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Protein

Protein transport protein Sec23A

Gene

Sec23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (By similarity). Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (PubMed:27354378).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cargo loading into COPII-coated vesicle Source: UniProtKB
  • Golgi organization Source: GO_Central
  • intracellular protein transport Source: MGI
  • macroautophagy Source: GO_Central
  • protein localization to plasma membrane Source: UniProtKB
  • regulation of cell shape Source: GO_Central
  • regulation of COPII vesicle coating Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-5694530 Cargo concentration in the ER
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23ACurated
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:Sec23aImported
Synonyms:Sec23, Sec23r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1349635 Sec23a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002051472 – 765Protein transport protein Sec23AAdd BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei308PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01405
MaxQBiQ01405
PaxDbiQ01405
PeptideAtlasiQ01405
PRIDEiQ01405

PTM databases

iPTMnetiQ01405
PhosphoSitePlusiQ01405
SwissPalmiQ01405

Expressioni

Tissue specificityi

High levels in brain and fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000020986 Expressed in 310 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_SEC23A
ExpressionAtlasiQ01405 baseline and differential
GenevisibleiQ01405 MM

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SEC23IP (PubMed:10400679). Interacts with HTR4 (PubMed:15466885). Interacts with SEC16A (PubMed:17428803). Interacts with SLC6A4 (PubMed:17452640). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles and allows the transport of this cargo from the endoplasmic reticulum to the Golgi. Interacts (via Gelsolin-like repeat) with CTAGE5 and MIA3; specifically involved in the transport of large cargos like the collagen COL7A1 (By similarity). Interacts with DDHD1 (PubMed:17428803).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SAR1AQ9NR312EBI-775901,EBI-3920694From Homo sapiens.

Protein-protein interaction databases

BioGridi203150, 8 interactors
DIPiDIP-32032N
IntActiQ01405, 13 interactors
MINTiQ01405
STRINGi10090.ENSMUSP00000021375

Structurei

3D structure databases

ProteinModelPortaliQ01405
SMRiQ01405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati632 – 718Gelsolin-likeSequence analysisAdd BLAST87

Domaini

The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs that include CTAGE5, MIA3 but also SEC31A. These interactions are probably competitive.By similarity

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG055039
InParanoidiQ01405
KOiK14006
OMAiDNFSIYP
OrthoDBiEOG091G063R
PhylomeDBiQ01405
TreeFamiTF300693

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISELNQPAEL LPQFSSIEYV VLRGPQMPLI FLYVVDTCIE DEDLQALKES
160 170 180 190 200
MQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLSAKQL
210 220 230 240 250
QEMLGLSKVP VTQATRGPQV QQPPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDIHGQFKM
410 420 430 440 450
GFGGTLEIKT SREIKISGAI GPCVSLNSKG PCVSENEIGT GGTCQWKICG
460 470 480 490 500
LSPTTTLAIY FEVVNQHNAP IPQGGRGAVQ FVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGEY HKDDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM
660 670 680 690 700
DTFFQILIYH GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,162
Last modified:January 10, 2003 - v2
Checksum:iC0FD4C2C1578B6A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1S3E9Q1S3_MOUSE
Protein transport protein SEC23
Sec23a
736Annotation score:

Sequence cautioni

The sequence BAA02209 differs from that shown. Reason: Frameshift at positions 88, 94, 110, 113, 116, 182, 184, 226, 279, 292, 296, 321, 352, 425, 452 and 567.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81 – 83KLW → TR in BAA02209 (PubMed:8417978).Curated3
Sequence conflicti91 – 92RN → D in BAA02209 (PubMed:8417978).Curated2
Sequence conflicti99A → S in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti108A → R in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti115 – 117SSI → QS in BAA02209 (PubMed:8417978).Curated3
Sequence conflicti129L → F in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti153 – 157MSLSL → TTFS in BAA02209 (PubMed:8417978).Curated5
Sequence conflicti172M → I in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti216 – 217RG → S in BAA02209 (PubMed:8417978).Curated2
Sequence conflicti263S → P in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti293P → S in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti310I → M in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti515A → R in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti523A → P in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti631P → R in BAA02209 (PubMed:8417978).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082671 mRNA Translation: AAL92480.1
BC034610 mRNA Translation: AAH34610.1
D12713 Genomic DNA Translation: BAA02209.1 Frameshift.
CCDSiCCDS25931.1
PIRiS28142 I60247
RefSeqiNP_033173.2, NM_009147.2
XP_006515691.1, XM_006515628.3
UniGeneiMm.491137

Genome annotation databases

EnsembliENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986
GeneIDi20334
KEGGimmu:20334
UCSCiuc007npw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082671 mRNA Translation: AAL92480.1
BC034610 mRNA Translation: AAH34610.1
D12713 Genomic DNA Translation: BAA02209.1 Frameshift.
CCDSiCCDS25931.1
PIRiS28142 I60247
RefSeqiNP_033173.2, NM_009147.2
XP_006515691.1, XM_006515628.3
UniGeneiMm.491137

3D structure databases

ProteinModelPortaliQ01405
SMRiQ01405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203150, 8 interactors
DIPiDIP-32032N
IntActiQ01405, 13 interactors
MINTiQ01405
STRINGi10090.ENSMUSP00000021375

PTM databases

iPTMnetiQ01405
PhosphoSitePlusiQ01405
SwissPalmiQ01405

Proteomic databases

EPDiQ01405
MaxQBiQ01405
PaxDbiQ01405
PeptideAtlasiQ01405
PRIDEiQ01405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986
GeneIDi20334
KEGGimmu:20334
UCSCiuc007npw.1 mouse

Organism-specific databases

CTDi10484
MGIiMGI:1349635 Sec23a

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG055039
InParanoidiQ01405
KOiK14006
OMAiDNFSIYP
OrthoDBiEOG091G063R
PhylomeDBiQ01405
TreeFamiTF300693

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-5694530 Cargo concentration in the ER
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

PROiPR:Q01405
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020986 Expressed in 310 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_SEC23A
ExpressionAtlasiQ01405 baseline and differential
GenevisibleiQ01405 MM

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC23A_MOUSE
AccessioniPrimary (citable) accession number: Q01405
Secondary accession number(s): Q8JZL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2003
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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