2.58 | A/B | 696-1026 | [»] | |
2YQ3 | X-ray | 3.29 | A/B | 696-1026 | [»] | |
SMRi | Q01499 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MEROPSi | S31.001 |
Proteomic databases
PRIDEi | Q01499 |
Enzyme and pathway databases
BRENDAi | 3.4.21.113, 925 |
Family and domain databases
Gene3Di | 2.30.140.40, 1 hit 2.60.320.20, 1 hit 2.60.40.3000, 1 hit 2.60.40.4200, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 2 hits 3.90.730.10, 1 hit |
InterProi | View protein in InterPro IPR021824, Capsid-C_pestivirus IPR011492, DEAD_Flavivir IPR043502, DNA/RNA_pol_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR022120, NS2 IPR030399, NS2_C74 IPR027417, P-loop_NTPase IPR008751, Peptidase_C53 IPR042542, Peptidase_C53_interaction IPR032521, Pestivirus_E2 IPR042309, Pestivirus_E2_A IPR042310, Pestivirus_E2_B IPR042311, Pestivirus_E2_D IPR000280, Pestivirus_NS3_S31 IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV IPR036430, RNase_T2-like_sf IPR033130, RNase_T2_His_AS_2 |
Pfami | View protein in Pfam PF11889, DUF3409, 1 hit PF07652, Flavi_DEAD, 1 hit PF00271, Helicase_C, 1 hit PF05550, Peptidase_C53, 1 hit PF12387, Peptidase_C74, 1 hit PF05578, Peptidase_S31, 1 hit PF16329, Pestivirus_E2, 1 hit PF00998, RdRP_3, 1 hit |
PRINTSi | PR00729, CDVENDOPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55895, SSF55895, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51692, PESTIVIRUS_NS2_PRO, 1 hit PS51535, PESTIVIRUS_NS3PRO, 1 hit PS51876, PV_NPRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS00531, RNASE_T2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | POLG_BVDVS | |
Accessioni | Q01499Primary (citable) accession number: Q01499 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families