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Entry version 147 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

V-type proton ATPase subunit a

Gene

vph-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase subunit a
Short name:
V-ATPase a subunit
Alternative name(s):
Vacuolar ATPase 98 kDa subunit
Vacuolar proton pump a subunit
Vacuolar proton translocating ATPase subunit a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vph-1
Synonyms:vph1
ORF Names:B8J24.100, NCU03463
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Linkage Group II, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU03463

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 409CytoplasmicSequence analysisAdd BLAST409
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei410 – 428HelicalSequence analysisAdd BLAST19
Topological domaini429 – 430VacuolarSequence analysis2
Transmembranei431 – 447HelicalSequence analysisAdd BLAST17
Topological domaini448 – 460CytoplasmicSequence analysisAdd BLAST13
Transmembranei461 – 490HelicalSequence analysisAdd BLAST30
Topological domaini491 – 544VacuolarSequence analysisAdd BLAST54
Transmembranei545 – 564HelicalSequence analysisAdd BLAST20
Topological domaini565 – 582CytoplasmicSequence analysisAdd BLAST18
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 648VacuolarSequence analysisAdd BLAST45
Transmembranei649 – 668HelicalSequence analysisAdd BLAST20
Topological domaini669 – 738CytoplasmicSequence analysisAdd BLAST70
Transmembranei739 – 763HelicalSequence analysisAdd BLAST25
Topological domaini764 – 784VacuolarSequence analysisAdd BLAST21
Transmembranei785 – 823HelicalSequence analysisAdd BLAST39
Topological domaini824 – 856CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001192221 – 856V-type proton ATPase subunit aAdd BLAST856

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q01290

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni689 – 710DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005230_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01290

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIYMFLQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka

The PANTHER Classification System

More...
PANTHERi
PTHR11629, PTHR11629, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01496, V_ATPase_I, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001293, ATP6V0A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01290-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKQDTPFR SADMSMVQLY ISNEIGREVC NALGELGLVH FRDLNSELSA
60 70 80 90 100
FQRAFTQDIR RLDNVERQLR YFHSQMEKAG IPLRKFDPDV DILTPPTTTE
110 120 130 140 150
IDELAERAQT LEQRVSSLNE SYETLKKREV ELTEWRWVLR EAGGFFDRAH
160 170 180 190 200
GNVEEIRAST DNDDAPLLQD VEQHNTAADV ERSFSGMNIG FVAGVIGRDR
210 220 230 240 250
VDAFERILWR TLRGNLYMNQ AEIPEPLIDP TINEPVLKNV FVIFAHGKEI
260 270 280 290 300
LAKIRRISES MGAEVYNVDE HSDLRRDQVH EVNARLEDVQ NVLRNTQQTL
310 320 330 340 350
EAELAQISQS LSAWMITISK EKAVYNTLNL FSYDRARRTL IAEGWCPTND
360 370 380 390 400
LPLIRSTLQD VNNRAGLSVP SIINEIRTNK TPPTYLKTNK FTEAFQTIVN
410 420 430 440 450
AYGTATYQEV NPAIPVIVTF PFLFAVMFGD FGHALIMLCA ALAMIYWEKP
460 470 480 490 500
LKKVTFELFA MVFYGRYIVL VMAVFSVYTG LIYNDVFSKS MTLFDSQWKW
510 520 530 540 550
VVPENFKEGM TVKAVLREPN GYRYPFGLDW RWHGTENELL FINSYKMKMA
560 570 580 590 600
IILGWAHMTY SLCFSYINAR HFKRPIDIWG NFVPGMIFFQ SIFGYLVLCI
610 620 630 640 650
IYKWSVDWFG TGRQPPGLLN MLIYMFLQPG TLDGGVELYP GQATVQVILL
660 670 680 690 700
LLAVIQVPIL LFLKPFYLRW ENNRARAKGY RGIGERSRVS ALDEDDEEDP
710 720 730 740 750
SNGDDYEGAA MLTHDEHGDG EHEEFEFGEV MIHQVIHTIE FCLNSVSHTA
760 770 780 790 800
SYLRLWALSL AHQQLSAVLW SMTMAKALES KGLGGAIFLV VAFAMFFVLS
810 820 830 840 850
VIILIIMEGV SAMLHSLRLA WVESFSKFAE FGGWPFTPFS FKQQLEESEE

LKEYIG
Length:856
Mass (Da):97,992
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF75E3737A7DA3DE8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U36396 Genomic DNA Translation: AAA93078.1
AL669990 Genomic DNA Translation: CAD21112.1
CM002237 Genomic DNA Translation: EAA26818.1

NCBI Reference Sequences

More...
RefSeqi
XP_956054.1, XM_950961.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA26818; EAA26818; NCU03463

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3872192

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU03463

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36396 Genomic DNA Translation: AAA93078.1
AL669990 Genomic DNA Translation: CAD21112.1
CM002237 Genomic DNA Translation: EAA26818.1
RefSeqiXP_956054.1, XM_950961.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ01290

Genome annotation databases

EnsemblFungiiEAA26818; EAA26818; NCU03463
GeneIDi3872192
KEGGincr:NCU03463

Organism-specific databases

VEuPathDBiFungiDB:NCU03463

Phylogenomic databases

HOGENOMiCLU_005230_0_0_1
InParanoidiQ01290
OMAiLIYMFLQ

Family and domain databases

InterProiView protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629, PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496, V_ATPase_I, 1 hit
PIRSFiPIRSF001293, ATP6V0A1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPH1_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01290
Secondary accession number(s): Q7RV48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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