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UniProtKB - Q01466 (MREC_BACSU)
Protein
Cell shape-determining protein MreC
Gene
mreC
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in formation and maintenance of cell shape. Required for the formation of proper helical filaments of MreB and for cell wall synthesis in the cylindrical part of the cell leading to cell elongation.
2 PublicationsGO - Molecular functioni
- protein self-association Source: UniProtKB
GO - Biological processi
- peptidoglycan-based cell wall biogenesis Source: UniProtKB
- regulation of cell shape Source: UniProtKB
Keywordsi
Biological process | Cell shape |
Enzyme and pathway databases
BioCyci | BSUB:BSU28020-MONOMER |
Protein family/group databases
TCDBi | 9.B.157.1.1, the cell shape-determining mrebcd (mrebcd) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cell shape-determining protein MreCAlternative name(s): Cell shape protein MreC Rod shape-determining protein MreC |
Gene namesi | Name:mreC Ordered Locus Names:BSU28020 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cell septum
- Membrane raft 1 Publication
Note: Localizes in helical patterns when associated with the cell membrane (PubMed:15745453). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:22882210).2 Publications
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell septum Source: UniProtKB
- membrane raft Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Loss of viability. Cells lacking sufficient quantities of this protein undergo morphological changes, namely, swelling and twisting of the cells followed by cell lysis. A polymeric material accumulates at one side of the division septum of the cells and the presence of this material correlates with the bending of the cell. After prolonged depletion in the presence of MgCl2, the cells become very short and fat and eventually spheroidal, but no significant lysis is observed. Addition of sucrose results in rounded cells. Cells are still capable of making division septa. Null mutants show little or no sign of a defined long axis and have a severe shape defect.4 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 229 – 230 | TS → AA: No effect on cell shape or cell viability. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000062766 | 24 – 290 | Cell shape-determining protein MreCAdd BLAST | 267 |
Proteomic databases
PaxDbi | Q01466 |
Interactioni
Subunit structurei
Self-associates.
Interacts with MreD and proteins that belong to class A and class B high-molecular-weight penicillin-binding proteins (PBP2b, PBP1, PBP2a, PBP3, PBP4, PBP2c, PBP2d, PBPH and PBP4b).
1 PublicationGO - Molecular functioni
- protein self-association Source: UniProtKB
Protein-protein interaction databases
IntActi | Q01466, 10 interactors |
STRINGi | 224308.BSU28020 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 58 – 111 | Sequence analysisAdd BLAST | 54 |
Sequence similaritiesi
Belongs to the MreC family.Curated
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | COG1792, Bacteria |
InParanoidi | Q01466 |
OMAi | RDMTVLN |
PhylomeDBi | Q01466 |
Family and domain databases
Gene3Di | 2.40.10.340, 1 hit 2.40.10.350, 1 hit |
InterProi | View protein in InterPro IPR042177, Cell/Rod_1 IPR042175, Cell/Rod_MreC_2 IPR007221, MreC |
PANTHERi | PTHR34138, PTHR34138, 1 hit |
Pfami | View protein in Pfam PF04085, MreC, 1 hit |
PIRSFi | PIRSF038471, MreC, 1 hit |
TIGRFAMsi | TIGR00219, mreC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q01466-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNKRLMLLL LCIIILVAMI GFSLKGGRNT TWPEKVIGDT TGVFQNIFHT
60 70 80 90 100
PAEFFAGIFE NINDLKNTYK ENERLREKLD GQTQYEAKLQ ELEEENKSLR
110 120 130 140 150
DELGHVKSIK DYKPILATVI ARSPDNWAKQ VTINKGTQQN VAKDMAVTNE
160 170 180 190 200
KGALIGKIKS SGLNNFTSAV QLLSDTDRNN RVATKISGKK GSKGYGLIEG
210 220 230 240 250
YDKEKKRLKM TIIERKDKQD VKKGDLIETS GTGGVFPEGL TIGEVTDIES
260 270 280 290
DSYGLTKVAY VKPAADLTDL NNVIVVNRDV PTVDTEEEGS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 | K → F in AAA22398 (PubMed:1400225).Curated | 1 | |
Sequence conflicti | 176 | T → P in AAA22398 (PubMed:1400225).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96343 Genomic DNA Translation: AAA22398.1 M95582 Genomic DNA Translation: AAA22606.1 AL009126 Genomic DNA Translation: CAB14762.2 |
PIRi | C45240 E69660 |
RefSeqi | NP_390680.2, NC_000964.3 WP_009967915.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14762; CAB14762; BSU_28020 |
GeneIDi | 937498 |
KEGGi | bsu:BSU28020 |
PATRICi | fig|224308.179.peg.3044 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96343 Genomic DNA Translation: AAA22398.1 M95582 Genomic DNA Translation: AAA22606.1 AL009126 Genomic DNA Translation: CAB14762.2 |
PIRi | C45240 E69660 |
RefSeqi | NP_390680.2, NC_000964.3 WP_009967915.1, NZ_JNCM01000036.1 |
3D structure databases
BMRBi | Q01466 |
SMRi | Q01466 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q01466, 10 interactors |
STRINGi | 224308.BSU28020 |
Protein family/group databases
TCDBi | 9.B.157.1.1, the cell shape-determining mrebcd (mrebcd) family |
Proteomic databases
PaxDbi | Q01466 |
Genome annotation databases
EnsemblBacteriai | CAB14762; CAB14762; BSU_28020 |
GeneIDi | 937498 |
KEGGi | bsu:BSU28020 |
PATRICi | fig|224308.179.peg.3044 |
Phylogenomic databases
eggNOGi | COG1792, Bacteria |
InParanoidi | Q01466 |
OMAi | RDMTVLN |
PhylomeDBi | Q01466 |
Enzyme and pathway databases
BioCyci | BSUB:BSU28020-MONOMER |
Family and domain databases
Gene3Di | 2.40.10.340, 1 hit 2.40.10.350, 1 hit |
InterProi | View protein in InterPro IPR042177, Cell/Rod_1 IPR042175, Cell/Rod_MreC_2 IPR007221, MreC |
PANTHERi | PTHR34138, PTHR34138, 1 hit |
Pfami | View protein in Pfam PF04085, MreC, 1 hit |
PIRSFi | PIRSF038471, MreC, 1 hit |
TIGRFAMsi | TIGR00219, mreC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MREC_BACSU | |
Accessioni | Q01466Primary (citable) accession number: Q01466 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | July 7, 2009 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families