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Protein

Di-N-acetylchitobiase

Gene

Ctbs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • chitinase activity Source: RGD
  • chitin binding Source: GO_Central
  • hydrolase activity, acting on glycosyl bonds Source: RGD

GO - Biological processi

  • chitin catabolic process Source: RGD
  • oligosaccharide catabolic process Source: RGD

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Di-N-acetylchitobiase (EC:3.2.1.-)
Gene namesi
Name:Ctbs
Synonyms:Ctb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621338 Ctbs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001196324 – 367Di-N-acetylchitobiaseAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01460
PRIDEiQ01460

Expressioni

Gene expression databases

BgeeiENSRNOG00000015573
GenevisibleiQ01460 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020972

Structurei

3D structure databases

ProteinModelPortaliQ01460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMSI Eukaryota
COG3858 LUCA
GeneTreeiENSGT00390000012891
HOGENOMiHOG000007829
HOVERGENiHBG005486
InParanoidiQ01460
KOiK12310
OMAiANCLDYS
OrthoDBiEOG091G0CA1
PhylomeDBiQ01460
TreeFamiTF332677

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDLLELT LLLLLPLLER LSAEDCPCSE ASLCRPIRHH RDFEVFVFDV
60 70 80 90 100
GQKTWKSYDW SQITTVAVFG KYDSELMCYA HSKGARVVLK GDVALKDIIN
110 120 130 140 150
PTFRASWIAQ KVALAKAQHM DGINIDIEQE VDCSSPEYEA LTALVRETTE
160 170 180 190 200
GFHREIEGSQ VTFDVAWSPK GIDKRCYNYT GIADACDFLF VMSYDEQSQI
210 220 230 240 250
WSECIAAANA PYNQTLTGYG DYLRMGISPR KLVMGIPWYG YDYICLNLSK
260 270 280 290 300
DDVCAIAKVP FRGAPCSDAA GHQVPYRVIM KQVNSSVSGS QWNQDQQAPY
310 320 330 340 350
YNYKDPTGRL HQVWYDNPRS ISLKAAFVKH YGLRGIGMWN ANCLDYSDDA
360
LAREQTEEMW GALRPRL
Length:367
Mass (Da):41,531
Last modified:July 1, 1993 - v1
Checksum:i29AB8BE4FC157C16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95768 mRNA Translation: AAA40924.1
BC088129 mRNA Translation: AAH88129.1
PIRiC44102
RefSeqiNP_112285.1, NM_031023.1
UniGeneiRn.11199

Genome annotation databases

EnsembliENSRNOT00000020972; ENSRNOP00000020972; ENSRNOG00000015573
GeneIDi81652
KEGGirno:81652

Similar proteinsi

Entry informationi

Entry nameiDIAC_RAT
AccessioniPrimary (citable) accession number: Q01460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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