Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 125 (02 Jun 2021)
Sequence version 2 (09 May 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Ankyrin repeat protein nuc-2

Gene

nuc-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls phosphorus acquisition.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat protein nuc-2
Alternative name(s):
Nuclease 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nuc-2
ORF Names:B23G1.010, NCU01847, NCU11426
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Linkage Group II, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU11426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000670641 – 1066Ankyrin repeat protein nuc-2Add BLAST1066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01317

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 166SPXPROSITE-ProRule annotationAdd BLAST166
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati268 – 298ANK 1Add BLAST31
Repeati336 – 366ANK 2Add BLAST31
Repeati370 – 399ANK 3Add BLAST30
Repeati403 – 432ANK 4Add BLAST30
Repeati435 – 465ANK 5Add BLAST31
Repeati470 – 499ANK 6Add BLAST30
Repeati503 – 532ANK 7Add BLAST30
Domaini717 – 1048GP-PDEAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni923 – 963DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi941 – 963Basic and acidic residuesSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002842_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR030395, GP_PDE_dom
IPR001995, Peptidase_A2_cat
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 3 hits
PF03009, GDPD, 1 hit
PF03105, SPX, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGKQIQKR QLEVPEYAAS FVNYKALKKL IKKLSATPIL PPQTDLRRAP
60 70 80 90 100
GEPLDTQSAL QANKATFFFQ IDRELDKVNA CYVQKEAELK IRLKTLLDKK
110 120 130 140 150
KALRSRSGGT SRRSTKFTTL QEGFQQFVND LNKLQQFVEI NGTAFSKILK
160 170 180 190 200
KWDKTAKSKT KELYLSRVVE KRPAFNPTVI SELSDQATTS LQELGAWADG
210 220 230 240 250
DNVSFETRPD HDHVVSTQHL LGTDEGDADT LLLDTVLSGN IDSLKDMLDR
260 270 280 290 300
MKATAAPDGS ADVSLAERVT RTFLASINEG SLEALKVLLD TGLVDIQSWD
310 320 330 340 350
DINERNCLHQ AAIYGNSFVL EYGLSKGVDA ERTDAYGRVP LHYASMHGRL
360 370 380 390 400
DMIDALLNAS PKTINLIDHD NFTPLVHSIV RNHLECVGRL LERSARIDPV
410 420 430 440 450
SDTDHVPLNL ACQHGSVAIV ELLLKHGAKI LADAEGLYPQ HLVARSGQTP
460 470 480 490 500
EILVLLKQYG ADLDQIDKLY GWTPLVHAAS EGNVPCLQAL LETGADPNIL
510 520 530 540 550
DEKDLPAMYY AAWEGHLECM KLLTPAKKEK AASELPPIHI GGALPPMASS
560 570 580 590 600
TAPMPMSLDA IDPIPALELP PPIIPLRRYG HNFLDTKTVV QISFEEDSEQ
610 620 630 640 650
PLLFFQDGKY PAARLTISSK SSDLIPKNII LPFQEDTRVA SFQIDNLESF
660 670 680 690 700
TLDFEVFPTY GAKVIAKTVA LPNIFRALLS SSGKCCLPLF DPRLRAIGQI
710 720 730 740 750
SFHVQIIKPF SGTPLEITDF ETYWKATSQF DTNTSTFVTG SSLSGDFVQI
760 770 780 790 800
YVQHTKDGVP VLWPRWTINC GGIDVPVSTL TLAQFQTVTA AARNRINLSE
810 820 830 840 850
LSTYTLDQIA DVHRILANIG ITLHEALFLL PKGMHVNIQV LYPTADEKAE
860 870 880 890 900
AKSSTAADDV NEFADAILSV VFDHARAQRA ERPDSVRSVV FSSYNPTLCT
910 920 930 940 950
ALNWKQPNFP VFLCNDMGRE DRKQQQQGSC SKGDGDEDMG GTTAASRREA
960 970 980 990 1000
ADERTLQSDG RRTSSIKDVV RTATSNNLMG LICCSRLLDM VPALVDAIKS
1010 1020 1030 1040 1050
HGLALVVDKS GEPEAANSKD SGDKQLGISG ALGGLAGSDP FPKLPKGVDG
1060
LLKSNGVLRF NEYIDV
Length:1,066
Mass (Da):117,115
Last modified:May 9, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E189EA92FB62B75
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EDO64869 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti857A → V in AAB03277 (PubMed:8917314).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51118 Genomic DNA Translation: AAB03277.1
BX284754 Genomic DNA Translation: CAD70463.1
CM002237 Genomic DNA Translation: EDO64869.2 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
S72479

NCBI Reference Sequences

More...
RefSeqi
XP_001727960.2, XM_001727908.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EDO64869; EDO64869; NCU11426

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5846981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU11426

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51118 Genomic DNA Translation: AAB03277.1
BX284754 Genomic DNA Translation: CAD70463.1
CM002237 Genomic DNA Translation: EDO64869.2 Sequence problems.
PIRiS72479
RefSeqiXP_001727960.2, XM_001727908.2

3D structure databases

SMRiQ01317
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiEDO64869; EDO64869; NCU11426
GeneIDi5846981
KEGGincr:NCU11426

Organism-specific databases

VEuPathDBiFungiDB:NCU11426

Phylogenomic databases

HOGENOMiCLU_002842_1_0_1
InParanoidiQ01317

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR030395, GP_PDE_dom
IPR001995, Peptidase_A2_cat
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom
PfamiView protein in Pfam
PF12796, Ank_2, 3 hits
PF03009, GDPD, 1 hit
PF03105, SPX, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 9 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUC2_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01317
Secondary accession number(s): A7UXH8, Q7RW36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 9, 2003
Last modified: June 2, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again