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Entry version 181 (12 Aug 2020)
Sequence version 2 (21 Feb 2001)
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Protein

Broad-complex core protein isoforms 1/2/3/4/5

Gene

br

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri636 – 659C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri666 – 689C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q01295

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Broad-complex core protein isoforms 1/2/3/4/5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:br
Synonyms:Br-C
ORF Names:CG11491
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283451, br

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470691 – 727Broad-complex core protein isoforms 1/2/3/4/5Add BLAST727

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q01295

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms Z1 accumulate slowly in mid instar larvae salivary glands at beginning of ecdysone response (94-114 hours of development at puff stage 1) and become the predominant isoform after 6 hours. Levels diminish at puff stage 2 and are moderately abundant in late larvae from stages 3-10. In prepupae, transcripts appear at puff stage 15 onwards, reaching maximum at stages 18-20. In gut, levels remain constant between stages 1-11. In Malpighian tubules, Z1 isoforms are seen at stages 3 and 7, but not at stage 11. In fat body and wing disks, low levels increase between stages 3 and 11. Isoform Z2 accumulates to a high level at the beginning of the ecdysone response during puff stage 1 and abruptly disappears after several hours. In prepupae, transcripts are reinduced at low levels. Low levels are seen in the Malpighian Tubules, gut and fat body between stages 1-11 and high levels in the wing disk. Isoform Z3; in mid instar larval salivary gland transcript accumulates to a high level at the beginning of the ecdysone response, 94-98 hours of development in puff stage 1, and abruptly disappears after several hours. Levels increase by puff stage 3 remaining abundant in late larvae until stage 10, then diminish by stage 11. In prepupae, transcripts are abundant and increase during puff stages 11-14 and 18-20. High levels are seen in Malpighian tubules, gut and fat body between stages 1-11 and low levels in wing disk.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Primary response to 20-hydroxyecdysone in third instar larval imaginal disks.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000210, Expressed in wing disc (Drosophila) and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01295, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01295, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
69091, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q01295, 10 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01295

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 97BTBPROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi203 – 207Poly-Ala5
Compositional biasi265 – 268Poly-Asn4
Compositional biasi439 – 444Poly-Thr6
Compositional biasi451 – 460Poly-Asn10
Compositional biasi479 – 490Poly-ThrAdd BLAST12
Compositional biasi533 – 543Poly-GlnAdd BLAST11
Compositional biasi546 – 558Poly-GlnAdd BLAST13
Compositional biasi565 – 568Poly-Gln4
Compositional biasi596 – 603Poly-Ala8
Compositional biasi714 – 720Poly-Gln7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri636 – 659C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri666 – 689C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GDHENSS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651, BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01295-1) [UniParc]FASTAAdd to basket
Also known as: BRCORE-TNT1-Q1-Z1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDTQHFCLR WNNYQSSITS AFENLRDDEA FVDVTLACEG RSIKAHRVVL
60 70 80 90 100
SACSPYFREL LKSTPCKHPV ILLQDVNFMD LHALVEFIYH GEVNVHQKSL
110 120 130 140 150
QSFLKTAEVL RVSGLTQQQA EDTHSHLAQI QNLANSGGRT PLNTHTQSLP
160 170 180 190 200
HPHHGSLHDD GGSSTLFSRQ GAGSPPPTAV PSLPSHINNQ LLKRMAMMHR
210 220 230 240 250
SSAAAAAEET SHAFKRLRGS DNSLPLSGAV GSGSNNNSPD LPPLHARSAS
260 270 280 290 300
PQQTPADFST IKHHNNNNTP PLKEEKRNGP TGNGNSGNGN GNGNGASNGN
310 320 330 340 350
GISISDKLGS LTPSPLARAG ADDVKSEPMD MVCSNNNANA NDEHSNDSTG
360 370 380 390 400
EHDANRSSSG DGGKGSLSSG NDEEIGDGLA SHHAAPQFIM SPAENKMFHA
410 420 430 440 450
AAFNFPNIDP SALLGLNTQL QQSGDLAVSP QGKLTTNATT TTTTINNSIT
460 470 480 490 500
NNNNNNNNNN YDYSLPTKNS NSQKTPSPTT TTLTTPTTTT PTRPTAITSA
510 520 530 540 550
SGICGLNLST FAANGSSSGG SNGGLSMTAL LPQQQQQQQQ QHQMSQQQQQ
560 570 580 590 600
QQQQQQQQGN SSSGQQQQPN GILACSTPKA NTPTTTQQQM YAAVMAAAAS
610 620 630 640 650
ASASTSGSAN SSLNNSNSTL NTSGGLNNSA SGGDDFRCNP CNKNLSSLTR
660 670 680 690 700
LKRHIQNVHM RPTKEPVCNI CKRVYSSLNS LRNHKSIYHR NLKQPKQEPG
710 720
VGATQAAANS FYHQQHQQQQ LNHHSSS
Length:727
Mass (Da):77,393
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97BBA20F3BD734D6
GO
Isoform 2 (identifier: Q01295-2) [UniParc]FASTAAdd to basket
Also known as: BRCORE-Q1-Z1

The sequence of this isoform differs from the canonical sequence as follows:
     432-495: Missing.

Show »
Length:663
Mass (Da):70,534
Checksum:iA91201DDCE557FD6
GO
Isoform 3 (identifier: Q01295-3) [UniParc]FASTAAdd to basket
Also known as: BRCORE-Q2-Z1

The sequence of this isoform differs from the canonical sequence as follows:
     432-478: Missing.

Show »
Length:680
Mass (Da):72,308
Checksum:i3D10B493DA14A9CD
GO
Isoform 4 (identifier: Q01295-4) [UniParc]FASTAAdd to basket
Also known as: BRCORE-Z2

The sequence of this isoform differs from the canonical sequence as follows:
     433-514: KLTTNATTTT...GLNLSTFAAN → NSPKKLFSCQ...KLYNQFNSSI
     515-727: Missing.

Show »
Length:514
Mass (Da):55,459
Checksum:i78160AB1B326CDD7
GO
Isoform 5 (identifier: Q01295-5) [UniParc]FASTAAdd to basket
Also known as: BRCORE-NS-Z3

The sequence of this isoform differs from the canonical sequence as follows:
     433-727: KLTTNATTTT...QQQLNHHSSS → PHSITRSAAT...ELGQPPPGIQ

Show »
Length:702
Mass (Da):74,145
Checksum:iB1A40D785201B832
GO
Isoform 6 (identifier: Q24206-1) [UniParc]FASTAAdd to basket
Also known as: BRCORE-Z4
The sequence of this isoform can be found in the external entry Q24206.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:880
Mass (Da):92,305
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D8FT05D8FT05_DROME
Broad, isoform O
br 2B5, 2Bc, A18, BR, Br
663Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W572Q9W572_DROME
Broad, isoform C
br 2B5, 2Bc, A18, BR, Br
880Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJB2E1JJB2_DROME
Broad, isoform P
br 2B5, 2Bc, A18, BR, Br
1,011Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IRX4Q8IRX4_DROME
Broad, isoform J
br 2B5, 2Bc, A18, BR, Br
514Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MSM6M9MSM6_DROME
Broad, isoform M
br 2B5, 2Bc, A18, BR, Br
724Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6H2EEH5A0A6H2EEH5_DROME
Broad, isoform R
br 2B5, 2Bc, A18, BR, Br
644Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA15629 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230V → L in CAA38477 (PubMed:1743483).Curated1
Sequence conflicti230V → L in CAA38474 (PubMed:1743483).Curated1
Sequence conflicti230V → L in CAA38475 (PubMed:1743483).Curated1
Sequence conflicti457 – 459Missing (PubMed:10731132).Curated3
Sequence conflicti460N → NN in CAA38477 (PubMed:1743483).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006836432 – 495Missing in isoform 2. CuratedAdd BLAST64
Alternative sequenceiVSP_006835432 – 478Missing in isoform 3. CuratedAdd BLAST47
Alternative sequenceiVSP_006839433 – 727KLTTN…HHSSS → PHSITRSAATSPTSSTSSPP SPPTALISPTSSLKGSLAAA VYSLHSHAHGHVLGHATSPP RPGSVGSSVGSNLCTSTSMG CGVNSGNNSGNNNGNNANNN SNNGNATNNNNNSSSSSTSP GSQATAAGGTVTQAGTPPLP LRMPPPTSGGINEPQECPYC RRTFSCYYSLKRHFQDKHEQ SDTLYVCEFCHRRYRTKNSL TTHKSLQHRGSSGMLKRLLK TTAIKHGLVGHGHGHGHVHH PHAHHHALSHPRTSLYDFTS ELGQPPPGIQ in isoform 5. CuratedAdd BLAST295
Alternative sequenceiVSP_006837433 – 514KLTTN…TFAAN → NSPKKLFSCQLCGKLLCSKA SLKRHIADKHAVRQEEYRCA ICERVYCSRNSLMTHIYTYH KSRPGEMEMKDIKLYNQFNS SI in isoform 4. CuratedAdd BLAST82
Alternative sequenceiVSP_006838515 – 727Missing in isoform 4. CuratedAdd BLAST213

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54666 mRNA Translation: CAA38477.1
X54665 mRNA Translation: CAA38476.1
X54663 mRNA Translation: CAA38474.1
X54664 mRNA Translation: CAA38475.1
AE014298 Genomic DNA Translation: AAF45648.1
AE014298 Genomic DNA Translation: AAF45651.2
AE014298 Genomic DNA Translation: AAN09054.1
AL009146 Genomic DNA Translation: CAA15629.1 Sequence problems.
AL009146 Genomic DNA Translation: CAA15626.1
AL009146 Genomic DNA Translation: CAA15628.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S21912
S21913
S21914

NCBI Reference Sequences

More...
RefSeqi
NP_001188525.1, NM_001201596.3 [Q01295-4]
NP_001188526.1, NM_001201597.1
NP_001188527.1, NM_001201598.1
NP_001245462.1, NM_001258533.1 [Q01295-2]
NP_524759.2, NM_080020.4
NP_726749.2, NM_166893.2 [Q01295-4]
NP_726750.1, NM_166894.4 [Q01295-5]
NP_726754.1, NM_166898.2 [Q01295-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070265; FBpp0070255; FBgn0283451 [Q01295-5]
FBtr0070266; FBpp0070256; FBgn0283451 [Q01295-2]
FBtr0300429; FBpp0289658; FBgn0283451 [Q01295-4]
FBtr0303562; FBpp0292595; FBgn0283451 [Q01295-4]
FBtr0308319; FBpp0300638; FBgn0283451 [Q01295-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44505

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54666 mRNA Translation: CAA38477.1
X54665 mRNA Translation: CAA38476.1
X54663 mRNA Translation: CAA38474.1
X54664 mRNA Translation: CAA38475.1
AE014298 Genomic DNA Translation: AAF45648.1
AE014298 Genomic DNA Translation: AAF45651.2
AE014298 Genomic DNA Translation: AAN09054.1
AL009146 Genomic DNA Translation: CAA15629.1 Sequence problems.
AL009146 Genomic DNA Translation: CAA15626.1
AL009146 Genomic DNA Translation: CAA15628.1
PIRiS21912
S21913
S21914
RefSeqiNP_001188525.1, NM_001201596.3 [Q01295-4]
NP_001188526.1, NM_001201597.1
NP_001188527.1, NM_001201598.1
NP_001245462.1, NM_001258533.1 [Q01295-2]
NP_524759.2, NM_080020.4
NP_726749.2, NM_166893.2 [Q01295-4]
NP_726750.1, NM_166894.4 [Q01295-5]
NP_726754.1, NM_166898.2 [Q01295-2]

3D structure databases

SMRiQ01295
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69091, 31 interactors
IntActiQ01295, 10 interactors

Proteomic databases

PRIDEiQ01295

Genome annotation databases

EnsemblMetazoaiFBtr0070265; FBpp0070255; FBgn0283451 [Q01295-5]
FBtr0070266; FBpp0070256; FBgn0283451 [Q01295-2]
FBtr0300429; FBpp0289658; FBgn0283451 [Q01295-4]
FBtr0303562; FBpp0292595; FBgn0283451 [Q01295-4]
FBtr0308319; FBpp0300638; FBgn0283451 [Q01295-2]
GeneIDi44505

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
103946
FlyBaseiFBgn0283451, br

Phylogenomic databases

OMAiGDHENSS

Enzyme and pathway databases

SignaLinkiQ01295

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
44505, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
br, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
44505

Gene expression databases

BgeeiFBgn0000210, Expressed in wing disc (Drosophila) and 27 other tissues
ExpressionAtlasiQ01295, baseline and differential
GenevisibleiQ01295, DM

Family and domain databases

InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 2 hits
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRC1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01295
Secondary accession number(s): O46065
, O46066, Q01293, Q01296, Q9W571, Q9W574
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 21, 2001
Last modified: August 12, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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