UniProtKB - Q01344 (IL5RA_HUMAN)
Protein
Interleukin-5 receptor subunit alpha
Gene
IL5RA
Organism
Homo sapiens (Human)
Status
Functioni
This is the receptor for interleukin-5. The alpha chain binds to IL5.
GO - Molecular functioni
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- interleukin-5 receptor activity Source: ProtInc
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- inflammatory response to antigenic stimulus Source: Ensembl
- MAPK cascade Source: Reactome
- positive regulation of leukocyte proliferation Source: GO_Central
- regulation of interleukin-5 production Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q01344 |
Reactomei | R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-912526, Interleukin receptor SHC signaling |
SignaLinki | Q01344 |
SIGNORi | Q01344 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-5 receptor subunit alphaShort name: IL-5 receptor subunit alpha Short name: IL-5R subunit alpha Short name: IL-5R-alpha Short name: IL-5RA Alternative name(s): CDw125 CD_antigen: CD125 |
Gene namesi | Name:IL5RA Synonyms:IL5R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000091181.19 |
HGNCi | HGNC:6017, IL5RA |
MIMi | 147851, gene |
neXtProti | NX_Q01344 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: ProtInc
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: ProtInc
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 342 | ExtracellularSequence analysisAdd BLAST | 322 | |
Transmembranei | 343 – 362 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 363 – 420 | CytoplasmicSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3568 |
OpenTargetsi | ENSG00000091181 |
PharmGKBi | PA29834 |
Miscellaneous databases
Pharosi | Q01344, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3580483 |
DrugBanki | DB12023, Benralizumab |
DrugCentrali | Q01344 |
GuidetoPHARMACOLOGYi | 1706 |
Polymorphism and mutation databases
BioMutai | IL5RA |
DMDMi | 116242525 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000010893 | 21 – 420 | Interleukin-5 receptor subunit alphaAdd BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 134 ↔ 155 | 1 Publication | ||
Disulfide bondi | 182 ↔ 196 | 1 Publication | ||
Glycosylationi | 216 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 244 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 269 ↔ 316 | 1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q01344 |
MaxQBi | Q01344 |
PaxDbi | Q01344 |
PeptideAtlasi | Q01344 |
PRIDEi | Q01344 |
ProteomicsDBi | 3479 57939 [Q01344-1] 57940 [Q01344-2] 57941 [Q01344-3] 5815 |
PTM databases
GlyGeni | Q01344, 4 sites |
iPTMneti | Q01344 |
PhosphoSitePlusi | Q01344 |
Expressioni
Tissue specificityi
Expressed on eosinophils and basophils.
Gene expression databases
Bgeei | ENSG00000091181, Expressed in right uterine tube and 108 other tissues |
ExpressionAtlasi | Q01344, baseline and differential |
Genevisiblei | Q01344, HS |
Organism-specific databases
HPAi | ENSG00000091181, Tissue enhanced (blood, fallopian tube) |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
Interacts with SDCBP.
2 PublicationsBinary interactionsi
Hide detailsQ01344
With | #Exp. | IntAct |
---|---|---|
CSF2RB [P32927] | 3 | EBI-1759442,EBI-1809771 |
IL5 [P05113] | 2 | EBI-1759442,EBI-2435811 |
JAK2 [O60674] | 2 | EBI-1759442,EBI-518647 |
Isoform 2 [Q01344-2]
With | #Exp. | IntAct |
---|---|---|
IL5 [P05113] | 4 | EBI-15957545,EBI-2435811 |
GO - Molecular functioni
- cytokine binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109782, 17 interactors |
DIPi | DIP-3510N |
ELMi | Q01344 |
IntActi | Q01344, 5 interactors |
STRINGi | 9606.ENSP00000412209 |
Miscellaneous databases
RNActi | Q01344, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q01344 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01344 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 123 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 241 – 334 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 94 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 322 – 326 | WSXWS motif | 5 | |
Motifi | 371 – 379 | Box 1 motif | 9 |
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QZNV, Eukaryota |
GeneTreei | ENSGT00940000160890 |
HOGENOMi | CLU_039945_0_0_1 |
InParanoidi | Q01344 |
OMAi | HAIDQVN |
OrthoDBi | 1151666at2759 |
PhylomeDBi | Q01344 |
TreeFami | TF331549 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR003532, Short_hematopoietin_rcpt_2_CS IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF09240, IL6Ra-bind, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01356, HEMATOPO_REC_S_F2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q01344-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW
60 70 80 90 100
KPNPDQEQRN VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT
110 120 130 140 150
ILQNDHSLLA SSWASAELHA PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ
160 170 180 190 200
VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE ECQEYSKDTL GRNIACWFPR
210 220 230 240 250
TFILSKGRDW LAVLVNGSSK HSAIRPFDQL FALHAIDQIN PPLNVTAEIE
260 270 280 290 300
GTRLSIQWEK PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD
310 320 330 340 350
LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGNDEHKPLR EWFVIVIMAT
360 370 380 390 400
ICFILLILSL ICKICHLWIK LFPPIPAPKS NIKDLFVTTN YEKAGSSETE
410 420
IEVICYIEKP GVETLEDSVF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ERY4 | E7ERY4_HUMAN | Interleukin-5 receptor subunit alph... | IL5RA | 325 | Annotation score: | ||
C9J6C4 | C9J6C4_HUMAN | Interleukin-5 receptor subunit alph... | IL5RA | 196 | Annotation score: | ||
C9J3K8 | C9J3K8_HUMAN | Interleukin-5 receptor subunit alph... | IL5RA | 109 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | A → S in AAA36110 (PubMed:1833065).Curated | 1 | |
Sequence conflicti | 212 | A → S in AAA59151 (PubMed:1732409).Curated | 1 | |
Sequence conflicti | 212 | A → S in AAA59152 (PubMed:1732409).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020654 | 129 | I → V2 PublicationsCorresponds to variant dbSNP:rs2290610Ensembl. | 1 | |
Natural variantiVAR_020655 | 262 | V → A1 PublicationCorresponds to variant dbSNP:rs17879690Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047762 | 123 – 331 | Missing in isoform 5. 1 PublicationAdd BLAST | 209 | |
Alternative sequenceiVSP_001678 | 333 – 335 | NDE → FSR in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_001680 | 333 | N → K in isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_001681 | 334 – 420 | Missing in isoform 3. 2 PublicationsAdd BLAST | 87 | |
Alternative sequenceiVSP_001679 | 336 – 420 | Missing in isoform 2. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_046742 | 365 – 420 | CHLWI…EDSVF → KLGPVRRKLKSSVI in isoform 4. 1 PublicationAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75914 mRNA Translation: AAA36110.1 X61176 mRNA Translation: CAA43483.1 X62156 mRNA Translation: CAA44081.1 M96651 mRNA Translation: AAA59151.1 M96652 mRNA Translation: AAA59152.1 AB288090 mRNA Translation: BAG49562.1 AK304256 mRNA Translation: BAG65122.1 AY642135 Genomic DNA Translation: AAT45457.1 AC022002 Genomic DNA No translation available. AC024060 Genomic DNA No translation available. |
CCDSi | CCDS2559.1 [Q01344-1] CCDS2560.1 [Q01344-2] CCDS46739.1 [Q01344-3] CCDS58813.1 [Q01344-4] |
PIRi | A40267 |
RefSeqi | NP_000555.2, NM_000564.4 [Q01344-1] NP_001230028.1, NM_001243099.1 [Q01344-4] NP_783851.1, NM_175724.2 [Q01344-3] NP_783852.1, NM_175725.2 [Q01344-2] NP_783853.1, NM_175726.3 [Q01344-1] NP_783854.1, NM_175727.2 [Q01344-3] NP_783855.1, NM_175728.2 [Q01344-2] |
Genome annotation databases
Ensembli | ENST00000256452; ENSP00000256452; ENSG00000091181 [Q01344-1] ENST00000311981; ENSP00000309196; ENSG00000091181 [Q01344-2] ENST00000383846; ENSP00000373358; ENSG00000091181 [Q01344-2] ENST00000430514; ENSP00000400400; ENSG00000091181 [Q01344-3] ENST00000438560; ENSP00000390753; ENSG00000091181 [Q01344-4] ENST00000446632; ENSP00000412209; ENSG00000091181 [Q01344-1] ENST00000456302; ENSP00000392059; ENSG00000091181 [Q01344-3] |
GeneIDi | 3568 |
KEGGi | hsa:3568 |
UCSCi | uc010hbs.4, human [Q01344-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75914 mRNA Translation: AAA36110.1 X61176 mRNA Translation: CAA43483.1 X62156 mRNA Translation: CAA44081.1 M96651 mRNA Translation: AAA59151.1 M96652 mRNA Translation: AAA59152.1 AB288090 mRNA Translation: BAG49562.1 AK304256 mRNA Translation: BAG65122.1 AY642135 Genomic DNA Translation: AAT45457.1 AC022002 Genomic DNA No translation available. AC024060 Genomic DNA No translation available. |
CCDSi | CCDS2559.1 [Q01344-1] CCDS2560.1 [Q01344-2] CCDS46739.1 [Q01344-3] CCDS58813.1 [Q01344-4] |
PIRi | A40267 |
RefSeqi | NP_000555.2, NM_000564.4 [Q01344-1] NP_001230028.1, NM_001243099.1 [Q01344-4] NP_783851.1, NM_175724.2 [Q01344-3] NP_783852.1, NM_175725.2 [Q01344-2] NP_783853.1, NM_175726.3 [Q01344-1] NP_783854.1, NM_175727.2 [Q01344-3] NP_783855.1, NM_175728.2 [Q01344-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OBX | X-ray | 1.35 | B | 413-420 | [»] | |
1OBZ | X-ray | 1.69 | P | 413-420 | [»] | |
3QT2 | X-ray | 2.55 | A/B | 20-335 | [»] | |
3VA2 | X-ray | 2.70 | C | 21-335 | [»] | |
6H41 | X-ray | 2.75 | A | 27-332 | [»] | |
SMRi | Q01344 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109782, 17 interactors |
DIPi | DIP-3510N |
ELMi | Q01344 |
IntActi | Q01344, 5 interactors |
STRINGi | 9606.ENSP00000412209 |
Chemistry databases
ChEMBLi | CHEMBL3580483 |
DrugBanki | DB12023, Benralizumab |
DrugCentrali | Q01344 |
GuidetoPHARMACOLOGYi | 1706 |
PTM databases
GlyGeni | Q01344, 4 sites |
iPTMneti | Q01344 |
PhosphoSitePlusi | Q01344 |
Polymorphism and mutation databases
BioMutai | IL5RA |
DMDMi | 116242525 |
Proteomic databases
MassIVEi | Q01344 |
MaxQBi | Q01344 |
PaxDbi | Q01344 |
PeptideAtlasi | Q01344 |
PRIDEi | Q01344 |
ProteomicsDBi | 3479 57939 [Q01344-1] 57940 [Q01344-2] 57941 [Q01344-3] 5815 |
Protocols and materials databases
ABCDi | Q01344, 1 sequenced antibody |
Antibodypediai | 2274, 383 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 3568 |
DisGeNETi | 3568 |
EuPathDBi | HostDB:ENSG00000091181.19 |
GeneCardsi | IL5RA |
HGNCi | HGNC:6017, IL5RA |
HPAi | ENSG00000091181, Tissue enhanced (blood, fallopian tube) |
MIMi | 147851, gene |
neXtProti | NX_Q01344 |
OpenTargetsi | ENSG00000091181 |
PharmGKBi | PA29834 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QZNV, Eukaryota |
GeneTreei | ENSGT00940000160890 |
HOGENOMi | CLU_039945_0_0_1 |
InParanoidi | Q01344 |
OMAi | HAIDQVN |
OrthoDBi | 1151666at2759 |
PhylomeDBi | Q01344 |
TreeFami | TF331549 |
Enzyme and pathway databases
PathwayCommonsi | Q01344 |
Reactomei | R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-912526, Interleukin receptor SHC signaling |
SignaLinki | Q01344 |
SIGNORi | Q01344 |
Miscellaneous databases
BioGRID-ORCSi | 3568, 2 hits in 841 CRISPR screens |
ChiTaRSi | IL5RA, human |
EvolutionaryTracei | Q01344 |
GeneWikii | Interleukin_5_receptor_alpha_subunit |
GenomeRNAii | 3568 |
Pharosi | Q01344, Tclin |
PROi | PR:Q01344 |
RNActi | Q01344, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091181, Expressed in right uterine tube and 108 other tissues |
ExpressionAtlasi | Q01344, baseline and differential |
Genevisiblei | Q01344, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR003532, Short_hematopoietin_rcpt_2_CS IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF09240, IL6Ra-bind, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01356, HEMATOPO_REC_S_F2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL5RA_HUMAN | |
Accessioni | Q01344Primary (citable) accession number: Q01344 Secondary accession number(s): B3IU77 Q6ISX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries