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Protein

Di-N-acetylchitobiase

Gene

CTBS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei143Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Di-N-acetylchitobiase (EC:3.2.1.-)
Gene namesi
Name:CTBS
Synonyms:CTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117151.12
HGNCiHGNC:2496 CTBS
MIMi600873 gene
neXtProtiNX_Q01459

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1486
OpenTargetsiENSG00000117151
PharmGKBiPA26997

Polymorphism and mutation databases

BioMutaiCTBS
DMDMi399376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38By similarityAdd BLAST38
ChainiPRO_000001196139 – 385Di-N-acetylchitobiaseAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ01459
PaxDbiQ01459
PeptideAtlasiQ01459
PRIDEiQ01459
ProteomicsDBi57956

PTM databases

iPTMnetiQ01459
PhosphoSitePlusiQ01459

Expressioni

Gene expression databases

BgeeiENSG00000117151
CleanExiHS_CTBS
ExpressionAtlasiQ01459 baseline and differential
GenevisibleiQ01459 HS

Organism-specific databases

HPAiCAB017043
HPA023594
HPA048810

Interactioni

Protein-protein interaction databases

BioGridi107868, 5 interactors
IntActiQ01459, 3 interactors
STRINGi9606.ENSP00000359664

Structurei

3D structure databases

ProteinModelPortaliQ01459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMSI Eukaryota
COG3858 LUCA
GeneTreeiENSGT00390000012891
HOGENOMiHOG000007829
HOVERGENiHBG005486
InParanoidiQ01459
KOiK12310
OMAiANCLDYS
OrthoDBiEOG091G0CA1
PhylomeDBiQ01459
TreeFamiTF332677

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPQLRRWR LVSSPPSGVP GLALLALLAL LALRLAAGTD CPCPEPELCR
60 70 80 90 100
PIRHHPDFEV FVFDVGQKTW KSYDWSQITT VATFGKYDSE LMCYAHSKGA
110 120 130 140 150
RVVLKGDVSL KDIIDPAFRA SWIAQKLNLA KTQYMDGINI DIEQEVNCLS
160 170 180 190 200
PEYDALTALV KETTDSFHRE IEGSQVTFDV AWSPKNIDRR CYNYTGIADA
210 220 230 240 250
CDFLFVMSYD EQSQIWSECI AAANAPYNQT LTGYNDYIKM SINPKKLVMG
260 270 280 290 300
VPWYGYDYTC LNLSEDHVCT IAKVPFRGAP CSDAAGRQVP YKTIMKQINS
310 320 330 340 350
SISGNLWDKD QRAPYYNYKD PAGHFHQVWY DNPQSISLKA TYIQNYRLRG
360 370 380
IGMWNANCLD YSGDAVAKQQ TEEMWEVLKP KLLQR
Length:385
Mass (Da):43,760
Last modified:July 1, 1993 - v1
Checksum:i0A9D14C8B26B52EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049197274V → I. Corresponds to variant dbSNP:rs15911Ensembl.1
Natural variantiVAR_020160310D → Y. Corresponds to variant dbSNP:rs3768249Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95767 mRNA Translation: AAA35684.1
AF085706
, AF085700, AF085701, AF085702, AF085703, AF085704, AF085705 Genomic DNA Translation: AAC35852.1
AL359762 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73232.1
CH471097 Genomic DNA Translation: EAW73233.1
BC126333 mRNA Translation: AAI26334.1
BC126335 mRNA Translation: AAI26336.1
CCDSiCCDS698.1
PIRiA44102
RefSeqiNP_004379.1, NM_004388.2
UniGeneiHs.513557

Genome annotation databases

EnsembliENST00000370630; ENSP00000359664; ENSG00000117151
GeneIDi1486
KEGGihsa:1486
UCSCiuc001dka.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDIAC_HUMAN
AccessioniPrimary (citable) accession number: Q01459
Secondary accession number(s): Q5VX50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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