Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

GO - Molecular functioni

GO - Biological processi

  • Fc-epsilon receptor signaling pathway Source: Reactome
  • immune response Source: UniProtKB
  • inflammatory response Source: InterPro

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
SignaLinkiQ01362
SIGNORiQ01362

Protein family/group databases

TCDBi1.A.37.3.2 the cd20 ca(2+) channel (cd20) family

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:MS4A2
Synonyms:APY, FCER1B, IGER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149534.8
HGNCiHGNC:7316 MS4A2
MIMi147138 gene
neXtProtiNX_Q01362

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 79HelicalSequence analysisAdd BLAST20
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 117HelicalSequence analysisAdd BLAST20
Topological domaini118 – 130CytoplasmicSequence analysisAdd BLAST13
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Topological domaini151 – 180ExtracellularSequence analysisAdd BLAST30
Transmembranei181 – 200HelicalSequence analysisAdd BLAST20
Topological domaini201 – 244CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2206
MalaCardsiMS4A2
OpenTargetsiENSG00000149534
PharmGKBiPA31109

Chemistry databases

DrugBankiDB00043 Omalizumab

Polymorphism and mutation databases

BioMutaiMS4A2
DMDMi232084

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586291 – 244High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphotyrosineBy similarity1
Modified residuei225PhosphotyrosineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei229PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ01362
PeptideAtlasiQ01362
PRIDEiQ01362
ProteomicsDBi57942

PTM databases

iPTMnetiQ01362
PhosphoSitePlusiQ01362

Expressioni

Tissue specificityi

Found on the surface of mast cells and basophils.

Gene expression databases

BgeeiENSG00000149534 Expressed in 100 organ(s), highest expression level in fundus of stomach
CleanExiHS_MS4A2
ExpressionAtlasiQ01362 baseline and differential
GenevisibleiQ01362 HS

Organism-specific databases

HPAiHPA059967

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).By similarity

Protein-protein interaction databases

BioGridi108500, 4 interactors
IntActiQ01362, 1 interactor
STRINGi9606.ENSP00000278888

Structurei

3D structure databases

ProteinModelPortaliQ01362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28C Eukaryota
ENOG4111DU9 LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000060211
HOVERGENiHBG051600
InParanoidiQ01362
KOiK08090
OMAiNKVPDDR
OrthoDBiEOG091G0IBB
PhylomeDBiQ01362
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW
60 70 80 90 100
LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY
110 120 130 140 150
PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII
160 170 180 190 200
NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT
210 220 230 240
ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL
Length:244
Mass (Da):26,534
Last modified:April 1, 1993 - v1
Checksum:iCE523102D5F567AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2E9A0A0B4J2E9_HUMAN
High affinity immunoglobulin epsilo...
MS4A2
199Annotation score:
E9PLJ1E9PLJ1_HUMAN
High affinity immunoglobulin epsilo...
MS4A2
41Annotation score:

Polymorphismi

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia (PubMed:8817330).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053515143T → M. Corresponds to variant dbSNP:rs35033981Ensembl.1
Natural variantiVAR_053516211N → K. Corresponds to variant dbSNP:rs535630Ensembl.1
Natural variantiVAR_003965237E → G Polymorphism; risk factor for atopic dermatitis and asthma. 2 PublicationsCorresponds to variant dbSNP:rs569108EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA Translation: BAA01440.1
M89796 Genomic DNA Translation: AAA60269.1
AB080913 Genomic DNA Translation: BAC66486.1
BC074800 mRNA Translation: AAH74800.1
BC074843 mRNA Translation: AAH74843.1
CCDSiCCDS7980.1
PIRiA42806
RefSeqiNP_000130.1, NM_000139.4
XP_011543152.1, XM_011544850.2
UniGeneiHs.386748

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534
GeneIDi2206
KEGGihsa:2206
UCSCiuc001nop.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA Translation: BAA01440.1
M89796 Genomic DNA Translation: AAA60269.1
AB080913 Genomic DNA Translation: BAC66486.1
BC074800 mRNA Translation: AAH74800.1
BC074843 mRNA Translation: AAH74843.1
CCDSiCCDS7980.1
PIRiA42806
RefSeqiNP_000130.1, NM_000139.4
XP_011543152.1, XM_011544850.2
UniGeneiHs.386748

3D structure databases

ProteinModelPortaliQ01362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108500, 4 interactors
IntActiQ01362, 1 interactor
STRINGi9606.ENSP00000278888

Chemistry databases

DrugBankiDB00043 Omalizumab

Protein family/group databases

TCDBi1.A.37.3.2 the cd20 ca(2+) channel (cd20) family

PTM databases

iPTMnetiQ01362
PhosphoSitePlusiQ01362

Polymorphism and mutation databases

BioMutaiMS4A2
DMDMi232084

Proteomic databases

PaxDbiQ01362
PeptideAtlasiQ01362
PRIDEiQ01362
ProteomicsDBi57942

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534
GeneIDi2206
KEGGihsa:2206
UCSCiuc001nop.4 human

Organism-specific databases

CTDi2206
DisGeNETi2206
EuPathDBiHostDB:ENSG00000149534.8
GeneCardsiMS4A2
HGNCiHGNC:7316 MS4A2
HPAiHPA059967
MalaCardsiMS4A2
MIMi147138 gene
neXtProtiNX_Q01362
OpenTargetsiENSG00000149534
PharmGKBiPA31109
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J28C Eukaryota
ENOG4111DU9 LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000060211
HOVERGENiHBG051600
InParanoidiQ01362
KOiK08090
OMAiNKVPDDR
OrthoDBiEOG091G0IBB
PhylomeDBiQ01362
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
SignaLinkiQ01362
SIGNORiQ01362

Miscellaneous databases

GeneWikiiMS4A2
GenomeRNAii2206
PROiPR:Q01362
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149534 Expressed in 100 organ(s), highest expression level in fundus of stomach
CleanExiHS_MS4A2
ExpressionAtlasiQ01362 baseline and differential
GenevisibleiQ01362 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCERB_HUMAN
AccessioniPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again