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Entry version 202 (13 Feb 2019)
Sequence version 4 (16 May 2012)
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Protein

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-6807878 COPI-mediated anterograde transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.28.1.1 the ankyrin (ankyrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin-2
Short name:
ANK-2
Alternative name(s):
Ankyrin-B
Brain ankyrin
Non-erythroid ankyrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2
Synonyms:ANKB1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145362.17

Human Gene Nomenclature Database

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HGNCi
HGNC:493 ANK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
106410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01484

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane, Mitochondrion, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Long QT syndrome 4 (LQT4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Long QT syndrome type 4 shows many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves and atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes and prolonged QT interval on EKG is not a consistent feature.
See also OMIM:600919
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0229341458E → G in LQT4; unknown pathological significance; abnormal calcium ion homeostasis, when tested in a heterologous system. 3 PublicationsCorresponds to variant dbSNP:rs72544141EnsemblClinVar.1
Natural variantiVAR_0229353740L → I in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs35530544EnsemblClinVar.1
Natural variantiVAR_0229363744T → N in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs121912705EnsemblClinVar.1
Natural variantiVAR_0229373906R → W in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs121912706EnsemblClinVar.1
Natural variantiVAR_0229383931E → K in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs45454496EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi975 – 977DAR → AAA: Prevents binding to SPTBN1. 1 Publication3
Mutagenesisi1000A → P: Prevents binding to SPTBN1. 1 Publication1
Mutagenesisi1100 – 1103ENGD → AAGA: Weak binding to SPTBN1. 1 Publication4

Keywords - Diseasei

Disease mutation, Long QT syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
287

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ANK2

MalaCards human disease database

More...
MalaCardsi
ANK2
MIMi600919 phenotype

Open Targets

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OpenTargetsi
ENSG00000145362

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
101016 Romano-Ward syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24799

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
387912917

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668851 – 3957Ankyrin-2Add BLAST3957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei378PhosphotyrosineBy similarity1
Modified residuei531PhosphotyrosineBy similarity1
Modified residuei846PhosphoserineCombined sources1
Modified residuei853PhosphothreonineBy similarity1
Modified residuei874PhosphoserineBy similarity1
Modified residuei1382PhosphotyrosineBy similarity1
Modified residuei1459PhosphoserineBy similarity1
Modified residuei1461PhosphoserineBy similarity1
Modified residuei1473PhosphoserineBy similarity1
Modified residuei1500PhosphoserineBy similarity1
Modified residuei1596PhosphoserineBy similarity1
Modified residuei1732PhosphoserineBy similarity1
Modified residuei1733PhosphoserineBy similarity1
Modified residuei1736PhosphoserineBy similarity1
Modified residuei1855PhosphoserineBy similarity1
Modified residuei1858PhosphoserineBy similarity1
Modified residuei1929PhosphoserineBy similarity1
Modified residuei2127PhosphoserineBy similarity1
Modified residuei2239PhosphothreonineBy similarity1
Modified residuei2243PhosphoserineBy similarity1
Modified residuei2269PhosphothreonineBy similarity1
Modified residuei2275PhosphoserineBy similarity1
Modified residuei2405PhosphoserineBy similarity1
Modified residuei2440PhosphoserineBy similarity1
Modified residuei2454PhosphoserineBy similarity1
Modified residuei2516PhosphoserineBy similarity1
Modified residuei2521PhosphoserineBy similarity1
Modified residuei2583PhosphothreonineBy similarity1
Modified residuei2679PhosphoserineBy similarity1
Modified residuei2701PhosphoserineBy similarity1
Modified residuei2781PhosphoserineBy similarity1
Modified residuei2795PhosphoserineBy similarity1
Modified residuei2956PhosphoserineBy similarity1
Modified residuei3075PhosphoserineBy similarity1
Modified residuei3078PhosphothreonineBy similarity1
Modified residuei3273PhosphoserineBy similarity1
Modified residuei3276PhosphoserineBy similarity1
Modified residuei3277PhosphoserineBy similarity1
Modified residuei3390PhosphoserineBy similarity1
Modified residuei3409PhosphoserineBy similarity1
Modified residuei3474PhosphoserineBy similarity1
Modified residuei3735PhosphoserineBy similarity1
Modified residuei3776PhosphothreonineBy similarity1
Modified residuei3797PhosphothreonineBy similarity1
Modified residuei3803PhosphothreonineBy similarity1
Modified residuei3814PhosphothreonineBy similarity1
Modified residuei3823PhosphoserineBy similarity1
Modified residuei3909PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q01484

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q01484

MaxQB - The MaxQuant DataBase

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MaxQBi
Q01484

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q01484

PeptideAtlas

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PeptideAtlasi
Q01484

PRoteomics IDEntifications database

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PRIDEi
Q01484

ProteomicsDB human proteome resource

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ProteomicsDBi
57958
57959 [Q01484-2]
57960 [Q01484-5]
57961 [Q01484-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q01484

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q01484

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q01484

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145362 Expressed in 231 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01484 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q01484 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015178
HPA008007
HPA035970

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHBG and SPTBN1 (PubMed:15262991, PubMed:15611082). Colocalizes with Na/K ATPase, Na/Ca exchanger and SPTBN1 (PubMed:19007774). Directly interacts with DMD; this interaction is necessary for DMD localization at the sarcolemma. Interacts with DCTN4; this interaction is required for DCTN4 retention at costameres. Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts (via death domain) with RABGAP1L (via Rab-GAP TBC domain) (PubMed:27718357).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106784, 22 interactors

Database of interacting proteins

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DIPi
DIP-37425N

Protein interaction database and analysis system

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IntActi
Q01484, 28 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000349588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13957
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8OX-ray2.20A966-1039[»]
A1073-1476[»]
A3562-3653[»]
4RLVX-ray3.49A28-873[»]
4RLYX-ray2.50A28-318[»]
5Y4DX-ray3.30A28-693[»]
5Y4EX-ray2.34A/B264-483[»]
A/B857-896[»]
5Y4FX-ray1.95A/B430-873[»]
5YIRX-ray2.75C/G/H1588-1614[»]
5YISX-ray2.20C/D1588-1614[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q01484

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01484

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati30 – 62ANK 1Add BLAST33
Repeati63 – 92ANK 2Add BLAST30
Repeati96 – 125ANK 3Add BLAST30
Repeati129 – 158ANK 4Add BLAST30
Repeati162 – 191ANK 5Add BLAST30
Repeati193 – 220ANK 6Add BLAST28
Repeati232 – 261ANK 7Add BLAST30
Repeati265 – 294ANK 8Add BLAST30
Repeati298 – 327ANK 9Add BLAST30
Repeati331 – 360ANK 10Add BLAST30
Repeati364 – 393ANK 11Add BLAST30
Repeati397 – 426ANK 12Add BLAST30
Repeati430 – 459ANK 13Add BLAST30
Repeati463 – 492ANK 14Add BLAST30
Repeati496 – 525ANK 15Add BLAST30
Repeati529 – 558ANK 16Add BLAST30
Repeati562 – 591ANK 17Add BLAST30
Repeati595 – 624ANK 18Add BLAST30
Repeati628 – 657ANK 19Add BLAST30
Repeati661 – 690ANK 20Add BLAST30
Repeati694 – 723ANK 21Add BLAST30
Repeati727 – 756ANK 22Add BLAST30
Repeati760 – 789ANK 23Add BLAST30
Repeati793 – 822ANK 24Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini968 – 1156ZU5 1PROSITE-ProRule annotationAdd BLAST189
Domaini1158 – 1304ZU5 2PROSITE-ProRule annotationAdd BLAST147
Domaini1450 – 1535Death 1PROSITE-ProRule annotationAdd BLAST86
Repeati1806 – 1817Repeat AAdd BLAST12
Repeati1818 – 1829Repeat AAdd BLAST12
Repeati1830 – 1841Repeat AAdd BLAST12
Repeati1842 – 1853Repeat AAdd BLAST12
Repeati1854 – 1865Repeat AAdd BLAST12
Repeati1866 – 1877Repeat AAdd BLAST12
Repeati1878 – 1889Repeat AAdd BLAST12
Repeati1890 – 1900Repeat A; approximateAdd BLAST11
Repeati1901 – 1912Repeat AAdd BLAST12
Repeati1913 – 1924Repeat AAdd BLAST12
Repeati1925 – 1935Repeat A; approximateAdd BLAST11
Repeati1936 – 1947Repeat AAdd BLAST12
Repeati1948 – 1959Repeat AAdd BLAST12
Repeati1960 – 1971Repeat AAdd BLAST12
Repeati1972 – 1983Repeat AAdd BLAST12
Domaini3569 – 3653Death 2PROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni966 – 1125Interaction with SPTBN11 PublicationAdd BLAST160
Regioni1289 – 1423UPA domainAdd BLAST135
Regioni1806 – 1983Repeat-rich regionAdd BLAST178

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin.1 Publication

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000169277

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG100442

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q01484

KEGG Orthology (KO)

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KOi
K10380

Database of Orthologous Groups

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OrthoDBi
1011028at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q01484

TreeFam database of animal gene trees

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TreeFami
TF351263

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q01484-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY
60 70 80 90 100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA
110 120 130 140 150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL
160 170 180 190 200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA
210 220 230 240 250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT
260 270 280 290 300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
310 320 330 340 350
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH
360 370 380 390 400
LLQHKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT
410 420 430 440 450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL
460 470 480 490 500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP
510 520 530 540 550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL
560 570 580 590 600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL
610 620 630 640 650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN
660 670 680 690 700
YGAETNIVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH
710 720 730 740 750
LAAQEDKVNV ADILTKHGAD QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ
760 770 780 790 800
GANVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI
810 820 830 840 850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG
860 870 880 890 900
DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR
910 920 930 940 950
SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG
960 970 980 990 1000
TENLDNVALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA
1010 1020 1030 1040 1050
PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGKLHLPTAP
1060 1070 1080 1090 1100
PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFAALRGK ERELVVLRSE
1110 1120 1130 1140 1150
NGDSWKEHFC DYTEDELNEI LNGMDEVLDS PEDLEKKRIC RIITRDFPQY
1160 1170 1180 1190 1200
FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP
1210 1220 1230 1240 1250
MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG
1260 1270 1280 1290 1300
FGGDAPTLRL LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW
1310 1320 1330 1340 1350
LIDCRQIQES VTFASQVYRE IICVPYMAKF VVFAKSHDPI EARLRCFCMT
1360 1370 1380 1390 1400
DDKVDKTLEQ QENFAEVARS RDVEVLEGKP IYVDCFGNLV PLTKSGQHHI
1410 1420 1430 1440 1450
FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL VHQAICNLNI
1460 1470 1480 1490 1500
TLPIYTKESE SDQEQEEEID MTSEKNDETE STETSVLKSH LVNEVPVLAS
1510 1520 1530 1540 1550
PDLLSEVSEM KQDLIKMTAI LTTDVSDKAG SIKVKELVKA AEEEPGEPFE
1560 1570 1580 1590 1600
IVERVKEDLE KVNEILRSGT CTRDESSVQS SRSERGLVEE EWVIVSDEEI
1610 1620 1630 1640 1650
EEARQKAPLE ITEYPCVEVR IDKEIKGKVE KDSTGLVNYL TDDLNTCVPL
1660 1670 1680 1690 1700
PKEQLQTVQD KAGKKCEALA VGRSSEKEGK DIPPDETQST QKQHKPSLGI
1710 1720 1730 1740 1750
KKPVRRKLKE KQKQKEEGLQ ASAEKAELKK GSSEESLGED PGLAPEPLPT
1760 1770 1780 1790 1800
VKATSPLIEE TPIGSIKDKV KALQKRVEDE QKGRSKLPIR VKGKEDVPKK
1810 1820 1830 1840 1850
TTHRPHPAAS PSLKSERHAP GSPSPKTERH STLSSSAKTE RHPPVSPSSK
1860 1870 1880 1890 1900
TEKHSPVSPS AKTERHSPAS SSSKTEKHSP VSPSTKTERH SPVSSTKTER
1910 1920 1930 1940 1950
HPPVSPSGKT DKRPPVSPSG RTEKHPPVSP GRTEKRLPVS PSGRTDKHQP
1960 1970 1980 1990 2000
VSTAGKTEKH LPVSPSGKTE KQPPVSPTSK TERIEETMSV RELMKAFQSG
2010 2020 2030 2040 2050
QDPSKHKTGL FEHKSAKQKQ PQEKGKVRVE KEKGPILTQR EAQKTENQTI
2060 2070 2080 2090 2100
KRGQRLPVTG TAESKRGVRV SSIGVKKEDA AGGKEKVLSH KIPEPVQSVP
2110 2120 2130 2140 2150
EEESHRESEV PKEKMADEQG DMDLQISPDR KTSTDFSEVI KQELEDNDKY
2160 2170 2180 2190 2200
QQFRLSEETE KAQLHLDQVL TSPFNTTFPL DYMKDEFLPA LSLQSGALDG
2210 2220 2230 2240 2250
SSESLKNEGV AGSPCGSLME GTPQISSEES YKHEGLAETP ETSPESLSFS
2260 2270 2280 2290 2300
PKKSEEQTGE TKESTKTETT TEIRSEKEHP TTKDITGGSE ERGATVTEDS
2310 2320 2330 2340 2350
ETSTESFQKE ATLGSPKDTS PKRQDDCTGS CSVALAKETP TGLTEEAACD
2360 2370 2380 2390 2400
EGQRTFGSSA HKTQTDSEVQ ESTATSDETK ALPLPEASVK TDTGTESKPQ
2410 2420 2430 2440 2450
GVIRSPQGLE LALPSRDSEV LSAVADDSLA VSHKDSLEAS PVLEDNSSHK
2460 2470 2480 2490 2500
TPDSLEPSPL KESPCRDSLE SSPVEPKMKA GIFPSHFPLP AAVAKTELLT
2510 2520 2530 2540 2550
EVASVRSRLL RDPDGSAEDD SLEQTSLMES SGKSPLSPDT PSSEEVSYEV
2560 2570 2580 2590 2600
TPKTTDVSTP KPAVIHECAE EDDSENGEKK RFTPEEEMFK MVTKIKMFDE
2610 2620 2630 2640 2650
LEQEAKQKRD YKKEPKQEES SSSSDPDADC SVDVDEPKHT GSGEDESGVP
2660 2670 2680 2690 2700
VLVTSESRKV SSSSESEPEL AQLKKGADSG LLPEPVIRVQ PPSPLPSSMD
2710 2720 2730 2740 2750
SNSSPEEVQF QPVVSKQYTF KMNEDTQEEP GKSEEEKDSE SHLAEDRHAV
2760 2770 2780 2790 2800
STEAEDRSYD KLNRDTDQPK ICDGHGCEAM SPSSSAAPVS SGLQSPTGDD
2810 2820 2830 2840 2850
VDEQPVIYKE SLALQGTHEK DTEGEELDVS RAESPQADCP SESFSSSSSL
2860 2870 2880 2890 2900
PHCLVSEGKE LDEDISATSS IQKTEVTKTD ETFENLPKDC PSQDSSITTQ
2910 2920 2930 2940 2950
TDRFSMDVPV SDLAENDEIY DPQITSPYEN VPSQSFFSSE ESKTQTDANH
2960 2970 2980 2990 3000
TTSFHSSEVY SVTITSPVED VVVASSSSGT VLSKESNFEG QDIKMESQQE
3010 3020 3030 3040 3050
STLWEMQSDS VSSSFEPTMS ATTTVVGEQI SKVIITKTDV DSDSWSEIRE
3060 3070 3080 3090 3100
DDEAFEARVK EEEQKIFGLM VDRQSQGTTP DTTPARTPTE EGTPTSEQNP
3110 3120 3130 3140 3150
FLFQEGKLFE MTRSGAIDMT KRSYADESFH FFQIGQESRE ETLSEDVKEG
3160 3170 3180 3190 3200
ATGADPLPLE TSAESLALSE SKETVDDEAD LLPDDVSEEV EEIPASDAQL
3210 3220 3230 3240 3250
NSQMGISAST ETPTKEAVSV GTKDLPTVQT GDIPPLSGVK QISCPDSSEP
3260 3270 3280 3290 3300
AVQVQLDFST LTRSVYSDRG DDSPDSSPEE QKSVIEIPTA PMENVPFTES
3310 3320 3330 3340 3350
KSKIPVRTMP TSTPAPPSAE YESSVSEDFL SSVDEENKAD EAKPKSKLPV
3360 3370 3380 3390 3400
KVPLQRVEQQ LSDLDTSVQK TVAPQGQDMA SIAPDNRSKS ESDASSLDSK
3410 3420 3430 3440 3450
TKCPVKTRSY TETETESRER AEELELESEE GATRPKILTS RLPVKSRSTT
3460 3470 3480 3490 3500
SSCRGGTSPT KESKEHFFDL YRNSIEFFEE ISDEASKLVD RLTQSEREQE
3510 3520 3530 3540 3550
IVSDDESSSA LEVSVIENLP PVETEHSVPE DIFDTRPIWD ESIETLIERI
3560 3570 3580 3590 3600
PDENGHDHAE DPQDEQERIE ERLAYIADHL GFSWTELARE LDFTEEQIHQ
3610 3620 3630 3640 3650
IRIENPNSLQ DQSHALLKYW LERDGKHATD TNLVECLTKI NRMDIVHLME
3660 3670 3680 3690 3700
TNTEPLQERI SHSYAEIEQT ITLDHSEGFS VLQEELCTAQ HKQKEEQAVS
3710 3720 3730 3740 3750
KESETCDHPP IVSEEDISVG YSTFQDGVPK TEGDSSATAL FPQTHKEQVQ
3760 3770 3780 3790 3800
QDFSGKMQDL PEESSLEYQQ EYFVTTPGTE TSETQKAMIV PSSPSKTPEE
3810 3820 3830 3840 3850
VSTPAEEEKL YLQTPTSSER GGSPIIQEPE EPSEHREESS PRKTSLVIVE
3860 3870 3880 3890 3900
SADNQPETCE RLDEDAAFEK GDDMPEIPPE TVTEEEYIDE HGHTVVKKVT
3910 3920 3930 3940 3950
RKIIRRYVSS EGTEKEEIMV QGMPQEPVNI EEGDGYSKVI KRVVLKSDTE

QSEDNNE
Length:3,957
Mass (Da):433,715
Last modified:May 16, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41C1A240CC5A3B72
GO
Isoform 2 (identifier: Q01484-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1477-3561: Missing.

Show »
Length:1,872
Mass (Da):205,795
Checksum:i425D5422CF5CE930
GO
Isoform 4 (identifier: Q01484-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MMNEDAAQKSDSGEKFNGSSQRRKRPK → MTTMLQ
     967-967: G → GRASPCLERDNSS
     1477-3561: Missing.

Note: No experimental confirmation available.
Show »
Length:1,863
Mass (Da):204,752
Checksum:i4E2B2DB97E1DDC0A
GO
Isoform 5 (identifier: Q01484-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1348: Missing.
     1477-3561: Missing.
     3870-3870: K → KELTEELGELEASSDEEAMVTTRVVRRRVIIQ

Show »
Length:555
Mass (Da):63,361
Checksum:iC0C03881D8E0EFD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8Y2H0Y8Y2_HUMAN
Ankyrin-2
ANK2
1,028Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCH6E9PCH6_HUMAN
Ankyrin-2
ANK2
1,048Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y931H0Y931_HUMAN
Ankyrin-2
ANK2
966Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9U4D6R9U4_HUMAN
Ankyrin-2
ANK2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z651B7Z651_HUMAN
cDNA FLJ61595, highly similar to An...
ANK2
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
1,611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHW9E9PHW9_HUMAN
Ankyrin-2
ANK2
1,730Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIY9D6RIY9_HUMAN
Ankyrin-2
ANK2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHC5D6RHC5_HUMAN
Ankyrin-2
ANK2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI25237 differs from that shown. Reason: Frameshift at position 1405.Curated
The sequence CAB42644 differs from that shown. CDS lacks C-terminal region which is nevertheless present in the underlying cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220V → I in CAD97827 (PubMed:17974005).Curated1
Sequence conflicti475 – 476GQ → PE in AAA62828 (PubMed:1833308).Curated2
Sequence conflicti2787A → R in CAB42644 (PubMed:8253844).Curated1
Sequence conflicti2999Q → L in CAB42644 (PubMed:8253844).Curated1
Sequence conflicti3140 – 3141EE → RY in AC093879 (PubMed:15815621).Curated2
Sequence conflicti3185D → S in CAB42644 (PubMed:8253844).Curated1
Sequence conflicti3699V → A in CAD97827 (PubMed:17974005).Curated1
Sequence conflicti3737A → S in CAA40279 (PubMed:1830053).Curated1
Sequence conflicti3737A → S in CAB42644 (PubMed:8253844).Curated1
Sequence conflicti3955 – 3956NN → SM in AC093879 (PubMed:15815621).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035606685G → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055504687N → S. Corresponds to variant dbSNP:rs29372EnsemblClinVar.1
Natural variantiVAR_0356071267G → R in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0229341458E → G in LQT4; unknown pathological significance; abnormal calcium ion homeostasis, when tested in a heterologous system. 3 PublicationsCorresponds to variant dbSNP:rs72544141EnsemblClinVar.1
Natural variantiVAR_0811351555V → D1 Publication1
Natural variantiVAR_0555052369V → A. Corresponds to variant dbSNP:rs28377576EnsemblClinVar.1
Natural variantiVAR_0356083653T → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0229353740L → I in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs35530544EnsemblClinVar.1
Natural variantiVAR_0229363744T → N in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs121912705EnsemblClinVar.1
Natural variantiVAR_0229373906R → W in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs121912706EnsemblClinVar.1
Natural variantiVAR_0229383931E → K in LQT4; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs45454496EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0370571 – 1348Missing in isoform 5. 1 PublicationAdd BLAST1348
Alternative sequenceiVSP_0370581 – 27MMNED…RKRPK → MTTMLQ in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037059967G → GRASPCLERDNSS in isoform 4. 1 Publication1
Alternative sequenceiVSP_0002681477 – 3561Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST2085
Alternative sequenceiVSP_0370603870K → KELTEELGELEASSDEEAMV TTRVVRRRVIIQ in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56957 mRNA Translation: CAA40278.1
X56958 mRNA Translation: CAA40279.2
Z26634 mRNA Translation: CAB42644.1 Sequence problems.
BX537758 mRNA Translation: CAD97827.1
AC004057 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
BC125235 mRNA Translation: AAI25236.1
BC125236 mRNA Translation: AAI25237.1 Frameshift.
M37123 Genomic DNA Translation: AAA62828.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3702.1 [Q01484-4]
CCDS43261.1 [Q01484-2]
CCDS54796.1 [Q01484-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
S37431

NCBI Reference Sequences

More...
RefSeqi
NP_001120965.1, NM_001127493.1 [Q01484-5]
NP_001139.3, NM_001148.4 [Q01484-4]
NP_066187.2, NM_020977.3 [Q01484-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.620557

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357077; ENSP00000349588; ENSG00000145362 [Q01484-4]
ENST00000394537; ENSP00000378044; ENSG00000145362 [Q01484-2]
ENST00000506722; ENSP00000421067; ENSG00000145362 [Q01484-5]
ENST00000510275; ENSP00000421023; ENSG00000145362 [Q01484-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:287

UCSC genome browser

More...
UCSCi
uc003ibd.5 human [Q01484-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ankyrin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56957 mRNA Translation: CAA40278.1
X56958 mRNA Translation: CAA40279.2
Z26634 mRNA Translation: CAB42644.1 Sequence problems.
BX537758 mRNA Translation: CAD97827.1
AC004057 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
BC125235 mRNA Translation: AAI25236.1
BC125236 mRNA Translation: AAI25237.1 Frameshift.
M37123 Genomic DNA Translation: AAA62828.1
CCDSiCCDS3702.1 [Q01484-4]
CCDS43261.1 [Q01484-2]
CCDS54796.1 [Q01484-5]
PIRiS37431
RefSeqiNP_001120965.1, NM_001127493.1 [Q01484-5]
NP_001139.3, NM_001148.4 [Q01484-4]
NP_066187.2, NM_020977.3 [Q01484-2]
UniGeneiHs.620557

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8OX-ray2.20A966-1039[»]
A1073-1476[»]
A3562-3653[»]
4RLVX-ray3.49A28-873[»]
4RLYX-ray2.50A28-318[»]
5Y4DX-ray3.30A28-693[»]
5Y4EX-ray2.34A/B264-483[»]
A/B857-896[»]
5Y4FX-ray1.95A/B430-873[»]
5YIRX-ray2.75C/G/H1588-1614[»]
5YISX-ray2.20C/D1588-1614[»]
ProteinModelPortaliQ01484
SMRiQ01484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106784, 22 interactors
DIPiDIP-37425N
IntActiQ01484, 28 interactors
STRINGi9606.ENSP00000349588

Protein family/group databases

TCDBi8.A.28.1.1 the ankyrin (ankyrin) family

PTM databases

iPTMnetiQ01484
PhosphoSitePlusiQ01484
SwissPalmiQ01484

Polymorphism and mutation databases

BioMutaiANK2
DMDMi387912917

Proteomic databases

EPDiQ01484
jPOSTiQ01484
MaxQBiQ01484
PaxDbiQ01484
PeptideAtlasiQ01484
PRIDEiQ01484
ProteomicsDBi57958
57959 [Q01484-2]
57960 [Q01484-5]
57961 [Q01484-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357077; ENSP00000349588; ENSG00000145362 [Q01484-4]
ENST00000394537; ENSP00000378044; ENSG00000145362 [Q01484-2]
ENST00000506722; ENSP00000421067; ENSG00000145362 [Q01484-5]
ENST00000510275; ENSP00000421023; ENSG00000145362 [Q01484-7]
GeneIDi287
KEGGihsa:287
UCSCiuc003ibd.5 human [Q01484-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
287
DisGeNETi287
EuPathDBiHostDB:ENSG00000145362.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANK2
GeneReviewsiANK2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0164018
HGNCiHGNC:493 ANK2
HPAiCAB015178
HPA008007
HPA035970
MalaCardsiANK2
MIMi106410 gene
600919 phenotype
neXtProtiNX_Q01484
OpenTargetsiENSG00000145362
Orphaneti101016 Romano-Ward syndrome
PharmGKBiPA24799

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155279
HOGENOMiHOG000169277
HOVERGENiHBG100442
InParanoidiQ01484
KOiK10380
OrthoDBi1011028at2759
PhylomeDBiQ01484
TreeFamiTF351263

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANK2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
287

Protein Ontology

More...
PROi
PR:Q01484

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145362 Expressed in 231 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ01484 baseline and differential
GenevisibleiQ01484 HS

Family and domain databases

CDDicd00204 ANK, 6 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01484
Secondary accession number(s): Q01485
, Q08AC7, Q08AC8, Q7Z3L5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 16, 2012
Last modified: February 13, 2019
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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