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Protein

N-acetylgalactosamine kinase

Gene

GALK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.1 Publication

Catalytic activityi

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Transition state stabilizerBy similarity1
Active sitei190Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 149ATP1 PublicationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • galactose metabolic process Source: InterPro

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.157 2681

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine kinase (EC:2.7.1.157)
Alternative name(s):
GalNAc kinase
Galactokinase 2
Gene namesi
Name:GALK2
Synonyms:GK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000156958.14
HGNCiHGNC:4119 GALK2
MIMi137028 gene
neXtProtiNX_Q01415

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156958
PharmGKBiPA28534

Polymorphism and mutation databases

DMDMi399518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846471 – 458N-acetylgalactosamine kinaseAdd BLAST458

Proteomic databases

EPDiQ01415
MaxQBiQ01415
PaxDbiQ01415
PeptideAtlasiQ01415
PRIDEiQ01415
ProteomicsDBi57943
57944 [Q01415-2]

PTM databases

iPTMnetiQ01415
PhosphoSitePlusiQ01415

Expressioni

Gene expression databases

BgeeiENSG00000156958
CleanExiHS_GALK2
ExpressionAtlasiQ01415 baseline and differential
GenevisibleiQ01415 HS

Organism-specific databases

HPAiHPA043564
HPA048267

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi108858, 15 interactors
STRINGi9606.ENSP00000453129

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Helixi13 – 15Combined sources3
Helixi17 – 30Combined sources14
Beta strandi35 – 47Combined sources13
Helixi52 – 54Combined sources3
Beta strandi58 – 73Combined sources16
Beta strandi75 – 77Combined sources3
Beta strandi79 – 85Combined sources7
Beta strandi91 – 93Combined sources3
Beta strandi102 – 104Combined sources3
Helixi107 – 121Combined sources15
Beta strandi130 – 136Combined sources7
Beta strandi142 – 144Combined sources3
Helixi146 – 162Combined sources17
Helixi168 – 179Combined sources12
Helixi180 – 182Combined sources3
Helixi189 – 196Combined sources8
Beta strandi201 – 206Combined sources6
Turni207 – 210Combined sources4
Beta strandi211 – 215Combined sources5
Beta strandi221 – 227Combined sources7
Helixi234 – 236Combined sources3
Helixi239 – 257Combined sources19
Turni262 – 264Combined sources3
Helixi268 – 275Combined sources8
Helixi279 – 289Combined sources11
Helixi297 – 304Combined sources8
Helixi308 – 314Combined sources7
Helixi318 – 320Combined sources3
Helixi328 – 351Combined sources24
Helixi356 – 373Combined sources18
Helixi380 – 391Combined sources12
Beta strandi395 – 399Combined sources5
Beta strandi404 – 413Combined sources10
Helixi414 – 416Combined sources3
Helixi417 – 429Combined sources13
Beta strandi442 – 446Combined sources5
Beta strandi453 – 457Combined sources5

3D structure databases

ProteinModelPortaliQ01415
SMRiQ01415
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01415

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 52Substrate binding4
Regioni187 – 190Substrate binding4

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.Curated

Phylogenomic databases

eggNOGiKOG0631 Eukaryota
COG0153 LUCA
GeneTreeiENSGT00530000063433
HOGENOMiHOG000241099
HOVERGENiHBG051696
InParanoidiQ01415
KOiK18674
OMAiYECSHPD
OrthoDBiEOG091G09BP
PhylomeDBiQ01415
TreeFamiTF324235

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000705 Galactokinase
IPR019741 Galactokinase_CS
IPR019539 GalKase_gal-bd
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF10509 GalKase_gal_bdg, 1 hit
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000530 Galactokinase, 1 hit
PRINTSiPR00473 GALCTOKINASE
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 2 hits
TIGRFAMsiTIGR00131 gal_kin, 1 hit
PROSITEiView protein in PROSITE
PS00106 GALACTOKINASE, 1 hit
PS00627 GHMP_KINASES_ATP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01415-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATESPATRR VQVAEHPRLL KLKEMFNSKF GSIPKFYVRA PGRVNIIGEH
60 70 80 90 100
IDYCGYSVLP MAVEQDVLIA VEPVKTYALQ LANTNPLYPD FSTSANNIQI
110 120 130 140 150
DKTKPLWHNY FLCGLKGIQE HFGLSNLTGM NCLVDGNIPP SSGLSSSSAL
160 170 180 190 200
VCCAGLVTLT VLGRNLSKVE LAEICAKSER YIGTEGGGMD QSISFLAEEG
210 220 230 240 250
TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF NIRVMECRLA
260 270 280 290 300
AKLLAKYKSL QWDKVLRLEE VQAKLGISLE EMLLVTEDAL HPEPYNPEEI
310 320 330 340 350
CRCLGISLEE LRTQILSPNT QDVLIFKLYQ RAKHVYSEAA RVLQFKKICE
360 370 380 390 400
EAPENMVQLL GELMNQSHMS CRDMYECSCP ELDQLVDICR KFGAQGSRLT
410 420 430 440 450
GAGWGGCTVS MVPADKLPSF LANVHKAYYQ RSDGSLAPEK QSLFATKPGG

GALVLLEA
Length:458
Mass (Da):50,378
Last modified:July 1, 1993 - v1
Checksum:i192B774938F32947
GO
Isoform 2 (identifier: Q01415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MATESPATRRVQVAEHP → MPVLYD

Show »
Length:447
Mass (Da):49,235
Checksum:i66D4925D605D1A4F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049123182I → V. Corresponds to variant dbSNP:rs35507772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428971 – 17MATES…VAEHP → MPVLYD in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84443 mRNA Translation: AAA58612.1
AF461816 mRNA Translation: AAP97708.1
BT006901 mRNA Translation: AAP35547.1
AC013452 Genomic DNA No translation available.
AC022306 Genomic DNA No translation available.
AC036102 Genomic DNA No translation available.
BC005141 mRNA Translation: AAH05141.1
CCDSiCCDS32236.1 [Q01415-2]
CCDS42034.1 [Q01415-1]
PIRiA46366
RefSeqiNP_001001556.1, NM_001001556.2 [Q01415-2]
NP_002035.1, NM_002044.3 [Q01415-1]
UniGeneiHs.122006
Hs.738080
Hs.738534

Genome annotation databases

EnsembliENST00000327171; ENSP00000316632; ENSG00000156958 [Q01415-2]
ENST00000560031; ENSP00000453129; ENSG00000156958 [Q01415-1]
GeneIDi2585
KEGGihsa:2585
UCSCiuc001zxi.3 human [Q01415-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGALK2_HUMAN
AccessioniPrimary (citable) accession number: Q01415
Secondary accession number(s): Q7Z4Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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